Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFα-induced MEK/ERK signalling

Arthritis Research and Therapy

Volumn 11, Issue 1, 2009, Pages

  Rockel, Jason S ^a   Bernier, Suzanne M ^a   Leask, Andrew ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; AGGRECAN; COLLAGEN TYPE 2; EARLY GROWTH RESPONSE FACTOR 1; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LINK PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; OLIGODEOXYNUCLEOTIDE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX9; TUMOR NECROSIS FACTOR ALPHA; AGC1 PROTEIN, RAT; COL2A1 PROTEIN, RAT; EGR1 PROTEIN, RAT; ENZYME INHIBITOR; PROTEOGLYCAN; SCLEROPROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; BIOSYNTHESIS; CARTILAGE CELL; CATABOLISM; CONTROLLED STUDY; DRUG TARGETING; EXTRACELLULAR MATRIX; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENE EXPRESSION; GENE IDENTIFICATION; GENE REPRESSION; GENETIC TRANSFECTION; IMMUNOBLOTTING; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; PROMOTER REGION; PROTEIN DNA BINDING; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; ANIMAL; CARTILAGE; CELL CULTURE; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AGGRECANS; ANIMALS; BLOTTING, WESTERN; CARTILAGE; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; EARLY GROWTH RESPONSE PROTEIN 1; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INHIBITORS; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION; GENE EXPRESSION REGULATION; MAP KINASE SIGNALING SYSTEM; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEOGLYCANS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 60949089801     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2595     Document Type: Article

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