Everolimus and sirolimus antagonize tacrolimus based calcineurin inhibition via competition for FK-binding protein 12

Biochemical Pharmacology

Volumn 77, Issue 7, 2009, Pages 1206-1212

  van Rossum, Huub H ^a   Romijn, Fred P H T M ^a   Smit, Nico P M ^a   de Fijter, Johan W ^a   van Pelt, Johannes ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Calcineurin; Everolimus; FK binding protein; Sirolimus; Tacrolimus; Transplantation

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; EVEROLIMUS; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 12; IMMUNOPHILIN; INTERLEUKIN 12; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; RAPAMYCIN; TACROLIMUS; UNCLASSIFIED DRUG;

ALLOTRANSPLANTATION; ARTICLE; CELL LYSATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG ANTAGONISM; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IC 50; IMMUNOSUPPRESSIVE TREATMENT; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RADIOASSAY; REPRODUCIBILITY;

BINDING, COMPETITIVE; CALCINEURIN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LEUKOCYTES, MONONUCLEAR; SIROLIMUS; TACROLIMUS; TACROLIMUS BINDING PROTEIN 1A;

EID: 61449150347     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.12.009     Document Type: Article

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