Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines

Cancer Chemotherapy and Pharmacology

Volumn 63, Issue 5, 2009, Pages 807-818

  Stoeger, Scott M ^a   Cowan, Kenneth H ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

DNA damage; Drug resistance; KSR1; NCI anticancer drug screen; Signal transduction

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOCHALASIN H; KINASE SUPPRESSOR OF RAS 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE; RAS PROTEIN; TUNICAMYCIN; UNCLASSIFIED DRUG; UO 126;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; DRUG SCREENING; DRUG SENSITIVITY; ENZYME ACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIVIRAL AGENTS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL PROLIFERATION; CELLS, CULTURED; CYTOCHALASINS; DRUG SCREENING ASSAYS, ANTITUMOR; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; FEMALE; FIBROBLASTS; HUMANS; MICE; MICE, KNOCKOUT; OVARIAN NEOPLASMS; PROTEIN KINASES; TUNICAMYCIN;

EID: 61449110093     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0794-7     Document Type: Article

References (64)

1. DC Allred GM Clark AK Tandon R Molina DC Tormey CK Osborne KW Gilchrist EG Mansour M Abeloff L Eudey 1992 HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma J Clin Oncol 10 599 605
2. M Alvarez K Paull A Monks C Hose JS Lee J Weinstein M Grever S Bates T Fojo 1995 Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen J Clin Invest 95 2205 2214
3. G Berton L Fumagalli C Laudanna C Sorio 1994 Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils J Cell Biol 126 1111 1121
4. MR Boyd 2004
5. RK Burt S Garfield K Johnson SS Thorgeirsson 1988 Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals Carcinogenesis 9 2329 2332
6. AM Cacace NR Michaud M Therrien K Mathes T Copeland GM Rubin DK Morrison 1999 Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression Mol Cell Biol 19 229 240
7. BA Carlson MM Dubay EA Sausville L Brizuela PJ Worland 1996 Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells Cancer Res 56 2973 2978
8. S Continolo A Baruzzi M Majeed E Caveggion L Fumagalli CA Lowell G Berton 2005 The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization Exp Cell Res 302 253 269
9. B Dickstein EM Valverius K Wosikowski M Saceda JW Pearson MB Martin SE Bates 1993 Increased epidermal growth factor receptor in an estrogen-responsive, adriamycin-resistant MCF-7 cell line J Cell Physiol 157 110 118
10. BM Dickstein K Wosikowski SE Bates 1995 Increased resistance to cytotoxic agents in ZR75B human breast cancer cells transfected with epidermal growth factor receptor Mol Cell Endocrinol 110 205 211
11. JM Gee JF Robertson IO Ellis RI Nicholson 2001 Phosphorylation of ERK1/2 mitogen-activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer Int J Cancer 95 247 254
12. D Gerlier N Thomasset 1986 Use of MTT colorimetric assay to measure cell activation J Immunol Methods 94 57 63
13. BA Gusterson RD Gelber A Goldhirsch KN Price J Save-Soderborgh R Anbazhagan J Styles CM Rudenstam R Golouh R Reed 1992 Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) breast cancer study group J Clin Oncol 10 1049 1056
14. MP Hagan A Yacoub P Dent 2007 Radiation-induced PARP activation is enhanced through EGFR-ERK signaling J Cell Biochem 12 12
15. P Hu Z Han AD Couvillon JH Exton 2004 Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death J Biol Chem 279 49420 49429 (Epub 2004 Aug 31)
16. C Huang K Jacobson MD Schaller 2004 MAP kinases and cell migration J Cell Sci 117 4619 4628
17. CC Hung T Ichimura JL Stevens JV Bonventre 2003 Protection of renal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation J Biol Chem 278 29317 29326 (Epub May 8 2003)
18. CC Jiang LH Chen S Gillespie YF Wang KA Kiejda XD Zhang P Hersey 2007 Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis Cancer Res 67 9750 9761
19. WE Kaminski A Piehler JJ Wenzel 2006 ABC A-subfamily transporters: structure, function and disease Biochim Biophys Acta 1762 510 524 (Epub 2006 Feb 28)
20. K Katagiri S Matsuura 1971 Antitumor activity of cytochalasin D J Antibiot (Tokyo) 24 722 723
21. DP Kelsell EE Norgett H Unsworth MT Teh T Cullup CA Mein PJ Dopping-Hepenstal BA Dale G Tadini P Fleckman KG Stephens VP Sybert SB Mallory BV North DR Witt E Sprecher AE Taylor A Ilchyshyn CT Kennedy H Goodyear C Moss D Paige JI Harper BD Young IM Leigh RA Eady EA O'Toole 2005 Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis Am J Hum Genet 76 794 803 (Epub 2005 Mar 8)
22. M Kim Y Yan RL Kortum SM Stoeger MK Sgagias K Lee RE Lewis KH Cowan 2005 Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity Cancer Res 65 3986 3992
23. YK Kim HJ Kim CH Kwon JH Kim JS Woo JS Jung JM Kim 2005 Role of ERK activation in cisplatin-induced apoptosis in OK renal epithelial cells J Appl Toxicol 25 374 382
24. HM Koo A Monks A Mikheev LV Rubinstein M Gray-Goodrich MJ McWilliams WG Alvord HK Oie AF Gazdar KD Paull H Zarbl GF Vande Woude 1996 Enhanced sensitivity to 1-beta-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes Cancer Res 56 5211 5216
25. K Kornfeld DB Hom HR Horvitz 1995 The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans Cell 83 903 913
26. RL Kortum DL Costanzo J Haferbier SJ Schreiner GL Razidlo MH Wu DJ Volle T Mori H Sakaue NV Chaika OV Chaika RE Lewis 2005 The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis Mol Cell Biol 25 7592 7604
27. RL Kortum HJ Johnson DL Costanzo DJ Volle GL Razidlo AM Fusello AS Shaw RE Lewis 2006 The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence Mol Cell Biol 26 2202 2214
28. RL Kortum RE Lewis 2004 The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells Mol Cell Biol 24 4407 4416
29. H Kurokawa AE Lenferink JF Simpson PI Pisacane MX Sliwkowski JT Forbes CL Arteaga 2000 Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells Cancer Res 60 5887 5894
30. C Lefevre S Audebert F Jobard B Bouadjar H Lakhdar O Boughdene-Stambouli C Blanchet-Bardon R Heilig M Foglio J Weissenbach M Lathrop JF Prud'homme J Fischer 2003 Mutations in the transporter ABCA12 are associated with lamellar ichthyosis type 2 Hum Mol Genet 12 2369 2378 (Epub 2003 Jul 15)
31. J Lozano R Xing Z Cai HL Jensen C Trempus W Mark R Cannon R Kolesnick 2003 Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice Cancer Res 63 4232 4238
32. SA Matheny C Chen RL Kortum GL Razidlo RE Lewis MA White 2004 Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP Nature 427 256 260
33. JA McCubrey LS Steelman WH Chappell SL Abrams EW Wong F Chang B Lehmann DM Terrian M Milella A Tafuri F Stivala M Libra J Basecke C Evangelisti AM Martelli RA Franklin 2006 Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance Biochim Biophys Acta 7 7
34. Y Miyata 2005 Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents Curr Pharm Des 11 1131 1138
35. A Monks D Scudiero P Skehan R Shoemaker K Paull D Vistica C Hose J Langley P Cronise A Vaigro-Wolff 1991 Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines J Natl Cancer Inst 83 757 766
36. DK Morrison 2001 KSR: a MAPK scaffold of the Ras pathway? J Cell Sci 114 1609 1612
37. J Moscow E Schneider B Sikic C Morrow K Cowan 2006
38. JA Moscow T Connolly TG Myers CC Cheng K Paull KH Cowan 1997 Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected cell lines Int J Cancer 72 184 190
39. J Muller S Ory T Copeland H Piwnica-Worms DK Morrison 2001 C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1 Mol Cell 8 983 993
40. P Natarajan JA May HM Sanderson M Zabe P Spangenberg S Heptinstall 2000 Effects of cytochalasin H, a potent inhibitor of cytoskeletal reorganisation, on platelet function Platelets 11 467 476
41. A Nguyen WR Burack JL Stock R Kortum OV Chaika M Afkarian WJ Muller KM Murphy DK Morrison RE Lewis J McNeish AS Shaw 2002 Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo Mol Cell Biol 22 3035 3045
42. DT Nguyen S Kebache A Fazel HN Wong S Jenna A Emadali EH Lee JJ Bergeron RJ Kaufman L Larose E Chevet 2004 Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress Mol Biol Cell 15 4248 4260 (Epub 2004 Jun 16)
43. KD Paull RH Shoemaker L Hodes A Monks DA Scudiero L Rubinstein J Plowman MR Boyd 1989 Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm J Natl Cancer Inst 81 1088 1092
44. DL Persons EM Yazlovitskaya W Cui JC Pelling 1999 Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin Clin Cancer Res 5 1007 1014
45. DL Persons EM Yazlovitskaya JC Pelling 2000 Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin J Biol Chem 275 35778 35785
46. GL Razidlo RL Kortum JL Haferbier RE Lewis 2004 Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation J Biol Chem 279 47808 47814 (Epub 2004 Sep 13)
47. LV Rubinstein RH Shoemaker KD Paull RM Simon S Tosini P Skehan DA Scudiero A Monks MR Boyd 1990 Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines J Natl Cancer Inst 82 1113 1118
48. EA Sausville SG Arbuck R Messmann D Headlee KS Bauer RM Lush A Murgo WD Figg T Lahusen S Jaken X Jing M Roberge E Fuse T Kuwabara AM Senderowicz 2001 Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms J Clin Oncol 19 2319 2333
49. RH Shoemaker 2006 The NCI60 human tumour cell line anticancer drug screen Nat Rev Cancer 6 813 823
50. LS Steelman SC Pohnert JG Shelton RA Franklin FE Bertrand JA McCubrey 2004 JAK/STAT, Raf/MEK/ERK, PI3 K/Akt and BCR-ABL in cell cycle progression and leukemogenesis Leukemia 18 189 218
51. M Sundaram M Han 1995 The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction Cell 83 889 901
52. G Szakacs JP Annereau S Lababidi U Shankavaram A Arciello KJ Bussey W Reinhold Y Guo GD Kruh M Reimers JN Weinstein MM Gottesman 2004 Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells Cancer Cell 6 129 137
53. E Szegezdi U Fitzgerald A Samali 2003 Caspase-12 and ER-stress-mediated apoptosis: the story so far Ann N Y Acad Sci 1010 186 194
54. M Therrien HC Chang NM Solomon FD Karim DA Wassarman GM Rubin 1995 KSR, a novel protein kinase required for RAS signal transduction Cell 83 879 888
55. L Vicentini P Mazzi E Caveggion S Continolo L Fumagalli JA Lapinet-Vera CA Lowell G Berton 2002 Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation J Immunol 168 6446 6454
56. X Wang JL Martindale NJ Holbrook 2000 Requirement for ERK activation in cisplatin-induced apoptosis J Biol Chem 275 39435 39443
57. X Wang GP Studzinski 2001 Phosphorylation of raf-1 by kinase suppressor of ras is inhibited by "MEK-specific" inhibitors PD 098059 and U0126 in differentiating HL60 cells Exp Cell Res 268 294 300
58. X Wang GP Studzinski 2004 Kinase suppressor of RAS (KSR) amplifies the differentiation signal provided by low concentrations 1, 25-dihydroxyvitamin D3 J Cell Physiol 198 333 342
59. X Wang TT Wang JH White GP Studzinski 2006 Induction of kinase suppressor of RAS-1(KSR-1) gene by 1, alpha25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5′-flanking region Oncogene. 25 7078 7085 (Epub 2006 May 29)
60. SQ Wei LH Sui JH Zheng GM Zhang YL Kao 2004 Role of ERK1/2 kinase in cisplatin-induced apoptosis in human ovarian carcinoma cells Chin Med Sci J 19 125 129
61. JM Wells HG Cutler RJ Cole 1976 Toxicity and plant growth regulator effects of cytochalasin H isolated from Phomopsis sp Can J Microbiol 22 1137 1143
62. H Xing K Kornfeld AJ Muslin 1997 The protein kinase KSR interacts with 14-3-3 protein and Raf Curr Biol 7 294 300
63. HR Xing C Cordon-Cardo X Deng W Tong L Campodonico Z Fuks R Kolesnick 2003 Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer Nat Med 9 1266 1268 (Epub 2003 Sep 7)
64. I Yahara F Harada S Sekita K Yoshihira S Natori 1982 Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitro J Cell Biol 92 69 78