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Physical Review E
Volumn 51, Issue 5, 1995, Pages 5058-5063
Spontaneous nucleation of microtubules
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EID: 6144289488     PISSN: 1063651X     EISSN: None     Source Type: Journal    
DOI: 10.1103/PhysRevE.51.5058     Document Type: Article
Times cited : (53)
References (16)
  • 8
    • 84927502571 scopus 로고    scopus 로고
    • D. Kuchnir Fygenson, Ph. D. thesis, Princeton University, 1995.
  • 9
    • 84927470393 scopus 로고    scopus 로고
    • In samples less than 25 mum thick nonspecific absorption of tubulin on glass becomes significant and the tubulin concentration is not well controlled. A measurement of this effect is given in [5].
  • 11
    • 84927465369 scopus 로고    scopus 로고
    • A parametrization of the microtubule length l to the turbidity Mstar at a wavelength of 0.35 mum scattered light gives Mstarapp 200 l2 for l<0.2 mum and Mstarapp 60 l -4 for l>0.2 mum (Appendix of [10]). The most sensitive case is the one with the fastest nucleation rate (C=19 μ M). In this case microtubules grow at a rate v approx 0.1 mum/sec and thus reach the linear regime in a time τ =2 sec after nucleation. Assuming the nucleation rate increases with time R(t) prop talpha, the turbidity at time t, integrated over all previous nucleation events, is Mstar(t) = tint0tR(t prime ) Mstar (l=v̇(t-t prime ) )d t prime pp [6/( α +1)( α +2)] tα+2 - [4/( α +1)] tα+1 +4 τ talpha to lowest order in tau, where both t and tau are in seconds. The first term dominates once t>2( α +2)/3. For typical values of α app 3, this happens when t>3 sec.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.