Genetic determined downregulation of both type 1 and type 2 cytokine pathways might be protective against pancreatic cancer

Annals of the New York Academy of Sciences

Volumn 1155, Issue , 2009, Pages 284-288

  Scola, Letizia ^a   Giacalone, Antonio ^a   Marasà, Lorenzo ^b   Mirabile, Monica ^a   Vaccarino, Loredana ^a   Forte, Giusi Irma ^a   Giannitrapani, Lydia ^a   Caruso, Calogero ^a   Montalto, Giuseppe ^a   Lio, Domenico ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b Azienda di Rilievo Nazionale e di Alta Specializzazione (ARNAS) Civico Benfratelli   (Italy)

Author keywords

Gene polymorphisms; IL 10; IL 4R ; Pancreatic cancer

Indexed keywords

CYTOKINE; CYTOKINE TYPE 1; CYTOKINE TYPE 2; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR ALPHA; UNCLASSIFIED DRUG;

CANCER RISK; CELL PROLIFERATION; CELL PROTECTION; CLINICAL ARTICLE; CLINICAL EVALUATION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; PANCREAS CANCER; RECEPTOR DOWN REGULATION; RISK FACTOR; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 61649083745     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2008.03686.x     Document Type: Conference Paper

References (22)

1. Perwez-Hussain, S. & C.C. Harris. 2007. Inflammation and cancer: An ancient link with novel potentials. Int. J. Cancer 121 : 2373 2380.
2. Feurino, L.W. et al. 2006. Current update of cytokines in pancreatic cancer: Pathogenic mechanisms, clinical indication, and therapeutic values. Cancer Invest. 24 : 696 703.
3. Russo, A., M. Autelitano & L. Bisanti. 2008. Metabolic syndrome and cancer risk. Eur. J. Cancer 44 : 293 297.
4. Goecke, H. et al. 2000. Macrophages infiltrating the tissue in chronic pancreatitis express the chemokine receptor CCR5. Surgery 128 : 806 814.
5. Lowenfels, A.B. et al. 1993. Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N. Engl. J. Med. 328 : 1433 1437.
6. Farrow, B. et al. 2004. Inflammatory mechanisms contributing to pancreatic cancer development. Ann. Surg. 239 : 763 769.
7. Mews, P. et al. 2002. Pancreatic stellate cells respond to inflammatory cytokines: Potential role in chronic pancreatitis. Gut 50 : 535 541.
8. Terabe, M. et al. 2006. CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcription 6 or transforming growth factor-B. Cancer Res. 66 : 3869 3875.
9. Li, M. et al. 2007. Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells. Cancer Lett. 248 : 58 67.
10. Scola, L. et al. 2006. Cytokine gene polymorphisms and breast cancer susceptibility. Ann. N. Y. Acad. Sci. 1089 : 104 109.
11. Battle, N.C. et al. 2007. Ethnicity-specific gene-gene interaction between IL-13 and IL-4Rα among African Americans with asthma. Am. J. Respir. Crit. Care Med. 175 : 881 887.
12. Mytar, B. et al. 2008. Human monocytes both enhance and inhibit the growth of human pancreatic cancer in SCID mice. Anticancer Res. 28 : 187 192.
13. Petersen, G.M. et al. 2006. Pancreatic cancer genetic epidemiology consortium. Cancer Epidemiol. Biomarkers Prev. 15 : 704 710.
14. Duell, E.J. et al. 2006. Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma. Cancer Epidemiol. Biomarkers Prev. 15 : 726 731.
15. Halma, M.A. et al. 2004. Interferon-gamma polymorphisms correlate with duration of survival in pancreatic cancer. Hum. Immunol. 65 : 1405 1408.
16. Lio, D. et al. 2005. TNFalpha, IFNgamma and IL-10 gene polymorphisms in a sample of Sicilian patients with coeliac disease. Dig. Liver Dis. 37 : 756 760.
17. Bellone, G. et al. 2006. Cooperative induction of a tolerogenic dendritic cell phenotype by cytokines secreted by pancreatic carcinoma cells. J. Immunol. 177 : 3448 3460.
18. Risma, K.A. et al. 2002. V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function. J. Immunol. 169 : 1604 1610.
19. Prokopchuk, O. et al. 2005. Interleukin-4 enhances proliferation of human pancreatic cancer cells: Evidence for autocrine and paracrine actions. Br. J. Cancer 92 : 921 928.
20. Olson, S.H. et al. 2007. Allergies, variants in IL-4 and IL-4R alpha genes, and risk of pancreatic cancer. Cancer Detect. Prev. 31 : 345 351.
21. Eriksson, N.E. et al. 1995. A prospective study of cancer incidence in a cohort examined for allergy. Allergy 50 : 718 722.
22. Stolzenberg-Solomon, R.Z. et al. 2002. A prospective study of medical conditions, anthropometry, physical activity, and pancreatic cancer in male smokers (Finland). Cancer Causes Control 13 : 417 426.