Expression level of enzymes related to in situ estrogen synthesis and clinicopathological parameters in breast cancer patients

Journal of Steroid Biochemistry and Molecular Biology

Volumn 113, Issue 3-5, 2009, Pages 195-201

  Suzuki, Masayo ^a   Ishida, Hiroyuki ^a   Shiotsu, Yukimasa ^a   Nakata, Taisuke ^a   Akinaga, Shiro ^a   Takashima, Shigemitsu ^b   Utsumi, Toshiaki ^c   Saeki, Toshiaki ^d   Harada, Nobuhiro ^c  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION SHIKOKU CANCER CENTER   (Japan)

^c FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Enzyme (STS, EST, aromatase, 17 HSD); Gene expression (RT PCR); Hormone; Receptor (ER, erbB2); Steroid; Tumor

Indexed keywords

AROMATASE; CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN; ESTROGEN SULFOTRANSFERASE; MESSENGER RNA; STERYL SULFATASE; TESTOSTERONE 17BETA DEHYDROGENASE; TESTOSTERONE 17BETA DEHYDROGENASE 1; TESTOSTERONE 17BETA DEHYDROGENASE 2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER RECURRENCE; CONTROLLED STUDY; ENZYME ASSAY; ESTROGEN SYNTHESIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PROTEIN EXPRESSION; UPREGULATION;

17-HYDROXYSTEROID DEHYDROGENASES; ADULT; AGED; AROMATASE; BREAST NEOPLASMS; CYCLIN D1; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; FEMALE; HUMANS; MIDDLE AGED; RECEPTOR, ERBB-2; RNA, MESSENGER; STERYL-SULFATASE; SULFOTRANSFERASES;

EID: 61349137531     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2008.12.008     Document Type: Article

References (26)

1. Labrie F., Simard J., Luu-The V., Pelletier G., Belghmi K., and Bélanger A. Structure, regulation and role of 3 beta-hydroxysteroid dehydrogenase, 17 beta-hydroxysteroid dehydrogenase and aromatase enzymes in the formation of sex steroids in classical and peripheral intracrine tissues. Baillieres Clin. Endocrinol. Metab. 8 (1994) 451-474
2. Labrie F. Adrenal androgens and intracrinology. Semin. Reprod. Med. 22 (2004) 299-309
3. Sasano H., Suzuki T., Nakata T., and Moriya T. New development in intracrinology of breast carcinoma. Breast Cancer 13 (2006) 129-136
4. Yue W., Wang J.-P., Hamilton C.J., Demers L.M., and Santen R.J. In situ aromatization enhances breast tumor estradiol levels and cellular proliferation. Cancer Res. 58 (1998) 927-932
5. Sasano H., and Harada N. Intratumoral aromatase in human breast, endometrial, and ovarian malignancies. Endocr. Rev. 19 (1998) 593-607
6. Poutanen M., Isomaa V., Peltoketo H., and Vihko R. Role of 17 beta-hydroxysteroid dehydrogenase type 1 in endocrine and intracrine estradiol biosynthesis. J. Steroid Biochem. Mol. Biol. 55 (1995) 525-532
7. Santner S.J., Feil P.D., and Santen R.J. In situ estrogen production via the estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway. J. Clin. Endocrinol. Metab. 59 (1984) 29-33
8. Sørlie T., Perou C.M., Tibshirani R., Aas T., Geisler S., Johnsen H., Hastie T., Eisen M.B., van de Rijn M., Jeffrey S.S., Thorsen T., Quist H., Matese J.C., Brown P.O., Botstein D., Eystein Lønning P., and Børresen-Dale A.L. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 10869-10874
9. van't Veer L.J., Dai H., van de Vijver M.J., He Y.D., Hart A.A., Mao M., Peterse H.L., van der Kooy K., Marton M.J., Witteveen A.T., Schreiber G.J., Kerkhoven R.M., Roberts C., Linsley P.S., Bernards R., and Friend S.H. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415 (2002) 530-536
10. Kristensen V.N., Harada N., Yoshimura N., Haraldsen E., Lonning P.E., Erikstein B., Kåresen R., Kristensen T., and Børresen-Dale A.L. Genetic variants of CYP19 (aromatase) and breast cancer risk. Oncogene 19 (2000) 1329-1333
11. Utsumi T., Yoshimura N., Takeuchi S., Ando J., Maruta M., Maeda K., and Harada N. Steroid sulfatase expression is an independent predictor of recurrence in human breast cancer. Cancer Res. 59 (1999) 377-381
12. Suzuki T., Moriya T., Ariga N., Kaneko C., Kanazawa M., and Sasano H. 17Beta-hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters. Br. J. Cancer 82 (2000) 518-523
13. Suzuki T., Nakata T., Miki Y., Kaneko C., Moriya T., Ishida T., Akinaga S., Hirakawa H., Kimura M., and Sasano H. Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma. Cancer Res. 63 (2003) 2762-2770
14. Yoshimura N., Harada N., Bukholm I., Karesen R., Borresen-Dale A.L., and Kristensen V.N. Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer. Breast Cancer Res. 6 (2004) R46-R55
15. Utsumi T., Yoshimura N., Takeuchi S., Maruta M., Maeda K., and Harada N. Elevated steroid sulfatase expression in breast cancers. J. Steroid Biochem. Mol. Biol. 73 (2000) 141-145
16. Santner S.J., Ohlsson-Wilhelm B., and Santen R.J. Estrone sulfate promotes human breast cancer cell replication and nuclear uptake of estradiol in MCF-7 cell cultures. Int. J. Cancer 54 (1993) 119-124
17. Evans T.R., Rowlands M.G., Law M., and Coombes R.C. Intratumoral oestrone sulphatase activity as a prognostic marker in human breast carcinoma. Br. J. Cancer 69 (1994) 555-561
18. Adams J.B., Pewnim T., Chandra D.P., Archibald L., and Foo M.S. A correlation between estrogen sulfotransferase levels and estrogen receptor status in human primary breast carcinoma. Cancer Res. 39 (1979) 5124-5126
19. Tseng L., Mazella J., Lee L.Y., and Stone M.L. Estrogen sulfatase and estrogen sulfotransferase in human primary mammary carcinoma. J. Steroid Biochem. 19 (1983) 1413-1417
20. Pasqualini J.R., Chetrite G., Blacker C., Feinstein M.C., Delalonde L., Talbi M., and Maloche C. Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients. J. Clin. Endocrinol. Metab. 81 (1996) 1460-1464
21. Gunnarsson C., Olsson B.M., Stål O., and Southeast Sweden Breast Cancer Group. Abnormal expression of 17beta-hydroxysteroid dehydrogenases in breast cancer predicts late recurrence. Cancer Res. 61 (2001) 8448-8451
22. Sasano H., Edwards D.P., Anderson T.J., Silverberg S.G., Evans D.B., Santen R.J., Ramage P., Simpson E.R., Bhatnagar A.S., and Miller W.R. Validation of new aromatase monoclonal antibodies for immunohistochemistry: progress report. J. Steroid Biochem. Mol. Biol. 86 (2003) 239-244
23. Pasqualini J.R., Chetrite G., and Le Nestour E. Control and expression of oestrone sulphatase activities in human breast cancer. J. Endocrinol. 150 (1996) S99-105
24. Rb phosphorylation during mitogenic stimulation of G1-arrested human breast cancer cells. Oncogene 12 (1996) 2315-2324
25. Zwijsen R.M., Wientjens E., Klompmaker R., von der Sman J., Bernards R., and Michalides R.J. CDK-independent activation of estrogen receptor by cyclin D1. Cell 88 (1997) 405-415
26. Hynes N.E., and Stern D.F. The biology of erbB-2/neu/Her-2 and its role in cancer. Biochem. Biophys. Acta 1198 (1994) 165-184