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Volumn 20, Issue 1, 2009, Pages 61-75

Characterization and potential clinical applications of autoantibodies against cytokines

Author keywords

Anti cytokine vaccination; Binding proteins; Cytokine autoantibodies; Cytokine deficiency; Immune deficiency

Indexed keywords

AUTOANTIBODY; CYTOKINE; IMMUNOGLOBULIN; INTERFERON;

EID: 60949092700     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2009.01.003     Document Type: Review
Times cited : (25)

References (212)
  • 1
    • 0028168264 scopus 로고
    • Anti-cytokine nature of natural human immunoglobulin: one possible mechanism of the clinical effect of intravenous immunoglobulin therapy
    • Abe Y., Horiuchi A., Miyake M., and Kimura S. Anti-cytokine nature of natural human immunoglobulin: one possible mechanism of the clinical effect of intravenous immunoglobulin therapy. Immunol Rev 139 (1994) 5-19
    • (1994) Immunol Rev , vol.139 , pp. 5-19
    • Abe, Y.1    Horiuchi, A.2    Miyake, M.3    Kimura, S.4
  • 3
    • 0029103416 scopus 로고
    • Interleukin-6 autoantibodies: possible biological and clinical significance
    • Hansen M.B., Svenson M., Diamant M., Abell K., and Bendtzen K. Interleukin-6 autoantibodies: possible biological and clinical significance. Leukemia 9 (1995) 1113-1115
    • (1995) Leukemia , vol.9 , pp. 1113-1115
    • Hansen, M.B.1    Svenson, M.2    Diamant, M.3    Abell, K.4    Bendtzen, K.5
  • 4
    • 33645461078 scopus 로고    scopus 로고
    • Human cytokine autoantibodies. Characteristics, test procedures and possible physiological and clinical significance
    • Hansen M.B. Human cytokine autoantibodies. Characteristics, test procedures and possible physiological and clinical significance. APMIS Suppl 59 (1996) 1-33
    • (1996) APMIS Suppl , vol.59 , pp. 1-33
    • Hansen, M.B.1
  • 5
    • 0030809459 scopus 로고    scopus 로고
    • Anti-cytokine autoantibodies: epiphenomenon or critical modulators of cytokine action
    • van der Meide P.H., and Schellekens H. Anti-cytokine autoantibodies: epiphenomenon or critical modulators of cytokine action. Biotherapy 10 (1997) 39-48
    • (1997) Biotherapy , vol.10 , pp. 39-48
    • van der Meide, P.H.1    Schellekens, H.2
  • 6
    • 0023727872 scopus 로고
    • Immunogenicity of different types of interferons in the treatment of hairy-cell leukemia
    • von W.P., Freund M., Dahle S., Jakschies D., Poliwode H., and Deicher H. Immunogenicity of different types of interferons in the treatment of hairy-cell leukemia. N Engl J Med 319 (1988) 1226-1227
    • (1988) N Engl J Med , vol.319 , pp. 1226-1227
    • von, W.P.1    Freund, M.2    Dahle, S.3    Jakschies, D.4    Poliwode, H.5    Deicher, H.6
  • 7
    • 0020078672 scopus 로고
    • Autoantibodies against human beta interferon following treatment with interferon
    • Vallbracht A., Treuner J., Manncke K.H., and Niethammer D. Autoantibodies against human beta interferon following treatment with interferon. J Interferon Res 2 (1982) 107-110
    • (1982) J Interferon Res , vol.2 , pp. 107-110
    • Vallbracht, A.1    Treuner, J.2    Manncke, K.H.3    Niethammer, D.4
  • 8
    • 0023893064 scopus 로고
    • Resistance to recombinant interferon alfa-2a in hairy-cell leukemia associated with neutralizing anti-interferon antibodies
    • Steis R.G., Smith J.W., Urba W.J., Clark J.W., Itri L.M., Evans L.M., et al. Resistance to recombinant interferon alfa-2a in hairy-cell leukemia associated with neutralizing anti-interferon antibodies. N Engl J Med 318 (1988) 1409-1413
    • (1988) N Engl J Med , vol.318 , pp. 1409-1413
    • Steis, R.G.1    Smith, J.W.2    Urba, W.J.3    Clark, J.W.4    Itri, L.M.5    Evans, L.M.6
  • 9
    • 0026073170 scopus 로고
    • The development of neutralizing antibodies in a patient receiving subcutaneous recombinant and natural interleukin-2
    • Kirchner H., Korfer A., Evers P., Szamel M.M., Knuver-Hopf J., Mohr H., et al. The development of neutralizing antibodies in a patient receiving subcutaneous recombinant and natural interleukin-2. Cancer 67 (1991) 1862-1864
    • (1991) Cancer , vol.67 , pp. 1862-1864
    • Kirchner, H.1    Korfer, A.2    Evers, P.3    Szamel, M.M.4    Knuver-Hopf, J.5    Mohr, H.6
  • 10
    • 0026331223 scopus 로고
    • Formation of neutralizing antibodies against natural interferon-beta, but not against recombinant interferon-gamma during adjuvant therapy for high-risk malignant melanoma patients
    • Dummer R., Muller W., Nestle F., Wiede J., Dues J., Lechner W., et al. Formation of neutralizing antibodies against natural interferon-beta, but not against recombinant interferon-gamma during adjuvant therapy for high-risk malignant melanoma patients. Cancer 67 (1991) 2300-2304
    • (1991) Cancer , vol.67 , pp. 2300-2304
    • Dummer, R.1    Muller, W.2    Nestle, F.3    Wiede, J.4    Dues, J.5    Lechner, W.6
  • 11
    • 0027981534 scopus 로고
    • Biological and clinical significance of neutralizing and binding antibodies to interferon-alpha (IFN-alpha) during therapy for chronic hepatitis C
    • Giannelli G., Antonelli G., Fera G., Del Vecchio S., Riva E., Broccia C., et al. Biological and clinical significance of neutralizing and binding antibodies to interferon-alpha (IFN-alpha) during therapy for chronic hepatitis C. Clin Exp Immunol 97 (1994) 4-9
    • (1994) Clin Exp Immunol , vol.97 , pp. 4-9
    • Giannelli, G.1    Antonelli, G.2    Fera, G.3    Del Vecchio, S.4    Riva, E.5    Broccia, C.6
  • 12
    • 0031978274 scopus 로고    scopus 로고
    • Development of neutralizing antibodies in patients with relapsing-remitting multiple sclerosis treated with IFN-beta1a
    • Antonelli G., Bagnato F., Pozzilli C., Simeoni E., Bastianelli S., Currenti M., et al. Development of neutralizing antibodies in patients with relapsing-remitting multiple sclerosis treated with IFN-beta1a. J Interferon Cytokine Res 18 (1998) 345-350
    • (1998) J Interferon Cytokine Res , vol.18 , pp. 345-350
    • Antonelli, G.1    Bagnato, F.2    Pozzilli, C.3    Simeoni, E.4    Bastianelli, S.5    Currenti, M.6
  • 13
    • 0025759062 scopus 로고
    • Neutralizing antibodies to interferon-alpha: relative frequency in patients treated with different interferon preparations
    • Antonelli G., Currenti M., Turriziani O., and Dianzani F. Neutralizing antibodies to interferon-alpha: relative frequency in patients treated with different interferon preparations. J Infect Dis 163 (1991) 882-885
    • (1991) J Infect Dis , vol.163 , pp. 882-885
    • Antonelli, G.1    Currenti, M.2    Turriziani, O.3    Dianzani, F.4
  • 14
    • 0030757162 scopus 로고    scopus 로고
    • Interferon antibodies in patients with infectious diseases. Anti-interferon antibodies
    • Antonelli G., Simeoni E., Currenti M., De Pisa F., Colizzi V., Pistello M., et al. Interferon antibodies in patients with infectious diseases. Anti-interferon antibodies. Biotherapy 10 (1997) 7-14
    • (1997) Biotherapy , vol.10 , pp. 7-14
    • Antonelli, G.1    Simeoni, E.2    Currenti, M.3    De Pisa, F.4    Colizzi, V.5    Pistello, M.6
  • 15
    • 0025186509 scopus 로고
    • A sensitive antiviral neutralization bioassay for measuring antibodies to interferons
    • Hansen M.B., Ross C., and Berg K. A sensitive antiviral neutralization bioassay for measuring antibodies to interferons. J Immunol Methods 127 (1990) 241-248
    • (1990) J Immunol Methods , vol.127 , pp. 241-248
    • Hansen, M.B.1    Ross, C.2    Berg, K.3
  • 16
    • 0026556296 scopus 로고
    • Natural human antibodies to gamma interferon interfere with the immunomodulating activity of the lymphokine
    • Turano A., Balsari A., Viani E., Landolfo S., Zanoni L., Gargiulo F., et al. Natural human antibodies to gamma interferon interfere with the immunomodulating activity of the lymphokine. Proc Natl Acad Sci USA 89 (1992) 4447-4451
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4447-4451
    • Turano, A.1    Balsari, A.2    Viani, E.3    Landolfo, S.4    Zanoni, L.5    Gargiulo, F.6
  • 19
    • 0025904630 scopus 로고
    • Spontaneous interferon-alpha antibodies in a patient with pure red cell aplasia and recurrent cutaneous carcinomas
    • Prummer O., Frickhofen N., Digel W., Heimpel H., and Porzsolt F. Spontaneous interferon-alpha antibodies in a patient with pure red cell aplasia and recurrent cutaneous carcinomas. Ann Hematol 62 (1991) 76-80
    • (1991) Ann Hematol , vol.62 , pp. 76-80
    • Prummer, O.1    Frickhofen, N.2    Digel, W.3    Heimpel, H.4    Porzsolt, F.5
  • 20
    • 0024392858 scopus 로고
    • Characterization of autoantibodies to vasoactive intestinal peptide in asthma
    • Paul S., Said S.I., Thompson A.B., Volle D.J., Agrawal D.K., Foda H., et al. Characterization of autoantibodies to vasoactive intestinal peptide in asthma. J Neuroimmunol 23 (1989) 133-142
    • (1989) J Neuroimmunol , vol.23 , pp. 133-142
    • Paul, S.1    Said, S.I.2    Thompson, A.B.3    Volle, D.J.4    Agrawal, D.K.5    Foda, H.6
  • 21
    • 0019964510 scopus 로고
    • Antibodies to alpha-interferon in a patient with systemic lupus erythematosus
    • Panem S., Check I.J., Henriksen D., and Vilcek J. Antibodies to alpha-interferon in a patient with systemic lupus erythematosus. J Immunol 129 (1982) 1-3
    • (1982) J Immunol , vol.129 , pp. 1-3
    • Panem, S.1    Check, I.J.2    Henriksen, D.3    Vilcek, J.4
  • 22
    • 0019890425 scopus 로고
    • Patient with circulating antibodies to alpha-interferon
    • Mogensen K.E., Daubas P., Gresser I., Sereni D., and Varet B. Patient with circulating antibodies to alpha-interferon. Lancet 2 (1981) 1227-1228
    • (1981) Lancet , vol.2 , pp. 1227-1228
    • Mogensen, K.E.1    Daubas, P.2    Gresser, I.3    Sereni, D.4    Varet, B.5
  • 23
    • 0021680237 scopus 로고
    • Characteristics of autoantibodies to human interferon in a patient with varicella-zoster disease
    • Pozzetto B., Mogensen K.E., Tovey M.G., and Gresser I. Characteristics of autoantibodies to human interferon in a patient with varicella-zoster disease. J Infect Dis 150 (1984) 707-713
    • (1984) J Infect Dis , vol.150 , pp. 707-713
    • Pozzetto, B.1    Mogensen, K.E.2    Tovey, M.G.3    Gresser, I.4
  • 25
    • 0022596891 scopus 로고
    • Natural antibodies to interferon-alpha and interferon-beta are a common feature of inbred mouse strains
    • De Maeyer-Guignard J., and De Maeyer-Guignard E. Natural antibodies to interferon-alpha and interferon-beta are a common feature of inbred mouse strains. J Immunol 136 (1986) 1708-1711
    • (1986) J Immunol , vol.136 , pp. 1708-1711
    • De Maeyer-Guignard, J.1    De Maeyer-Guignard, E.2
  • 26
    • 0024595042 scopus 로고
    • Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
    • Hansen M.B., Nielsen S.E., and Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 119 (1989) 203-210
    • (1989) J Immunol Methods , vol.119 , pp. 203-210
    • Hansen, M.B.1    Nielsen, S.E.2    Berg, K.3
  • 28
    • 0025049877 scopus 로고
    • Autoantibodies to crude human leucocyte interferon (IFN), native human IFN, recombinant human IFN-alpha 2b and human IFN-gamma in healthy blood donors
    • Ross C., Hansen M.B., Schyberg T., and Berg K. Autoantibodies to crude human leucocyte interferon (IFN), native human IFN, recombinant human IFN-alpha 2b and human IFN-gamma in healthy blood donors. Clin Exp Immunol 82 (1990) 57-62
    • (1990) Clin Exp Immunol , vol.82 , pp. 57-62
    • Ross, C.1    Hansen, M.B.2    Schyberg, T.3    Berg, K.4
  • 29
    • 0024588193 scopus 로고
    • IgG autoantibodies against interleukin 1 alpha in sera of normal individuals
    • Svenson M., Poulsen L.K., Fomsgaard A., and Bendtzen K. IgG autoantibodies against interleukin 1 alpha in sera of normal individuals. Scand J Immunol 29 (1989) 489-492
    • (1989) Scand J Immunol , vol.29 , pp. 489-492
    • Svenson, M.1    Poulsen, L.K.2    Fomsgaard, A.3    Bendtzen, K.4
  • 30
    • 0024355298 scopus 로고
    • Auto-antibodies to tumour necrosis factor alpha in healthy humans and patients with inflammatory diseases and gram-negative bacterial infections
    • Fomsgaard A., Svenson M., and Bendtzen K. Auto-antibodies to tumour necrosis factor alpha in healthy humans and patients with inflammatory diseases and gram-negative bacterial infections. Scand J Immunol 30 (1989) 219-223
    • (1989) Scand J Immunol , vol.30 , pp. 219-223
    • Fomsgaard, A.1    Svenson, M.2    Bendtzen, K.3
  • 32
    • 0032463373 scopus 로고    scopus 로고
    • Anti-IL-8 autoantibodies and complexes in rheumatoid arthritis: polyclonal activation in chronic synovial tissue inflammation
    • Peichl P., Pursch E., Broll H., and Lindley I.J. Anti-IL-8 autoantibodies and complexes in rheumatoid arthritis: polyclonal activation in chronic synovial tissue inflammation. Rheumatol Int 18 (1999) 141-145
    • (1999) Rheumatol Int , vol.18 , pp. 141-145
    • Peichl, P.1    Pursch, E.2    Broll, H.3    Lindley, I.J.4
  • 33
    • 0032521450 scopus 로고    scopus 로고
    • Antibody to granulocyte-macrophage colony-stimulating factor is a dominant anti-cytokine activity in human IgG preparations
    • Svenson M., Hansen M.B., Ross C., Diamant M., Rieneck K., Nielsen H., et al. Antibody to granulocyte-macrophage colony-stimulating factor is a dominant anti-cytokine activity in human IgG preparations. Blood 91 (1998) 2054-2061
    • (1998) Blood , vol.91 , pp. 2054-2061
    • Svenson, M.1    Hansen, M.B.2    Ross, C.3    Diamant, M.4    Rieneck, K.5    Nielsen, H.6
  • 34
    • 0028960469 scopus 로고
    • High avidity IFN-neutralizing antibodies in pharmaceutically prepared human IgG
    • Ross C., Svenson M., Hansen M.B., Vejlsgaard G.L., and Bendtzen K. High avidity IFN-neutralizing antibodies in pharmaceutically prepared human IgG. J Clin Invest 95 (1995) 1974-1978
    • (1995) J Clin Invest , vol.95 , pp. 1974-1978
    • Ross, C.1    Svenson, M.2    Hansen, M.B.3    Vejlsgaard, G.L.4    Bendtzen, K.5
  • 35
    • 0030823544 scopus 로고    scopus 로고
    • Increased in vivo antibody activity against interferon alpha, interleukin-1alpha, and interleukin-6 after high-dose Ig therapy
    • Ross C., Svenson M., Nielsen H., Lundsgaard C., Hansen M.B., and Bendtzen K. Increased in vivo antibody activity against interferon alpha, interleukin-1alpha, and interleukin-6 after high-dose Ig therapy. Blood 90 (1997) 2376-2380
    • (1997) Blood , vol.90 , pp. 2376-2380
    • Ross, C.1    Svenson, M.2    Nielsen, H.3    Lundsgaard, C.4    Hansen, M.B.5    Bendtzen, K.6
  • 36
    • 0027363250 scopus 로고
    • Binding of cytokines to pharmaceutically prepared human immunoglobulin
    • Svenson M., Hansen M.B., and Bendtzen K. Binding of cytokines to pharmaceutically prepared human immunoglobulin. J Clin Invest 92 (1993) 2533-2539
    • (1993) J Clin Invest , vol.92 , pp. 2533-2539
    • Svenson, M.1    Hansen, M.B.2    Bendtzen, K.3
  • 37
    • 0027518383 scopus 로고
    • Gastric interleukin-8 and IgA IL-8 autoantibodies in Helicobacter pylori infection
    • Crabtree J.E., Peichl P., Wyatt J.I., Stachl U., and Lindley I.J. Gastric interleukin-8 and IgA IL-8 autoantibodies in Helicobacter pylori infection. Scand J Immunol 37 (1993) 65-70
    • (1993) Scand J Immunol , vol.37 , pp. 65-70
    • Crabtree, J.E.1    Peichl, P.2    Wyatt, J.I.3    Stachl, U.4    Lindley, I.J.5
  • 38
    • 0028962363 scopus 로고
    • Increased levels of antibodies to IFN-gamma in human and experimental African trypanosomiasis
    • Bonfanti C., Caruso A., Bakhiet M., Olsson T., Turano A., and Kristensson K. Increased levels of antibodies to IFN-gamma in human and experimental African trypanosomiasis. Scand J Immunol 41 (1995) 49-52
    • (1995) Scand J Immunol , vol.41 , pp. 49-52
    • Bonfanti, C.1    Caruso, A.2    Bakhiet, M.3    Olsson, T.4    Turano, A.5    Kristensson, K.6
  • 41
    • 0027711870 scopus 로고
    • Antibodies to interferon alpha in patients
    • Antonelli G., and Dianzani F. Antibodies to interferon alpha in patients. Arch Virol Suppl 8 (1993) 271-277
    • (1993) Arch Virol Suppl , vol.8 , pp. 271-277
    • Antonelli, G.1    Dianzani, F.2
  • 42
    • 34248329481 scopus 로고    scopus 로고
    • GM-CSF autoantibodies in pulmonary alveolar proteinosis
    • Bendtzen K., Svenson M., and Hansen M.B. GM-CSF autoantibodies in pulmonary alveolar proteinosis. N Engl J Med 356 (2007) 2001
    • (2007) N Engl J Med , vol.356 , pp. 2001
    • Bendtzen, K.1    Svenson, M.2    Hansen, M.B.3
  • 43
    • 0037387254 scopus 로고    scopus 로고
    • Anti-cytokine autoantibodies in autoimmunity: preponderance of neutralizing autoantibodies against interferon-alpha, interferon-omega and interleukin-12 in patients with thymoma and/or myasthenia gravis
    • Meager A., Wadhwa M., Dilger P., Bird C., Thorpe R., Newsom-Davis J., et al. Anti-cytokine autoantibodies in autoimmunity: preponderance of neutralizing autoantibodies against interferon-alpha, interferon-omega and interleukin-12 in patients with thymoma and/or myasthenia gravis. Clin Exp Immunol 132 (2003) 128-136
    • (2003) Clin Exp Immunol , vol.132 , pp. 128-136
    • Meager, A.1    Wadhwa, M.2    Dilger, P.3    Bird, C.4    Thorpe, R.5    Newsom-Davis, J.6
  • 44
  • 45
  • 46
    • 0035104673 scopus 로고    scopus 로고
    • Anti-interleukin-8 autoantibody in the tracheobronchial aspirate of infants with chronic lung disease
    • Takasaki J., and Ogawa Y. Anti-interleukin-8 autoantibody in the tracheobronchial aspirate of infants with chronic lung disease. Pediatr Int 43 (2001) 48-52
    • (2001) Pediatr Int , vol.43 , pp. 48-52
    • Takasaki, J.1    Ogawa, Y.2
  • 47
    • 0035131611 scopus 로고    scopus 로고
    • Anti-interleukin 8 autoantibody: interleukin 8 complexes in the acute respiratory distress syndrome. Relationship between the complexes and clinical disease activity
    • Kurdowska A., Noble J.M., Steinberg K.P., Ruzinski J.T., Hudson L.D., and Martin T.R. Anti-interleukin 8 autoantibody: interleukin 8 complexes in the acute respiratory distress syndrome. Relationship between the complexes and clinical disease activity. Am J Respir Crit Care Med 163 (2001) 463-468
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 463-468
    • Kurdowska, A.1    Noble, J.M.2    Steinberg, K.P.3    Ruzinski, J.T.4    Hudson, L.D.5    Martin, T.R.6
  • 48
    • 0037608961 scopus 로고    scopus 로고
    • Interleukin-8 and anti-interleukin-8 autoantibodies in gingival cervicular fluid from patients with periodontitis
    • Kurdowska A.K., Noble J.M., and Adcock J.E. Interleukin-8 and anti-interleukin-8 autoantibodies in gingival cervicular fluid from patients with periodontitis. J Periodontal Res 38 (2003) 73-78
    • (2003) J Periodontal Res , vol.38 , pp. 73-78
    • Kurdowska, A.K.1    Noble, J.M.2    Adcock, J.E.3
  • 49
    • 2442664146 scopus 로고    scopus 로고
    • Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury
    • Krupa A., Kato H., Matthay M.A., and Kurdowska A.K. Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol 286 (2004) L1105-L1113
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286
    • Krupa, A.1    Kato, H.2    Matthay, M.A.3    Kurdowska, A.K.4
  • 51
    • 33847627159 scopus 로고    scopus 로고
    • Anti-interleukin 8 autoantibody:interleukin 8 immune complexes visualized by laser confocal microscopy in injured lung
    • Allen T.C., Fudala R., Nash S.E., and Kurdowska A. Anti-interleukin 8 autoantibody:interleukin 8 immune complexes visualized by laser confocal microscopy in injured lung. Arch Pathol Lab Med 131 (2007) 452-456
    • (2007) Arch Pathol Lab Med , vol.131 , pp. 452-456
    • Allen, T.C.1    Fudala, R.2    Nash, S.E.3    Kurdowska, A.4
  • 52
    • 40449106777 scopus 로고    scopus 로고
    • Recurrent staphylococcal cellulitis and subcutaneous abscesses in a child with autoantibodies against IL-6
    • Puel A., Picard C., Lorrot M., Pons C., Chrabieh M., Lorenzo L., et al. Recurrent staphylococcal cellulitis and subcutaneous abscesses in a child with autoantibodies against IL-6. J Immunol 180 (2008) 647-654
    • (2008) J Immunol , vol.180 , pp. 647-654
    • Puel, A.1    Picard, C.2    Lorrot, M.3    Pons, C.4    Chrabieh, M.5    Lorenzo, L.6
  • 54
    • 33846889015 scopus 로고    scopus 로고
    • GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis
    • Uchida K., Beck D.C., Yamamoto T., Berclaz P.Y., Abe S., Staudt M.K., et al. GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis. N Engl J Med 356 (2007) 567-579
    • (2007) N Engl J Med , vol.356 , pp. 567-579
    • Uchida, K.1    Beck, D.C.2    Yamamoto, T.3    Berclaz, P.Y.4    Abe, S.5    Staudt, M.K.6
  • 55
    • 0035984101 scopus 로고    scopus 로고
    • Autoantibodies against interleukin 1alpha in rheumatoid arthritis: association with long term radiographic outcome
    • Graudal N.A., Svenson M., Tarp U., Garred P., Jurik A.G., and Bendtzen K. Autoantibodies against interleukin 1alpha in rheumatoid arthritis: association with long term radiographic outcome. Ann Rheum Dis 61 (2002) 598-602
    • (2002) Ann Rheum Dis , vol.61 , pp. 598-602
    • Graudal, N.A.1    Svenson, M.2    Tarp, U.3    Garred, P.4    Jurik, A.G.5    Bendtzen, K.6
  • 57
    • 9144235409 scopus 로고    scopus 로고
    • Naturally occurring anti-IFN-gamma autoantibody and severe infections with Mycobacterium cheloneae and Burkholderia cocovenenans
    • Hoflich C., Sabat R., Rosseau S., Temmesfeld B., Slevogt H., Docke W.D., et al. Naturally occurring anti-IFN-gamma autoantibody and severe infections with Mycobacterium cheloneae and Burkholderia cocovenenans. Blood 103 (2004) 673-675
    • (2004) Blood , vol.103 , pp. 673-675
    • Hoflich, C.1    Sabat, R.2    Rosseau, S.3    Temmesfeld, B.4    Slevogt, H.5    Docke, W.D.6
  • 59
    • 25444487466 scopus 로고    scopus 로고
    • Anti-IFN-gamma autoantibodies in disseminated nontuberculous mycobacterial infections
    • Patel S.Y., Ding L., Brown M.R., Lantz L., Gay T., Cohen S., et al. Anti-IFN-gamma autoantibodies in disseminated nontuberculous mycobacterial infections. J Immunol 175 (2005) 4769-4776
    • (2005) J Immunol , vol.175 , pp. 4769-4776
    • Patel, S.Y.1    Ding, L.2    Brown, M.R.3    Lantz, L.4    Gay, T.5    Cohen, S.6
  • 60
    • 0038207976 scopus 로고    scopus 로고
    • Autoantibodies to IL-12 in myasthenia gravis patients with thymoma; effects on the IFN-gamma responses of healthy CD4+ T cells
    • Zhang W., Liu J.L., Meager A., Newsom-Davis J., and Willcox N. Autoantibodies to IL-12 in myasthenia gravis patients with thymoma; effects on the IFN-gamma responses of healthy CD4+ T cells. J Neuroimmunol 139 (2003) 102-108
    • (2003) J Neuroimmunol , vol.139 , pp. 102-108
    • Zhang, W.1    Liu, J.L.2    Meager, A.3    Newsom-Davis, J.4    Willcox, N.5
  • 61
    • 12444300180 scopus 로고    scopus 로고
    • Spontaneous production of anti-IFN-alpha and anti-IL-12 autoantibodies by thymoma cells from myasthenia gravis patients suggests autoimmunization in the tumor
    • Shiono H., Wong Y.L., Matthews I., Liu J.L., Zhang W., Sims G., et al. Spontaneous production of anti-IFN-alpha and anti-IL-12 autoantibodies by thymoma cells from myasthenia gravis patients suggests autoimmunization in the tumor. Int Immunol 15 (2003) 903-913
    • (2003) Int Immunol , vol.15 , pp. 903-913
    • Shiono, H.1    Wong, Y.L.2    Matthews, I.3    Liu, J.L.4    Zhang, W.5    Sims, G.6
  • 62
    • 0034087493 scopus 로고    scopus 로고
    • Pulmonary alveolar proteinosis is a disease of decreased availability of GM-CSF rather than an intrinsic cellular defect
    • Thomassen M.J., Yi T., Raychaudhuri B., Malur A., and Kavuru M.S. Pulmonary alveolar proteinosis is a disease of decreased availability of GM-CSF rather than an intrinsic cellular defect. Clin Immunol 95 (2000) 85-92
    • (2000) Clin Immunol , vol.95 , pp. 85-92
    • Thomassen, M.J.1    Yi, T.2    Raychaudhuri, B.3    Malur, A.4    Kavuru, M.S.5
  • 63
    • 0036787956 scopus 로고    scopus 로고
    • Autoantibodies against granulocyte macrophage colony-stimulating factor are diagnostic for pulmonary alveolar proteinosis
    • Bonfield T.L., Russell D., Burgess S., Malur A., Kavuru M.S., and Thomassen M.J. Autoantibodies against granulocyte macrophage colony-stimulating factor are diagnostic for pulmonary alveolar proteinosis. Am J Respir Cell Mol Biol 27 (2002) 481-486
    • (2002) Am J Respir Cell Mol Biol , vol.27 , pp. 481-486
    • Bonfield, T.L.1    Russell, D.2    Burgess, S.3    Malur, A.4    Kavuru, M.S.5    Thomassen, M.J.6
  • 64
    • 9144247674 scopus 로고    scopus 로고
    • High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis
    • Uchida K., Nakata K., Trapnell B.C., Terakawa T., Hamano E., Mikami A., et al. High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis. Blood 103 (2004) 1089-1098
    • (2004) Blood , vol.103 , pp. 1089-1098
    • Uchida, K.1    Nakata, K.2    Trapnell, B.C.3    Terakawa, T.4    Hamano, E.5    Mikami, A.6
  • 65
    • 0028218523 scopus 로고
    • IL-6-anti-IL-6 autoantibody complexes with IL-6 activity in sera from some patients with systemic sclerosis
    • Suzuki H., Takemura H., Yoshizaki K., Koishihara Y., Ohsugi Y., Okano A., et al. IL-6-anti-IL-6 autoantibody complexes with IL-6 activity in sera from some patients with systemic sclerosis. J Immunol 152 (1994) 935-942
    • (1994) J Immunol , vol.152 , pp. 935-942
    • Suzuki, H.1    Takemura, H.2    Yoshizaki, K.3    Koishihara, Y.4    Ohsugi, Y.5    Okano, A.6
  • 67
    • 0029895865 scopus 로고    scopus 로고
    • Autoantibodies to IL-1 alpha in sera from umbilical cords, children, and adults, and from patients with juvenile chronic arthritis
    • Muller K., Hansen M.B., Zak M., Nielsen S., Pedersen F.K., de Nully P., et al. Autoantibodies to IL-1 alpha in sera from umbilical cords, children, and adults, and from patients with juvenile chronic arthritis. Scand J Rheumatol 25 (1996) 164-167
    • (1996) Scand J Rheumatol , vol.25 , pp. 164-167
    • Muller, K.1    Hansen, M.B.2    Zak, M.3    Nielsen, S.4    Pedersen, F.K.5    de Nully, P.6
  • 69
    • 16544381633 scopus 로고    scopus 로고
    • Reduced anti-TNFalpha autoantibody levels coincide with flare in systemic lupus erythematosus
    • Sjowall C., Ernerudh J., Bengtsson A.A., Sturfelt G., and Skogh T. Reduced anti-TNFalpha autoantibody levels coincide with flare in systemic lupus erythematosus. J Autoimmunol 22 (2004) 315-323
    • (2004) J Autoimmunol , vol.22 , pp. 315-323
    • Sjowall, C.1    Ernerudh, J.2    Bengtsson, A.A.3    Sturfelt, G.4    Skogh, T.5
  • 71
    • 0029793315 scopus 로고    scopus 로고
    • Increased incidence of neutralizing autoantibodies against interleukin-1 alpha (IL-1 alpha) in nondestructive chronic polyarthritis
    • Jouvenne P., Fossiez F., Garrone P., Djossou O., Banchereau J., and Miossec P. Increased incidence of neutralizing autoantibodies against interleukin-1 alpha (IL-1 alpha) in nondestructive chronic polyarthritis. J Clin Immunol 16 (1996) 283-290
    • (1996) J Clin Immunol , vol.16 , pp. 283-290
    • Jouvenne, P.1    Fossiez, F.2    Garrone, P.3    Djossou, O.4    Banchereau, J.5    Miossec, P.6
  • 72
    • 0031980161 scopus 로고    scopus 로고
    • Cytokine autoantibodies in multiple sclerosis, aseptic meningitis and stroke
    • Elkarim R.A., Mustafa M., Kivisakk P., Link H., and Bakhiet M. Cytokine autoantibodies in multiple sclerosis, aseptic meningitis and stroke. Eur J Clin Invest 28 (1998) 295-299
    • (1998) Eur J Clin Invest , vol.28 , pp. 295-299
    • Elkarim, R.A.1    Mustafa, M.2    Kivisakk, P.3    Link, H.4    Bakhiet, M.5
  • 73
    • 0024235902 scopus 로고
    • Presence of interferon and anti-interferon in patients with systemic lupus erythematosus
    • von W.P., Jakschies D., Hartung K., and Deicher H. Presence of interferon and anti-interferon in patients with systemic lupus erythematosus. Rheumatol Int 8 (1988) 225-230
    • (1988) Rheumatol Int , vol.8 , pp. 225-230
    • von, W.P.1    Jakschies, D.2    Hartung, K.3    Deicher, H.4
  • 74
    • 0027078439 scopus 로고
    • Inhibition of the biological activity of human interferon-gamma by antipeptide antibodies
    • Caruso A., Viani E., Tiberio L., Pollara P., Monti E., Bonfanti C., et al. Inhibition of the biological activity of human interferon-gamma by antipeptide antibodies. J Interferon Res 12 (1992) 49-54
    • (1992) J Interferon Res , vol.12 , pp. 49-54
    • Caruso, A.1    Viani, E.2    Tiberio, L.3    Pollara, P.4    Monti, E.5    Bonfanti, C.6
  • 75
    • 0026690770 scopus 로고
    • Anti-interleukin-6 autoantibodies in rheumatic diseases. Increased frequency in the sera of patients with systemic sclerosis
    • Takemura H., Suzuki H., Yoshizaki K., Ogata A., Yuhara T., Akama T., et al. Anti-interleukin-6 autoantibodies in rheumatic diseases. Increased frequency in the sera of patients with systemic sclerosis. Arthritis Rheum 35 (1992) 940-943
    • (1992) Arthritis Rheum , vol.35 , pp. 940-943
    • Takemura, H.1    Suzuki, H.2    Yoshizaki, K.3    Ogata, A.4    Yuhara, T.5    Akama, T.6
  • 76
    • 0025087327 scopus 로고
    • Demonstration of neutralizing autoantibodies against IL-1 alpha in sera from patients with rheumatoid arthritis
    • Suzuki H., Kamimura J., Ayabe T., and Kashiwagi H. Demonstration of neutralizing autoantibodies against IL-1 alpha in sera from patients with rheumatoid arthritis. J Immunol 145 (1990) 2140-2146
    • (1990) J Immunol , vol.145 , pp. 2140-2146
    • Suzuki, H.1    Kamimura, J.2    Ayabe, T.3    Kashiwagi, H.4
  • 77
    • 0025740590 scopus 로고
    • Anti-IL-1 alpha autoantibodies in patients with rheumatic diseases and in healthy subjects
    • Suzuki H., Ayabe T., Kamimura J., and Kashiwagi H. Anti-IL-1 alpha autoantibodies in patients with rheumatic diseases and in healthy subjects. Clin Exp Immunol 85 (1991) 407-412
    • (1991) Clin Exp Immunol , vol.85 , pp. 407-412
    • Suzuki, H.1    Ayabe, T.2    Kamimura, J.3    Kashiwagi, H.4
  • 78
    • 0024834224 scopus 로고
    • Interleukin-1-inhibitory IgG in sera from some patients with rheumatoid arthritis
    • Suzuki H., Akama T., Okane M., Kono I., Matsui Y., Yamane K., et al. Interleukin-1-inhibitory IgG in sera from some patients with rheumatoid arthritis. Arthritis Rheum 32 (1989) 1528-1538
    • (1989) Arthritis Rheum , vol.32 , pp. 1528-1538
    • Suzuki, H.1    Akama, T.2    Okane, M.3    Kono, I.4    Matsui, Y.5    Yamane, K.6
  • 79
    • 0028209394 scopus 로고
    • Functional characterization of cytokine autoantibodies in chronic renal failure patients
    • Sunder-Plassmann G., Kapiotis S., Gasche C., and Klaar U. Functional characterization of cytokine autoantibodies in chronic renal failure patients. Kidney Int 45 (1994) 1484-1488
    • (1994) Kidney Int , vol.45 , pp. 1484-1488
    • Sunder-Plassmann, G.1    Kapiotis, S.2    Gasche, C.3    Klaar, U.4
  • 81
    • 0026599644 scopus 로고
    • Human neutrophil activating peptide/interleukin 8 acts as an autoantigen in rheumatoid arthritis
    • Peichl P., Ceska M., Broell H., Effenberger F., and Lindley I.J. Human neutrophil activating peptide/interleukin 8 acts as an autoantigen in rheumatoid arthritis. Ann Rheum Dis 51 (1992) 19-22
    • (1992) Ann Rheum Dis , vol.51 , pp. 19-22
    • Peichl, P.1    Ceska, M.2    Broell, H.3    Effenberger, F.4    Lindley, I.J.5
  • 82
    • 0033042152 scopus 로고    scopus 로고
    • Gastric mucosal interleukin-8 and IL-8 antibody concentrations related to prevailing Helicobacter pylori infections. A Danish-Albanian study
    • Nielsen O.H., Horn T., Prifti S., Peichl P., Scheibel J.H., and Lindley I.J. Gastric mucosal interleukin-8 and IL-8 antibody concentrations related to prevailing Helicobacter pylori infections. A Danish-Albanian study. Dan Med Bull 46 (1999) 249-252
    • (1999) Dan Med Bull , vol.46 , pp. 249-252
    • Nielsen, O.H.1    Horn, T.2    Prifti, S.3    Peichl, P.4    Scheibel, J.H.5    Lindley, I.J.6
  • 83
    • 0022355610 scopus 로고
    • Autoantibody to vasoactive intestinal peptide in human circulation
    • Paul S., Heinz-Erian P., and Said S.I. Autoantibody to vasoactive intestinal peptide in human circulation. Biochem Biophys Res Commun 130 (1985) 479-485
    • (1985) Biochem Biophys Res Commun , vol.130 , pp. 479-485
    • Paul, S.1    Heinz-Erian, P.2    Said, S.I.3
  • 84
    • 0023679049 scopus 로고
    • Human autoantibody to vasoactive intestinal peptide: increased incidence in muscular exercise
    • Paul S., and Said S.I. Human autoantibody to vasoactive intestinal peptide: increased incidence in muscular exercise. Life Sci 43 (1988) 1079-1084
    • (1988) Life Sci , vol.43 , pp. 1079-1084
    • Paul, S.1    Said, S.I.2
  • 85
    • 0026741855 scopus 로고
    • Serum-induced suppression of interferon (IFN) activity. Lack of evidence for the presence of specific autoantibodies to IFN-alpha in normal human sera
    • Hansen M.B., Svenson M., and Bendtzen K. Serum-induced suppression of interferon (IFN) activity. Lack of evidence for the presence of specific autoantibodies to IFN-alpha in normal human sera. Clin Exp Immunol 88 (1992) 559-562
    • (1992) Clin Exp Immunol , vol.88 , pp. 559-562
    • Hansen, M.B.1    Svenson, M.2    Bendtzen, K.3
  • 86
    • 9244239707 scopus 로고    scopus 로고
    • High levels of neutralizing IL-6 autoantibodies in 0.1% of apparently healthy blood donors
    • Galle P., Svenson M., Bendtzen K., and Hansen M.B. High levels of neutralizing IL-6 autoantibodies in 0.1% of apparently healthy blood donors. Eur J Immunol 34 (2004) 3267-3275
    • (2004) Eur J Immunol , vol.34 , pp. 3267-3275
    • Galle, P.1    Svenson, M.2    Bendtzen, K.3    Hansen, M.B.4
  • 88
    • 0026828978 scopus 로고
    • Effects of human anti-IL-1 alpha autoantibodies on receptor binding and biological activities of IL-1
    • Svenson M., Hansen M.B., Kayser L., Rasmussen A.K., Reimert C.M., and Bendtzen K. Effects of human anti-IL-1 alpha autoantibodies on receptor binding and biological activities of IL-1. Cytokine 4 (1992) 125-133
    • (1992) Cytokine , vol.4 , pp. 125-133
    • Svenson, M.1    Hansen, M.B.2    Kayser, L.3    Rasmussen, A.K.4    Reimert, C.M.5    Bendtzen, K.6
  • 89
    • 0025225511 scopus 로고
    • Distribution and characterization of autoantibodies to interleukin 1 alpha in normal human sera
    • Svenson M., Bagge H.M., and Bendtzen K. Distribution and characterization of autoantibodies to interleukin 1 alpha in normal human sera. Scand J Immunol 32 (1990) 695-701
    • (1990) Scand J Immunol , vol.32 , pp. 695-701
    • Svenson, M.1    Bagge, H.M.2    Bendtzen, K.3
  • 90
    • 35248878595 scopus 로고    scopus 로고
    • Accepting clocks that tell time poorly: fluid-phase versus standard ELISA autoantibody assays
    • Liu E., and Eisenbarth G.S. Accepting clocks that tell time poorly: fluid-phase versus standard ELISA autoantibody assays. Clin Immunol 125 (2007) 120-126
    • (2007) Clin Immunol , vol.125 , pp. 120-126
    • Liu, E.1    Eisenbarth, G.S.2
  • 91
    • 0028962880 scopus 로고
    • Influence of interleukin-6 (IL-6) autoantibodies on IL-6 binding to cellular receptors
    • Hansen M.B., Svenson M., Abell K., Yasukawa K., Diamant M., and Bendtzen K. Influence of interleukin-6 (IL-6) autoantibodies on IL-6 binding to cellular receptors. Eur J Immunol 25 (1995) 348-354
    • (1995) Eur J Immunol , vol.25 , pp. 348-354
    • Hansen, M.B.1    Svenson, M.2    Abell, K.3    Yasukawa, K.4    Diamant, M.5    Bendtzen, K.6
  • 92
    • 0027181936 scopus 로고
    • Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4
    • Colotta F., Re F., Muzio M., Bertini R., Polentarutti N., Sironi M., et al. Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science 261 (1993) 472-475
    • (1993) Science , vol.261 , pp. 472-475
    • Colotta, F.1    Re, F.2    Muzio, M.3    Bertini, R.4    Polentarutti, N.5    Sironi, M.6
  • 93
    • 0034919056 scopus 로고    scopus 로고
    • Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines
    • Mantovani A., Locati M., Vecchi A., Sozzani S., and Allavena P. Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines. Trends Immunol 22 (2001) 328-336
    • (2001) Trends Immunol , vol.22 , pp. 328-336
    • Mantovani, A.1    Locati, M.2    Vecchi, A.3    Sozzani, S.4    Allavena, P.5
  • 95
    • 0027463210 scopus 로고
    • High-affinity IgG autoantibodies to IL-6 in sera of normal individuals are competitive inhibitors of IL-6 in vitro
    • Hansen M.B., Svenson M., Diamant M., and Bendtzen K. High-affinity IgG autoantibodies to IL-6 in sera of normal individuals are competitive inhibitors of IL-6 in vitro. Cytokine 5 (1993) 72-80
    • (1993) Cytokine , vol.5 , pp. 72-80
    • Hansen, M.B.1    Svenson, M.2    Diamant, M.3    Bendtzen, K.4
  • 97
    • 33847679967 scopus 로고    scopus 로고
    • Transfusion-related inhibition of cytokines (TRICK). Experimental transfer of neutralizing autoantibodies to interleukin-6 by plasma transfusions
    • Hansen M.B., Galle P., Salomo M., Svenson M., Dickmeiss E., and Gimsing P. Transfusion-related inhibition of cytokines (TRICK). Experimental transfer of neutralizing autoantibodies to interleukin-6 by plasma transfusions. Vox Sang 92 (2007) 213-223
    • (2007) Vox Sang , vol.92 , pp. 213-223
    • Hansen, M.B.1    Galle, P.2    Salomo, M.3    Svenson, M.4    Dickmeiss, E.5    Gimsing, P.6
  • 98
    • 33646469222 scopus 로고    scopus 로고
    • Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis
    • Richards P.J., Nowell M.A., Horiuchi S., McLoughlin R.M., Fielding C.A., Grau S., et al. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis Rheum 54 (2006) 1662-1672
    • (2006) Arthritis Rheum , vol.54 , pp. 1662-1672
    • Richards, P.J.1    Nowell, M.A.2    Horiuchi, S.3    McLoughlin, R.M.4    Fielding, C.A.5    Grau, S.6
  • 99
    • 33748848714 scopus 로고    scopus 로고
    • Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer
    • Rose-John S., Scheller J., Elson G., and Jones S.A. Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol 80 (2006) 227-236
    • (2006) J Leukoc Biol , vol.80 , pp. 227-236
    • Rose-John, S.1    Scheller, J.2    Elson, G.3    Jones, S.A.4
  • 100
    • 0028919153 scopus 로고
    • Interleukin-6 (IL-6) autoantibodies and blood IL-6 measurements
    • Hansen M.B., Svenson M., Diamant M., Ross C., and Bendtzen K. Interleukin-6 (IL-6) autoantibodies and blood IL-6 measurements. Blood 85 (1995) 1145
    • (1995) Blood , vol.85 , pp. 1145
    • Hansen, M.B.1    Svenson, M.2    Diamant, M.3    Ross, C.4    Bendtzen, K.5
  • 101
    • 35248858705 scopus 로고    scopus 로고
    • A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1
    • Zhang L., Barker J.M., Babu S., Su M., Stenerson M., Cheng M., et al. A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1. Clin Immunol 125 (2007) 131-137
    • (2007) Clin Immunol , vol.125 , pp. 131-137
    • Zhang, L.1    Barker, J.M.2    Babu, S.3    Su, M.4    Stenerson, M.5    Cheng, M.6
  • 102
    • 0027717349 scopus 로고
    • Specific binding of interleukin 1 (IL-1) beta and IL-1 receptor antagonist (IL-1ra) to human serum. High-affinity binding of IL-1ra to soluble IL-1 receptor type I
    • Svenson M., Hansen M.B., Heegaard P., Abell K., and Bendtzen K. Specific binding of interleukin 1 (IL-1) beta and IL-1 receptor antagonist (IL-1ra) to human serum. High-affinity binding of IL-1ra to soluble IL-1 receptor type I. Cytokine 5 (1993) 427-435
    • (1993) Cytokine , vol.5 , pp. 427-435
    • Svenson, M.1    Hansen, M.B.2    Heegaard, P.3    Abell, K.4    Bendtzen, K.5
  • 104
    • 0028013066 scopus 로고
    • Brief report: alleviation of systemic manifestations of Castleman's disease by monoclonal anti-interleukin-6 antibody
    • Beck J.T., Hsu S.M., Wijdenes J., Bataille R., Klein B., Vesole D., et al. Brief report: alleviation of systemic manifestations of Castleman's disease by monoclonal anti-interleukin-6 antibody. N Engl J Med 330 (1994) 602-605
    • (1994) N Engl J Med , vol.330 , pp. 602-605
    • Beck, J.T.1    Hsu, S.M.2    Wijdenes, J.3    Bataille, R.4    Klein, B.5    Vesole, D.6
  • 105
    • 0027130635 scopus 로고
    • Effects of an anti-interleukin-6 (IL-6) murine monoclonal antibody in a patient with acute monoblastic leukemia
    • Bataille R., Zhang X.G., Wijdenes J., Schved J.F., and Klein B. Effects of an anti-interleukin-6 (IL-6) murine monoclonal antibody in a patient with acute monoblastic leukemia. Med Oncol Tumor Pharmacother 10 (1993) 185-188
    • (1993) Med Oncol Tumor Pharmacother , vol.10 , pp. 185-188
    • Bataille, R.1    Zhang, X.G.2    Wijdenes, J.3    Schved, J.F.4    Klein, B.5
  • 106
    • 0031882207 scopus 로고    scopus 로고
    • Distinct classes of chaperoned IL-6 in human blood: differential immunological and biological availability
    • Ndubuisi M.I., Patel K., Rayanade R.J., Mittelman A., May L.T., and Sehgal P.B. Distinct classes of chaperoned IL-6 in human blood: differential immunological and biological availability. J Immunol 160 (1998) 494-501
    • (1998) J Immunol , vol.160 , pp. 494-501
    • Ndubuisi, M.I.1    Patel, K.2    Rayanade, R.J.3    Mittelman, A.4    May, L.T.5    Sehgal, P.B.6
  • 108
    • 0025787311 scopus 로고
    • Murine anti-human IL-6 monoclonal antibody prolongs the half-life in circulating blood and thus prolongs the bioactivity of human IL-6 in mice
    • Mihara M., Koishihara Y., Fukui H., Yasukawa K., and Ohsugi Y. Murine anti-human IL-6 monoclonal antibody prolongs the half-life in circulating blood and thus prolongs the bioactivity of human IL-6 in mice. Immunology 74 (1991) 55-59
    • (1991) Immunology , vol.74 , pp. 55-59
    • Mihara, M.1    Koishihara, Y.2    Fukui, H.3    Yasukawa, K.4    Ohsugi, Y.5
  • 109
    • 0029034740 scopus 로고
    • Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma
    • Bataille R., Barlogie B., Lu Z.Y., Rossi J.F., Lavabre-Bertrand T., Beck T., et al. Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma. Blood 86 (1995) 685-691
    • (1995) Blood , vol.86 , pp. 685-691
    • Bataille, R.1    Barlogie, B.2    Lu, Z.Y.3    Rossi, J.F.4    Lavabre-Bertrand, T.5    Beck, T.6
  • 110
    • 0028577593 scopus 로고
    • Pharmacokinetics of interleukin-6 during therapy with anti-interleukin-6 monoclonal antibodies: enhanced clearance of interleukin-6 by a combination of three anti-interleukin-6 antibodies
    • Montero-Julian F.A., Gautherot E., Wijdenes J., Klein B., and Brailly H. Pharmacokinetics of interleukin-6 during therapy with anti-interleukin-6 monoclonal antibodies: enhanced clearance of interleukin-6 by a combination of three anti-interleukin-6 antibodies. J Interferon Res 14 (1994) 301-302
    • (1994) J Interferon Res , vol.14 , pp. 301-302
    • Montero-Julian, F.A.1    Gautherot, E.2    Wijdenes, J.3    Klein, B.4    Brailly, H.5
  • 112
    • 0030823269 scopus 로고    scopus 로고
    • Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist
    • Ciapponi L., Maione D., Scoumanne A., Costa P., Hansen M.B., Svenson M., et al. Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist. Nat Biotechnol 15 (1997) 997-1001
    • (1997) Nat Biotechnol , vol.15 , pp. 997-1001
    • Ciapponi, L.1    Maione, D.2    Scoumanne, A.3    Costa, P.4    Hansen, M.B.5    Svenson, M.6
  • 115
    • 33845879373 scopus 로고    scopus 로고
    • TNFalpha kinoid vaccination-induced neutralizing antibodies to TNFalpha protect mice from autologous TNFalpha-driven chronic and acute inflammation
    • Le Buanec H., Delavallee L., Bessis N., Paturance S., Bizzini B., Gallo R., et al. TNFalpha kinoid vaccination-induced neutralizing antibodies to TNFalpha protect mice from autologous TNFalpha-driven chronic and acute inflammation. Proc Natl Acad Sci USA 103 (2006) 19442-19447
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 19442-19447
    • Le Buanec, H.1    Delavallee, L.2    Bessis, N.3    Paturance, S.4    Bizzini, B.5    Gallo, R.6
  • 116
  • 117
    • 0034681145 scopus 로고    scopus 로고
    • Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice
    • Richard M., Grencis R.K., Humphreys N.E., Renauld J.C., and Van S.J. Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice. Proc Natl Acad Sci USA 97 (2000) 767-772
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 767-772
    • Richard, M.1    Grencis, R.K.2    Humphreys, N.E.3    Renauld, J.C.4    Van, S.J.5
  • 118
    • 33751254750 scopus 로고    scopus 로고
    • Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis
    • Rohn T.A., Jennings G.T., Hernandez M., Grest P., Beck M., Zou Y., et al. Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. Eur J Immunol 36 (2006) 2857-2867
    • (2006) Eur J Immunol , vol.36 , pp. 2857-2867
    • Rohn, T.A.1    Jennings, G.T.2    Hernandez, M.3    Grest, P.4    Beck, M.5    Zou, Y.6
  • 119
    • 0033976230 scopus 로고    scopus 로고
    • Cytokine vaccination: neutralising IL-1alpha autoantibodies induced by immunisation with homologous IL-1alpha
    • Svenson M., Hansen M.B., Thomsen A.R., Diamant M., Nansen A., Rieneck K., et al. Cytokine vaccination: neutralising IL-1alpha autoantibodies induced by immunisation with homologous IL-1alpha. J Immunol Methods 236 (2000) 1-8
    • (2000) J Immunol Methods , vol.236 , pp. 1-8
    • Svenson, M.1    Hansen, M.B.2    Thomsen, A.R.3    Diamant, M.4    Nansen, A.5    Rieneck, K.6
  • 120
    • 10944221275 scopus 로고    scopus 로고
    • Development of an anti-IL-12 p40 auto-vaccine: protection in experimental autoimmune encephalomyelitis at the expense of increased sensitivity to infection
    • Uyttenhove C., Arendse B., Stroobant V., Brombacher F., and van Snick J. Development of an anti-IL-12 p40 auto-vaccine: protection in experimental autoimmune encephalomyelitis at the expense of increased sensitivity to infection. Eur J Immunol 34 (2004) 3572-3581
    • (2004) Eur J Immunol , vol.34 , pp. 3572-3581
    • Uyttenhove, C.1    Arendse, B.2    Stroobant, V.3    Brombacher, F.4    van Snick, J.5
  • 122
    • 39749102391 scopus 로고    scopus 로고
    • Fungal infections complicating tumor necrosis factor alpha blockade therapy
    • Tsiodras S., Samonis G., Boumpas D.T., and Kontoyiannis D.P. Fungal infections complicating tumor necrosis factor alpha blockade therapy. Mayo Clin Proc 83 (2008) 181-194
    • (2008) Mayo Clin Proc , vol.83 , pp. 181-194
    • Tsiodras, S.1    Samonis, G.2    Boumpas, D.T.3    Kontoyiannis, D.P.4
  • 123
    • 33751165258 scopus 로고    scopus 로고
    • Infection and musculoskeletal conditions: bacterial and opportunistic infections during anti-TNF therapy
    • Strangfeld A., and Listing J. Infection and musculoskeletal conditions: bacterial and opportunistic infections during anti-TNF therapy. Best Pract Res Clin Rheumatol 20 (2006) 1181-1195
    • (2006) Best Pract Res Clin Rheumatol , vol.20 , pp. 1181-1195
    • Strangfeld, A.1    Listing, J.2
  • 124
    • 40749152243 scopus 로고    scopus 로고
    • Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial
    • Yokota S., Imagawa T., Mori M., Miyamae T., Aihara Y., Takei S., et al. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. Lancet 371 (2008) 998-1006
    • (2008) Lancet , vol.371 , pp. 998-1006
    • Yokota, S.1    Imagawa, T.2    Mori, M.3    Miyamae, T.4    Aihara, Y.5    Takei, S.6
  • 125
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial
    • Smolen J.S., Beaulieu A., Rubbert-Roth A., Ramos-Remus C., Rovensky J., Alecock E., et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet 371 (2008) 987-997
    • (2008) Lancet , vol.371 , pp. 987-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3    Ramos-Remus, C.4    Rovensky, J.5    Alecock, E.6
  • 126
    • 39249084392 scopus 로고    scopus 로고
    • Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases
    • Bustamante J., Boisson-Dupuis S., Jouanguy E., Picard C., Puel A., Abel L., et al. Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases. Curr Opin Immunol 20 (2008) 39-48
    • (2008) Curr Opin Immunol , vol.20 , pp. 39-48
    • Bustamante, J.1    Boisson-Dupuis, S.2    Jouanguy, E.3    Picard, C.4    Puel, A.5    Abel, L.6
  • 127
    • 0027240729 scopus 로고
    • Antibodies chaperone circulating IL-6. Paradoxical effects of anti-IL-6 "neutralizing" antibodies in vivo
    • May L.T., Neta R., Moldawer L.L., Kenney J.S., Patel K., and Sehgal P.B. Antibodies chaperone circulating IL-6. Paradoxical effects of anti-IL-6 "neutralizing" antibodies in vivo. J Immunol 151 (1993) 3225-3236
    • (1993) J Immunol , vol.151 , pp. 3225-3236
    • May, L.T.1    Neta, R.2    Moldawer, L.L.3    Kenney, J.S.4    Patel, K.5    Sehgal, P.B.6
  • 128
    • 0024409143 scopus 로고
    • Antibody-mediated enhancement of hormone activity
    • Aston R., Cowden W.B., and Ada G.L. Antibody-mediated enhancement of hormone activity. Mol Immunol 26 (1989) 435-446
    • (1989) Mol Immunol , vol.26 , pp. 435-446
    • Aston, R.1    Cowden, W.B.2    Ada, G.L.3
  • 129
    • 0028328436 scopus 로고
    • Impaired immune and acute-phase responses in interleukin-6-deficient mice
    • Kopf M., Baumann H., Freer G., Freudenberg M., Lamers M., Kishimoto T., et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368 (1994) 339-342
    • (1994) Nature , vol.368 , pp. 339-342
    • Kopf, M.1    Baumann, H.2    Freer, G.3    Freudenberg, M.4    Lamers, M.5    Kishimoto, T.6
  • 132
    • 33748997948 scopus 로고    scopus 로고
    • Cytokine networks-towards new therapies for rheumatoid arthritis
    • McInnes I.B., and Liew F.Y. Cytokine networks-towards new therapies for rheumatoid arthritis. Nat Clin Pract Rheumatol 1 (2005) 31-39
    • (2005) Nat Clin Pract Rheumatol , vol.1 , pp. 31-39
    • McInnes, I.B.1    Liew, F.Y.2
  • 134
    • 0345358581 scopus 로고    scopus 로고
    • Beneficial autoimmunity to proinflammatory mediators restrains the consequences of self-destructive immunity
    • Wildbaum G., Nahir M.A., and Karin N. Beneficial autoimmunity to proinflammatory mediators restrains the consequences of self-destructive immunity. Immunity 19 (2003) 679-688
    • (2003) Immunity , vol.19 , pp. 679-688
    • Wildbaum, G.1    Nahir, M.A.2    Karin, N.3
  • 135
    • 0038540612 scopus 로고    scopus 로고
    • Therapeutic vaccination to block receptor-ligand interactions
    • Spohn G., and Bachmann M.F. Therapeutic vaccination to block receptor-ligand interactions. Expert Opin Biol Ther 3 (2003) 469-476
    • (2003) Expert Opin Biol Ther , vol.3 , pp. 469-476
    • Spohn, G.1    Bachmann, M.F.2
  • 136
    • 0347135823 scopus 로고    scopus 로고
    • Therapeutic vaccination for chronic diseases: a new class of drugs in sight
    • Bachmann M.F., and Dyer M.R. Therapeutic vaccination for chronic diseases: a new class of drugs in sight. Nat Rev Drug Discov 3 (2004) 81-88
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 81-88
    • Bachmann, M.F.1    Dyer, M.R.2
  • 137
    • 33750027235 scopus 로고    scopus 로고
    • A second vaccine revolution for the new epidemics of the 21st century
    • Dyer M.R., Renner W.A., and Bachmann M.F. A second vaccine revolution for the new epidemics of the 21st century. Drug Discov Today 11 (2006) 1028-1033
    • (2006) Drug Discov Today , vol.11 , pp. 1028-1033
    • Dyer, M.R.1    Renner, W.A.2    Bachmann, M.F.3
  • 138
    • 0028170090 scopus 로고
    • A randomized, placebo-controlled, blind anti-AIDS clinical trial: safety and immunogenicity of a specific anti-IFN alpha immunization
    • Gringeri A., Santagostino E., Mannucci P.M., Tradati F., Cultraro D., Buzzi A., et al. A randomized, placebo-controlled, blind anti-AIDS clinical trial: safety and immunogenicity of a specific anti-IFN alpha immunization. J Acquir Immune Defic Syndrome 7 (1994) 978-988
    • (1994) J Acquir Immune Defic Syndrome , vol.7 , pp. 978-988
    • Gringeri, A.1    Santagostino, E.2    Mannucci, P.M.3    Tradati, F.4    Cultraro, D.5    Buzzi, A.6
  • 139
    • 33845660797 scopus 로고    scopus 로고
    • Individualized monitoring of drug bioavailability and immunogenicity in rheumatoid arthritis patients treated with the tumor necrosis factor alpha inhibitor infliximab
    • Bendtzen K., Geborek P., Svenson M., Larsson L., Kapetanovic M.C., and Saxne T. Individualized monitoring of drug bioavailability and immunogenicity in rheumatoid arthritis patients treated with the tumor necrosis factor alpha inhibitor infliximab. Arthritis Rheum 54 (2006) 3782-3789
    • (2006) Arthritis Rheum , vol.54 , pp. 3782-3789
    • Bendtzen, K.1    Geborek, P.2    Svenson, M.3    Larsson, L.4    Kapetanovic, M.C.5    Saxne, T.6
  • 140
    • 0030771836 scopus 로고    scopus 로고
    • Interleukin-6: an antagonizing problem becomes a solution
    • Rettig M.B. Interleukin-6: an antagonizing problem becomes a solution. Nat Biotechnol 15 (1997) 952-953
    • (1997) Nat Biotechnol , vol.15 , pp. 952-953
    • Rettig, M.B.1
  • 141
    • 35748943527 scopus 로고    scopus 로고
    • Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation
    • Galle P., Jensen L., Andersson C., Cuzzocrea S., Di Paola R., Nicoletti F., et al. Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation. Int Immunopharmacol 7 (2007) 1704-1713
    • (2007) Int Immunopharmacol , vol.7 , pp. 1704-1713
    • Galle, P.1    Jensen, L.2    Andersson, C.3    Cuzzocrea, S.4    Di Paola, R.5    Nicoletti, F.6
  • 142
    • 50249187809 scopus 로고    scopus 로고
    • Early and long-lasting protection from arthritis in tumour necrosis factor alpha (TNFalpha) transgenic mice vaccinated against TNF alpha
    • Delavallee L., Le Buanec H., Bessis N., Assier E., Denys A., Bizzini B., et al. Early and long-lasting protection from arthritis in tumour necrosis factor alpha (TNFalpha) transgenic mice vaccinated against TNF alpha. Ann Rheum Dis 67 (2008) 1332-1338
    • (2008) Ann Rheum Dis , vol.67 , pp. 1332-1338
    • Delavallee, L.1    Le Buanec, H.2    Bessis, N.3    Assier, E.4    Denys, A.5    Bizzini, B.6
  • 143
    • 0035313439 scopus 로고    scopus 로고
    • In vivo neutralization of human IL-6 (hIL-6) achieved by immunization of hIL-6-transgenic mice with a hIL-6 receptor antagonist
    • De Benadetti F., Pignatti P., Vivarelli M., Meazza C., Ciliberto G., Savino R., et al. In vivo neutralization of human IL-6 (hIL-6) achieved by immunization of hIL-6-transgenic mice with a hIL-6 receptor antagonist. J Immunol 166 (2001) 4334-4340
    • (2001) J Immunol , vol.166 , pp. 4334-4340
    • De Benadetti, F.1    Pignatti, P.2    Vivarelli, M.3    Meazza, C.4    Ciliberto, G.5    Savino, R.6
  • 145
    • 34948886115 scopus 로고    scopus 로고
    • Targets of anticytokine therapy and the risk of infections in humans and mice
    • van de Vosse E., and van Agtmael M.A. Targets of anticytokine therapy and the risk of infections in humans and mice. Curr Opin Rheumatol 19 (2007) 626-635
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 626-635
    • van de Vosse, E.1    van Agtmael, M.A.2
  • 146
    • 33644830598 scopus 로고    scopus 로고
    • Reply to 'blood pressure vaccine shot down by safety concerns'
    • Bachmann M.F., Nussberger J., Tissot A.C., and Jennings G.T. Reply to 'blood pressure vaccine shot down by safety concerns'. Nat Med 12 (2006) 270
    • (2006) Nat Med , vol.12 , pp. 270
    • Bachmann, M.F.1    Nussberger, J.2    Tissot, A.C.3    Jennings, G.T.4
  • 147
    • 0029800642 scopus 로고    scopus 로고
    • Anti-interleukin-6 autoantibodies in plasma are associated with an increased frequency of infections and increased mortality of patients with alcoholic cirrhosis
    • Homann C., Hansen M.B., Graudal N., Hasselqvist P., Svenson M., Bendtzen K., et al. Anti-interleukin-6 autoantibodies in plasma are associated with an increased frequency of infections and increased mortality of patients with alcoholic cirrhosis. Scand J Immunol 44 (1996) 623-629
    • (1996) Scand J Immunol , vol.44 , pp. 623-629
    • Homann, C.1    Hansen, M.B.2    Graudal, N.3    Hasselqvist, P.4    Svenson, M.5    Bendtzen, K.6
  • 148
    • 0033102085 scopus 로고    scopus 로고
    • Anti-IFN alpha immunization raises the IFN alpha-neutralizing capacity of serum-an adjuvant to antiretroviral tritherapy
    • Zagury D., Lecoq H., Gervi I., Le Buanec H., Zagury J.F., Bizzini B., et al. Anti-IFN alpha immunization raises the IFN alpha-neutralizing capacity of serum-an adjuvant to antiretroviral tritherapy. Biomed Pharmacother 53 (1999) 90-92
    • (1999) Biomed Pharmacother , vol.53 , pp. 90-92
    • Zagury, D.1    Lecoq, H.2    Gervi, I.3    Le Buanec, H.4    Zagury, J.F.5    Bizzini, B.6
  • 149
    • 0034940764 scopus 로고    scopus 로고
    • Toward a new generation of vaccines: the anti-cytokine therapeutic vaccines
    • Zagury D., Burny A., and Gallo R.C. Toward a new generation of vaccines: the anti-cytokine therapeutic vaccines. Proc Natl Acad Sci USA 98 (2001) 8024-8029
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8024-8029
    • Zagury, D.1    Burny, A.2    Gallo, R.C.3
  • 150
    • 0842348085 scopus 로고    scopus 로고
    • Anti-cytokine Ab immune therapy: present status and perspectives
    • Zagury D., and Gallo R.C. Anti-cytokine Ab immune therapy: present status and perspectives. Drug Discov Today 9 (2004) 72-81
    • (2004) Drug Discov Today , vol.9 , pp. 72-81
    • Zagury, D.1    Gallo, R.C.2
  • 152
    • 0028093003 scopus 로고
    • Formation of autoantibodies, including anti-cytokine antibodies, is a hallmark of the immune response of early B cells
    • Kearney J.F. Formation of autoantibodies, including anti-cytokine antibodies, is a hallmark of the immune response of early B cells. J Interferon Res 14 (1994) 151-152
    • (1994) J Interferon Res , vol.14 , pp. 151-152
    • Kearney, J.F.1
  • 153
    • 33947694597 scopus 로고    scopus 로고
    • Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1)
    • Strobel P., Murumagi A., Klein R., Luster M., Lahti M., Krohn K., et al. Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1). J Pathol 211 (2007) 563-571
    • (2007) J Pathol , vol.211 , pp. 563-571
    • Strobel, P.1    Murumagi, A.2    Klein, R.3    Luster, M.4    Lahti, M.5    Krohn, K.6
  • 154
    • 33749370201 scopus 로고    scopus 로고
    • Differentially methylated alleles in a distinct region of the human interleukin-1alpha promoter are associated with allele-specific expression of IL-1alpha in CD4+ T cells
    • van Rietschoten J.G., Verzijlbergen K.F., Gringhuis S.I., van der Pouw Kraan T.C., Bayley J.P., Wierenga E.A., et al. Differentially methylated alleles in a distinct region of the human interleukin-1alpha promoter are associated with allele-specific expression of IL-1alpha in CD4+ T cells. Blood 108 (2006) 2143-2149
    • (2006) Blood , vol.108 , pp. 2143-2149
    • van Rietschoten, J.G.1    Verzijlbergen, K.F.2    Gringhuis, S.I.3    van der Pouw Kraan, T.C.4    Bayley, J.P.5    Wierenga, E.A.6
  • 155
    • 33745899048 scopus 로고    scopus 로고
    • Alternative splicing: new insights from global analyses
    • Blencowe B.J. Alternative splicing: new insights from global analyses. Cell 126 (2006) 37-47
    • (2006) Cell , vol.126 , pp. 37-47
    • Blencowe, B.J.1
  • 157
    • 0037112208 scopus 로고    scopus 로고
    • Viral IL-6-induced cell proliferation and immune evasion of interferon activity
    • Chatterjee M., Osborne J., Bestetti G., Chang Y., and Moore P.S. Viral IL-6-induced cell proliferation and immune evasion of interferon activity. Science 298 (2002) 1432-1435
    • (2002) Science , vol.298 , pp. 1432-1435
    • Chatterjee, M.1    Osborne, J.2    Bestetti, G.3    Chang, Y.4    Moore, P.S.5
  • 158
    • 0345735665 scopus 로고    scopus 로고
    • Molecular mechanisms for viral mimicry of a human cytokine: activation of gp130 by HHV-8 interleukin-6
    • Boulanger M.J., Chow D.C., Brevnova E., Martick M., Sandford G., Nicholas J., et al. Molecular mechanisms for viral mimicry of a human cytokine: activation of gp130 by HHV-8 interleukin-6. J Mol Biol 335 (2004) 641-654
    • (2004) J Mol Biol , vol.335 , pp. 641-654
    • Boulanger, M.J.1    Chow, D.C.2    Brevnova, E.3    Martick, M.4    Sandford, G.5    Nicholas, J.6
  • 160
    • 6344268944 scopus 로고    scopus 로고
    • Mechanisms of soluble cytokine receptor generation
    • Levine S.J. Mechanisms of soluble cytokine receptor generation. J Immunol 173 (2004) 5343-5348
    • (2004) J Immunol , vol.173 , pp. 5343-5348
    • Levine, S.J.1
  • 161
    • 0017105643 scopus 로고
    • Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection
    • Gresser I., Tovey M.G., Bandu M.E., Maury C., and Brouty-Boye D. Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection. J Exp Med 144 (1976) 1305-1315
    • (1976) J Exp Med , vol.144 , pp. 1305-1315
    • Gresser, I.1    Tovey, M.G.2    Bandu, M.E.3    Maury, C.4    Brouty-Boye, D.5
  • 162
    • 37349029705 scopus 로고    scopus 로고
    • Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells
    • Ireland D.D., Stohlman S.A., Hinton D.R., Atkinson R., and Bergmann C.C. Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells. J Virol 82 (2008) 300-310
    • (2008) J Virol , vol.82 , pp. 300-310
    • Ireland, D.D.1    Stohlman, S.A.2    Hinton, D.R.3    Atkinson, R.4    Bergmann, C.C.5
  • 163
    • 54849176000 scopus 로고    scopus 로고
    • Dual therapeutic effects of interferon-alpha gene therapy in a rat hepatocellular carcinoma model with liver cirrhosis
    • Huang K.W., Huang Y.C., Tai K.F., Chen B.H., Lee P.H., and Hwang L.H. Dual therapeutic effects of interferon-alpha gene therapy in a rat hepatocellular carcinoma model with liver cirrhosis. Mol Ther 10 (2008) 1681-1687
    • (2008) Mol Ther , vol.10 , pp. 1681-1687
    • Huang, K.W.1    Huang, Y.C.2    Tai, K.F.3    Chen, B.H.4    Lee, P.H.5    Hwang, L.H.6
  • 164
    • 47949127385 scopus 로고    scopus 로고
    • IFN-alpha and IFN-lambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity
    • Maher S.G., Sheikh F., Scarzello A.J., Romero-Weaver A.L., Baker D.P., Donnelly R.P., et al. IFN-alpha and IFN-lambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity. Cancer Biol Ther 7 (2008) 1109-1115
    • (2008) Cancer Biol Ther , vol.7 , pp. 1109-1115
    • Maher, S.G.1    Sheikh, F.2    Scarzello, A.J.3    Romero-Weaver, A.L.4    Baker, D.P.5    Donnelly, R.P.6
  • 166
    • 0032103249 scopus 로고    scopus 로고
    • Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection
    • Dorman S.E., and Holland S.M. Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection. J Clin Invest 101 (1998) 2364-2369
    • (1998) J Clin Invest , vol.101 , pp. 2364-2369
    • Dorman, S.E.1    Holland, S.M.2
  • 168
    • 3042785881 scopus 로고    scopus 로고
    • Autoantibodies against granulocyte-macrophage colony stimulating factor and interleukin-3 are rare in patients with Felty's syndrome
    • Hellmich B., Ciaglo A., Schatz H., and Coakley G. Autoantibodies against granulocyte-macrophage colony stimulating factor and interleukin-3 are rare in patients with Felty's syndrome. Ann Rheum Dis 63 (2004) 862-866
    • (2004) Ann Rheum Dis , vol.63 , pp. 862-866
    • Hellmich, B.1    Ciaglo, A.2    Schatz, H.3    Coakley, G.4
  • 170
    • 0030856428 scopus 로고    scopus 로고
    • Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia
    • van der P.T., Keogh C.V., Guirao X., Buurman W.A., Kopf M., and Lowry S.F. Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia. J Infect Dis 176 (1997) 439-444
    • (1997) J Infect Dis , vol.176 , pp. 439-444
    • van der, P.T.1    Keogh, C.V.2    Guirao, X.3    Buurman, W.A.4    Kopf, M.5    Lowry, S.F.6
  • 171
    • 40649087885 scopus 로고    scopus 로고
    • Anti-interleukin-8 autoantibody:interleukin-8 immune complexes in acute lung injury/acute respiratory distress syndrome
    • Fudala R., Krupa A., Stankowska D., Allen T.C., and Kurdowska A.K. Anti-interleukin-8 autoantibody:interleukin-8 immune complexes in acute lung injury/acute respiratory distress syndrome. Clin Sci (Lond) 114 (2008) 403-412
    • (2008) Clin Sci (Lond) , vol.114 , pp. 403-412
    • Fudala, R.1    Krupa, A.2    Stankowska, D.3    Allen, T.C.4    Kurdowska, A.K.5
  • 172
    • 60949106760 scopus 로고    scopus 로고
    • Mechanism of epithelial injury triggered by anti-IL-8 autoantibody:IL-8 immune complexes
    • Stankowska D.L., Fudala R., and Kurdowska A.K. Mechanism of epithelial injury triggered by anti-IL-8 autoantibody:IL-8 immune complexes. Proc Am Thorac Soc 5 (2008) 365-366
    • (2008) Proc Am Thorac Soc , vol.5 , pp. 365-366
    • Stankowska, D.L.1    Fudala, R.2    Kurdowska, A.K.3
  • 173
    • 0024438465 scopus 로고
    • Evidence that tumor necrosis factor has an important role in antibacterial resistance
    • Havell E.A. Evidence that tumor necrosis factor has an important role in antibacterial resistance. J Immunol 143 (1989) 2894-2899
    • (1989) J Immunol , vol.143 , pp. 2894-2899
    • Havell, E.A.1
  • 174
    • 0037955831 scopus 로고    scopus 로고
    • Anti-cytokine therapeutics and infections
    • Dinarello C.A. Anti-cytokine therapeutics and infections. Vaccine 21 Suppl 2 (2003) S24-S34
    • (2003) Vaccine , vol.21 , Issue.SUPPL. 2
    • Dinarello, C.A.1
  • 175
    • 0031770390 scopus 로고    scopus 로고
    • Induction of cytokines and anti-cytokine autoantibodies in cerebrospinal fluid (CSF) during experimental bacterial meningitis
    • Bakhiet M., Mustafa M., Zhu J., Harris R., Lindquist L., Link H., et al. Induction of cytokines and anti-cytokine autoantibodies in cerebrospinal fluid (CSF) during experimental bacterial meningitis. Clin Exp Immunol 114 (1998) 398-402
    • (1998) Clin Exp Immunol , vol.114 , pp. 398-402
    • Bakhiet, M.1    Mustafa, M.2    Zhu, J.3    Harris, R.4    Lindquist, L.5    Link, H.6
  • 176
    • 33745127736 scopus 로고    scopus 로고
    • Clinical significance of anti-GM-CSF antibodies in idiopathic pulmonary alveolar proteinosis
    • Lin F.C., Chang G.D., Chern M.S., Chen Y.C., and Chang S.C. Clinical significance of anti-GM-CSF antibodies in idiopathic pulmonary alveolar proteinosis. Thorax 61 (2006) 528-534
    • (2006) Thorax , vol.61 , pp. 528-534
    • Lin, F.C.1    Chang, G.D.2    Chern, M.S.3    Chen, Y.C.4    Chang, S.C.5
  • 177
    • 0023698746 scopus 로고
    • Chemotactic activity of recombinant human granulocyte colony-stimulating factor
    • Wang J.M., Chen Z.G., Colella S., Bonilla M.A., Welte K., Bordignon C., et al. Chemotactic activity of recombinant human granulocyte colony-stimulating factor. Blood 72 (1988) 1456-1460
    • (1988) Blood , vol.72 , pp. 1456-1460
    • Wang, J.M.1    Chen, Z.G.2    Colella, S.3    Bonilla, M.A.4    Welte, K.5    Bordignon, C.6
  • 178
    • 0031447257 scopus 로고    scopus 로고
    • Natural and therapy-induced anti-GM-CSF and anti-G-CSF antibodies in human serum
    • Revoltella R.P., Laricchia-Robbio L., Moscato S., Genua A., and Liberati A.M. Natural and therapy-induced anti-GM-CSF and anti-G-CSF antibodies in human serum. Leuk Lymphoma 26 Suppl 1 (1997) 29-34
    • (1997) Leuk Lymphoma , vol.26 , Issue.SUPPL. 1 , pp. 29-34
    • Revoltella, R.P.1    Laricchia-Robbio, L.2    Moscato, S.3    Genua, A.4    Liberati, A.M.5
  • 179
    • 0036743999 scopus 로고    scopus 로고
    • Autoantibodies against granulocyte colony-stimulating factor in Felty's syndrome and neutropenic systemic lupus erythematosus
    • Hellmich B., Csernok E., Schatz H., Gross W.L., and Schnabel A. Autoantibodies against granulocyte colony-stimulating factor in Felty's syndrome and neutropenic systemic lupus erythematosus. Arthritis Rheum 46 (2002) 2384-2391
    • (2002) Arthritis Rheum , vol.46 , pp. 2384-2391
    • Hellmich, B.1    Csernok, E.2    Schatz, H.3    Gross, W.L.4    Schnabel, A.5
  • 180
    • 0032469128 scopus 로고    scopus 로고
    • The rhGM-CSF-EPO hybrid protein MEN 11300 induces anti-EPO antibodies and severe anaemia in rhesus monkeys
    • Coscarella A., Liddi R., Di Loreto M., Bach S., Faiella A., van der Meide P.H., et al. The rhGM-CSF-EPO hybrid protein MEN 11300 induces anti-EPO antibodies and severe anaemia in rhesus monkeys. Cytokine 10 (1998) 964-969
    • (1998) Cytokine , vol.10 , pp. 964-969
    • Coscarella, A.1    Liddi, R.2    Di Loreto, M.3    Bach, S.4    Faiella, A.5    van der Meide, P.H.6
  • 182
    • 0032731103 scopus 로고    scopus 로고
    • Circulating autoantibodies to erythropoietin are associated with human immunodeficiency virus type 1-related anemia
    • Sipsas N.V., Kokori S.I., Ioannidis J.P., Kyriaki D., Tzioufas A.G., and Kordossis T. Circulating autoantibodies to erythropoietin are associated with human immunodeficiency virus type 1-related anemia. J Infect Dis 180 (1999) 2044-2047
    • (1999) J Infect Dis , vol.180 , pp. 2044-2047
    • Sipsas, N.V.1    Kokori, S.I.2    Ioannidis, J.P.3    Kyriaki, D.4    Tzioufas, A.G.5    Kordossis, T.6
  • 183
    • 0016425950 scopus 로고
    • Pure red cell aplasia (PRCA): response of three patients of cyclophosphamide and/or antilymphocyte globulin (ALG) and demonstration of two types of serum IgG inhibitors to erythropoiesis
    • Marmont A., Peschle C., Sanguineti M., and Condorelli M. Pure red cell aplasia (PRCA): response of three patients of cyclophosphamide and/or antilymphocyte globulin (ALG) and demonstration of two types of serum IgG inhibitors to erythropoiesis. Blood 45 (1975) 247-261
    • (1975) Blood , vol.45 , pp. 247-261
    • Marmont, A.1    Peschle, C.2    Sanguineti, M.3    Condorelli, M.4
  • 184
    • 22144457874 scopus 로고    scopus 로고
    • Improvement of collagen-induced arthritis by active immunization against murine IL-1beta peptides designed by molecular modelling
    • Bertin-Maghit S.M., Capini C.J., Bessis N., Chomilier J., Muller S., Abbas A., et al. Improvement of collagen-induced arthritis by active immunization against murine IL-1beta peptides designed by molecular modelling. Vaccine 23 (2005) 4228-4235
    • (2005) Vaccine , vol.23 , pp. 4228-4235
    • Bertin-Maghit, S.M.1    Capini, C.J.2    Bessis, N.3    Chomilier, J.4    Muller, S.5    Abbas, A.6
  • 185
    • 43649107676 scopus 로고    scopus 로고
    • Active immunization with IL-1 displayed on virus-like particles protects from autoimmune arthritis
    • Spohn G., Keller I., Beck M., Grest P., Jennings G.T., and Bachmann M.F. Active immunization with IL-1 displayed on virus-like particles protects from autoimmune arthritis. Eur J Immunol 38 (2008) 877-887
    • (2008) Eur J Immunol , vol.38 , pp. 877-887
    • Spohn, G.1    Keller, I.2    Beck, M.3    Grest, P.4    Jennings, G.T.5    Bachmann, M.F.6
  • 186
    • 34248569682 scopus 로고    scopus 로고
    • Novel cytokine peptide-based vaccines: an interleukin-4 vaccine suppresses airway allergic responses in mice
    • Ma Y., Hayglass K.T., Becker A.B., Halayko A.J., Basu S., Simons F.E., et al. Novel cytokine peptide-based vaccines: an interleukin-4 vaccine suppresses airway allergic responses in mice. Allergy 62 (2007) 675-682
    • (2007) Allergy , vol.62 , pp. 675-682
    • Ma, Y.1    Hayglass, K.T.2    Becker, A.B.3    Halayko, A.J.4    Basu, S.5    Simons, F.E.6
  • 187
    • 40949128356 scopus 로고    scopus 로고
    • A recombinant DNA plasmid encoding the human interleukin-5 breaks immunological tolerance and inhibits airway inflammation in a murine model of asthma
    • Tan G.H., Su J.M., Wang C.C., Huang F.Y., Wang H., Huang Y.H., et al. A recombinant DNA plasmid encoding the human interleukin-5 breaks immunological tolerance and inhibits airway inflammation in a murine model of asthma. Int Arch Allergy Immunol 145 (2008) 313-323
    • (2008) Int Arch Allergy Immunol , vol.145 , pp. 313-323
    • Tan, G.H.1    Su, J.M.2    Wang, C.C.3    Huang, F.Y.4    Wang, H.5    Huang, Y.H.6
  • 188
    • 0031775979 scopus 로고    scopus 로고
    • A novel cancer vaccine composed of human-recombinant epidermal growth factor linked to a carrier protein: report of a pilot clinical trial
    • Gonzalez G., Crombet T., Catala M., Mirabal V., Hernandez J.C., Gonzalez Y., et al. A novel cancer vaccine composed of human-recombinant epidermal growth factor linked to a carrier protein: report of a pilot clinical trial. Ann Oncol 9 (1998) 431-435
    • (1998) Ann Oncol , vol.9 , pp. 431-435
    • Gonzalez, G.1    Crombet, T.2    Catala, M.3    Mirabal, V.4    Hernandez, J.C.5    Gonzalez, Y.6
  • 189
    • 33847041123 scopus 로고    scopus 로고
    • Therapeutic vaccination with epidermal growth factor (EGF) in advanced lung cancer: analysis of pooled data from three clinical trials
    • Gonzalez G., Crombet T., Neninger E., Viada C., and Lage A. Therapeutic vaccination with epidermal growth factor (EGF) in advanced lung cancer: analysis of pooled data from three clinical trials. Hum Vaccin 3 (2007) 8-13
    • (2007) Hum Vaccin , vol.3 , pp. 8-13
    • Gonzalez, G.1    Crombet, T.2    Neninger, E.3    Viada, C.4    Lage, A.5
  • 190
    • 34548037645 scopus 로고    scopus 로고
    • Putting the brakes on angiogenesis through a novel VEGF-KLH (kinoid) vaccine
    • Nair J.R., Bansal S., and Lee K.P. Putting the brakes on angiogenesis through a novel VEGF-KLH (kinoid) vaccine. Expert Rev Vaccines 6 (2007) 491-496
    • (2007) Expert Rev Vaccines , vol.6 , pp. 491-496
    • Nair, J.R.1    Bansal, S.2    Lee, K.P.3
  • 191
    • 34247339635 scopus 로고    scopus 로고
    • DNA vaccination against VEGF receptor 2 reduces atherosclerosis in LDL receptor-deficient mice
    • Petrovan R.J., Kaplan C.D., Reisfeld R.A., and Curtiss L.K. DNA vaccination against VEGF receptor 2 reduces atherosclerosis in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 27 (2007) 1095-1100
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1095-1100
    • Petrovan, R.J.1    Kaplan, C.D.2    Reisfeld, R.A.3    Curtiss, L.K.4
  • 193
    • 0036913333 scopus 로고    scopus 로고
    • A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth
    • Niethammer A.G., Xiang R., Becker J.C., Wodrich H., Pertl U., Karsten G., et al. A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth. Nat Med 8 (2002) 1369-1375
    • (2002) Nat Med , vol.8 , pp. 1369-1375
    • Niethammer, A.G.1    Xiang, R.2    Becker, J.C.3    Wodrich, H.4    Pertl, U.5    Karsten, G.6
  • 194
    • 33846255485 scopus 로고    scopus 로고
    • A novel DNA vaccine encoding PDGFRbeta suppresses growth and dissemination of murine colon, lung and breast carcinoma
    • Kaplan C.D., Kruger J.A., Zhou H., Luo Y., Xiang R., and Reisfeld R.A. A novel DNA vaccine encoding PDGFRbeta suppresses growth and dissemination of murine colon, lung and breast carcinoma. Vaccine 24 (2006) 6994-7002
    • (2006) Vaccine , vol.24 , pp. 6994-7002
    • Kaplan, C.D.1    Kruger, J.A.2    Zhou, H.3    Luo, Y.4    Xiang, R.5    Reisfeld, R.A.6
  • 196
    • 35448939297 scopus 로고    scopus 로고
    • A potential immunotherapy approach: mucosal immunization with an IL-13 peptide-based virus-like particle vaccine in a mouse asthma model
    • Ma Y., Ma A.G., and Peng Z. A potential immunotherapy approach: mucosal immunization with an IL-13 peptide-based virus-like particle vaccine in a mouse asthma model. Vaccine 25 (2007) 8091-8099
    • (2007) Vaccine , vol.25 , pp. 8091-8099
    • Ma, Y.1    Ma, A.G.2    Peng, Z.3
  • 197
    • 34548437104 scopus 로고    scopus 로고
    • Novel recombinant interleukin-13 peptide-based vaccine reduces airway allergic inflammatory responses in mice
    • Ma Y., Hayglass K.T., Becker A.B., Fan Y., Yang X., Basu S., et al. Novel recombinant interleukin-13 peptide-based vaccine reduces airway allergic inflammatory responses in mice. Am J Respir Crit Care Med 176 (2007) 439-445
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 439-445
    • Ma, Y.1    Hayglass, K.T.2    Becker, A.B.3    Fan, Y.4    Yang, X.5    Basu, S.6
  • 198
    • 33751243318 scopus 로고    scopus 로고
    • Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis
    • Uyttenhove C., and van Snick J. Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis. Eur J Immunol 36 (2006) 2868-2874
    • (2006) Eur J Immunol , vol.36 , pp. 2868-2874
    • Uyttenhove, C.1    van Snick, J.2
  • 199
    • 8444235333 scopus 로고    scopus 로고
    • Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the p28 subunit of IL-27
    • Goldberg R., Zohar Y., Wildbaum G., Geron Y., Maor G., and Karin N. Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the p28 subunit of IL-27. J Immunol 173 (2004) 6465-6471
    • (2004) J Immunol , vol.173 , pp. 6465-6471
    • Goldberg, R.1    Zohar, Y.2    Wildbaum, G.3    Geron, Y.4    Maor, G.5    Karin, N.6
  • 200
    • 3142719733 scopus 로고    scopus 로고
    • Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27
    • Goldberg R., Wildbaum G., Zohar Y., Maor G., and Karin N. Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27. J Immunol 173 (2004) 1171-1178
    • (2004) J Immunol , vol.173 , pp. 1171-1178
    • Goldberg, R.1    Wildbaum, G.2    Zohar, Y.3    Maor, G.4    Karin, N.5
  • 201
    • 1942437446 scopus 로고    scopus 로고
    • TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model
    • Waterston A.M., Salway F., Andreakos E., Butler D.M., Feldmann M., and Coombes R.C. TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model. Br J Cancer 90 (2004) 1279-1284
    • (2004) Br J Cancer , vol.90 , pp. 1279-1284
    • Waterston, A.M.1    Salway, F.2    Andreakos, E.3    Butler, D.M.4    Feldmann, M.5    Coombes, R.C.6
  • 202
    • 0038376618 scopus 로고    scopus 로고
    • TNFalpha DNA vaccination prevents clinical manifestations of experimental antiphospholipid syndrome
    • Blank M., Krause I., Wildbaum G., Karin N., and Shoenfeld Y. TNFalpha DNA vaccination prevents clinical manifestations of experimental antiphospholipid syndrome. Lupus 12 (2003) 546-549
    • (2003) Lupus , vol.12 , pp. 546-549
    • Blank, M.1    Krause, I.2    Wildbaum, G.3    Karin, N.4    Shoenfeld, Y.5
  • 203
    • 0029303388 scopus 로고
    • Anti-alpha interferon immunization: safety and immunogenicity in asymptomatic HIV positive patients at high risk of disease progression
    • Gringeri A., Santagostino E., Mannucci P.M., Siracusano L., Marinoni A., Criscuolo M., et al. Anti-alpha interferon immunization: safety and immunogenicity in asymptomatic HIV positive patients at high risk of disease progression. Cell Mol Biol (Noisy-le-grand) 41 (1995) 381-387
    • (1995) Cell Mol Biol (Noisy-le-grand) , vol.41 , pp. 381-387
    • Gringeri, A.1    Santagostino, E.2    Mannucci, P.M.3    Siracusano, L.4    Marinoni, A.5    Criscuolo, M.6
  • 204
    • 1542429111 scopus 로고    scopus 로고
    • Absence of clinical, virological, and immunological signs of progression in HIV-1-infected patients receiving active anti-interferon-alpha immunization: a 30-month follow-up report
    • Gringeri A., Santagostino E., Cusini M., Muca-Perja M., Marinoni A., Mannucci P.M., et al. Absence of clinical, virological, and immunological signs of progression in HIV-1-infected patients receiving active anti-interferon-alpha immunization: a 30-month follow-up report. J Acquir Immune Defic Syndr Hum Retrovirol 13 (1996) 55-67
    • (1996) J Acquir Immune Defic Syndr Hum Retrovirol , vol.13 , pp. 55-67
    • Gringeri, A.1    Santagostino, E.2    Cusini, M.3    Muca-Perja, M.4    Marinoni, A.5    Mannucci, P.M.6
  • 205
    • 0033102084 scopus 로고    scopus 로고
    • IFN alpha kinoid vaccine in conjunction with tritherapy, a weapon to combat immunopathogenesis in AIDS
    • Bizzini B., Volpato I., Lachgar A., Cohen P., and Gringeri A. IFN alpha kinoid vaccine in conjunction with tritherapy, a weapon to combat immunopathogenesis in AIDS. Biomed Pharmacother 53 (1999) 87-89
    • (1999) Biomed Pharmacother , vol.53 , pp. 87-89
    • Bizzini, B.1    Volpato, I.2    Lachgar, A.3    Cohen, P.4    Gringeri, A.5
  • 206
    • 19044387972 scopus 로고    scopus 로고
    • A novel therapeutic vaccine approach, targeting RANKL, prevents bone destruction in bone-related disorders
    • Juji T., Hertz M., Aoki K., Horie D., Ohya K., Gautam A., et al. A novel therapeutic vaccine approach, targeting RANKL, prevents bone destruction in bone-related disorders. J Bone Miner Metab 20 (2002) 266-268
    • (2002) J Bone Miner Metab , vol.20 , pp. 266-268
    • Juji, T.1    Hertz, M.2    Aoki, K.3    Horie, D.4    Ohya, K.5    Gautam, A.6
  • 207
    • 38449086622 scopus 로고    scopus 로고
    • Targeting osteoporosis and rheumatoid arthritis by active vaccination against RANKL
    • Spohn G., and Bachmann M.F. Targeting osteoporosis and rheumatoid arthritis by active vaccination against RANKL. Adv Exp Med Biol 602 (2007) 135-142
    • (2007) Adv Exp Med Biol , vol.602 , pp. 135-142
    • Spohn, G.1    Bachmann, M.F.2
  • 208
    • 0033846366 scopus 로고    scopus 로고
    • C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis
    • Youssef S., Maor G., Wildbaum G., Grabie N., Gour-Lavie A., and Karin N. C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis. J Clin Invest 106 (2000) 361-371
    • (2000) J Clin Invest , vol.106 , pp. 361-371
    • Youssef, S.1    Maor, G.2    Wildbaum, G.3    Grabie, N.4    Gour-Lavie, A.5    Karin, N.6
  • 209
    • 0032794139 scopus 로고    scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by MIP-1alpha and MCP-1 naked DNA vaccines
    • Youssef S., Wildbaum G., and Karin N. Prevention of experimental autoimmune encephalomyelitis by MIP-1alpha and MCP-1 naked DNA vaccines. J Autoimmunol 13 (1999) 21-29
    • (1999) J Autoimmunol , vol.13 , pp. 21-29
    • Youssef, S.1    Wildbaum, G.2    Karin, N.3
  • 210
    • 0033818187 scopus 로고    scopus 로고
    • A targeted DNA vaccine encoding fas ligand defines its dual role in the regulation of experimental autoimmune encephalomyelitis
    • Wildbaum G., Westermann J., Maor G., and Karin N. A targeted DNA vaccine encoding fas ligand defines its dual role in the regulation of experimental autoimmune encephalomyelitis. J Clin Invest 106 (2000) 671-679
    • (2000) J Clin Invest , vol.106 , pp. 671-679
    • Wildbaum, G.1    Westermann, J.2    Maor, G.3    Karin, N.4
  • 211
    • 33847084328 scopus 로고    scopus 로고
    • A novel DNA vaccine targeting macrophage migration inhibitory factor protects joints from inflammation and destruction in murine models of arthritis
    • Onodera S., Ohshima S., Tohyama H., Yasuda K., Nishihira J., Iwakura Y., et al. A novel DNA vaccine targeting macrophage migration inhibitory factor protects joints from inflammation and destruction in murine models of arthritis. Arthritis Rheum 56 (2007) 521-530
    • (2007) Arthritis Rheum , vol.56 , pp. 521-530
    • Onodera, S.1    Ohshima, S.2    Tohyama, H.3    Yasuda, K.4    Nishihira, J.5    Iwakura, Y.6
  • 212
    • 56349138520 scopus 로고    scopus 로고
    • A novel DNA vaccine-targeting macrophage migration inhibitory factor improves the survival of mice with sepsis
    • Tohyama S., Onodera S., Tohyama H., Yasuda K., Nishihira J., Mizue Y., et al. A novel DNA vaccine-targeting macrophage migration inhibitory factor improves the survival of mice with sepsis. Gene Ther 23 (2008) 1513-1522
    • (2008) Gene Ther , vol.23 , pp. 1513-1522
    • Tohyama, S.1    Onodera, S.2    Tohyama, H.3    Yasuda, K.4    Nishihira, J.5    Mizue, Y.6


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