Can cardiac fibrosis be prevented? Mast cell inhibition versus anti-chymase activity

European Journal of Cardio-thoracic Surgery

Volumn 35, Issue 3, 2009, Pages 553-554

  Akgul, Ahmet ^a  

^a TURKIYE YUKSEK IHTISAS HOSPITAL   (Turkey)

Author keywords

Basic FGF; Chymase; Fibrosis; Mast cell; TGF 1

Indexed keywords

CHYMASE; FIBROBLAST GROWTH FACTOR; PROTEIN KINASE C; PROTEINASE; TRANSFORMING GROWTH FACTOR BETA;

ENZYME ACTIVITY; ENZYME INHIBITION; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE FIBROSIS; LETTER; MAST CELL; MAST CELL DEGRANULATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CARDIOMYOPATHIES; CHYMASES; ENZYME INHIBITORS; FIBROSIS; MALE; MAST CELLS; RATS; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 60849125708     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2008.11.021     Document Type: Letter

References (5)

1. Kanemitsu H., Takai S., Tsuneyoshi H., Yoshikawa E., Nishina T., Miyazaki M., Ikeda T., and Komeda M. Chronic chymase inhibition preserves cardiac function after left ventricular repair in rats. Eur J Cardiothorac Surg 33 1 (2008) 25-31
2. Akgul A., Skrabal C.A., Thompson L.O., Loebe M., Lafuente J.A., Noon G.P., and Youker K.A. Role of mast cells and their mediators in failing myocardium under mechanical support. J Heart Lung Transplant 23 6 (2004) 709-715
3. Akgul A., Youker K.A., Noon G.P., and Loebe M. Quantitative changes in mast cell populations after left ventricular assist device implantation. ASAIO J 51 3 (2005) 275-280
4. Palaniyandi S.S., Inagaki K., and Mochly-Rosen D. Mast cells and εPKC: a role in cardiac remodeling in hypertension-induced heart failure. J Mol Cell Cardiol 45 6 (2008) 779-786
5. Akgul A. Cardiac mast cells [In Turkish]. Turkiye Klinikleri J Cardiovasc Sci 21 (2007) 63-65