Determination of methimazole in pharmaceutical preparations using an HPLC method coupled with an iodine-azide post-column reaction

Journal of Liquid Chromatography and Related Technologies

Volumn 32, Issue 3, 2009, Pages 383-398

  Zakrzewski, Robert ^a  

^a UNIVERSITY OF LODZ   (Poland)

Author keywords

HPLC; Iodine azide reaction; Methimazole; Post column reaction; Tablets analysis

Indexed keywords

ACETONITRILE; CHROMATOGRAPHIC ANALYSIS; EFFLUENTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; INDUSTRIAL CHEMICALS; IODINE; SUGAR (SUCROSE);

HPLC; IODINE-AZIDE REACTION; METHIMAZOLE; POST-COLUMN REACTION; TABLETS ANALYSIS;

DRUG PRODUCTS;

ACETONITRILE; AZIDE; CARBON; IODINE; SODIUM AZIDE; THIAMAZOLE; WATER;

ACCURACY; ARTICLE; DRUG DETERMINATION; DRUG PURITY; DRUG STRUCTURE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PH MEASUREMENT; REACTION TIME; SEPARATION TECHNIQUE; SPECTROPHOTOMETRY; VALIDATION PROCESS;

EID: 61649092586     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070802631451     Document Type: Article

References (23)

1. Swonger, A.K.; Matejski, M.P. Nursing Pharmacology. An Integrated Approach to Drug Theraphy and Nursing Practice; Scott, Foresman, and Company: London, 1988; 1166.
2. Jorgensen, E.C. Thyroid hormones and antithyroid drugs, in Medicinal Chemistry; Burger, A., Ed.; Wiley-Interscience: New York, 1970, 838.
3. Pinzauti, S.; Papeschi, G.; La Porta, E. Potentiometric titration of thiols, cationic surfactants and halides using a solid-state silver - silver sulphide electrode. J. Pharm. Biomed. Anal. 1983, 1, 47-53.
4. Aslanoglu, M.; Peker, N.J. Potentiometric and voltammetric determination of methimazole. Pharm. Biomed. Anal. 2003, 33, 1143-1147.
5. Ciesielski, W. Coulometric titration of 6-mercaptopurine, methylthioimidazole and methylthiouracil with iodine in alkaline medium. Chem. Anal. (Warsaw) 1991, 36, 555-563.
6. Niolic, K.; Velasevic, K. Coulometric determination of methimazole. Pharmazie 1987, 42, 698.
7. Berka, A.; Velaseviv, K.; Nikolic, K. Conductometric determination of methimazole. Pharmazie 1989, 44, 499.
8. Moretti, G.; Cammarata, P.; Francassi, F.; Giambenedetti, M.; Borghese, A. Determination of thyreostatic residues in cattle plasma by high-performance liquid chromatography with ultraviolet detection. J. Chromatogr. Biomed. Anal. 1993, 616, 291-296.
9. Zhang, S.; Sun, W.; Zhang, W.; Oi, W.; Jin, L.; Yamamoto, K.; Tao, S.; Jin, J. Determination of thiocompounds by liquid chromatography with amperometric detection at a Nafion/indium hexacyanoferrate film modified electrode. Anal. Chim. Acta 1999, 386, 21-30.
10. Aletrari, M.; Kanari, P.; Partassides, D.; Loizou, E. Study of the british Pharmacopeia method on methimazole (thiamazole) content in carbimazole tablets. J. Pharm. Biomed. Anal. 1998, 16, 785-792.
11. Wang, A.; Zhang, L.; Zhang, S.; Fang, Y. Determination of thiols following their separation by CZE with amperometric detection at a carbon electrode. J. Pharm. Biomed. Anal. 2000, 23, 429-436.
12. Bahramifar, N.; Yamini, Y.; Shamsipur, M. Investigation on the supercritical carbon dioxide extraction of some polar drugs from spiked matrices and tablets. J. Supercrit. Fluids 2005, 35, 205-211.
13. Economou, A.; Tzanavaras, P.D.; Notou, M.; Themelis, D.G. Determination of methimazole and carbimazole by flow injection with chemiluminescence detection based on the inhibition of the Cu(II)-catalysed luminol-hydrogen peroxide reaction. Anal. Chim. Acta 2004, 505, 129-133.
14. Sanchez-Pedreno, C.; Albero, M.I.; Garcia, M.S.; Rodenas, V. Flow injection spectrophotometric determination of carbimazole and methimazole. Anal. Chim. Acta 1995, 308, 457-461.
15. Kossakowski, J.; Klopocki, T.; Kurył, T.; Żbikowski, B. Assays of 1-methyl-2-thioimidazole. Acta Pol. Pharm. 1972, 29, 469-473.
16. Ciesielski, W. Spectrophotometric determination of methylthiouracil and 1-methyl-2-thioimidazole with the use of iodine-azide reaction. Acta Pol. Pharm. 1987, 44, 202-205.
17. Zakrzewski, R.; Ciesielski, W. Application of iodine-azide reaction as post-column reaction in HPLC for determination of 2-thiobarbituric acid. Chromatographia 2004, 59, 683-689.
18. Zakrzewski, R.; Ciesielski, W. Determination of thiopental in urine sample with high performance liquid chromatography using iodine-azide reaction as a post-column detection system. J. Chromatogr. B. 2005, 824, 327-332.
19. Ciesielski, W.; Kinart, C.M. Studies on the iodine-azide reaction induced by vitamin B1 in hethanol-water systems in terms of mixed solvent structure. Polish J. Chem. 1993, 67, 59-66.
20. Miura, Y.; Fukasawa, K.; Koh, T. Determination of sulfur anions at the ppb level by ion chromatography utilizing their catalytic effects on the post-column reaction of iodine with azide. J. Chromatogr. A. 1998, 804, 143-150.
21. Miura, Y.; Watanabe, M. Ion-pair chromatography of polythionates and thiosulfates with detection based on their catalytic effects on the post-column azide-iodine reaction. J. Chromatogr. A. 2001, 920, 163-171.
22. Kurzawa, J. The iodine-azide reaction induced by mercaptopyrimidines and its application in chemical analysis. Chem. Anal. (Warsaw) 1987, 32, 875-890.
23. Kurzawa, J. Determination of micro- and nanogram amounts of sulphur(II) compounds by flow continuous analysis with application of the induced iodine-azide reaction. Chem. Anal. (Warsaw) 1988, 33, 771-777.