Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 6, 2009, Pages 1811-1814

  Chai, Xiaoyun ^a   Zhang, Jun ^a   Yu, Shichong ^a   Hu, Honggang ^a   Zou, Yan ^a   Zhao, Qingjie ^a   Dan, Zhigang ^a   Zhang, Dazhi ^a   Wu, Qiuye ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antifungal activity; CYP51; Molecular docking; Synthesis; Triazole

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; AMPHOTERICIN B; ANTIFUNGAL AGENT; FLUCONAZOLE; FLUCONAZOLE DERIVATIVE; ITRACONAZOLE; KETOCONAZOLE; RAVUCONAZOLE; STEROL 14ALPHA DEMETHYLASE; TERBINAFINE; UNCLASSIFIED DRUG; VORICONAZOLE;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HYDROPHOBICITY; MICROSPORUM GYPSEUM; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN;

ANTIFUNGAL AGENTS; CATALYTIC DOMAIN; CHEMISTRY, PHARMACEUTICAL; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; FLUCONAZOLE; FUNGAL PROTEINS; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; PROPANOLS; PROTEIN BINDING; TRIAZOLES;

FUNGI;

EID: 61349104868     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.048     Document Type: Article

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