The stress response to bilateral femoral fractures: A comparison of primary intramedullary nailing and external fixation

Journal of Orthopaedic Trauma

Volumn 23, Issue 2, 2009, Pages 90-98

  Gray, A C ^a   White, T O ^c   Clutton, E ^b   Christie, J ^c   Hawes, B D ^c   Robinson, C M ^c  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c NONE

Author keywords

Damage control; Embolism; Femoral fracture; Intramedullary; Stress response

Indexed keywords

ANTITHROMBIN III;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMUR FRACTURE; FRACTURE EXTERNAL FIXATION; HYPOVOLEMIC SHOCK; INTRAMEDULLARY NAILING; LEUKOCYTE COUNT; LUNG EMBOLISM; LUNG LAVAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTHROMBIN TIME; SHEEP; STRESS; ANIMAL; BONE NAIL; COMPARATIVE STUDY; DISEASE MODEL; ECHOCARDIOGRAPHY; ECHOGRAPHY; EXTERNAL FIXATOR; HEMODYNAMICS; INSTRUMENTATION; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SHOCK;

ANIMALS; BONE NAILS; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; EXTERNAL FIXATORS; FEMORAL FRACTURES; FRACTURE FIXATION, INTRAMEDULLARY; HEMODYNAMICS; MALE; PULMONARY EMBOLISM; SHEEP; SHOCK;

EID: 61549115021     PISSN: 08905339     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOT.0b013e31819194c6     Document Type: Article

References (37)

1. Robinson CM. Current concepts of respiratory insufficiency syndromes after fracture. J Bone Joint Surg Am. 2001;83-B:781-791. (Pubitemid 32785542)
2. Christie J, Robinson CM, Pell AC, et al. Transcardiac echocardiography during invasive intramedullary procedures. J Bone Joint Surg Br. 1995;77B:450-455.
3. Poole GV, Tinsley M, Tsao AK, et al. Abbreviated Injury Scale does not reflect the added morbidity of multiple lower extremity fractures. J Trauma. 1996;40:951-954. (Pubitemid 126425032)
4. Behrman SW, Fabian TC, Kudsk KA, et al. Improved outcome with femur fractures: early vs. delayed fixation. J Trauma. 1990;30:792-797.
5. Bone LB, Anders MJ, Rohrbacher BJ. Treatment of femoral fractures in the multiply injured patient with thoracic injury. Clin Orthop. 1998;347:57-61.
6. Pinney SJ, Keating JF, Meek RN. Fat embolism syndrome in isolated femoral fractures: does timing of nailing influence incidence? Injury. 1998;29:131-133.
7. Bone LB, Johnson KD, Weigelt J, et al. Early versus delayed stabilization of femoral fractures. A prospective randomized study. J Bone Joint Surg Am. 1989;71:336-340. (Pubitemid 19116683)
8. Border JR. Death from severe trauma: open fractures to multiple organ dysfunction syndrome. J Trauma. 1995;39:12-22.
9. Dunham CM, Bosse MJ, Clancy TV, et al. Practice management guidelines for the optimal timing of long-bone fracture stabilization in polytrauma patients: the EAST Practice Management Guidelines Work Group. J Trauma. 2001;50:958-967.
10. Pape HC, Giannoudis P, Krettek C. The timing of fracture treatment in polytrauma patients: relevance of damage control orthopedic surgery. Am J Surg. 2002;183:622-629. (Pubitemid 34722527)
11. Buttaro M, Mocetti E, Alfie V, et al. Fat embolism and related effects during reamed and unreamed intramedullary nailing in a pig model. J Orthop Trauma. 2002;16:239-244. (Pubitemid 34436324)
12. Heim D, Regazzoni P, Tsakiris DA, et al. Intramedullary nailing and pulmonary embolism: does unreamed nailing prevent embolization? An in vivo study in rabbits. J Trauma. 1995;38:899-906.
13. Kropfl A, Davies J, Berger U, et al. Intramedullary pressure and bone marrow fat extravasation in reamed and unreamed femoral nailing. J Orthop Res. 1999;17:261-268. (Pubitemid 29190500)
14. Neudeck F, Wozasek GE, Obertacke U, et al. Nailing versus plating in thoracic trauma: an experimental study in sheep. J Trauma. 1996;40:980-984. (Pubitemid 26179392)
15. Pape HC, Dwenger A, Regel G, et al. Pulmonary damage after intramedullary femoral nailing in traumatized sheep - is there an effect from different nailing methods? J Trauma. 1992;33:574-581.
16. Schemitsch EH, Jain R, Turchin DC, et al. Pulmonary effects of fixation of a fracture with a plate compared with intramedullary nailing. A canine model of fat embolism and fracture fixation. J Bone Joint Surg Am. 1997;79:984-996. (Pubitemid 27310568)
17. White TO, Clutton RE, Salter D, et al. The early response to major trauma and intramedullary nailing. J Bone Joint Surg Br. 2006;88:823-827. (Pubitemid 43971152)
18. Ereth MH, Weber JG, Abel MD, et al. Cemented versus noncemented total hip arthroplasty - embolism, hemodynamics, and intrapulmonary shunting. Mayo Clin Proc. 1992;67:1066-1074.
19. Copeland CE, Mitchell KA, Brumback RJ, et al. Mortality in patients with bilateral femoral fractures. J Orthop Trauma. 1998;12:315-319.
20. Nork SE, Agel J, Russell GV, et al. Mortality after reamed intramedullary nailing of bilateral femur fractures. Clin Orthop Relat Res. 2003;415:272-278. (Pubitemid 37329064)
21. Giannoudis PV, Cohen A, Hinsche A, et al. Simultaneous bilateral femoral fractures: systemic complications in 14 cases. Int Orthop. 2000;24:264-267.
22. Lieurance R, Benjamin JB, Rappaport WD. Blood loss and transfusion in patients with isolated femur fractures. J Orthop Trauma. 1992;6:175-179.
23. Blow O, Magliore L, Claridge JA, et al. The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma. J Trauma. 1999;47:964-969.
24. Crowl AC, Young JS, Kahler DM, et al. Occult hypoperfusion is associated with increased morbidity in patients undergoing early femur fracture fixation. J Trauma. 2000;48:260-267.
25. Jarisch A, Richter H. Die afferenten Bahnan des Veratrineffektes in den Herznerven. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1939;193:355-371.
26. Gabrielsen GW, Smith EN. Physiological responses associated with feigned death in the American opossum. Acta Physiol Scand. 1985;123:393-398.
27. Tachakra SS, Sevitt S. Hypoxaemia after fractures. J Bone Joint Surg Br. 1975;57:197-203.
28. Riseborough EJ, Herndon JH. Alterations in pulmonary function, coagulation and fat metabolism in patients with fractures of the lower limbs. Clin Orthop. 1976;115:248-267.
29. Moed BR, Watson JT. Retrograde intramedullary nailing, without reaming, of fractures of the femoral shaft in multiply injured patients. J Bone Joint Surg Am. 1995;77:1520-1527.
30. Mousavi M, David R, Schwendenwein I, et al. Influence of controlled reaming on fat intravasation after femoral osteotomy in sheep. Clin Orthop. 2002;394:263-270. (Pubitemid 34062733)
31. Robinson CM, Ludlam CA, Ray DC, et al. The coagulative and cardiorespiratory responses to reamed intramedullary nailing of isolated fractures. J Bone Joint Surg Br. 2001;83:963-973. (Pubitemid 32923126)
32. Pape HC, Bartels M, Pohlemann T, et al. Coagulatory response after femoral instrumentation after severe trauma in sheep. J Trauma. 1998;45:720-728. (Pubitemid 28480573)
33. Pugin J, Widmer MC, Kossodo S, et al. Human neutrophils secrete gelatinase B in vitro and in vivo in response to endotoxin and proinflammatory mediators. Am J Respir Cell Mol Biol. 1999;20:458-464. (Pubitemid 129504868)
34. Keel M, Ecknauer E, Stocker R, et al. Different pattern of local and systemic release of proinflammatory and anti-inflammatory mediators in severely injured patients with chest trauma. J Trauma. 1996;40:907-912. (Pubitemid 126425028)
35. Giannoudis PV, Smith RM, Banks RE, et al. Stimulation of inflammatory markers after blunt trauma. Br J Surg. 1998;85:986-990.
36. Chinard FP. Quantitative assessment of epithelial lining fluid in the lung. Am J Physiol. 1992;263:L617-L618.
37. Rennard SI, Basset G, Lecossier D, et al. Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution. J Appl Physiol. 1986;60:532-538. (Pubitemid 16019939)