Multidimensional en-Face OCT imaging of the retina

Optics Express

Volumn 17, Issue 5, 2009, Pages 4112-4133

  Rosen, Richard B ^a,b   Hathaway, Mark ^c,d   Rogers, John ^c   Pedro, Justin ^c   Garcia, Patricia ^a,b   Laissue, Philippe ^d   Dobre, George M ^d   Podoleanu, Adrian Gh ^d  

^a NEW YORK EYE AND EAR INFIRMARY   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c Ophthalmic Technologies Inc   (Canada)

^d UNIVERSITY OF KENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENCE; SCANNING;

CONFOCAL IMAGE; CONFOCAL IMAGING; FLUORESCENCE IMAGE; HARDWARE CHANNELS; INDOCYANINE GREEN; MOVEMENT ARTIFACTS; SCANNING LASER OPHTHALMOSCOPY; SPECTRAL OCT;

OPTICAL TOMOGRAPHY;

DIAGNOSTIC AGENT; FLUORESCENT DYE; INDOCYANINE GREEN;

ARTICLE; COMPARATIVE STUDY; DIABETIC RETINOPATHY; EQUIPMENT DESIGN; EVALUATION; EYE FUNDUS; HISTOLOGY; HUMAN; IMAGE PROCESSING; INSTRUMENTATION; LASER; LIGHT RELATED PHENOMENA; METHODOLOGY; OPHTHALMOSCOPE; OPHTHALMOSCOPY; OPTICAL COHERENCE TOMOGRAPHY; PATHOLOGY; RETINA; RETINA DISEASE; STATISTICS; SUBRETINAL NEOVASCULARIZATION;

CHOROIDAL NEOVASCULARIZATION; DIABETIC RETINOPATHY; EQUIPMENT DESIGN; FLUORESCENT DYES; FUNDUS OCULI; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INDOCYANINE GREEN; LASERS; OPHTHALMOSCOPES; OPHTHALMOSCOPY; OPTICAL PHENOMENA; RETINA; RETINAL DISEASES; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 61549109795     PISSN: None     EISSN: 10944087     Source Type: Journal    
DOI: 10.1364/OE.17.004112     Document Type: Article

References (29)

1. R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of Fourier domain vs. time domain optical coherence tomography," Opt. Express 11, 889-894 (2003).
2. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069 (2003).
3. A. Gh. Podoleanu, G. M. Dobre, and D. A. Jackson, "En-face coherence imaging using galvanometer scanner modulation," Opt. Lett. 23, 147-149 (1998).
4. A. Gh. Podoleanu, M. Seeger, G. M. Dobre, D. J. Webb, D. A. Jackson, and F. Fitzke, "Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry," J. Biomed. Opt. 3, 12-20 (1998).
5. C. C. Rosa, J. Rogers, J. Pedro, R. Rosen, and A. Podoleanu, "Multi-scan time domain OCT for retina imaging," Appl. Opt. 46, 1795-1807 (2007).
6. A. Gh. Podoleanu and D. A. Jackson, "Combined optical coherence tomograph and scanning laser ophthalmoscope," Electron. Lett. 34, 1088-1090 (1998).
7. M. Pircher, E. Gotzinger, and C. K. Hitzenberger, "Dynamic focus in optical coherence tomography for retinal imaging," J. Biomed Opt. 11, 054013 (2006).
8. M. Pircher, B. Baumann, E. Götzinger, and C. K. Hitzenberger, "Retinal cone mosaic imaged with transversal scanning OCT," Opt. Lett. 31, 1821-1823 (2006).
9. S. Tuohy, A. Bradu, A. Gh. Podoleanu, and N. Chateau, "Correcting ocular aberrations with a high stroke deformable mirror," Proc.SPIE 6627 66271L (2007).
10. D. Merino, Ch. Dainty, A. Bradu, and A.Gh. Podoleanu, "Adaptive optics enhanced simultaneous en-face optical coherence tomography and scanning laser ophthalmoscopy," Opt. Express 14, 3345-3353 (2006).
11. M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner, and C. K. Hitzenberger, "Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography," Opt. Lett. 33, 22-24 (2008).
12. A. Gh. Podoleanu and R. B. Rosen, "Combinations of techniques in imaging the retina with high resolution," Prog. Retin. Eye Res. 27, 464-499 (2008).
13. C. K. Hitzenberger, P. Trost, P. Lo, and Q. Zhou, "Three-dimensional imaging of the human retina by high-speed optical coherence tomography," Opt. Express 11, 2753-2761 (2003).
14. R. Huber, D. C. Adler, V. G. Srinivasan, and J. G. Fujimoto, "Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second," Opt. Letters 32, 2049-2051 (2007).
15. A. Gh. Podoleanu, G. M. Dobre, R. G. Cucu, R. B. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L A. Yannuzzi, Y. Fisher, D. Orlock, R Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
16. A. Gh. Podoleanu and D. A. Jackson, "Noise analysis of a combined optical coherence tomograph and a confocal scanning ophthalmoscope," Appl. Opt. 38, 2116-2127 (1999).
17. B. R. Masters, "Three-dimensional confocal microscopy of the human optic nerve in vivo," Opt. Express 3, 356-359 (1998).
18. A. Gh. Podoleanu, I. Charalambous, L. Plesea, A. Dogariu, and R. B. Rosen, "Correction of distortions in OCT imaging of the eye," Phys. Med. Biol. 49, 1277-1294 (2004).
19. R. G. Cucu, A.Gh. Podoleanu, A. Rogers, J. Pedro, and R. B. Rosen, "Combined confocal scanning ophthalmoscopy/en face T-scan based ultrahigh resolution OCT of the human retina in vivo," Opt. Lett. 31, 1684-1687 (2006).
20. A. Gh. Podoleanu, G. M. Dobre, R. Cernat, J. A. Rogers, J. Pedro, R. B. Rosen, and P. Garcia, "Investigations of the eye fundus using a simultaneous optical coherence tomography/indocyanine green fluorescence imaging system," J. Biomed. Opt. 12, 014019 (2007).
21. M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
22. H. Lim, M. Mujat, C. Kerbage, E. C. Lee, Y. Chen, T. C. Chen, and J. F. de Boer, "High-speed imaging of human retina in vivo with swept-source optical coherence tomography," Opt. Express 14, 12902-12908 (2006).
23. M. E. J. Van Velthoven, F. D. Verbraak, L. A. Yannuzzi, R. B. Rosen, A. Gh. Podoleanu, and M. D. De Smet, "Imaging the retina by en-face optical coherence tomography," Retina 26, 129-136 (2006).
24. Y. Hong, S. Makita, M. Yamanari, M. Miura, S. Kim, T. Yatagai, and Y. Yasuno, "Three-dimensional visualization of choroidal vessels by using standard and ultra-high resolution scattering optical coherence angiography," Opt. Express 15, 7538-7550 (2007).
25. S. L. Jiao, C. Y. Wu, R. W. Knighton, G. Gregoři, and C. A. Puliafito, "Registration of high-density cross sectional images to the fundus image in spectral-domain ophthalmic optical coherence tomography," Opt. Express 14, 3368-3376 (2006).
26. Y. Yasuno, Y. J. Hong, M. Makita, M. Yamanari, M. Akiba, M. Miura, and T. Yatagai, "In vivo high-contrast imaging of deep posterior eye by 1-μm swept source optical coherence tomography and scattering optical coherence angiography," Opt. Express 15, 6121-6139 (2007).
27. M. Pircher, B. Baumann, E. Goetzinger, H. Sattmann, and C. K. Hitzenberger, "Simultaneous SLO/OCT imaging of the human retina with axial eye motion correction," Opt. Express 15, 16922-16932 (2007).
28. P. Thévenaz, U.E. Ruttimann, and M. Unser, "A pyramid approach to subpixel registration based on intensity," IEEE Trans. Image Process. 7, 27-41 (1998).
29. MATLAB, http://www.mathworks.com/products/matlab.