Spironolactone effective hypertension in the elderly due to 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) impairment: Contributory role of determining serum cortisol/cortisone ratio as a marker of 11β-HSD2 activity

Internal Medicine

Volumn 47, Issue 24, 2008, Pages 2157-2164

  Inada, Mitsuo ^a   Iwasaki, Keiko ^a   Imai, Chihiro ^a   Hashimoto, Satoshi ^a  

^a Kizuyabashitakeda Hospital   (Japan)

Author keywords

11 HSD2 impairment; Mineralocorticoid excess; Serum cortisol cortisone ratio; Urinary cortisol cortisone ratio ; Urinary THF+allo THF THE ratio

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ALDOSTERONE; DEXAMETHASONE; GLYCYRRHIZA EXTRACT; HYDROCORTISONE; PIOGLITAZONE; POTASSIUM; PREDNISONE; SPIRONOLACTONE; SULFONYLUREA; TETRAHYDROCORTISOL;

AGED; ALDOSTERONE BLOOD LEVEL; ALDOSTERONE URINE LEVEL; ANEMIA; APPARENT MINERALOCORTICOID EXCESS SYNDROME; ARTERIAL GAS; ARTICLE; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; COMORBIDITY; COMPUTER ASSISTED TOMOGRAPHY; CONSCIOUSNESS DISORDER; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DEXAMETHASONE SUPPRESSION TEST; DRUG EFFICACY; DRUG WITHDRAWAL; ELDERLY CARE; ELECTROCARDIOGRAM; ENZYME ACTIVITY; ENZYME DEFICIENCY; FEMALE; GLYCYRRHIZA; HEART RIGHT BUNDLE BRANCH BLOCK; HEMIPLEGIA; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERTENSION; HYPOKALEMIA; MALE; METABOLIC ALKALOSIS; MIDDLE CEREBRAL ARTERY; MOTOR DYSFUNCTION; MUSCLE WEAKNESS; NON INSULIN DEPENDENT DIABETES MELLITUS; PLASMA RENIN ACTIVITY; POTASSIUM URINE LEVEL; PROTEIN URINE LEVEL; SINGLE DRUG DOSE; SODIUM RESTRICTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; AGED; BIOLOGICAL MARKERS; CORTISONE; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; HYDROCORTISONE; HYPERTENSION; MALE; SPIRONOLACTONE;

EID: 61749085602     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.47.1165     Document Type: Article

References (13)

1. Inada M. A 87-year-old woman with mineralocorticoid excess due to 11β-HSD2 deficiency. Nippon Ronen Igakkai Zasshi (Japanese J Geriatrics) 44: 513-516, 2007 (in Japanese, Abstract in English).
2. Inada M, Iwasaki K, Imai C, Hashimoto S. Two elderly patients with mineralocorticoid excess due to 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) impairment. Intern Med 47: 631-636, 2008.
3. Ulick S, Levine LS, Gunczler Y, et al. A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol. J Clin Endocrinol Metab 49: 757-764, 1979.
4. White FC, Mune T, Agarwal AK. 11β-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr Rev 18: 135-156, 1977.
5. Best R, Walker BR. Additional value of measurement of urinary cortisone and unconjugated cortisol metabolites in assessing the activity of 11β-hydroxysteroid dehydrogenase in vivo. Clin Endocrinol 47: 231-236, 1997.
6. Carvajal CA, Gonzalez AA, Romero DG, et al. Two homozygous mutation in the 11β-hydroxysteroid dehydrogenase type 2 gene in a case of apparent mineralocorticoid excess. J Clin Endocrinol Metab 88: 2501-2507, 2003.
7. Inagaki K, Ohzuka F, Suzuki G, et al. A case of apparent mineralocorticoid excess state, induced by hypothyroidism. Nippon Naibunpi Gakkai Zasshi (Folia Endocrinol Japonica) 104, 2006 (Abstract in Japanese).
8. Homma K, Hasegawa T, Masumoto M, et al. Reference values for urinary steroid in Japanese newborn infants: Gas chromatography/mass spectrometry in selected ion monitoring. Endocrine J 50: 783-792, 2003.
9. Wake DI, Walker BR. 11β-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome. Mol Cell Endocrinol 215: 45-54, 2004.
10. Masuzaki H, Paterson J, Shinyama H, et al. A transgenic model of visceral obesity and the metabolic syndrome. Science 294: 2166-2170, 2001.
11. Masuzaki H, Yamamoto H, Kenyon CJ, et al. Transgenic amplication of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest 112: 83-90, 2003.
12. Liddle GW, Bledsoe T, Coppage WS. A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion. Trans Assoc Am Physicians 76: 199-213, 1963.
13. Shimkets RA, Warnock DG, Bositis CM, et al. Liddle's syndrome: heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel. Cell 79: 407-414, 1994.