Toxic effects of oral administration of extracts of dried calyx of Hibiscus sabdariffa linn. (malvaceae)

Phytotherapy Research

Volumn 23, Issue 3, 2009, Pages 412-416

  Fakeye, Titilayo O ^a,b   Pal, Anirban ^a   Bawankule, D U ^c   Yadav, N P ^c   Khanuja, S P S ^a  

^a CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

^b UNIVERSITY OF IBADAN   (Nigeria)

^c NONE

Author keywords

Chronic toxicity profile; Hibiscus sabdariffa extracts; Rats

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; HIBISCUS SABDARIFFA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CHRONIC TOXICITY; CONTROLLED STUDY; DEATH; DIARRHEA; FOOD INTAKE; HEMATOLOGY; HIBISCUS; HISTOPATHOLOGY; MALE; MUSCULAR DYSTROPHY; NONHUMAN; RAT; SOLVENT EXTRACTION; WEIGHT REDUCTION;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BODY WEIGHT; CHOLESTEROL; CREATININE; HIBISCUS; LEUKOCYTE COUNT; MALE; ORGAN SIZE; PLANT EXTRACTS; RATS; SPLEEN; TOXICITY TESTS, CHRONIC;

ANIMALIA; HIBISCUS SABDARIFFA; MALVACEAE; RATTUS;

EID: 61449096527     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2644     Document Type: Article

References (20)

1. Akindahunsi AA, Olaleye MT. 2003. Toxicological investigation of aqueous-methanolic extract of the calyces of Hibiscus sabdariffa L. J Ethnopharmacol 89: 161-164.
2. Ali BH, Wabel NA, Blunden G. 2005. Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review. Phytother Res 19: 369-375.
3. Ali MB, Salih WM. 1991. Investigations of the antispasmodic potential of Hibiscus sabdariffa calyces. J Ethnopharmacol 31: 249-257.
4. Chen CC, Hsu JD, Wang SF et al. 2003. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J Agric Food Chem 51: 5472-5477.
5. Du CT, Francis FJ. 1973. Anthocyanins of flower of Hibiscus sabdariffa. J Food Sci 38: 310-312.
6. Gibson CM, Pinto DS, Murphy SA et al. 2003. Association of creatinine clearance on presentation in acute myocardial infarction with subsequent mortality. J Am Coll Cardiol 42:1535-1543.
7. Hawcroft DM. 1987. Diagnostic Enzymology Analytical Chemistry by Open Learning. Published by permission of the controller of Her Majesty's Stationery Office: London, 186-221.
8. Herrera-Arellano A, Flores-Romero S, Chavez-Soto MA, Tortoriello J. 2004. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine 11: 375-382.
9. Nakamura Y, Hidaka M, Masaki H, Seto H, Udzumo T. 1990. Major anthocyanin of flower of Hibiscus sabdariffa. Agric Biol Chem 54: 3345-3351.
10. Odigie IP, Ettarh RR, Adigun SA. 2003. Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats. J Ethnopharmacol 86: 181-185.
11. Onyenekwe PC, Ajani EO, Ameh DA, Gamaniel KS. 1999. Anti-hypertensive effect of rosselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats. Cell Biochem Function 17: 199-206.
12. Orisakwe OE, Husaini DC, Afonne OJ. 2004. Testicular effects of sub-chronic administration of Hibiscus sabdariffa calyx aqueous extract in rats. Reprod Toxicol 18: 295-298.
13. Owulade MO, Eghianruwa KI, Daramola FO. 2004. Effects of aqueous extracts of Hibiscus sabdariffa calyces and Ocimum gratisimum leaves in intestinal transits in rats. Afr J Biomed Res 7: 31-33.
14. Tanaka T, Kawamori T, Ohnishi M et al. 1994. Chemoprevention of 4-nitroquinoline-1-oxide-induced oral carcinogenesis by dietary protocatechuic acid during initiation and postinitiation phases. Cancer Res 54: 2359-2365.
15. Tanaka T, Kojima T, Kawamori T, Mori H. 1995. Chemoprevention of digestive organs carcinogenesis by natural product protocatechuic acid. Cancer Suppl 75: 1433-1439.
16. Tseng TH, Hsu JD, Lo MH et al. 1998. Inhibitory effect of Hibiscus protocatechuic acid on tumor promotion in mouse skin. Cancer Lett 126: 199-207.
17. Tseng TH, Kao ES, Chu CY, Chou FP, Lin Wu HW, Wang CJ. 1997. Protective effects of dried flower extracts of Hibiscus sabdariffa L. against oxidative stress in rat primary hepatocytes. Food Chem Toxicol 35: 1159-1164.
18. Tsuda T, Shiga K, Ohshima K, Kawakishi S, Osawa T. 1996. Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L. Biochem Pharmacol 52: 1033-1039.
19. Wang CJ, Wang JM, Lin WL, Chu CY, Tseng TH. 2000. Protective effects of Hibiscus anthocyanin against tert-butyl hydroperoxide-induced hepatic toxicity in rats. Food Chem Toxicol 38: 411-416.
20. Wrolstad RE, Durst RW, Lee J. 2005. Tracking color pigment changes in anthocyanin products. Trends Food Sci Technol 16: 423-428.