Structures of alternatively spliced isoforms of human ketohexokinase

Acta Crystallographica Section D: Biological Crystallography

Volumn 65, Issue 3, 2009, Pages 201-211

  Trinh, Chi H ^a   Asipu, Aruna ^b   Bonthron, David T ^b   Phillips, Simon E V ^a,c  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c DIAMOND LIGHT SOURCE LTD   (United Kingdom)

Author keywords

Alternatively spliced isoforms; Fructokinase; Fructosuria; Ketohexokinase

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENYLYLIMIDODIPHOSPHATE; FRUCTOKINASE; FRUCTOSE; HYBRID PROTEIN; KETOHEXOKINASE; MAGNESIUM;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; ENZYME ACTIVE SITE; GENETICS; HUMAN; METABOLISM; MISSENSE MUTATION; MOLECULAR GENETICS; PHOSPHORYLATION; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; ADENYLYL IMIDODIPHOSPHATE; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; FRUCTOKINASES; FRUCTOSE; HUMANS; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PHOSPHORYLATION; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 61349167051     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444908041115     Document Type: Article

References (46)

1. Altschul, S., Thomas, L., Madden, A., Schäffer, A., Zhang, J., Zhang, Z., Miller, W. & Lipman, D. J. (1997). Nucleic Acids Res. 25, 3389-3402.
2. Asipu, A., Hayward, B. E., O'Reilly, J. & Bonthron, D. T. (2003). Diabetes, 52, 2426-2432.
3. Bais, R., James, H.M., Rofe, A.M. & Conyers, R. A. (1985). Biochem. J. 230, 53-60.
4. Boesiger, P., Buchli, R., Meier, D., Steinmann, B. & Gitzelmann, R. (1994). Pediatr. Res. 36, 436-440.
5. Bonthron, D. T., Brandy, N., Donaldson, I. A. & Steinmann, B. (1994). Hum. Mol. Genet. 3, 1627-1631.
6. Bork, P., Sander, C. & Valencia, A. (1993). Protein Sci. 2,31-40.
7. Brünger, A. T. (1992). Nature (London), 355, 472-475.
8. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J.-S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T. & Warren, G. L. (1998). Acta Cryst. D54, 905-921.
9. Cao, P., Gong, Y., Tang, L., Leung, Y. C. & Jiang, T. (2006). J. Struct. Biol. 154, 327-332.
10. Cheng, G., Bennett, E. M., Begley, T. P. & Ealick, S. E. (2002). Structure, 10, 225-235.
11. Clamp, M., Cuff, J., Searle, S. M. & Barton, G. J. (2004). Bioinformatics, 12, 426-427.
12. Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.
13. Cornell, W. D., Cieplak, P., Bayly, C. I., Gould, I. R., Merz, K. M., Ferguson, D. M., Spellmeyer, D. C., Fox, T., Caldwell, J. W. & Kollman, P. A. (1995). J. Am. Chem. Soc. 117, 5179-5197.
14. DeLano, W. L. (2002). The PyMOL Molecular Graphics System. DeLano Scientific, Palo Alto, California, USA.
15. Emsley, P. & Cowtan, K. (2004). Acta Cryst. D60, 2126-2132.
16. Engh, R. A. & Huber, R. (1991). Acta Cryst. A47, 392-400.
17. Gold, N. D. & Jackson, R. M. (2006). Nucleic Acids Res. 34, D231-D234.
18. Hansen, T., Arnfors, L., Ladenstein, R. & Schönheit, P. (2007). Extremophiles, 11, 105-114.
19. Hayward, B. E. & Bonthron, D. T. (1998). Eur. J. Biochem. 257, 85-91.
20. Hayward, S., Kitao, A. & Berendsen, H. J. C. (1997). Proteins, 27, 425-437.
21. Ito, S., Fushinobu, S., Jeong, J. J., Yoshioka, I., Koga, S., Shoun, H. & Wakagi, T. (2003). J. Mol. Biol. 331, 871-883.
22. Ito, S., Fushinobu, S., Yoshioka, I., Koga, S., Matsuzawa, H. & Wakagi, T. (2001). Structure, 9, 205-214.
23. Johnson, R. J., Segal,M. S., Sautin, Y., Nakagawa, T., Feig, D. I., Kang, D. H., Gersch, M. S., Benner, S. & Sanchez-Lozada, L. G. (2007). Am. J. Clin. Nutr. 86, 899-906.
24. Jones, T. A., Zou, J.-Y., Cowan, S. W. & Kjeldgaard, M. (1991). Acta Cryst. A47, 110-119.
25. Kabsch, W. & Sander, C. (1983). Biopolymers, 22, 2577-2637.
26. Koo, H. Y., Wallig, M. A., Chung, B. H., Nara, T. Y., Cho, B. H. & Nakamura, M. T. (2008). Biochim. Biophys. Acta, 1782, 341-348.
27. Larkin, M. A., Blackshields, G., Brown, N. P., Chenna, R., McGettigan, P. A., McWilliam, H., Valentin, F., Wallace, I. M., Wilm, A., Lopez, R., Thompson, J. D., Gibson, T. J. & Higgins, D. G. (2007). Bioinformatics, 21, 2947-2948.
28. Laskowski, R. A., MacArthur, M. W., Moss, D. S. & Thornton, J. M. (1993). J. Appl. Cryst. 26, 283-291.
29. Leslie, A. G. W. (1992). Jnt CCP4/ESF-EACBM Newsl. Protein Crystallogr. 26.
30. Lovell, S. C., Davis, I. W., Arendall, W. B. III, de Bakker, P. I. W., Word, J. M., Prisant, M. G., Richardson, J. S. & Richardson, D. C. (2003). Proteins, 50, 437-450.
31. Mathews, I. I., Erion, M. D. & Ealick, S. E. (1998). Biochemistry, 37, 15607-15620.
32. Murshudov, G. N., Vagin, A. A. & Dodson, E. J. (1997). Acta Cryst. D53, 240-255.
33. Navaza, J. (1994). Acta Cryst. A50, 157-163.
34. Ohshima, N., Inagaki, E., Yasuike, K., Takio, K. & Tahirov, T. H. (2004). J. Mol. Biol. 340, 477-489.
35. Pearlman, D. A., Case, D. A., Caldwell, J. W., Ross, W. S., Cheatham, T. E., Debolt, S., Ferguson, D., Seibel, G. & Kollman, P. (1995). Comput. Phys. Commun. 91, 1-41.
36. Raushel, F. M. & Cleland, W. W. (1977). Biochemistry, 16, 2169-2175.
37. Safo, M. K., Musayev, F. N., Hunt, S. & di Salvo, M. L. (2004). J. Bacteriol. 186, 8074-8082.
38. Schumacher, M. A., Scott, D. M., Mathews, I. I., Ealick, S. E., Roos, D. S., Ullman, B. & Brennan, R. G. (2000). J. Mol. Biol. 296, 549-567.
39. Sigrell, J. A., Cameron, A. D., Jones, T. A. & Mowbray, S. L. (1998). Stucture, 6, 183-193.
40. Sigrell, J. A., Cameron, A. D. & Mowbray, S. L. (1999). J. Mol. Biol. 290, 1009-1018.
41. Steinmann, B., Gitzelman, R. & Van den Berghe, G. (2001). The Metabolic and Molecular Bases of Inherited Disease, 8th ed., edited by C. R. Scriver, A. L. Beaudet & W. S. Sly, pp. 1489-1520. New York: McGraw-Hill.
42. Terwilliger, T. C. (2000). Acta Cryst. D56, 965-972.
43. Terwilliger, T. C. & Berendzen, J. (1999). Acta Cryst. D55, 849-861.
44. Wu, L.-F., Reizer, A., Reizer, J., Cai, B., Tomich, J. M. & Saier, M. H. Jr (1991). J. Bacteriol. 173, 3117-3127.
45. Zhang, Y., Dougherty, M., Downs, D. M. & Ealick, S. E. (2004). Structure, 12, 1809-1821.
46. Zhang, Y., el Kouni, M. H. & Ealick, S. E. (2006). Acta Cryst. D62, 140-145.