Effects of continuous and pulsatile PTH treatments on rat bone marrow stromal cells

Biochemical and Biophysical Research Communications

Volumn 380, Issue 4, 2009, Pages 791-796

  Yang, Chiming ^a   Frei, Hanspeter ^a   Burt, Helen M ^a   Rossi, Fabio ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

CFU F; Continuous PTH; Dexamethasone; Differentiation; Intermittent PTH; Marrow stromal cells (MSCs); Mesenchymal stem cells; Parathyroid hormone (PTH); Proliferation

Indexed keywords

ALKALINE PHOSPHATASE; DEXAMETHASONE; MESSENGER RNA; OSTEOCALCIN; PARATHYROID HORMONE RECEPTOR 1; PARATHYROID HORMONE[1-34];

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; CELL ACTIVITY; CELL ASSAY; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CLONOGENESIS; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFECT; ENZYME ACTIVITY; GENE EXPRESSION; GENE EXPRESSION PROFILING; IN VITRO STUDY; MITOGENESIS; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; REGULATORY MECHANISM; STROMA CELL;

ALKALINE PHOSPHATASE; ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; COLONY-FORMING UNITS ASSAY; DEXAMETHASONE; FIBROBLASTS; OSTEOCALCIN; OSTEOGENESIS; PARATHYROID HORMONE; RATS; RECEPTOR, PARATHYROID HORMONE, TYPE 1; STROMAL CELLS;

RATTUS;

EID: 60849108894     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.01.167     Document Type: Article

References (20)

1. Aubin J.E. Regulation of osteoblast formation and function. Rev. Endocr. Metab. Disord. 2 (2001) 81-94
2. Granero-Molto F., Weis J.A., Longobardi L., and Spagnoli A. Role of mesenchymal stem cells in regenerative medicine: application to bone and cartilage repair. Expert Opin. Biol. Ther. 8 (2008) 255-268
3. Baksh D., Song L., and Tuan R.S. Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J. Cell. Mol. Med. 8 (2004) 301-316
4. Compston J.E. Skeletal actions of intermittent parathyroid hormone: effects on bone remodelling and structure. Bone 40 (2007) 1447-1452
5. Marx S.J. Hyperparathyroid and hypoparathyroid disorders. N. Engl. J. Med. 343 (2000) 1863-1875
6. Hodsman A.B., Bauer D.C., Dempster D.W., Dian L., Hanley D.A., Harris S.T., Kendler D.L., McClung M.R., Miller P.D., Olszynski W.P., Orwoll E., and Yuen C.K. Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use. Endocr. Rev. 26 (2005) 688-703
7. Rickard D.J., Wang F.L., Rodriguez-Rojas A.M., Wu Z., Trice W.J., Hoffman S.J., Votta B., Stroup G.B., Kumar S., and Nuttall M.E. Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells. Bone 39 (2006) 1361-1372
8. Rickard D.J., Sullivan T.A., Shenker B.J., Leboy P.S., and Kazhdan I. Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev. Biol. 161 (1994) 218-228
9. Ishizuya T., Yokose S., Hori M., Noda T., Suda T., Yoshiki S., and Yamaguchi A. Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells. J. Clin. Invest. 99 (1997) 2961-2970
10. Atmani H., Chappard D., and Basle M.F. Proliferation and differentiation of osteoblasts and adipocytes in rat bone marrow stromal cell cultures: effects of dexamethasone and calcitriol. J. Cell. Biochem. 89 (2003) 364-372
11. Herbertson A., and Aubin J.E. Dexamethasone alters the subpopulation make-up of rat bone marrow stromal cell cultures. J. Bone Miner. Res. 10 (1995) 285-294
12. Aubin J.E. Osteoprogenitor cell frequency in rat bone marrow stromal populations: role for heterotypic cell-cell interactions in osteoblast differentiation. J. Cell. Biochem. 72 (1999) 396-410
13. Herbertson A., and Aubin J.E. Cell sorting enriches osteogenic populations in rat bone marrow stromal cell cultures. Bone 21 (1997) 491-500
14. Wang Y.H., Liu Y., and Rowe D.W. Effects of transient PTH on early proliferation, apoptosis, and subsequent differentiation of osteoblast in primary osteoblast cultures. Am. J. Physiol. Endocrinol. Metab. 292 (2007) E594-E603
15. Jilka R.L. Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone 40 (2007) 1434-1446
16. Simmons D.J., Seitz P., Kidder L., Klein G.L., Waeltz M., Gundberg C.M., Tabuchi C., Yang C., and Zhang R.W. Partial characterization of rat marrow stromal cells. Calcif. Tissue Int. 48 (1991) 326-334
17. Jilka R.L., Weinstein R.S., Bellido T., Roberson P., Parfitt A.M., and Manolagas S.C. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. J. Clin. Invest. 104 (1999) 439-446
18. Turksen K., and Aubin J.E. Positive and negative immunoselection for enrichment of two classes of osteoprogenitor cells. J. Cell Biol. 114 (1991) 373-384
19. Kostenuik P.J., Harris J., Halloran B.P., Turner R.T., Morey-Holton E.R., and Bikle D.D. Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I. J. Bone Miner. Res. 14 (1999) 21-31
20. Aubin J.E. Bone stem cells. J. Cell. Biochem. Suppl. 30-31 (1998) 73-82