Unparalleled Contribution of Technetium-99m to Medicine Over 5 Decades

JACC: Cardiovascular Imaging

Volumn 2, Issue 3, 2009, Pages 364-368

  Eckelman, William C ^a  

^a Dr Eckelman is the Editor in Chief of Nuclear Medicine and Biology based in Bethesda   (United States)

Author keywords

instant kit; myocardial perfusion; Tc 99m generator; Tc 99m peptides

Indexed keywords

CHELATING AGENT; IODINE 123; MOLYBDENUM 99; PENTETATE TECHNETIUM TC 99M; TECHNETIUM 99M;

ARTICLE; DIAGNOSTIC VALUE; HALF LIFE TIME; HEART MUSCLE PERFUSION; HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; PREDICTIVE VALUE OF TESTS; RADIONUCLIDE IMAGING; RADIOPHARMACEUTICALS; TECHNETIUM; UNITED STATES;

EID: 61649106720     PISSN: 1936878X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcmg.2008.12.013     Document Type: Article

References (33)

1. Myers W.G. Georg Charles de Hevesy: the father of nuclear medicine. J Nucl Med 20 (1979) 590-594
2. Wolf A.P., Christman D.R., Fowler J.S., et al. Synthesis of radiopharmaceuticals and labelled compounds using short-lived isotopes. Radiopharmaceuticals and Labelled Compounds (1973), IAEA, Vienna, Austria 345-351
3. Eckelman W.C. A nuclear medicine odyssey. In: Mazzi U. (Ed) (2002), Servizi Grafici Editoriali snc, Padova, Italy Proceedings of the Seventh International Symposium on Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine. XLVII-LII
4. Louis Pasteur. Lecture, University of Lille. December 7, 1854. Available at: http://www.notablebiographies.com/index.html. Accessed January 22, 2009.
5. Segre E. The adventurous history of the discovery of technetium. In: Nicolini M., Bandoli G., and Mazzi U. (Eds). Technetium in Chemistry and Nuclear Medicine 2 (1986), Raven Press, New York, NY 1-10
6. Segre E., and Seaborg G.T. Nuclear isomerism in element 43. Phys Rev 54 (1938) 772
7. Richards P. Technetium-99m: the early days. In: Mazzi U. (Ed). Proceedings of the Seventh International Symposium on Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine (1990), Servizi Grafici Editoriali snc, Padova, Italy 1-9
8. Richards P. A survey of the production at Brookhaven National Laboratory of radioisotopes for Medical research in V. congresso nucleare "Rome", comitato nazional ricerche nucleari 2 (1960) 223-244
9. Richards P., and Steigman J. Chemistry of technetium as applied to radiopharmaceuticals. In: Subramanian G., Rhodes B.A., Cooper J.F., and Sodd V.J. (Eds). Radiopharmaceuticals (1975), Society for Nuclear Medicine, New York, NY 23-35
10. Harper P.V., Lathrop K., and Gottschalk A. Pharmacodynamics of some technetium-99m preparations. Radioactive Pharmaceuticals 6 (1964), U.S. Atomic Energy Commission, Washington, DC 335-358
11. Richards P., Tucker W.D., and Srivastava S.C. Technetium-99m: an historical perspective. Int J Appl Radiat Isot 33 (1982) 793-799
12. Eckelman W.C., and Richards P. Instant 99mTc-DTPA. J Nucl Med 11 (1970) 761
13. Steigman J., and Eckelman W.C. The Chemistry of Technetium in Medicine (1993), National Academy Press, Washington, DC NAS-NS-3204
14. 99mTc. J Am Chem Soc 100 (1978) 5570-5571
15. 99mTc. J Am Chem Soc 100 (1978) 5571-5572
16. Eckelman W.C. Imaging of muscarinic receptors in the central nervous system. Curr Pharm Des 12 (2006) 3901-3913
17. Eckelman W.C., and Babich J.W. Synthesis and validation of fatty acid analogs radiolabeled by nonisotopic substitution. J Nucl Cardiol 14 Suppl (2007) S100-S109
18. Kung H.F., Kung M.P., Wey S.P., Lin K.J., and Yen T.C. Clinical acceptance of a molecular imaging agent: a long march with [99mTc]TRODAT. Nucl Med Biol 34 (2007) 787-789
19. Femia F.J., Maresca K.P., Hillier S.M., et al. Synthesis and evaluation of a series of 99mTc(CO)3+ lisinopril complexes for in vivo imaging of angiotensin-converting enzyme expression. J Nucl Med 49 (2008) 970-977
20. Holman B.L., Jones A.G., Lister-James J., et al. A new Tc-99m-labeled myocardial imaging agent, hexakis (t-butylisonitrile)-technetium (I) (Tc-99m TBI). Initial experience in the human. J Nucl Med 25 (1984) 1350-1355
21. Kelly J.D., Forster A.M., Higley B., et al. Technetium-99m-tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging. J Nucl Med 34 (1993) 222-227
22. 99mTc complex for myocardial imaging. J Nucl Med 30 (1989) 1830-1837
23. Ehrlich C., et al. Experimental researches on specific therapy. On immunity with special reference to the relationship between distribution and action of antigens (1908), Royal Institute of Public Health 107 (London: Lewis)
24. Schibli R., and Schubiger P.A. Current use and future potential of organometallic radiopharmaceuticals. Eur J Nucl Med Mol Imaging 29 (2002) 1529-1542
25. García-Garayoa E., and Schubiger P.A. Peptide-based radiopharmaceuticals radiolabeled with Tc-99m and Re-188 as potential diagnostic and therapeutic agents. In: Mazzi U. (Ed). Proceedings of the Seventh International Symposium on Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine (2006), Servizi Grafici Editoriali snc, Padova, Italy 247-262
26. Eckelman W.C., Reba R.C., and Kelloff G.J. Targeted imaging: an important biomarker for understanding disease progression in the era of personalized medicine. Drug Discov Today 13 (2008) 748-759
27. Society of Nuclear Medicine, Preliminary Draft Report of the SNM Isotope Availability Task Group, June 2008. Available at: http://interactive.snm.org/docs/DRAFT_report_7.15.08.pdf. Accessed January 22, 2009.
28. Making Medical Isotopes. Report of the Task Force on Alternatives for Medical-Isotope Production. 2008 TRIUMF, Canada. Available at: http://admin.triumf.ca/facility/5yp/comm/Report-vPREPUB.pdf. Accessed January 22, 2009.
29. Jongen D.D. ADONIS: The Proton-Driven Neutron Source for Radioisotope Production (1999), IAEA-TECDOC-1065, Vienna, Austria 139-146 IAEA
30. Lagunas-Solar M.C., Kiefer P.M., Carvacho O.F., Lagunas C.A., and Cha Y.P. Cyclotron production of NCA 99mTc and 99Mo. An alternative non-reactor supply source of instant 99mTc and 99Mo-99mTc generators. Int J Rad Appl Instrum [A] 42 (1991) 643-657
31. Takács S., Szcs Z., Tárkányi F., Hermanne A., and Sonck M. Evaluation of proton induced reactions on 100Mo: New cross sections for production of 99mTc and 99Mo. J Radioanalytical and Nuclear Chemistry 257 (2003) 195-201
32. Smith M.F., Daube-Witherspoon M.E., Plascjak P.S., et al. Device-dependent activity estimation and decay correction of radionuclide mixtures with application to Tc-94m PET studies. Med Phys 28 (2001) 36-45
33. Foster R., and Kaplan S. Creative Destruction (2001), Currency Books, New York, NY