The correlation of hepatitis B virus pre-S mutation with cellular oxidative DNA damage in hepatocellular carcinoma

Hepato-Gastroenterology

Volumn 55, Issue 88, 2008, Pages 2028-2032

  Gwak, Geum Youn ^a   Lee, Dong Ho ^a   Moon, Tae Gun ^a   Choi, Moon Seok ^a   Lee, Joon Hyeok ^a   Koh, Kwang Cheol ^a   Paik, Seung Woon ^a   Park, Cheol Keun ^a   Joh, Jae Won ^a   Yoo, Byung Chul ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

8 OxoG; ER stress; Hepatitis B virus; Hepatocellular carcinoma; OGG1; Pre S mutation

Indexed keywords

8 HYDROXYGUANINE; DNA GLYCOSYLTRANSFERASE; HEPATITIS B SURFACE ANTIGEN; PROTEIN OGG1; UNCLASSIFIED DRUG; VIRUS DNA;

ADULT; ARTICLE; CANCER TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA EXTRACTION; DNA SEQUENCE; ENDOPLASMIC RETICULUM STRESS; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; VIRUS MUTANT; VIRUS MUTATION;

AGED; CARCINOMA, HEPATOCELLULAR; DNA DAMAGE; DNA GLYCOSYLASES; ENDOPLASMIC RETICULUM; FEMALE; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; LIVER NEOPLASMS; MALE; MIDDLE AGED; MUTATION; OXIDATIVE STRESS; PROTEIN PRECURSORS; VIRAL ENVELOPE PROTEINS;

EID: 60849119296     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Arbuthnot P, Kew M: Hepatitis B virus and hepatocellular carcinoma. Int J Exp Pathol 2001; 82: 77-100.
2. Bosch FX: Global epidemiology of hepatocellular carcinoma. In: Okuda K, Tabor E, eds. Liver Cancer. New York: Churchill Livingstone, 1997: 13-28.
3. Beasley J, Hwang LY, Lin CC, Chien CS: Hepatocellular carcinoma and HBV. A prospective study of 22,707 men in Taiwan. Lancet 1981; 2: 1129-1133.
4. Tiollais P, Pourcel C, Dejean A: The hepatitis B virus. Nature 1985; 317: 489-495.
5. Berthelot P, Neurath R, Courouce AM, Brechot C. Degos F, Tron F, Girard M: Hepatitis B vaccines with pre-S gene product. Lancet 1986; 1: 1150.
6. Neurath AR, Adamowicz P, Kent SB, Riottot MM, Strick N, Parker K, Offensperger W, Petit MA, Wahl S, Budkowska A, et al.: Characterization of monoclonal antibodies specific for the pre-S2 region of the hepatitis B virus envelope protein. Mol Immunol 1986; 23: 991-997.
7. Milich DR, McNamara MK, McLachlan A, Thornton GB, Chisari FV: Distinct H-2-linked reugulation of T-cell responses to the pre-S and S regions of the same hepatitis B surface antigen polypeptide allows circumvention of nonresponsiveness to the S region. Proc Natl Acad Sci USA 1985; 82: 8168-8172.
8. Milich DR, Thornton GB, Neurath AR, Kent SB, Michel ML, Tiollais P, Chisari FV: Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen. Science 1985; 228: 1195-1199.
9. Gunther S, Fischer L, Pult I, Sterneck M, Will H: Naturally occurring variants of hepatitis B virus. Adv Virus Res 1999; 52: 25-137.
10. Wang HC, Chang WT, Chang WW, Wu HC, Huang W, Lei HY, Lei MD, Fausto N, Su IJ: Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes. Hepatology 2005; 41: 761-770.
11. Wang HC, Huang W, Lai MD, Su IJ: Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesis. Cancer Sci 2006; 97: 683-688.
12. Hsieh YH, Su IJ, Wang HC, Chang WW, Lei HY, Lei MD, Chang WT, Huang W: Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis 2004; 25: 2023-2032.
13. Shafritz DA, Kew MC: Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. N Engl J Med 1981; 305:1067-1073.
14. Hsu T, Moroy T, Etiemble J, Louise A, Trepo C, Tiollais P, Buendia MA: Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma. Cell 1988; 55: 627-635.
15. Natoli G, Avantaggiati ML, Chirillo P, Costanzo A, Artini M, Balsano C, Levrero M: Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus trans-activator pX. Mol Cell Biol 1994; 14: 989-998.
16. Natoli G, Avantaggiati ML, Chirillo P, Puri PL, Ianni A, Balsano C, Levrero M: Ras- and Raf-dependent activation of c-jun transcriptional activity by the hepatitis B virus trans-activator pX. Oncogene 1994; 9: 2837-2843.
17. Choi MS, Kim DY, Lee DH, Lee JH, Koh KC, Paik SW, Rhee JC, Yoo BC: Clinical significance of pre-S mutations in patients with genotype C hepatitis B virus infection. J Viral Hepat 2007; 14: 161-168.
18. Ma Y, Hendershot LM: The unfolding tale of the unfolded protein response. Cell 2001; 107: 827-830.
19. Feldman DE, Chauhan V, Koong AC: The unfolded protein esponse: a novel component of the hypoxic stress response in tumors. Mol Cancer Res 2005; 3: 597-605.
20. Hollstein M, Shomer B, Greenblatt M, Soussi T, Hovig E, Montesano R, Harris CC: Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation. Nucleic Acids Res 1996; 24: 141-146.
21. Tajiri T, Maki H, Sekiguchi M: Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli. Mutat Res 1995; 336: 257-267.