Comparative QSAR modelling of 2-phenylindole-3-carbaldehyde derivatives as potential antimitotic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 6, 2009, Pages 1737-1739

  Halder, Amit Kumar ^a   Adhikari, Nilanjan ^a   Jha, Tarun ^a  

^a JADAVPUR UNIVERSITY   (India)

Author keywords

2 Phenylindole 3 carbaldehyde derivatives; Antimitotic agents; Electrostatic potential charges; MLR FA; QSAR modelling

Indexed keywords

2 PHENYLINDOLE 3 CARBALDEHYDE DERIVATIVE; ANTIMITOTIC AGENT; CHLORINE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; FACTORIAL ANALYSIS; HUMAN; HUMAN CELL; IC 50; MULTIPLE LINEAR REGRESSION ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL ANALYSIS; SUBSTITUTION REACTION;

ANTIMITOTIC AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MICROTUBULES; MITOSIS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REGRESSION ANALYSIS;

EID: 61349119473     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.081     Document Type: Article

References (25)

1. Lodish H., Berk A., Matsudaira P., Kaiser C.A., Krieger M., Scott M.P., Zipurski S.L., and Darnell J. Molecular Cell Biology (2004), W.H. Freeman, New York Chapter 20
2. Alberts B., Bray D., Lewis J., Raff M., Roberts K., and Watson J.D. Molecular Biology of the Cell (1994), Garland, New York Chapter 18
3. Jordan M.A., and Wilson L. Nat. Rev. Cancer 4 (1987) 253
4. Tripathi K.D. Essentials of Medical Pharmacology (2003), Jaypee, New Delhi Chapter 60
5. Kaufmann D., Pojarova M., Vogel S., Liebl R., Gastpar R., Gross D., Nishino T., Pfaller T., and Angerer E. Bioorg. Med. Chem. 15 (2007) 5122
6. Hall H., Mohney B., and Kier L.B. Quant. Struct. - Act. Relat. 10 (1991) 43
7. de Gregorio C., Kier L.B., and Hall L.H. J. Comput.-Aided Mol. Des. 12 (1998) 557
8. Carrasco R., Padron A.J., and Galvez J. J. Pharm. Pharmaceut. Sci. 7 (2004) 19
9. Mouse: a computer program developed by Department of Pharmaceutical Technology of Jadavpur University, India.
10. Hypercube, Inc. Hyperchem, Professional Release 7.0 Hypercube Inc., Gainesville.
11. DRAGON web version 2.1 is developed by Milano Chemometrics and QSAR Research Group, Dipartimento di Scienze dell'Ambiente e del Territorio Universitàdegli Studi di Milano, Bicocca.
12. Balaban A.T. Chem. Phys. Lett. 89 (1982) 399
13. Barysz M., Jashari G., Lall R.S., Srivastava A.K., and Trinajstic N. In: King R.B. (Ed). Chemical Applications of Topology and Graph Theory (1983), Elsevier, Amsterdam 222
14. Randic M. J. Chem. Inf. Comput. Sci. 41 (2001) 607
15. Bonchev D. Information Theoretic Indices for Characterization of Chemical Structures (1983), RSP-Wiley, Chichetser
16. Magnuson V.R., Harriss D.K., and Basak S.C. In: King R.B. (Ed). Studies in Physical and Theoretical Chemistry (1983), Elsevier, Amsterdam 178
17. Basak S.C., and Gute G.D. SAR QSAR Environ. Res. 7 (1997) 1
18. Lovasz L., and Pelikan J. Period. Math. Hung. 3 (1973) 175
19. Balaban A.T. Pure Appl.Chem. 55 (1983) 199
20. Todeschini R., and Consonni V. Handbook of Molecular Descriptors (2000), Wiley-VCH, Weinheim
21. Chem 3D Pro Version 5.0 and Chem Draw Ultra Version 5.0, Programs of CambridgeSoft Corporation, USA.
22. Leach A.R. Molecular Modeling: Principles and Applications (2001), Pearson, London Chapter 4
23. Franke R. The Theoretical Drug Design Methods (1984), Elsevier, Amsterdam
24. Leonard J.T., and Roy K. Bioorg. Med. Chem. Lett. 16 (2006) 4467
25. Leonard J.T., and Roy K. Bioorg. Med. Chem. 14 (2006) 1039