Simultaneous analysis of aconitine, mesaconitine, hypaconitine, and jesaconitine in whole blood by LC-MS-MS using a new polymer column

Forensic Toxicology

Volumn 27, Issue 1, 2009, Pages 7-11

  Hattori, Hideki ^a   Hirata, Yukari ^b   Hamajima, Makoto ^b   Kaneko, Rina ^c   Ito, Kenjiro ^a   Ishii, Akira ^c   Suzuki, Osamu ^d   Seno, Hiroshi ^a  

^a AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Aconitine; Hypaconitine; Jesaconitine; LC MS MS; Mesaconitine; New polymer column

Indexed keywords

ACONITINE; DEXTROMETHORPHAN; HYPACONITINE; JESACONITINE; MESACONITINE; POLYMER;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; FORENSIC TOXICOLOGY; HUMAN; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

RATTUS;

EID: 61349196808     PISSN: 18608965     EISSN: 18608973     Source Type: Journal    
DOI: 10.1007/s11419-008-0060-z     Document Type: Article

References (14)

1. M. Mizugaki K. Ito 2005
2. S.P. Elliot 2002 A case of fatal poisoning with the aconitine plant: quantitative analysis in biological fluid Sci Justice 42 111 115
3. R. Pullela L. Young B. Gallagher S.P. Avis E.W. Randell 2008 A case of fatal aconitine poisoning by monkshood ingestion J Forensic Sci 53 491 494
4. A.A. Van Landegheim E.A. De Letter W.E. Lambert C.H. Van Peteghem M.H.A. Piette 2007 Aconitine involvement in an unusual homicide case Int J Legal Med 121 214 219
5. H. Ohta Y. Seto N. Tsunoda Y. Takahashi K. Matsuura K. Ogasawara 1998 Determination of Aconitum alkaloids in blood and urine samples II. Capillary liquid chromatographicfrit fast atom bombardment mass spectrometric analysis J Chromatogr B 714 215 221
6. Y. Fujita M. Fujita H. Niitsu K. Oikawa K. Terui T. Akatsu M. Kikuchi N. Sato H. Aoki K. Takahashi S. Endo 2005 A simple and rapid method for analysis of Aconitium alkaloids in serum and urine using liquid chromatography electrospray ionization mass spectrometry J Trad Med 22 49 54
7. R. Kaneko S. Hattori S. Furuta M. Hamajima Y. Hirata K. Watanabe H. Seno A. Ishii 2006 Sensitive analysis of aconitine, hypaconitine, mesaconitine and jesaconitine in human body fluids and Aconitum tubers by LC/ESI-TOF-MS J Mass Spectrom 41 810 814
8. S.-K. Wong S.-K. Tsui S.-Y. Kwan 2002 Analysis of proprietary Chinese medicines for the presence of toxic ingredients by LC/MS/MS J Pharm Biomed Anal 30 161 170
9. J. Beike L. Frommherz M. Wood B. Brinkman H. Köhler 2004 Determination of aconitine in body fluids by LC-MSMS Int J Legal Med 118 289 293
10. J. Beyer F.T. Peters T. Kraemer H.H. Maurer 2007 Detection and validated quantification of toxic alkaloids in human blood plasma-comparison of LC-APCI-MS with LC-ESI-MS/MS J Mass Spectrom 42 621 633
11. Z. Wang Z. Wang J. Wen Y. He 2007 Simultaneous determination of three Aconitum alkaloids in urine by LC-MS-MS J Pharm Biomed Anal 45 145 148
12. F. Zhang M.-H. Tang L.-J. Chen R. Li X.-H. Wang J.-G. Duan X. Zhao Y.-Q. Wei 2008 Simultaneous quantitation of aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine and benzoylhypaconine in human plasma by liquid chromatography-tandem mass spectrometry and pharmacokinetics evaluation of "SHEN-FU" injectable powder J Chromatogr B 873 173 179
13. H. Hattori K. Ito M. Iwai T. Arinobu Y. Mizutani T. Kumazawa A. Ishii O. Suzuki H. Seno 2007 Rapid analysis of sertraline, fluvoxamine, and paroxetine in serum specimens by LC-MS-MS using a new polymer column Forensic Toxicol 25 100 103
14. H. Hattori T. Arinobu M. Iwai K. Masuda O. Suzuki H. Seno 2005 Analysis of butyrophenones in whole blood specimens by LC/MS/MS using a new polymer column Jpn J Forensic Toxicol 23 13 17