Atypical hyperplasia of the marginal zone of b follicles in a polymorphic epstein-barr virus-associated lymphoproliferative disorder occurring in an adolescent with human immunodeficiency virus infection

Pediatric and Developmental Pathology

Volumn 12, Issue 1, 2009, Pages 59-62

  Dargent, Jean Louis ^a   Haller, Annick ^b   Durdurez, Jean Pierre ^c   Gennotte, Anne Françeoise ^c  

^a INSTITUTE OF PATHOLOGY AND GENETICS   (Belgium)

^b JULES BORDET INSTITUTE   (Belgium)

^c SAINT PIERRE UNIVERSITY HOSPITAL   (Belgium)

Author keywords

B cell; EBV; HIV; Memory B cell; Polyclonal; Polymorphic lymphoproliferative disorder

Indexed keywords

VIRUS RNA;

ADOLESCENT; ARTICLE; B LYMPHOCYTE; CASE REPORT; CONGENITAL INFECTION; EPSTEIN BARR VIRUS; EPSTEIN BARR VIRUS ASSOCIATED LYMPHOPROLIFERATIVE DISORDER; FEMALE; HISTIOCYTE; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOBLAST; LYMPHOCYTE; LYMPHOID HYPERPLASIA; LYMPHOPROLIFERATIVE DISEASE; PHENOTYPE; PLASMA CELL; PRIORITY JOURNAL; VIRUS INFECTION;

ADENOIDS; ADOLESCENT; ANTIGENS, CD; B-LYMPHOCYTES; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; GERMINAL CENTER; HIV INFECTIONS; HUMANS; HYPERPLASIA; IN SITU HYBRIDIZATION; LYMPHOPROLIFERATIVE DISORDERS; POLYMERASE CHAIN REACTION; REED-STERNBERG CELLS;

EID: 61449201965     PISSN: 10935266     EISSN: 16155742     Source Type: Journal    
DOI: 10.2350/08-07-0497.1     Document Type: Article

References (24)

1. Beissner RS, Rappaport ES, Diaz JA. Fatal case of Epstein-Barr virus-induced lymphoproliferative disorder associated with a human immunodeficiency virus infection. Arch Pathol Lab Med 1987;111:250-253.
2. Joshi VV Kauffman S, Oleske JM, et al. Polyclonal polymorphic B-cell lymphoproliferative disorder with prominent pulmonary involvement in children with acquired immune deficiency syndrome. Cancer 1987;59:1455-1462.
3. Kingma DW, Weiss WB, Jaffe ES, Kumar S, Frekko K, Raffeld M. Epstein-Barr virus latent membrane protein-1 oncogene deletions: correlations with malignancy in Epstein-Barr virus-associated lymphoproliferative disorders and malignant lymphomas. Blood 1996;88:242-251.
4. Raphael M, Asso-Bonnet M, El Mansouri S, Martin A. Les hyperplasies lymphoïdes liées au virus de l'immunodéficience humaine et au virus d'Epstein-Barr: relations avec la pathologie lymphomateuse. Ann Pathol 1998;18:325-330.
5. Martin A, Flaman JM, Frebourg T, et al. Functional analysis of the p53 protein in AIDS-related non-Hodgkin's lymphomas and polymorphic lymphoproliferations. Br J Haematol 1998;101:311-317.
6. Tao J, Valderrama E. Epstein-Barr virus-associated polymorphic B-cell lymphoproliferative disorders in the lungs of children with AIDS:a report of two cases. Am J Surg Pathol 1999;23:560-566.
7. Nador RG, Chadburn A, Gundappa G, Cesarman E, Said JW, Knowles DM. Human immunodeficiency virus (HIV)-associated polymorphic lymphoproliferative disorders. Am J Surg Pathol 2003;27:293-302.
8. Loughrey M, Trivett M, Lade S, Murray W, Turner H, Waring P. Diagnostic application of Epstein-Barr virus-encoded RNA in situ hybridisation. Pathology 2004;36:301-308.
9. Martin SI, Zukerberg L, Robbins GK. Reactive Epstein-Barr virus-related polyclonal lymphoproliferative disorder in a patient with AIDS. Clin Infect Dis 2005;41:e76-e79.
10. Manfredi R, Sabbatani S, Gianelli U, Marinacci G. Epstein-Barr virus-associated nasopharyngeal carcinoma and local polymorphic B-cell lymphoproliferative disorder in a patient with HIV disease. J Int Assoc Physicians AIDS Care 2007;6:255-259.
11. Dargent JL, Lespagnard L, Kornreich A, Hermans P, Clumeck N, Verhest A. HIV-associated multinucleated giant cells in lymphoid tissue of the Waldeyer's ring: a detailed study. Mod Pathol 2000;13:1293-1299.
12. Shibata D, Weiss LM, Nathwani BN, Brynes RK, Levine AM. Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodkin's lymphoma.Blood 1991;77:1527-1533.
13. Dolcetti R, Gloghini A, De Vita S, et al. Characteristics of EBV-infected cells in HIV-related lymphadenopathy: implications for the pathogenesis of EBV-associated and EBV-unrelated lymphomas of HIV-seropositive individuals. Int J Cancer 1995;63:652-659.
14. Brousset P, Schlaifer D, Roda D, Massip P, Marchou B, Delsol G. Characterization of Epstein-Barr virus-infected cells in benign lymphadenopathy of patients seropositive for human immunodeficiency virus. Hum Pathol 1996;27:263-268.
15. Van Baarle D, Hovenkamp E, Callan MFC, et al. Dysfunctional Epstein-Barr virus (EBV)-specific CD8+ T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma. Blood 2001;98:146-155.
16. Nathwani BN, Sasu SJ, Ahsanuddin AN, Hernandez AM, Drachen-berg MR. The critical role of histology in an era of genomics and proteomics: a commentary and reflection. Adv Anat Pathol 2007;14:375-400.
17. Tsao L, Hsi ED. The clinicopathologic spectrum of posttransplanta-tion lymphoproliferative disorders. Arch Pathol Lab Med 2007;131:1209-1218.
18. Falini B, Fizzotti M, Pucciarini A, et al. A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood 2000;95:2084-2092.
19. Carbone A, Gloghini A, Larocca LM, et al. Expression profile of MUM1/IRF4, BCL-6, and CD138/syndecan-1 defines novel histoge-netic subsets of human immunodeficiency virus-related lymphomas. Blood 2001;97:744-751.
20. Laichalk LL, Hochberg D, Babcock GJ, Freeman RB, Thorley-LawsonDA. The dispersalofmucosal memoryB cells: evidencefrom persistent EBV infection. Immunity 2002;16:745-754.
21. Anagnostopoulos I, Hummel M, Falini B, Joehrens K, Stein H. Epstein-Barr virus infection of monocytoid B-cell proliferates: an early feature of primary viral infection? Am J Surg Pathol 2005;29:595-601.
22. Brighenti A, Andrulis M, Geissinger E, Roth S, Müller-Hermelink HK, Rüdiger T. Extrafollicular proliferation of B cells in the absence of follicular hyperplasia: a distinct reaction pattern in lymph nodes correlated with primary or recall type responses. Histopathology 2005;47:90-100.
23. Küppers R. B cells under influence: transformation of B cells by Epstein-Barr virus. Nat Rev Immunol 2003;3:801-812.
24. Ehsan A, Fan H, Eagan PA, Siddiqui HA, Gulley ML. Accumulation of p53 in infectious mononucleosis tissues. Hum Pathol 2000;31:1397-1403.