Design and QSAR study of analogs of γ-tocotrienol with enhanced antiproliferative activity against human breast cancer cells

Journal of Molecular Graphics and Modelling

Volumn 27, Issue 7, 2009, Pages 777-783

  Nikolic, Katarina ^a   Agababa, Danica ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Tocopherol; Tocotrienol; Cholesterol; Human breast cancer; Lysine; QSAR

Indexed keywords

ANTI-TUMOR DRUGS; ANTICANCER EFFECTS; ANTIPROLIFERATIVE ACTIVITIES; B3LYP/6-31G; BASIS SETS; CROSS VALIDATIONS; DENSITY FUNCTIONAL; DESCRIPTORS; HUMAN BREAST CANCER; HUMAN BREAST CANCER CELLS; LYSINE; MCF-7 CELLS; MULTIPLE LINEAR REGRESSIONS; PHYSICO CHEMICALS; QSAR; QSAR MODELS; QSAR STUDIES; QUANTITATIVE STRUCTURE - ACTIVITY RELATIONSHIPS; REGRESSION MODELS; VITAMIN-E;

AMINO ACIDS; BIOCHEMISTRY; CELL CULTURE; CHOLESTEROL; MOLECULAR GRAPHICS; REGRESSION ANALYSIS; SULFUR COMPOUNDS; VITAMINS;

DENSITY FUNCTIONAL THEORY;

ALPHA TOCOPHEROL; ALPHA TOCOPHEROL DERIVATIVE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; CHOLESTEROL DERIVATIVE; GAMMA TOCOTRIENOL; LYSYL GAMMA TOCOTRIENOL; N,N,N TRIMETHYLLYSYL GAMMA TOCOTRIENOL; PHENYLSELENOSUCCINYL 1ALPHA TOCOPHEROL; PHENYLSELENOSUCCINYL 4ALPHA TOCOPHEROL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN MCF 7; DENSITY FUNCTIONAL THEORY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; MOLECULAR ELECTRONICS; MOLECULAR MODEL; MULTIPLE LINEAR REGRESSION ANALYSIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL MODEL; VALIDATION STUDY;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMANS; COMPUTER-AIDED DESIGN; DRUG DESIGN; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; LINEAR MODELS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REPRODUCIBILITY OF RESULTS; VITAMIN E;

EID: 61549132609     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmgm.2008.11.007     Document Type: Article

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