Characterization of the enhancing effect of protamine on the proliferative activity of hepatocyte growth factor in rat hepatocytes

Pharmaceutical Research

Volumn 26, Issue 4, 2009, Pages 1012-1021

  Liu, Ke Xin ^a,c,d   Kato, Yukio ^a,e   Matsumoto, Kunio ^b,e   Nakamura, Toshikazu ^b   Kaku, Taiichi ^d   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c DALIAN MEDICAL UNIVERSITY   (China)

^d Japan Bioproducts Industry Co Ltd   (Japan)

^e KANAZAWA UNIVERSITY   (Japan)

Author keywords

Clearance; Heparan sulfate proteoglycan (HSPG); Heparin; Hepatocyte growth factor (HGF); Protamine

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; HEPARIN; IODINE 125; PROTAMINE SULFATE; PROTEOHEPARAN SULFATE; RECOMBINANT SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SEPHAROSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; AUTOPHOSPHORYLATION; CELL CULTURE; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG BINDING; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENTIATION; LIVER CELL; LIVER CLEARANCE; LIVER PERFUSION; LIVER REGENERATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

1-NAPHTHYLISOTHIOCYANATE; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPARIN; HEPATOCYTE GROWTH FACTOR; HEPATOCYTES; HUMANS; LIVER; MALE; PHOSPHORYLATION; PROTAMINES; PROTEOGLYCANS; PROTO-ONCOGENE PROTEINS C-MET; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 61449238007     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9810-1     Document Type: Article

References (40)

1. T. Nakamura T. Nishizawa M. Hagiya T. Seki M. Shimonishi A. Sugimura K. Tashiro S. Shimizu 1989 Molecular cloning and expression of human hepatocyte growth factor Nature. 342 440 443
2. T. Nakamura H. Teramoto A. Icto A. Ichihara 1986 Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures Proc. Natl. Acad. Sci. U. S. A. 83 6489 6493
3. Y. Ishiki H. Ohnishi Y. Muto K. Matsumoto T. Nakamura 1992 Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and for potent anti-hepatitis action in vivo Hepatology. 16 1227 1235
4. Y. Kato K. X. Liu T. Nakamura Y. Sugiyama 1994 Heparin-hepatocyte growth factor complex with low plasma clearance and retained hepatocyte proliferating activity Hepatology. 20 417 424
5. J. K. Spix E. Y. Chay E. R. Block J. K. Klarlund 2007 Hepatocyte growth factor induces epithelial cell motility through transactivation of the epidermal growth factor receptor Exp. Cell Res. 313 3319 3325
6. Y. Matsumoto T. Motoki S. Kubota M. Takigawa H. Tsubouchi E. Gohda 2008 Inhibition of tumor-stromal interaction through HGF/Met signaling by valproic acid Biochem. Biophys. Res. Commun. 366 110 116
7. A. Catizone G. Ricci J. D. Bravo M. Galdieri 2006 Hepatocyte growth factor modulates in vitro survival and proliferation of germ cells during postnatal testis development J. Endocrinol. 189 137 146
8. E. Cacci M. Salani S. Anastasi I. Perroteau G. Poiana S. Biagioni G. Augusti-Tocco 2003 Hepatocyte growth factor stimulates cell motility in cultures of the striatal progenitor cells ST14A J. Neurosci. Res. 74 760 768
9. M. Johansson G. Mattsson A. Andersson L. Jansson P. O. Carlsson 2006 Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats Endocrinology. 147 2315 2324
10. K. X. Liu Y. Kato T. Terasaki T. Nakamura Y. Sugiyama 1995 Change in hepatic handling of hepatocyte growth factor during liver regeneration in rats Am. J. Physiol. 269 G745 G753
11. 4-intoxicated rats Hepatology. 17 651 660
12. S. Hagiwara T. Otsuka Y. Yamazaki T. Kosone N. Sohara T. Ichikawa K. Sato S. Kakizaki H. Takagi M. Mori 2007 Overexpression of NK2 promotes liver fibrosis in carbon tetrachloride-induced chronic liver injury Liver Int. 28 126 131
13. Y. H. Lee Y. J. Suzuki A. J. Griffin R. M. Day 2008 Hepatocyte growth factor regulates cyclooxygenase-2 expression via beta-catenin, Akt, and p42/p44 MAPK in human bronchial epithelial cells Am. J. Physiol. 294 L778 L786
14. E. Vigna L. Naldini L. Tamagnone P. Longati A. Bardelli F. Maina C. Ponzetto P. M. Comoglio 1994 Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene Cell Mol. Biol. 40 597 604
15. C. C. Lee K. M. Yamada 1995 Alternatively spliced juxtamembrane domain of a tyrosine kinase receptor is a multifunctional regulatory site. Deletion alters cellular tyrosine phosphorylation pattern and facilitates binding of phosphatidylinositol-3-OH kinase to the hepatocyte growth factor receptor J. Biol. Chem. 270 507 510
16. A. Bardelli C. Ponzetto P. M. Comoglio 1994 Identification of functional domains in the hepatocyte growth factor and its receptor by molecular engineering J. Biotechnol. 37 109 122
17. K. X. Liu Y. Kato M. Narukawa D. C. Kim M. Hanano O. Higuchi T. Nakamura Y. Sugiyama 1992 The importance of the liver in the plasma clearance of hepatocyte growth factor in rats Am. J. Physiol. 263 G642 G649
18. K. X. Liu Y. Kato T. Terasaki S. Aoki K. Okumura T. Nakamura Y. Sugiyama 1995 Contribution of parenchymal and non-parenchymal liver cell to the clearance of hepatocyte growth factor from the circulation in rats Pharm. Res. 12 737 1740
19. K. X. Liu Y. Kato T. I. Kaku K. Okumura T. Nakamura Y. Sugiyama 1998 Protamine enhances the proliferative activity of hepatocyte growth factor Am. J. Physiol. 274 G21 G28
20. K. X. Liu Y. Kato T. I. Kaku T. Nakamura Y. Sugiyama 1997 Existence of two nonlinear elimination mechanisms for hepatocyte growth factor in rats Am. J. Physiol. 273 5 Pt 1 E891 E897
21. L. E. Kemp B. Mulloy E. Gherardi 2006 Signalling by HGF/SF and Met: the role of heparin sulphate co-receptors Biochem. Soc. Trans. 34 Pt 3 414 417
22. K. Matsumoto T. Nakamura 2008 NK4 gene therapy targeting HGF-Met and angiogenesis Front. Biosci. 13 1943 1951
23. Y. L. Yin H. L. Chen H. M. Kuo S. P. He 2008 NK3 and NK4 of HGF enhance filamin production via STAT pathway, but not NK1 and NK2 in human breast cancer cells Acta Pharmacol. Sin. 29 728 735
24. A. Krishnan K. Viker H. Rietema M. Telgenkamp B. Knudsen M. Charlton 2007 Prolonged engraftment of human hepatocytes in mice transgenic for the deleted form of human hepatocyte growth factor Hepatol. Res. 37 854 862
25. V. C. Yang Y. Y. Fu C. C. Teng S. C. Ma J. N. Shanberge 1994 A method for the quantitation of protamine in plasma Thromb. Res. 74 427 434
26. S. Miyauchi Y. Sawada T. Iga M. Hanano Y. Sugiyama 1993 Comparison of the hepatic uptake clearances of fifteen drugs with a wide range of membrane permeabilities in isolated rat hepatocytes and perfused rat livers Pharm. Res. 10 434 440
27. M. Kato Y. Kato T. Nakamura Y. Sugiyama 1999 Efficient extraction by the liver governs overall elimination of hepatocyte growth factor in rats J. Pharmacol. Exp. Ther. 290 373 379
28. K. Komamura J. Miyazaki E. Imai K. Matsumoto T. Nakamura M. Hori 2008 Hepatocyte growth factor gene therapy for hypertension Methods Mol. Biol. 423 393 404
29. R. Gong A. Rifai Y. Ge S. Chen L. D. Dworkin 2008 Hepatocyte growth factor suppresses proinflammatory NFkappaB activation through GSK3beta inactivation in renal tubular epithelial cells J. Biol. Chem. 283 7401 7410
30. T. H. Cheng W. T. Lee J. S. Jeng C. M. Wu G. C. Liu M. Y. Chiang Y. M. Wang 2006 Synthesis and characterization of a novel paramagnetic macromolecular complex [Gd(TTDASQ-protamine)] Dalton Trans. 21 5149 5155
31. E. Moreno J. C. Meneu J. Calvo B. Perez A. G. Sesma A. Manrique I. Vegh A. M. Aragon M. Grau A. Gimeno C. Jimenez R. Gomez A. Moreno M. Abradelo I. Garcia A. de la Calle 2005 Modulation of hepatocyte growth factor plasma levels in relation to the dose of exogenous heparin administered: an experimental study in rats Transplant. Proc. 37 3943 3947
32. D. C. West C. G. Rees L. Duchesne S. J. Patey C. J. Terry J. E. Turnbull M. Delehedde C. W. Heegaard F. Allain C. Vanpouille D. Ron D. G. Fernig 2005 Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2 J. Biol. Chem. 280 13457 13464
33. D. Naka T. Ishii T. Shimomura T. Hishida H. Hara 1993 Heparin modulates the receptor-binding and mitogenic activity of hepatocyte growth factor on hepatocytes Exp Cell Res. 209 317 324
34. R. H. Schwall L. Y. Chang P. J. Godowski D. W. Kahn K. J. Hillan K. D. Bauer T. F. Zioncheck 1996 Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2 J.Cell Biol. 133 709 718
35. M. Machide K. Kamitori S. Kohsaka 2000 Hepatocyte growth factor-induced differential activation of phospholipase Cgamma1 and phosphatidylinositol 3-kinase is regulated by tyrosine phosphatase, SHP-1 in astrocytes J. Biol. Chem. 275 31392 31398
36. M. Hecht M. Papoutsi H. D. Tran J. Wilting L. Schweigerer 2004 Hepatocyte growth factor/c-Met signaling promotes the progression of experimental human neuroblastomas Cancer Res. 64 6109 6118
37. V. Crljen S. Volinia H. Banfic 2002 Hepatocyte growth factor activates phosphoinositide 3-kinase C2 beta in renal brush-border plasma membranes Biochem. J. 365 Pt 3 791 799
38. Y. Okano K. Mizuno S. Osada T. Nakamura Y. Nozawa 1993 Tyrosine phosphorylation of phospholipase C gamma in c-met/HGF receptor-stimulated hepatocytes: comparison with HepG2 hepatocarcinoma cells Biochem. Biophys. Res. Commun. 190 842 842
39. J. A. Price J. Caldwell N. J. Hewitt 2006 The effect of EGF and the comitogen, norepinephrine, on the proliferative responses of fresh and cryopreserved rat and mouse hepatocytes Cryobiology. 53 182 193
40. V. B. Lokeshwar S. S. Huang J. S. Huang 1989 Protamine enhances epidermal growth factor (EGF)-stimulated mitogenesis by increasing cell surface EGF receptor number J. Biol. Chem. 264 19318 19326