CREB mediates prostaglandin F2α-induced MUC5AC overexpression

Journal of Immunology

Volumn 182, Issue 4, 2009, Pages 2349-2356

  Chung, Wen Cheng ^a   Ryu, Seung Hee ^a   Sun, Hongxia ^a   Zeldin, Darryl C ^b   Koo, Ja Seok ^a,c  

^a UNIVERSITY OF TEXAS   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MUCIN; MUCIN 5AC; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROTEIN KINASE C; S6 KINASE; CREB1 PROTEIN, HUMAN; MUC5AC PROTEIN, HUMAN;

AIRWAY OBSTRUCTION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INFLAMMATION; MUCUS SECRETION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; BIOSYNTHESIS; DNA MICROARRAY; EPITHELIUM CELL; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WESTERN BLOTTING;

BLOTTING, WESTERN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DINOPROST; EPITHELIAL CELLS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MUCIN 5AC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RESPIRATORY MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 61449121024     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0713637     Document Type: Article

References (37)

1. Rose, M. C., and J. A. Voynow. 2006. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol. Rev. 86: 245-278.
2. Voynow, J. A., S. J. Gendler, and M. C. Rose. 2006. Regulation of mucin genes in chronic inflammatory airway diseases. Am. J. Respir. Cell Mol. Biol. 34: 661-665.
3. Thornton, D. J., T. Gray, P. Nettesheim, M. Howard, J. S. Koo, and J. K. Sheehan. 2000. Characterization of mucins from cultured normal human tracheobronchial epithelial cells. Am. J. Physiol. 278: L1118-L1128.
4. Kirkham, S., J. K. Sheehan, D. Knight, P. S. Richardson, and D. J. Thornton. 2002. Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. Biochem. J. 361: 537-546.
5. Fahy, J. V. 2001. Remodeling of the airway epithelium in asthma. Am. J. Respir. Crit. Care Med. 164(Suppl.): 46-51.
6. Koo, J. S., Y. D. Kim, A. M. Jetten, P. Belloni, and P. Nettesheim. 2002. Overexpression of mucin genes induced by interleukin-1β, tumor necrosis factor-α, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor α antagonist. Exp. Lung Res. 28: 315-332.
7. Shelhamer, J. H., S. J. Levine, T. Wu, D. B. Jacoby, M. A. Kaliner, and S. I. Rennard. 1995. NIH conference. Airway inflammation. Ann. Intern. Med. 123: 288-304.
8. Proud, D., R. M. Naclerio, J. M. Gwaltney, and J. O. Hendley. 1990. Kinins are generated in nasal secretions during natural rhinovirus colds. J. Infect. Dis. 161: 120-123.
9. Kim, Y. D., E. J. Kwon, T. K. Kwon, S. H. Baek, S. Y. Song, and J. S. Suh. 2000. Regulation of IL-1β-mediated MUC2 gene in NCI-H292 human airway epithelial cells. Biochem. Biophys. Res. Commun. 274: 112-116.
10. Kim, Y. D., E. J. Kwon, D. W. Park, S. Y. Song, S. K. Yoon, and S. H. Baek. 2002. Interleukin-1β induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells. Mol. Pharmacol. 62: 1112-1118.
11. Kim, Y. D., J. Y. Jeon, H. J. Woo, J. C. Lee, J. H. Chung, S. Y. Song, S. K. Yoon, and S. H. Baek. 2002. Interleukin-1β induces MUC2 gene expression and mucin secretion via activation of PKC-MEK/ERK, and PI3K in human airway epithelial cells. J. Korean Med. Sci. 17: 765-771.
12. 2 receptors, and cyclic AMP-protein kinase A signaling. Mol. Pharmacol. 66: 337-346.
13. Gray, T., R. Coakley, A. Hirsh, D. Thornton, S. Kirkham, J. S. Koo, L. Burch, R. Boucher, and P. Nettesheim. 2004. Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1β in human bronchial epithelia. Am. J. Physiol. 286: L320-L330.
14. Song, K. S., W. J. Lee, K. C. Chung, J. S. Koo, E. J. Yang, J. Y. Choi, and J. H. Yoon. 2003. Interleukin-1β and tumor necrosis factor-α induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. J. Biol. Chem. 278: 23243-23250.
15. Gavett, S. H., S. L. Madison, P. C. Chulada, P. E. Scarborough, W. Qu, J. E. Boyle, H. F. Tiano, C. A. Lee, R. Langenbach, V. L. Roggli, and D. C. Zeldin. 1999. Allergic lung responses are increased in prostaglandin H synthase-deficient mice. J. Clin. Invest. 104: 721-732.
16. Tilley, S. L., T. M. Coffman, and B. H. Koller. 2001. Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J. Clin. Invest. 108: 15-23.
17. Carey, M. A., D. R. Germolec, R. Langenbach, and D. C. Zeldin. 2003. Cyclooxygenase enzymes in allergic inflammation and asthma. Prostaglandins Leukot. Essent. Fatty Acids 69: 157-162.
18. Hata, A. N., and R. M. Breyer. 2004. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharmacol. Ther. 103: 147-166.
19. 2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells. J. Biol. Chem. 280: 6676-6681.
20. Spicer, S. S., and J. R. Martinez. 1984. Mucin biosynthesis and secretion in the respiratory tract. Environ. Health Perspect. 55: 193-204.
21. Rich, B., A. C. Peatfield, I. P. Williams, and P. S. Richardson. 1984. Effects of prostaglandins E1, E2, and F2 alpha on mucin secretion from human bronchi in vitro. Thorax 39: 420-423.
22. Kim, K. C., J. Nassiri, and J. S. Brody. 1989. Mechanisms of airway goblet cell mucin release: studies with cultured tracheal surface epithelial cells. Am. J. Respir. Cell Mol. Biol. 1: 137-143.
23. 2 alpha receptor is coupled to Gq in cDNA-transfected Chinese hamster ovary cells. Biochem. Biophys. Res. Commun. 200: 756-762.
24. Abramovitz, M., M. Adam, Y. Boie, M. Carriere, D. Denis, C. Godbout, S. Lamontagne, C. Rochette, N. Sawyer, N. M. Tremblay, et al. 2000. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim. Biophys. Acta 1483: 285-293.
25. 2α-FP receptor interaction in human endometrial adenocarcinomas. Cancer Res. 65: 7707-7716.
26. 2α synthesis via the F-series-prostanoid receptor and extracellular signal-regulated kinase 1/2 signaling pathway. Endocrinology 146: 4657-4664.
27. Mayr, B., and M. Montminy. 2001. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell Biol. 2: 599-609.
28. Kim, S. W., J. S. Hong, S. H. Ryu, W. C. Chung, J. H. Yoon, and J. S. Koo. 2007. Regulation of mucin gene expression by CREB via a nonclassical RA signaling pathway. Mol. Cell. Biol. 27: 6933-6947.
29. Chiappara, G., P. Chanez, A. Bruno, E. Pace, F. Pompeo, J. Bousquet, G. Bonsignore, and M. Gjomarkaj. 2007. Variable p-CREB expression depicts different asthma phenotypes. Allergy 62: 787-794.
30. Gray, T. E., K. Guzman, C. W. Davis, L. H. Abdullah, and P. Nettesheim. 1996. Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 14: 104-112.
31. Koo, J. S., A. M. Jetten, P. Belloni, J. H. Yoon, Y. D. Kim, and P. Nettesheim. 1999. Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells. Biochem. J. 338(Pt 2): 351-357.
32. Aggarwal, S., S. W. Kim, K. Cheon, F. H. Tabassam, J. H. Yoon, and J. S. Koo. 2006. Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells. Mol. Biol. Cell 17: 566-575.
33. Gray, T., P. Nettesheim, C. Basbaum, and J. Koo. 2001. Regulation of mucin gene expression in human tracheobronchial epithelial cells by thyroid hormone. Biochem. J. 353: 727-734.
34. Park, J. A., F. He, L. D. Martin, Y. Li, B. N. Chorley, and K. B. Adler. 2005. Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase Cδ-mediated mechanism. Am. J. Pathol. 167: 651-661.
35. 2α-induced hypertrophy of vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 338: 910-918.
36. Johannessen, M., M. P. Delghandi, and U. Moens. 2004. What turns CREB on? Cell Signal. 16: 1211-1227.
37. Gately, S., and W. W. Li. 2004. Multiple roles of COX-2 in tumor angiogenesis: a target for antiangiogenic therapy. Semin. Oncol. 31: 2-11.