Role of human transcription elongation factor DSIF in the suppression of senescence and apoptosis

Genes to Cells

Volumn 14, Issue 3, 2009, Pages 343-354

  Komori, Toshiharu ^a   Inukai, Naoto ^a,b   Yamada, Tomoko ^a,c   Yamaguchi, Yuki ^a   Handa, Hiroshi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRB SENSITIVITY INDUCING FACTOR; PROTEIN P53; TRANSCRIPTION ELONGATION FACTOR; TRANSCRIPTION FACTOR POL II; TRANSCRIPTION FACTOR SPT4; TRANSCRIPTION FACTOR SPT5; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; CELL LINE; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE REPRESSION; GENE TARGETING; GENETIC ANALYSIS; HUMAN; HUMAN CELL; KNOCKOUT GENE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN DEPLETION; RNA ANALYSIS; SENESCENCE; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

AGING; APOPTOSIS; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 61349174723     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2008.01273.x     Document Type: Article

References (30)

1. Aida, M., Chen, Y., Nakajima, K., Yamaguchi, Y., Wada, T. & Handa, H. (2006) Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB gene. Mol. Cell. Biol. 26, 6094-6104.
2. Andrulis, E.D., Guzman, E., Doring, P., Werner, J. & Lis, J.T. (2000) High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: Roles in promoter proximal pausing and transcription elongation. Genes Dev. 14, 2635-2649.
3. Basrai, M.A., Kingsbury, J., Koshland, D., Spencer, F. & Hieter, P. (1996) Faithful chromosome transmission requires Spt4p, a putative regulator of chromatin structure in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 2838-2847.
4. Burckin, T., Nagel, R., Mandel-Gutfreund, Y., Shiue, L., Clark, T.A., Chong, J.L., Chang, T.H., Squazzo, S., Hartzog, G. & Ares, M. Jr (2005) Exploring functional relationships between components of the gene expression machinery. Nat. Struct. Mol. Biol. 12, 175-182.
5. Cheng, B. & Price, D.H. (2007) Properties of RNA polymerase II elongation complexes before and after the P-TEFb-mediated transition into productive elongation. J. Biol. Chem. 282, 21901-21912.
6. Gilmour, D.S. & Lis, J.T. (1984) Detecting protein-DNA interactions in vivo: Distribution of RNA polymerase on specific bacterial genes. Proc. Natl Acad. Sci. USA 81, 4275-4279.
7. Guo, S., Yamaguchi, Y., Schilbach, S., Wada, T., Lee, J., Goddard, A., French, D., Handa, H. & Rosenthal, A. (2000) A regulator of transcriptional elongation controls vertebrate neuronal development. Nature 408, 366-369.
8. Hartzog, G.A., Wada, T., Handa, H. & Winston, F. (1998) Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae. Genes Dev. 12, 357-369.
9. Inukai, N., Yamaguchi, Y., Kuraoka, I., Yamada, T., Kamijo, S., Kato, J., Tanaka, K. & Handa, H. (2004) A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis. J. Biol. Chem. 279, 8190-8195.
10. Ivanov, D., Kwak, Y.T., Guo, J. & Gaynor, R.B. (2000) Domains in the SPT5 protein that modulate its transcriptional regulatory properties. Mol. Cell. Biol. 20, 2970-2983.
11. Kaplan, C.D., Morris, J.R., Wu, C. & Winston, F. (2000) Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster. Genes Dev. 14, 2623-2634.
12. Keegan, B.R., Feldman, J.L., Lee, D.H., Koos, D.S., Ho, R.K., Stainier, D.Y. & Yelon, D. (2002) The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo. Development 129, 1623-1632.
13. Li, C. & Wong, W.H. (2001) Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection. Proc. Natl Acad. Sci. USA 98, 31-36.
14. Li, X. & Manley, J.L. (2006) Cotranscriptional processes and their influence on genome stability. Genes Dev. 20, 1838-1847.
15. Malagon, F. & Aguilera, A. (1996) Differential intrachromosomal hyper-recombination phenotype of spt4 and spt6 mutants of S. cerevisiae. Curr. Genet. 30, 101-106.
16. Narita, T., Yung, T.M., Yamamoto, J., Tsuboi, Y., Tanabe, H., Tanaka, K., Yamaguchi, Y. & Handa, H. (2007) NELF interacts with CBC and participates in 3′ end processing of replication-dependent histone mRNAs. Mol. Cell 26, 349-365.
17. Newman, J.C. & Weiner, A.M. (2005) L2L: A simple tool for discovering the hidden significance in microarray expression data. Genome Biol. 6, R81.
18. Saunders, A., Core, L.J. & Lis, J.T. (2006) Breaking barriers to transcription elongation. Nat. Rev. Mol. Cell Biol. 7, 557-567.
19. Sehgal, P.B., Darnell, J.E. Jr & Tamm, I. (1976) The inhibition by DRB (5,6-dichloro-1-b-D-ribofuranosylbenzimidazole) of hnRNA and mRNA production in HeLa cells. Cell 9, 473-480.
20. Shim, E.Y., Walker, A.K., Shi, Y. & Blackwell, T.K. (2002) CDK-9/ cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo. Genes Dev. 16, 2135-2146.
21. Sims, R.J. III, Belotserkovskaya, R. & Reinberg, D. (2004) Elongation by RNA polymerase II: The short and long of it. Genes Dev. 18, 2437-2468.
22. Swanson, M.S., Malone, E.A. & Winston, F. (1991) SPT5, an essential gene important for normal transcription in Saccharomyces cerevisiae, encodes an acidic nuclear protein with a carboxy-terminal repeat. Mol. Cell. Biol. 11, 3009-3019.
23. Swanson, M.S. & Winston, F. (1992) SPT4, SPT5 and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiae. Genetics 132, 325-336.
24. Wada, T., Takagi, T., Yamaguchi, Y., Ferdous, A., Imai, T., Hirose, S., Sugimoto, S., Yano, K., Hartzog, G.A., Winston, F., Buratowski, S. & Handa, H. (1998a) DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. Genes Dev. 12, 343-356.
25. Wada, T., Takagi, T., Yamaguchi, Y., Watanabe, D. & Handa, H. (1998b) Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro. EMBO J. 17, 7395-7403.
26. Whitfield, M.L., Sherlock, G., Saldanha, A.J., Murray, J.I., Ball, C.A., Alexander, K.E., Matese, J.C., Perou, C.M., Hurt, M.M., Brown, P.O. & Botstein, D. (2002) Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol. Biol. Cell 13, 1977-2000.
27. Wu, C.H., Yamaguchi, Y., Benjamin, L.R., Horvat-Gordon, M., Washinsky, J., Enerly, E., Larsson, J., Lambertsson, A., Handa, H. & Gilmour, D. (2003) NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. Genes Dev. 17, 1402-1414.
28. Yamada, T., Yamaguchi, Y., Inukai, N., Okamoto, S., Mura, T. & Handa, H. (2006) P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation. Mol. Cell 21, 227-237.
29. Yamaguchi, Y., Takagi, T., Wada, T., Yano, K., Furuya, A., Sugimoto, S., Hasegawa, J. & Handa, H. (1999a) NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Cell 97, 41-51.
30. Yamaguchi, Y., Wada, T., Watanabe, D., Takagi, T., Hasegawa, J. & Handa, H. (1999b) Structure and function of the human transcription elongation factor DSIF. J. Biol. Chem. 274, 8085-8092.