Transcript levels of different cytokines and chemokines correlate with clinical and endoscopic activity in ulcerative colitis

BMC Gastroenterology

Volumn 9, Issue , 2009, Pages

  Zahn, Alexandra ^a   Giese, Thomas ^b   Karner, Max ^a   Braun, Annika ^a   Hinz, Ulf ^b   Stremmel, Wolfgang ^a   Ehehalt, Robert ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALGRANULIN B; CXCL2 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 8; ALPHA CHEMOKINE; BIOLOGICAL MARKER; MESSENGER RNA;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COLON BIOPSY; DISEASE ACTIVITY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; INTESTINE ENDOSCOPY; MALE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TISSUE LEVEL; ULCERATIVE COLITIS; ADOLESCENT; CLINICAL TRIAL; ENDOSCOPY; GENETICS; HOSPITALIZATION; METABOLISM; MIDDLE AGED; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL MODEL;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; CALGRANULIN B; CHEMOKINES, CXC; COLITIS, ULCERATIVE; ENDOSCOPY; FEMALE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 61349187008     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-9-13     Document Type: Article

References (20)

1. Autschbach F Giese T Gassler N Sido B Heuschen G Heuschen U Zuna I Schulz P Weckauf H Berger I et al Cytokine/chemokine messenger-RNA expression profiles in ulcerative colitis and Crohn's disease Virchows Arch 2002, 441(5):500-513 10.1007/s00428-002-0684-z 12447682
2. Sartor RB Cytokines in intestinal inflammation: Pathophysiological and clinical considerations Gastroenterology 1994, 106(2):533-539 8299918
3. Gotteland M Lopez M Munoz C Saez R Altshiller H Llorens P Brunser O Local and systemic liberation of proinflammatory cytokines in ulcerative colitis Dig Dis Sci 1999, 44(4):830-835 10.1023/A:1026690631693 10219845
4. Stallmach A Giese T Schmidt C Ludwig B Mueller-Molaian I Meuer SC Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn's disease Int J Colorectal Dis 2004, 19(4):308-315 10.1007/ s00384-003-0554-4 14605835
5. Schmidt C Giese T Ludwig B Menges M Schilling M Meuer SC Zeuzem S Stallmach A Increased cytokine transcripts in pouchitis reflect the degree of inflammation but not the underlying entity Int J Colorectal Dis 2006, 21(5):419-426 10.1007/s00384-005-0024-2 16133004
6. Raddatz D Bockemuhl M Ramadori G Quantitative measurement of cytokine mRNA in inflammatory bowel disease: Relation to clinical and endoscopic activity and outcome Eur J Gastroenterol Hepatol 2005, 17(5):547-557 10.1097/00042737-200505000-00012 15827446
7. Kusugami K Fukatsu A Tanimoto M Shinoda M Haruta J Kuroiwa A Ina K Kanayama K Ando T Matsuura T et al Elevation of interleukin-6 in inflammatory bowel disease is macrophage- and epithelial cell-dependent Dig Dis Sci 1995, 40(5):949-959 10.1007/BF02064182 7729284
8. Mazzucchelli L Hauser C Zgraggen K Wagner H Hess M Laissue JA Mueller C Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation Am J Pathol 1994, 144(5):997-1007 1887375 8178948
9. Keshavarzian A Fusunyan RD Jacyno M Winship D MacDermott RP Sanderson IR Increased interleukin-8 (IL-8) in rectal dialysate from patients with ulcerative colitis: Evidence for a biological role for IL-8 in inflammation of the colon Am J Gastroenterol 1999, 94(3):704-712 10.1111/ j.1572-0241.1999.00940.x 10086655
10. Mahida YR Ceska M Effenberger F Kurlak L Lindley I Hawkey CJ Enhanced synthesis of neutrophil-activating peptide-1/interleukin-8 in active ulcerative colitis Clin Sci (Lond) 1992, 82(3):273-275 1312411
11. Nielsen OH Rudiger N Gaustadnes M Horn T Intestinal interleukin-8 concentration and gene expression in inflammatory bowel disease Scand J Gastroenterol 1997, 32(10):1028-1034 10.3109/00365529709011220 9361176
12. Mitsuyama K Toyonaga A Sasaki E Watanabe K Tateishi H Nishiyama T Saiki T Ikeda H Tsuruta O Tanikawa K IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn's disease Clin Exp Immunol 1994, 96(3):432-436 1534558 8004812
13. Stremmel W Ehehalt R Autschbach F Karner M Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: A randomized trial Ann Intern Med 2007, 147(9):603-610 17975182
14. Stremmel W Merle U Zahn A Autschbach F Hinz U Ehehalt R Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis Gut 2005, 54(7):966-971 1774598 15951544 10.1136/gut.2004.052316
15. Rachmilewitz D Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: A randomised trial Bmj 1989, 298(6666):82-86 1835436 2563951
16. Raab Y Gerdin B Ahlstedt S Hallgren R Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis Gut 1993, 34(9):1203-1206 1375454 8406154 10.1136/gut.34.9.1203
17. Uguccioni M Gionchetti P Robbiani DF Rizzello F Peruzzo S Campieri M Baggiolini M Increased expression of IP-10, IL-8, MCP-1, and MCP-3 in ulcerative colitis Am J Pathol 1999, 155(2):331-336 1866859 10433925
18. Lugering N Stoll R Schmid KW Kucharzik T Stein H Burmeister G Sorg C Domschke W The myeloic related protein MRP8/14 (27E10 antigen) - usefulness as a potential marker for disease activity in ulcerative colitis and putative biological function Eur J Clin Invest 1995, 25(9):659-664 10.1111/j.1365-2362.1995.tb01982.x 7498239
19. Lugering N Stoll R Kucharzik T Schmid KW Rohlmann G Burmeister G Sorg C Domschke W Immunohistochemical distribution and serum levels of the Ca(2+)-binding proteins MRP8, MRP14 and their heterodimeric form MRP8/14 in Crohn's disease Digestion 1995, 56(5):406-414 10.1159/000201267 8549885
20. Widmer U Manogue KR Cerami A Sherry B Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines J Immunol 1993, 150(11):4996-5012 8496601