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Volumn 877, Issue 8-9, 2009, Pages 791-798
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Development and validation of a high throughput and robust LC-MS/MS with electrospray ionization method for simultaneous quantitation of diltiazem and its two metabolites in human plasma: Application to a bioequivalence study
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Author keywords
Acquity; Diltiazem; Human plasma; LC MS MS; N desmethylediltiazem; O desacetylediltiazem; UPLC
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Indexed keywords
ACETONITRILE;
AMMONIUM COMPOUNDS;
BIOMOLECULES;
CHROMATOGRAPHIC ANALYSIS;
ETHERS;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HIGH PRESSURE LIQUID CHROMATOGRAPHY;
IONIZATION;
LIQUIDS;
MASS SPECTROMETRY;
METABOLISM;
METABOLITES;
PLASMA (HUMAN);
PLASMAS;
SOLVENT EXTRACTION;
THROUGHPUT;
ACQUITY;
DILTIAZEM;
HUMAN PLASMA;
LC-MS/MS;
N-DESMETHYLEDILTIAZEM;
O-DESACETYLEDILTIAZEM;
UPLC;
ELECTROSPRAY IONIZATION;
ACETONITRILE;
AMMONIUM ACETATE;
DEACETYLDILTIAZEM;
DILTIAZEM;
N NORDILTIAZEM;
TERT BUTYL METHYL ETHER;
ZIPRASIDONE;
ACCURACY;
ADULT;
ARTICLE;
BIOEQUIVALENCE;
CONCENTRATION (PARAMETERS);
CONTROLLED STUDY;
DRUG DETERMINATION;
DRUG FORMULATION;
DRUG ISOLATION;
DRUG STRUCTURE;
ELECTROSPRAY;
ELUTION;
FLOW RATE;
HIGH THROUGHPUT SCREENING;
HUMAN;
HUMAN EXPERIMENT;
LIQUID CHROMATOGRAPHY;
LIQUID LIQUID EXTRACTION;
MALE;
MASS SPECTROMETRY;
MONITORING;
MULTIPLE REACTION MONITORING;
NORMAL HUMAN;
PLASMA;
PRIORITY JOURNAL;
QUANTITATIVE ANALYSIS;
STANDARD;
VALIDATION STUDY;
AUTOMATION;
CHROMATOGRAPHY, LIQUID;
DILTIAZEM;
HUMANS;
MALE;
SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;
TANDEM MASS SPECTROMETRY;
THERAPEUTIC EQUIVALENCY;
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EID: 61549099282
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2009.02.016 Document Type: Article |
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Times cited : (20)
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References (16)
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