Vaccination against fasciolosis by a multivalent vaccine of stage-specific antigens

Veterinary Parasitology

Volumn 160, Issue 3-4, 2009, Pages 230-236

  Jayaraj, Ramamoorthi ^a   Piedrafita, David ^b   Dynon, Kemperley ^b   Grams, Rudi ^c   Spithill, Terry W ^d   Smooker, Peter M ^a  

^a RMIT UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c THAMMASAT UNIVERSITY   (Thailand)

^d CHARLES STURT UNIVERSITY   (Australia)

Author keywords

Cathepsin; Fasciola; Vaccination

Indexed keywords

CATHEPSIN B; CATHEPSIN L; CATHEPSIN L1G; CATHEPSIN L5; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FASCIOLA HEPATICA; FASCIOLIASIS; HUMORAL IMMUNITY; IMMUNE RESPONSE; LIVER INJURY; MALE; NONHUMAN; RAT; VACCINATION;

ANIMALS; ANTIBODY FORMATION; ANTIGENS, HELMINTH; CATHEPSIN B; CATHEPSIN L; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FASCIOLA HEPATICA; FASCIOLIASIS; LIFE CYCLE STAGES; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; VACCINATION;

FASCIOLA; FASCIOLA HEPATICA; RATTUS;

EID: 60849102127     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2008.10.099     Document Type: Article

References (39)

1. Beckham S.A., Law R.H., Smooker P.M., Quinsey N.S., Caffrey C.R., McKerrow J.H., Pike R.N., and Spithill T.W. Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite. Biol. Chem. 387 (2006) 1053-1061
2. Berasain P., Carmona C., Frangione B., Dalton J.P., and Goni F. Fasciola hepatica: parasite-secreted proteinases degrade all human IgG subclasses: determination of the specific cleavage sites and identification of the immunoglobulin fragments produced. Exp. Parasitol. 94 (2000) 99-110
3. Berasain P., Goni F., McGonigle S., Dowd A., Dalton J.P., Frangione B., and Carmona C. Proteinases secreted by Fasciola hepatica degrade extracellular matrix and basement membrane components. J. Parasitol. 83 (1997) 1-5
4. Brennan G.P., Fairweather I., Trudgett A., Hoey E., McCoy, McConville M., Meaney M., Robinson M., McFerran N., Ryan L., Lanusse C., Mottier L., Alvarez L., Solana H., Virkel G., and Brophy P.M. Understanding triclabendazole resistance. Exp. Mol. Pathol. 82 (2007) 104-109
5. Cancela M., Acosta D., Rinaldi G., Silva E., Duran R., Roche L., Zaha A., Carmona C., and Tort J.F. A distinctive repertoire of cathepsins is expressed by juvenile invasive Fasciola hepatica. Biochimie 90 (2008) 1461-1475
6. Chapman C.B., and Mitchell G.F. Proteolytic cleavage of immunoglobulin by enzymes released by Fasciola hepatica. Vet. Parasitol. 11 (1982) 165-178
7. Dalton J.P., and Heffernan M. Thiol proteases released in vitro by Fasciola hepatica. Mol. Biochem. Parasitol. 35 (1989) 161-166
8. Dalton J.P., McGonigle S., Rolph T.P., and Andrews S.J. Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin. Infect. Immun. 64 (1996) 5066-5074
9. Dalton J.P., Neill S.O., Stack C., Collins P., Walshe A., Sekiya M., Doyle S., Mulcahy G., Hoyle D., Khaznadji E., Moire N., Brennan G., Mousley A., Kreshchenko N., Maule A.G., and Donnelly S.M. Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines. Int. J. Parasitol. 33 (2003) 1173-1181
10. Dowd A.J., Smith A.M., McGonigle S., and Dalton J.P. Purification and characterisation of a second cathepsin L proteinase secreted by the parasitic trematode Fasciola hepatica. Eur. J. Biochem. 223 (1994) 91-98
11. Dowd A.J., Tort J., Roche L., Ryan T., and Dalton J.P. Isolation of a cDNA encoding Fasciola hepatica cathepsin L2 and functional expression in Saccharomyces cerevisiae. Mol. Biochem. Parasitol. 88 (1997) 163-174
12. Hillyer G.V. Fasciola antigens as vaccines against fascioliasis and schistosomiasis. J. Helminthol. 79 (2005) 241-247
13. Irving J.A., Spithill T.W., Pike R.N., Whisstock J.C., and Smooker P.M. The evolution of enzyme specificity in Fasciola spp. J. Mol. Evol. 57 (2003) 1-15
14. Kennedy N.J., Spithill T.W., Tennent J., Wood P.R., and Piedrafita D. DNA vaccines in sheep: CTLA-4 mediated targeting and CpG motifs enhance immunogenicity in a DNA prime/protein boost strategy. Vaccine 24 (2006) 970-979
15. Kesik M., Jedlina-Panasiuk L., Kozak-Cieszczyk M., Plucienniczak A., and Wedrychowicz H. Enteral vaccination of rats against Fasciola hepatica using recombinant cysteine proteinase (cathepsin L1). Vaccine 25 (2007) 3619-3628
16. Klebe R.J., Harriss J.V., Sharp Z.D., and Douglas M.G. A general method for polyethylene-glycol-induced genetic transformation of bacteria and yeast. Gene 25 (1983) 333-341
17. Kofta W., Mieszczanek J., Plucienniczak G., and Wedrychowicz H. Successful DNA immunisation of rats against fasciolosis. Vaccine 18 (2000) 2985-2990
18. Law R.H., Smooker P.M., Irving J.A., Piedrafita D., Ponting R., Kennedy N.J., Whisstock J.C., Pike R.N., and Spithill T.W. Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection. Infect. Immunity 71 (2003) 6921-6932
19. Mas-Coma S. Epidemiology of fascioliasis in human endemic areas. J. Helminthol. 79 (2005) 207-216
20. McGonigle L., Mousley A., Marks N.J., Brennan G.P., Dalton J.P., Spithill T.W., Day T.A., and Maule A.G. The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration. Int. J. Parasitol. 38 (2008) 149-155
21. Meemon K., Grams R., Vichasri-Grams S., Hofmann A., Korge G., Viyanant V., Upatham E.S., Habe S., and Sobhon P. Molecular cloning and analysis of stage and tissue-specific expression of cathepsin B encoding genes from Fasciola gigantica. Mol. Biochem. Parasitol. 136 (2004) 1-10
22. Meeusen E.N., and Piedrafita D. Exploiting natural immunity to helminth parasites for the development of veterinary vaccines. Int. J. Parasitol. 33 (2003) 1285-1290
23. Mulcahy G., O'Connor F., Clery D., Hogan S.F., Dowd A.J., Andrews S.J., and Dalton J.P. Immune responses of cattle to experimental anti-Fasciola hepatica vaccines. Res. Vet. Sci. 67 (1999) 27-33
24. Overend D.J., and Bowen F.L. Resistance of Fasciola hepatica to triclabendazole. Aust. Vet. J. 72 (1995) 275-276
25. Piacenza L., Acosta D., Basmadjian I., Dalton J.P., and Carmona C. Vaccination with cathepsin L proteinases and with leucine aminopeptidase induces high levels of protection against fascioliasis in sheep. Infect. Immunity 67 (1999) 1954-1961
26. Piedrafita D., Parsons J.C., Sandeman R.M., Wood P.R., Estuningsih S.E., Partoutomo S., and Spithill T.W. Antibody-dependent cell-mediated cytotoxicity to newly excysted juvenile Fasciola hepatica in vitro is mediated by reactive nitrogen intermediates. Parasite Immunol. 23 (2001) 473-482
27. Piedrafita D., Raadsma H.W., Prowse R., and Spithill T.W. Immunology of the host-parasite relationship in fasciolosis (Fasciola hepatica and Fasciola gigantica). Can. J. Zool. 82 (2004) 233-250
28. Prowse R.K., Chaplin P., Robinson H.C., and Spithill T.W. Fasciola hepatica cathepsin L suppresses sheep lymphocyte proliferation in vitro and modulates surface CD4 expression on human and ovine T cells. Parasite Immunol. 24 (2002) 57-66
29. Raadsma H.W., Kingsford N.M., Suharyanta, Spithill T.W., and Piedrafita D. Host responses during experimental infection with Fasciola gigantica or Fasciola hepatica in Merino sheep. I. Comparative immunological and plasma biochemical changes during early infection. Vet. Parasitol. 143 (2007) 275-286
30. Reszka N., Cornelissen J.B., Harmsen M.M., Bienkowska-Szewczyk K., de Bree J., Boersma W.J., and Rijsewijk F.A. Fasciola hepatica procathepsin L3 protein expressed by a baculovirus recombinant can partly protect rats against fasciolosis. Vaccine 23 (2005) 2987-2993
31. Roche L., Dowd A.J., Tort J., McGonigle S., MacSweeney A., Curley G.P., Ryan T., and Dalton J.P. Functional expression of Fasciola hepatica cathepsin L1 in Saccharomyces cerevisiae. Eur. J. Biochem. 245 (1997) 373-380
32. Sajid M., and McKerrow J.H. Cysteine proteases of parasitic organisms. Mol. Biochem. Parasitol. 120 (2002) 1-21
33. Smooker P.M., Rainczuk A., Kennedy N., and Spithill T.W. DNA vaccines and their application against parasites-promise, limitations and potential solutions. Biotechnol. Annu. Rev. 10 (2004) 189-236
34. Smooker P.M., Whisstock J.C., Irving J.A., Siyaguna S., Spithill T.W., and Pike R.N. A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica. Protein Sci. 9 (2000) 2567-2572
35. Valero M.A., De Renzi M., Panova M., Garcia-Bodelon M.A., Periago M.V., Ordonez D., and Mas-Coma S. Crowding effect on adult growth, pre-patent period and egg shedding of Fasciola hepatica. Parasitology 133 (2006) 453-463
36. Valero M.A., Panova M., Comes A.M., Fons R., and Mas-Coma S. Patterns in size and shedding of Fasciola hepatica eggs by naturally and experimentally infected murid rodents. J. Parasitol. 88 (2002) 308-313
37. Valero M.A., Panova M., and Mas-Coma S. Phenotypic analysis of adults and eggs of Fasciola hepatica by computer image analysis system. J. Helminthol. 79 (2005) 217-225
38. Wijffels G.L., Panaccio M., Salvatore L., Wilson L., Walker I.D., and Spithill T.W. The secreted cathepsin L-like proteinases of the trematode, Fasciola hepatica, contain 3-hydroxyproline residues. Biochem. J. 299 Pt 3 (1994) 781-790
39. Wilson L.R., Good R.T., Panaccio M., Wijffels G.L., Sandeman R.M., and Spithill T.W. Fasciola hepatica: characterization and cloning of the major cathepsin B protease secreted by newly excysted juvenile liver fluke. Exp. Parasitol. 88 (1998) 85-94