Delta sleep-inducing peptide alters bispectral index, the electroencephalogram and heart rate variability when used as an adjunct to isoflurane anaesthesia

European Journal of Anaesthesiology

Volumn 26, Issue 2, 2009, Pages 128-134

  Pomfrett, Chris J D ^a   Dolling, Stuart ^b   Anders, Nicola R K ^c   Glover, David G ^c   Bryan, Angella ^c   Pollard, Brian J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b HOPE HOSPITAL   (United Kingdom)

^c MANCHESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

Anaesthesia; Electrocardiograph: analysis; Electroencephalography: delta rhythm; Inhalation: pharmacology

Indexed keywords

DELTA SLEEP INDUCING PEPTIDE; ISOFLURANE; PLACEBO; PROPOFOL; INHALATION ANESTHETIC AGENT;

ANESTHESIA LEVEL; ARTICLE; BISPECTRAL INDEX; BLOOD BRAIN BARRIER; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELTA RHYTHM; DRUG EFFECT; DRUG SAFETY; ELECTROENCEPHALOGRAPHY; FEMALE; HEART RATE VARIABILITY; HUMAN; LEFT HEMISPHERE; PARASYMPATHETIC TONE; RANDOMIZED CONTROLLED TRIAL; RIGHT HEMISPHERE; DOSE RESPONSE; HEART RATE;

ANESTHETICS, INHALATION; DELTA SLEEP-INDUCING PEPTIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; FEMALE; HEART RATE; HUMANS; ISOFLURANE;

EID: 61549103748     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0b013e32831c8644     Document Type: Article

References (16)

1. Monnier M, Dudler L, Gachter R, Schoenenberger GA. Transport of the synthetic peptide DSIP through the blood-brain barrier in rabbit. Experientia 1977;33:1609-1610. (Pubitemid 8237097)
2. Monnier M, Dudler L, Gachter R, et al. The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide. Experientia 1977;33:548-552. (Pubitemid 8072804)
3. Schoenenberger GA, Monnier M. Characterization of a deltaelectroencephalogram (-sleep)-inducing peptide. Proc Natl Acad SciU SA 1977;74:1282-1286.
4. Pollard BJ, Pomfrett CJD. Delta sleep-inducing peptide. Eur J Anaesthesiol 2001;18:419-422.
5. Schneider-Helmert D, Graf M, Schoenenberger GA. Synthetic delta-sleepinducing peptide improves sleep in insomniacs. Lancet 1981;1:1256-1257. (Pubitemid 11104696)
6. Pokrovsky VM, Osadchiy OE. Regulatory peptides as modulators of vagal influence on cardiac rhythm. Can J Physiol Pharmacol 1995;73:1235-1245.
7. Pomfrett CJD, Alkire MT. Respiratory sinus arrhythmia as an index of anaesthetic depth: evidence from functional imaging studies. J Physiol (Lond) 1999; 518 P: 180.
8. Rampil IJ. A primer for EEG signal processing in anesthesia. Anesthesiology 1998;89:980-1002.
9. Pomfrett CJD. R-R intervals and the depth of anaesthesia. In: Adams AP, Cashman JN, editors. Recent advances in anaesthesia and analgesia. Edinburgh: Churchill Livingstone; 1995. pp. 89-105.
10. Grigorev VV, Ivanova TA, Kustova EA, et al. Effects of delta sleep-inducing peptide on pre and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats. Bull Exp Biol Med 2006;142:186-188.
11. Sudakov KV, Umriukhin PE, Rayevsky KS. Delta-sleep inducing peptide and neuronal activity after glutamate microiontophoresis: the role of NMDA-receptors. Pathophysiology 2004;11:81-86.
12. Sethi NK, Sethi PK, Torgovnick J, et al. EMG artifact in brain death electroencephalogram, is it a cry of 'medullary death'? Clinic Neurol Neurosurg 2008;110:729-731.
13. Morimoto Y, Hagihira S, Koizumi Y, et al. The relationship between bispectral index and electroencephalographic parameters during isoflurane anesthesia. Anesth Analg 2004;98:1336-1340. (Pubitemid 38525589)
14. Monk TG, Saini V, Weldon BC, Sigl JC. Anesthetic management and oneyear mortality after noncardiac surgery. Anesth Analg 2005;100:4-10. (Pubitemid 40013594)
15. Bruhn J, Boullon TW, Shafer SL. Electromyographic activity falsely elevates the bispectral index. Anesthesiology 2000;92:1485-1487. (Pubitemid 30257213)
16. Liu N, Chazot T, Huybrechts I, et al. The influence of a muscle relaxant bolus on bispectral and Datex-Ohmeda entropy values during propofolremifentanyl induced loss of consciousness. Anesth Analg 2005;101:1713-1718. (Pubitemid 41720626)