Simultaneous densitometric determination of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in some commercial gingers

Journal of Liquid Chromatography and Related Technologies

Volumn 32, Issue 4, 2009, Pages 567-577

  Melianita, Fenny ^a   Witha, Josephine ^a   Arifin, Saiful ^a   Kartinasari, Wiwin Farina ^b   Indrayanto, Gunawan ^b,c  

^a PT Natura Laboratoria Prima   (Indonesia)

^b Bernofarm Pharmaceutical Company   (Indonesia)

^c AIRLANGGA UNIVERSITY   (Indonesia)

Author keywords

10 Gingerol; 6 Gingerol; 6 Shogaol; 8 Gingerol; Densitometry; Ginger; HPTLC; Zingiber officinale

Indexed keywords

DRUG PRODUCTS; ESTERS; EXTRACTION; FOOD ADDITIVES; METHANOL; QUALITY ASSURANCE; QUALITY FUNCTION DEPLOYMENT; TOLUENE; TOTAL QUALITY MANAGEMENT;

10-GINGEROL; 6-GINGEROL; 6-SHOGAOL; 8-GINGEROL; DENSITOMETRY; GINGER; HPTLC; ZINGIBER OFFICINALE;

QUALITY CONTROL;

10 GINGEROL; 6 GINGEROL; 6 SHOGAOL; 8 GINGEROL; ACETIC ACID ETHYL ESTER; GINGER EXTRACT; METHANOL; TOLUENE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; DENSITOMETRY; GINGER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; THIN LAYER CHROMATOGRAPHY; VALIDATION STUDY;

ZINGIBER OFFICINALE;

EID: 61749091667     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070802671598     Document Type: Article

References (21)

1. Materia Medika Indonesia Jilid II Indonesian Herbal Drugs Vol. 2; Derektorat Jendral Pengawas Obat dan Makanan, Jakarta, Indonesia, 1978, 113-121.
2. Mukherjee, P. Quality Control of Herbal Drugs, Business Horizons: New Delhi, India, 288-289, 767-769.
3. British Pharmacopoeia 2003, Volume 1; The Stationary Office: London, 2003; 866-867.
4. The Japanese Pharmacopoeia, 14th Ed.; English Version, Society of Japanese Pharmacopoeia: Tokyo, 2001; 927.
5. Pharmacopoeia of the People's Republic of China, Volume 1; English Edition, Chemical Industry Press: Beijing, China, 1997; 205-206.
6. Wang, W.H.; Wang, Z.M.; Xu, L.Z.; Yang, S.L. HPLC determination of 6-gingerol in rhizoma Zingiberis recens. Zhongguo Zhong Yao Za Zhi. 2002, 27 (5), 348-349.
7. Wohlmuth, H.; Leach, D.N.; Smith, M.K.; Myers, S.P. Gingerol content of diploid and tetraploid clones of ginger (Zingiber officinale Roscoe). J. Agric. Food Chem. 2005, 53 (14), 5772-5778.
8. Smith, R.M. Analysis of the pungent principles of ginger and grains of paradise by high-performance liquid chromatography using electrochemical detection. Chromatographia. 1982, 16 (1), 155-157.
9. Wood, A.B. Determination of the pungent principles of chillies and ginger by reversed-phase high-performance liquid chromatography with use of a single standard substance. 1987, 2 (1), 1-12.
10. Schwertner, H.A.; Rios, D.C.; Pascoe, J. Variation in concentration and labeling of ginger root dietary supplements, Obstet. Gynecol. 2006, 107 (6), 1337-1343.
11. Yoshikawa, M.; Hatakeyama, S.; Chatani, N.; Nishino, Y.; Yamahara, J. Qualitative and quantitative analysis of bioactive principles in Zingiberis Rhizoma by means of high performance liquid chromatography and gas liquid chromatography. On the evaluation of Zingiberis Rhizoma and chemical change of constituents during Zingiberis Rhizoma processing. Yakugaku Zasshi. 1993, 113 (4), 307-315.
12. Conell, D.W.; Sutherland, M.D. A re-examination of gingerol, shogaol and zingerone, the pungent principle of ginger (Zingiber offinale Roescoe). Aus. J. Chem. 1969, 22 (5), 1033-1043.
13. Rai, S.; Mukherjee, K.; Mal, M.; Wahile, A.; Saha, B.P.; Mukherjee, P.K. Determination of 6-gingerol in ginger (Zingiber officinale) using high-performance thin-layer chromatography. J. Sep. Sci. 2006, 29 (15), 2292-2295.
14. Melianita, F.; Cholifah, S.; Sumarlik, E.; Kartinasari, W.F.; Indrayanto, G. Simultaneous densitometric dtermination of 6-gingerol and 6-shogaol in some commercial ginger (Zingiber officinale Roscoe). J. Liq. Chromatogr. & Rel. Technol. 2007, 2941-2951.
15. Lee, S.; Khoo, C.; Halstead, C.W.; Huynh, T.; Bensoussan, A. Liquid chromatographic determination of 6-, 8-, 10-gingerol and 6-shogaol in Ginger (Zingiber officinale) as the raw herb and dried aqueous exctract. J. AOAC Inter. 2007, 90, 1219-1226.
16. Anonim, Identification of Ginger, MOA010; Camag: Muttenz, 2006.
17. Funk, W.; Damman, V.; Donnervert, G. Qualitätssicherung in der Analytischen Chemie; VCH: Weinheim, New York, Basel, Cambridge, 1992; 12-36, 161-180.
18. Yuwono, M.; Indrayanto, G. Validation of Chromatographic Methods of Analysis, in Profiles of Drugs Substances, Excipients and Related Methodology, Brittain, H. Ed.; Vol. 32; Elsevier Academic Press: San Diego, New York, Boston, London, Sydney, Tokyo, Toronto, 2005; 243-258.
19. Carr, G.P.; Wahlich, J.C. A practical approach to method validation in pharmaceutical analysis. J. Pharm. Biomed. Anal. 1990, 8, 613-618.
20. Ferenczi-Fodor, K.; Vegh, Z.; Nagy-Turak, A.; Renger, B.; Zeller, M.J. Validation and quality assurance of planar chromatography procedures in pharmaceutical analysis. J. AOAC Inter. 2001, 84, 1265-1276.
21. Garofolo, F. BioAnalytical Method Validation, in Analytical Method Validation and Instrument Performance Verification; Wiley-Interscience: Hoboken, NJ, 2004, 105-138.