Evaluation of Ki-67 antigen expression in the zona reticularis of the adrenal cortex of female rats in persistent estrus

Human Reproduction

Volumn 24, Issue 3, 2009, Pages 705-709

  Da Silva, Benedito Borges ^a,c   Lopes Costa, Pedro Vitor ^a   Dos Santos, Alesse Ribeiro ^a   Pires, Cleicilene Gomes ^a   Borges, Carine Soares ^a   Gontijo, José Antônio ^b  

^a FEDERAL UNIVERSITY OF PIAUÍ   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c Jockey Club de Sao Paulo   (Brazil)

Author keywords

Adrenal; Ki 67; Persistent estrus; Polycystic ovary; Rat

Indexed keywords

BIOLOGICAL MARKER; FORMALDEHYDE; KI 67 ANTIGEN; TESTOSTERONE PROPIONATE;

ADRENAL CORTEX; ADRENAL GLAND; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; ESTRUS; FEMALE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; NONHUMAN; OVARY POLYCYSTIC DISEASE; RAT; STUDENT T TEST; WISTAR HANNOVER RAT; WISTAR RAT;

ANIMALIA; RATTUS;

EID: 61449176959     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/den451     Document Type: Article

References (29)

1. Azziz R, Black V, Hines GA, Fox LM, Boots LR. Adrenal androgen excess in the polycystic ovary syndrome: sensitivity and responsivity of the hypothalamic-pituitary-adrenal axis. J Clin Endocrinol Metab 1998; 83:2317-2323.
2. Baillargeon JP, Carpentier A. Role of insulin in the hyperandrogenemia of lean women with polycystic ovary syndrome and normal insulin sensitivity. Fertil Steril 2007;88:886-893.
3. Barraclough CA. Production of anovulatory, sterile rats by single injections of testosterone propionate. Endocrinology 1961;68:62- 67.
4. Bell JB, Gould RP, Hyatt PJ, Tait JF, Tait SA. Properties of rat adrenal zona reticularis cells: production and stimulation of certain steroids. J Endocrinol 1979;83:435-447.
5. Belosi C, Selvaggi L, Apa R, Guido M, Romualdi D, Fulghesu AM, Lanzone A. Is the PCOS diagnosis solved by ESHRE/ASRM 2003 consensus or could it include ultrasound examination of the ovarian stroma? Hum Reprod 2006;21:3108-3115.
6. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 1:307-310.
7. Carmina E, Koyama T, Chang L, Stanczyk FZ, Lobo RA. Does ethnicity influence the prevalence of adrenal hyperandrogenism and insulin resistance in polycystic ovary syndrome? Am J Obstet Gynecol 1992; 167:1807- 1812.
8. Chang WY, Knochenhauer ES, Bartolucci AA, Azziz R. Phenotypic spectrum of polycystic ovary syndrome: clinical and biochemical characterization of the three major clinical subgroups. Fertil Steril 2005; 83:1717-1723.
9. da Silva BB, Rocha Gontijo JA, Crété AR, de Jesus Simões M. Evaluation of body weight in androgenized female rats. Clin Exp Obstet Gynecol 2002; 29:97-99.
10. da Silva BB, Lopes IM, Gebrim LH. Effects of raloxifene on normal breast tissue from premenopausal women. Breast Cancer Res Treat 2006; 95:99-103.
11. da Silva BB, Lopes-Costa PV, Rosal MA, Pires CG, dos Santos LG, Gontijo JA, Alencar AP, de Jesus Simões M. Morphological and morphometric analysis of the adrenal cortex of androgenized female rats. Gynecol Obstet Invest 2007;64:44-48.
12. Gerdes J. Ki-67 and other proliferation markers useful for immunohistological diagnostic and prognostic evaluations in human malignancies. Semin Cancer Biol 1990;1:199-206.
13. Gorski RA, Wagner JW. Gonadal activity and sexual differentiation of the hypothalamus. Endocrinology 1965;76:226-239.
14. Harris GW, Levine S. Sexual differentiation of the brain and its experimental control. J Physiol 1965;181:379-400.
15. Hoffman DI, Klove K, Lobo RA. The prevalence and significance of elevated dehydroepiandrosterone sulfate levels in anovulatory women. Fertil Steril 1984;42:76-81.
16. Holt PR, Moss SF, Kapetanakis AM, Petrotos A, Wang S. Is Ki-67 a better proliferative marker in the colon than proliferating cell nuclear antigen? Cancer Epidemiol Biomarkers Prev 1997;6:131-135.
17. Mitani F, Mukai K, Miyamoto H, Suematsu M, Ishimura Y. The undifferentiated cell zone is a stem cell zone in adult rat adrenal cortex. Biochim Biophys Acta 2003;1619:317-324.
18. Moran C, Reyna R, Boots LS, Azziz R. Adrenocortical hyperresponsiveness to corticotropin in polycystic ovary syndrome patients with adrenal androgen excess. Fertil Steril 2004;81:126-131.
19. Norman RJ, Dewailly D, Legro RS, Hickey TE. Polycystic ovary syndrome. Lancet 2007;370:685-697.
20. Pelletier G, Li S, Luu-The V, Tremblay Y, Bélanger A, Labrie F. Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads. J Endocrinol 2001;171:373-383.
21. Pignatelli D, Xiao F, Gouveia AM, Ferreira JG, Vinson GP. Adrenarche in the rat. J Endocrinol 2006;191:301-308.
22. Singh KB. Persistent estrus rat models of polycystic ovary disease: an update. Fertil Steril 2005;84:1228-1234.
23. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (2004). Revised 2003 Consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25.
24. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84:3666-3672.
25. White PC, Curnow KM, Pascoe L. Disorders of steroid 11 beta-hydroxylase isozymes. Endocr Rev 1994;15:421-438.
26. Wrenn TR, Wood JR, Bitman J. Oestrogen responses of rats neonatally sterilized with steroids. J Endocrinol 1969;45:415-420.
27. Xita N, Tsatsoulis A. Review: fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studies. J Clin Endocrinol Metab 2006; 91:1660-1666.
28. Yildiz BO, Goodarzi MO, Guo X, Rotter JI, Azziz R. Heritability of dehydroepiandrosterone sulfate in women with polycystic ovary syndrome and their sisters. Fertil Steril 2006;86:1688-1693.
29. Zhou R, Bird IM, Dumesic DA, Abbott DH. Adrenal hyperandrogenism is induced by fetal androgen excess in a rhesus monkey model of polycystic ovary syndrome. J Clin Endocrinol Metab 2005; 90:6630-6637.