A model for functional recovery and cortical reintegration after hemifacial composite tissue allotransplantation

Plastic and Reconstructive Surgery

Volumn 123, Issue SUPPL.2S, 2009, Pages

  Lee, W P Andrew ^a   Washington, Kia M ^a   Solari, Mario G ^a   Sacks, Justin M ^a   Horibe, Elaine K ^a   Unadkat, Jignesh V ^a   Carvell, George E ^a   Simons, Daniel J ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPRENORPHINE; CYCLOSPORIN A;

ALLOTRANSPLANTATION; ANIMAL TISSUE; BRAIN CORTEX; BROWN NORWAY RAT; CONFERENCE PAPER; CONVALESCENCE; ELECTRIC ACTIVITY; ELECTROMYOGRAPHY; FACIAL TRANSPLANTATION; GRAFT VERSUS HOST REACTION; INTEGRATION; ISOGRAFT; MOTOR NERVE; MOTOR PERFORMANCE; NERVE CONDUCTION; NERVE STIMULATION; NONHUMAN; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RAT; SENSORY NERVE; SENSORY STIMULATION; SOMATOSENSORY CORTEX; TISSUE TRANSPLANTATION; VIBRISSA; ANIMAL; ANIMAL MODEL; ARTICLE; FACE; INNERVATION; METHODOLOGY; NERVE REGENERATION; PHYSIOLOGY; PLASTIC SURGERY;

ANIMALS; FACE; FACIAL TRANSPLANTATION; MODELS, ANIMAL; NERVE REGENERATION; RATS; RECOVERY OF FUNCTION; SOMATOSENSORY CORTEX; SURGICAL FLAPS; TRANSPLANTATION, HOMOLOGOUS; VIBRISSAE;

EID: 61749089889     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/PRS.0b013e318191bca2     Document Type: Conference Paper

References (29)

1. Gander B, Brown CS, Vasilic D, et al. Composite tissue allo-transplantation of the hand and face: A new frontier in transplant and reconstructive surgery. Transpl Int. 2006;19: 868-880.
2. Petit F, Minns AB, Dubernard JM, Hettiaratchy S, Lee WP. Composite tissue allotransplantation and reconstructive surgery: First clinical applications. Ann Surg. 2003;237:19-25.
3. Gordon CR, Nazzal J, Lozano-Calderan SA, et al. From experimental rat hindlimb to clinical face composite tissue allotransplantation: Historical background and current status. Microsurgery 2006;26:566-572.
4. Devauchelle B, Badet L, Lengele B, et al. First human face allograft: Early report. Lancet 2006;368:203-209.
5. Giraux P, Sirigu A, Schneider F, Dubernard JM. Cortical reorganization in motor cortex after graft of both hands. Nat Neurosci. 2001;4:691-692.
6. Farne A, Roy AC, Giraux P, Dubernard JM, Sirigu A. Face or hand, not both: Perceptual correlates of reafferentation in a former amputee. Curr Biol. 2002;12:1342-1346.
7. Brenneis C, Loscher WN, Egger KE, et al. Cortical motor activation patterns following hand transplantation and replantation. J Hand Surg. (Br.) 2005;30:530-533.
8. Lanzetta M, Pozzo M, Bottin A, Merletti R, Farina D. Reinnervation of motor units in intrinsic muscles of a transplanted hand. Neurosci Lett. 2005;373:138-143.
9. Abrams M, Widenfalk J. Emerging strategies to promote improved functional outcome after peripheral nerve injury. Restor Neurol Neurosci. 2005;23:367-382.
10. Landin L, Cavadas PC. The mystacial pad flap: A functional facial flap in rats. Ann Plast Surg. 2006;56:107-108.
11. Berg RW, Kleinfeld D. Rhythmic whisking by rat: Retraction as well as protraction of the vibrissae is under active muscular control. J Neurophysiol. 2003;89:104-117.
12. Dorfl J. The musculature of the mystacial vibrissae of the white mouse. J Anat. 1982;135:147-154.
13. Welker WI. Analysis of sniffing of the albino rat. Behaviour 1964;22:223-244.
14. Mattox DE, Felix H. Surgical anatomy of the rat facial nerve. Am J Otol. 1987;8:43-47.
15. Nichols CM, Myckatyn TM, Rickman SR, Fox IK, Hadlock T, Mackinnon SE. Choosing the correct functional assay: A comprehensive assessment of functional tests in the rat. Be-hav Brain Res. 2005;163:143-158.
16. Dorfl J. The innervation of the mystacial region of the white mouse: A topographical study. J Anat. 1985;142:173-184.
17. Woolsey TA, Van der Loos H. The structural organization of layer IV in the somatosensory region (SI) of mouse cerebral cortex: The description of a cortical field composed of discrete cytoarchitectonic units. Brain Res. 1970;17:205-242.
18. Fox K. Anatomical pathways and molecular mechanisms for plasticity in the barrel cortex. Neuroscience 2002;111:799-814.
19. Kossut M. Experience-dependent changes in function and anatomy of adult barrel cortex. Exp Brain Res. 1998;123:110-116.
20. Frostig RD. Functional organization and plasticity in the adult rat barrel cortex: Moving out-of-the-box. Curr Opin Neurobiol. 2006;16:445-450.
21. Bermudez L. Face transplant: Is it worth it? Plast Reconstr Surg. 2006;117:1891-1896.
22. Lanzetta M, Petruzzo P, Vitale G, et al. Human hand transplantation: What have we learned? Transplant Proc. 2004;36: 664-668.
23. Ulusal BG, Ulusal AE, Ozmen S, Zins JE, Siemionow MZ. A new composite facial and scalp transplantation model in rats. Plast Reconstr Surg. 2003;112:1302-1311.
24. Yazici I, Unal S, Siemionow M. Composite hemiface/calvaria transplantation model in rats. Plast Reconstr Surg. 2006;118: 1321-1327.
25. Hadlock TA, Heaton J, Cheney M, Mackinnon SE. Functional recovery after facial and sciatic nerve crush injury in the rat. Arch Facial Plast Surg. 2005;7:17-20.
26. Renehan WE, Munger BL. Degeneration and regeneration of peripheral nerve in the rat trigeminal system: II. Response to nerve lesions. J Comp Neurol. 1986;249:429-459.
27. Carvell GE, Simons DJ. Biometric analyses of vibrissal tactile discrimination in the rat. J Neurosci. 1990;10:2638-2648.
28. Wall JT, Kaas JH, Sur M, Nelson RJ, Felleman DJ, Merzenich MM. Functional reorganization in somatosensory cortical areas 3b and 1 of adult monkeys after median nerve repair: Possible relationships to sensory recovery in humans. J Neu-rosci. 1986;6:218-233.
29. Welker C. Microelectrode delineation of fine grain somato-topic organization of (SmI) cerebral neocortex in albino rat. Brain Res. 1971;26:259-275.