Characterization of MHC class-I restricted TCRαβ+ CD4- CD8- double negative T cells recognizing the gp100 antigen from a melanoma patient after gp100 vaccination

Cancer Immunology, Immunotherapy

Volumn 58, Issue 5, 2009, Pages 709-718

  Voelkl, Simon ^a,b   Moore, Tamson V ^c   Rehli, Michael ^b   Nishimura, Michael I ^c,d   MacKensen, Andreas ^a   Fischer, Karin ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c UNIVERSITY OF CHICAGO   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Cancer vaccination; DN T cells; Melanoma; T cell receptor; Tumor associated antigen; Tumor specific T cells

Indexed keywords

GAMMA INTERFERON; GLYCOPROTEIN GP 100; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TUMOR NECROSIS FACTOR;

ANTIGEN RECOGNITION; ARTICLE; CANCER IMMUNIZATION; CANCER PATIENT; CELL CLONE; CYTOKINE RELEASE; HUMAN; HUMAN CELL; MELANOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN ISOLATION; T LYMPHOCYTE; TUMOR IMMUNITY;

ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, NEOPLASM; CANCER VACCINES; CELL LINE, TUMOR; CLONE CELLS; CYTOTOXICITY, IMMUNOLOGIC; GRANZYMES; HLA-A2 ANTIGEN; HUMANS; IMMUNOPHENOTYPING; IMMUNOTHERAPY, ACTIVE; INTERFERON-GAMMA; INTERLEUKINS; MELANOMA; MEMBRANE GLYCOPROTEINS; PERFORIN; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 61349112040     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-008-0593-3     Document Type: Article

References (45)

1. K Fischer S Voelkl J Heymann GK Przybylski K Mondal M Laumer L Kunz-Schughart CA Schmidt R Andreesen A Mackensen 2005 Isolation and characterization of human antigen-specific TCR alpha beta+ CD4-CD8- double-negative regulatory T cells Blood 105 2828 2835
2. RM Zinkernagel PC Doherty 1997 The discovery of MHC restriction Immunol Today 18 14 17
3. J Sprent M Schaefer D Lo R Korngold 1986 Functions of purified L3T4+ and Lyt-2+ cells in vitro and in vivo Immunol Rev 91 195 218
4. MI Nishimura D Avichezer MC Custer CS Lee C Chen MR Parkhurst RA Diamond PF Robbins DJ Schwartzentruber SA Rosenberg 1999 MHC class I-restricted recognition of a melanoma antigen by a human CD4+ tumor infiltrating lymphocyte Cancer Res 59 6230 6238
5. Y Takahama A Kosugi A Singer 1991 Phenotype, ontogeny, and repertoire of CD4-CD8- T cell receptor alpha beta+ thymocytes. Variable influence of self-antigens on T cell receptor V beta usage. J Immunol 146 1134 1141
6. LR Herron RA Eisenberg E Roper VN Kakkanaiah PL Cohen BL Kotzin 1993 Selection of the T cell receptor repertoire in Lpr mice J Immunol 151 3450 3459
7. MM Landolfi N Van Houten JQ Russell R Scollay JR Parnes RC Budd 1993 CD2-CD4-CD8- lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2+ CD4+ CD8+ thymic precursor J Immunol 151 1086 1096
8. DM Hammond PS Nagarkatti LR Gote A Seth MR Hassuneh M Nagarkatti 1993 Double-negative T cells from MRL-lpr/lpr mice mediate cytolytic activity when triggered through adhesion molecules and constitutively express perforin gene J Exp Med 178 2225 2230
9. Z Cai J Sprent 1994 Resting and activated T cells display different requirements for CD8 molecules J Exp Med 179 2005 2015
10. KJ Young LS Kay MJ Phillips L Zhang 2003 Antitumor activity mediated by double-negative T cells Cancer Res 63 8014 8021
11. JA Ledbetter WE Seaman TT Tsu LA Herzenberg 1981 Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity J Exp Med 153 1503 1516
12. MH Newberg JP Ridge DR Vining RD Salter VH Engelhard 1992 Species specificity in the interaction of CD8 with the alpha 3 domain of MHC class I molecules J Immunol 149 136 142
13. H Wedemeyer XS He M Nascimbeni AR Davis HB Greenberg JH Hoofnagle TJ Liang H Alter B Rehermann 2002 Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection J Immunol 169 3447 3458
14. RD Salter AM Norment BP Chen C Clayberger AM Krensky DR Littman P Parham 1989 Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8 Nature 338 345 347
15. Rudd CE, Anderson P, Morimoto C, Streuli M, Schlossman SF (1989) Molecular interactions T-cell subsets and a role of the CD4/CD8:p56lck complex in human T-cell activation. Immunol Rev 111:225-266
16. D Muller K Pederson R Murray JA Frelinger 1991 A single amino acid substitution in an MHC class I molecule allows heteroclitic recognition by lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes J Immunol 147 1392 1397
17. KC Garcia CA Scott A Brunmark FR Carbone PA Peterson IA Wilson L Teyton 1996 CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes Nature 384 577 581
18. MA Daniels SC Jameson 2000 Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers J Exp Med 191 335 346
19. A Mackensen G Carcelain S Viel MC Raynal H Michalaki F Triebel J Bosq T Hercend 1994 Direct evidence to support the immunosurveillance concept in a human regressive melanoma J Clin Invest 93 1397 1402
20. N Meidenbauer A Zippelius MJ Pittet M Laumer S Vogl J Heymann M Rehli B Seliger S Schwarz FA Le Gal PY Dietrich R Andreesen P Romero A Mackensen 2004 High frequency of functionally active Melan-a-specific T cells in a patient with progressive immunoproteasome-deficient melanoma Cancer Res 64 6319 6326
21. RD Salter DN Howell P Cresswell 1985 Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids Immunogenetics 21 235 246
22. N Meidenbauer J Marienhagen M Laumer S Vogl J Heymann R Andreesen A Mackensen 2003 Survival and tumor localization of adoptively transferred Melan-A-specific T cells in melanoma patients J Immunol 170 2161 2169
23. C Pannetier J Even P Kourilsky 1995 T-cell repertoire diversity and clonal expansions in normal and clinical samples Immunol Today 16 176 181
24. J Hendriks Y Xiao J Borst 2003 CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool J Exp Med 198 1369 1380
25. ME van Berkel MA Oosterwegel 2006 CD28 and ICOS: similar or separate costimulators of T cells? Immunol Lett 105 115 122
26. AD Weinberg AT Vella M Croft 1998 OX-40: life beyond the effector T cell stage Semin Immunol 10 471 480
27. AT Cheuk GJ Mufti BA Guinn 2004 Role of 4-1BB:4-1BB ligand in cancer immunotherapy Cancer Gene Ther 11 215 226
28. GG Callender HR Rosen JJ Roszkowski GE Lyons M Li T Moore N Brasic MD McKee MI Nishimura 2006 Identification of a hepatitis C virus-reactive T cell receptor that does not require CD8 for target cell recognition Hepatology 43 973 981
29. LT van der Veken RS Hagedoorn MM van Loenen R Willemze JH Falkenburg MH Heemskerk 2006 Alphabeta T-cell receptor engineered gammadelta T cells mediate effective antileukemic reactivity Cancer Res 66 3331 3337
30. ZX Zhang L Yang KJ Young B DuTemple L Zhang 2000 Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression Nat Med 6 782 789
31. ZX Zhang Y Ma H Wang J Arp J Jiang X Huang KM He B Garcia J Madrenas R Zhong 2006 Double-negative T cells, activated by xenoantigen, lyse autologous B and T cells using a perforin/granzyme-dependent, Fas-Fas ligand-independent pathway J Immunol 177 6920 6929
32. Y Ma KM He B Garcia W Min A Jevnikar ZX Zhang 2008 Adoptive transfer of double negative T regulatory cells induces B-cell death in vivo and alters rejection pattern of rat-to-mouse heart transplantation Xenotransplantation 15 56 63
33. JJ Roszkowski GE Lyons WM Kast C Yee K Van Besien MI Nishimura 2005 Simultaneous generation of CD8+ and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor Cancer Res 65 1570 1576
34. TM Clay MC Custer J Sachs P Hwu SA Rosenberg MI Nishimura 1999 Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity J Immunol 163 507 513
35. DJ Cole DP Weil J Shilyansky M Custer Y Kawakami SA Rosenberg MI Nishimura 1995 Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen Cancer Res 55 748 752
36. GE Lyons T Moore N Brasic M Li JJ Roszkowski MI Nishimura 2006 Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells Cancer Res 66 11455 11461
37. J Kuball FW Schmitz RH Voss EA Ferreira R Engel P Guillaume S Strand P Romero C Huber LA Sherman M Theobald 2005 Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR Immunity 22 117 129
38. KB Urdahl JC Sun MJ Bevan 2002 Positive selection of MHC class Ib-restricted CD8(+) T cells on hematopoietic cells Nature Immunol 3 772 779
39. F Van Laethem SD Sarafova JH Park X Tai L Pobezinsky TI Guinter S Adoro A Adams SO Sharrow L Feigenbaum A Singer 2007 Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC Immunity 27 735 750
40. MM Landolfi N van Houten JQ Russell R Scollay JR Parnes RC Budd 1993 CD2-CD4-CD8- lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2+ CD4+ CD8+ thymic precursor J Immunol 151 186 1096
41. S Wadsworth K Yui RM Siegel DE Tenenholz JA Hirsch MI Greene 1990 Origin and selection of peripheral CD4-CD8- T cells bearing alpha/beta T cell antigen receptors in autoimmune gld mice Eur J Immunol 20 723 730
42. A Bristeau-Leprince V Mateo A Lim A Maqerus-Chatinet E Solary A Fischer F Rieuy-Laucat ML Gouqeon 2008 Human TCR alpha/beta+ CD4-CD8- double-negative T cells in patients with autoimmune lymphoproliferative syndrome express restricted Vbeta TCR diversity and are clonally related to CD8+ T cells J Immunol 181 440 842
43. MS Ford ZX Zhang W Chen L Zhang 2006 Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors J Immunol 177 2803 2809
44. JE Buhlmann SK Elkin AH Sharpe 2003 A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection J Immunol 170 5421 5428
45. JX Gao H Zhang XF Bai J Wen X Zheng J Liu P Zheng Y Liu 2002 Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells J Exp Med 195 959 971