An easy access to the exocyclic lactams analogous of the central nervous system active tricyclic nitroxapine, mianserine and chlothiapine agents using N-acyliminium chemistry

Heterocycles

Volumn 76, Issue 2, 2008, Pages 1017-1022

  Hadou, Abderrahmane ^a,b   Hamid, Abdulkareem ^a   Mathouet, Hilarion ^a   Deïda, Mohamed Fadel ^b   Daïch, Adam ^a  

^a UNIVERSITÉ DU HAVRE   (France)

^b University of Nouakchott El Asriya   (Mauritania)

Author keywords

Cationic Cyclization; CNS Activity; Dibenzo(thia, oxa or a)zepine; N Acyliminium Ion

Indexed keywords

EID: 61349124307     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/COM-08-S(N)97     Document Type: Article

References (23)

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19. For recent paper in this area, see:. Zhang W., Huang L., and Wang J. Synthesis (2006) 2053
20. 2, AcOEt/cyclohexane (4:1)] and recrystallized from the indicated solvents to give the expected tricyclic product.
21. 2 (251.28): C, 76.48; H, 5.21; N, 5.57. Found: C, 76.31; H, 5.09; N, 5.48.
22. 2 (249.27): C 77.10; H 4.45; N 5.62. Found: C 76.92; H 4.30; N 5.48.
23. 2 (263.29): C 77.55; H 4.98; N 5.32. Found: C 77.33; H 4.76; N 5.16.