A genome-wide genetic signature of Jewish ancestry perfectly separates individuals with and without full Jewish ancestry in a large random sample of European Americans

Genome Biology

Volumn 10, Issue 1, 2009, Pages

  Need, Anna C ^a   Kasperavičiũte, Dalia ^a   Cirulli, Elizabeth T ^a   Goldstein, David B ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; EUROPEAN AMERICAN; GENE CLUSTER; GENE IDENTIFICATION; GENETIC LINE; GENETIC SCREENING; GENETIC VARIABILITY; GENOME ANALYSIS; HEREDITY; HETEROZYGOTE DETECTION; HUMAN; JEW; PLESIOMORPHY; POPULATION GENETICS; PRINCIPAL COMPONENT ANALYSIS; SELF REPORT; CAUCASIAN; CLUSTER ANALYSIS; GENETICS; HUMAN GENOME; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICS;

CLUSTER ANALYSIS; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC VARIATION; GENETICS, POPULATION; GENOME, HUMAN; HUMANS; JEWS; POLYMORPHISM, SINGLE NUCLEOTIDE; PRINCIPAL COMPONENT ANALYSIS;

EID: 60849097246     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2009-10-1-r7     Document Type: Article

References (12)

1. Thomas MG Parfitt T Weiss DA Skorecki K Wilson JF le Roux M Bradman N Goldstein DB Y chromosomes traveling south: The cohen modal haplotype and the origins of the Lemba - the "Black Jews of Southern Africa". Am J Hum Genet 2000, 66:674-686. 1288118 10677325 10.1086/ 302749
2. Thomas MG Weale ME Jones AL Richards M Smith A Redhead N Torroni A Scozzari R Gratrix F Tarekegn A Wilson JF Capelli C Bradman N Goldstein DB Founding mothers of Jewish communities: Geographically separated Jewish groups were independently founded by very few female ancestors. Am J Hum Genet 2002, 70:1411-1420. 379128 11992249 10.1086/340609
3. Ostrer H A genetic profile of contemporary Jewish populations. Nat Rev Genet 2001, 2:891-898. 10.1038/35098506 11715044
4. Behar DM Metspalu E Kivisild T Achilli A Hadid Y Tzur S Pereira L Amorim A Quintana-Murci L Majamaa K Herrnstadt C Howell N Balanovsky O Kutuev I Pshenichnov A Gurwitz D Bonne-Tamir B Torroni A Villems R Skorecki K The matrilineal ancestry of Ashkenazi Jewry: Portrait of a recent founder event. Am J Hum Genet 2006, 78:487-497. 1380291 16404693 10.1086/500307
5. Behar DM Garrigan D Kaplan ME Mobasher Z Rosengarten D Karafet TM Quintana-Murci L Ostrer H Skorecki K Hammer MF Contrasting patterns of Y chromosome variation in Ashkenazi Jewish and host non-Jewish European populations. Hum Genet 2004, 114:354-365. 10.1007/s00439-003-1073-7 14740294
6. Rosenberg NA Pritchard JK Weber JL Cann HM Kidd KK Zhivotovsky LA Feldman MW Genetic structure of human populations. Science 2002, 298:2381-2385. 10.1126/science.1078311 12493913
7. Price AL Butler J Patterson N Capelli C Pascali VL Scarnicci F Ruiz-Linares A Groop L Saetta AA Korkolopoulou P Seligsohn U Waliszewska A Schirmer C Ardlie K Ramos A Nemesh J Arbeitman L Goldstein DB Reich D Hirschhorn JN Discerning the ancestry of European Americans in genetic association studies. PLoS Genet 2008, 4:e236. 2211542 18208327 10.1371/ journal.pgen.0030236
8. Price AL Patterson NJ Plenge RM Weinblatt ME Shadick NA Reich D Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006, 38:904. 10.1038/ng1847 16862161
9. Jakobsson M Scholz SW Scheet P Gibbs JR VanLiere JM Fung HC Szpiech ZA Degnan JH Wang K Guerreiro R Bras JM Schymick JC Hernandez DG Traynor BJ Simon-Sanchez J Matarin M Britton A Leemput van de J Rafferty I Bucan M Cann HM Hardy JA Rosenberg NA Singleton AB Genotype, haplotype and copy-number variation in worldwide human populations. Nature 2008, 451:998-1003. 10.1038/nature06742 18288195
10. Goldstein DB Jacob's Legacy: A Genetic View of Jewish History New Haven, CT: Yale University Press 2008.
11. Purcell S Neale B Todd-Brown K Thomas L Ferreira MA Bender D Maller J Sklar P de Bakker PI Daly MJ Sham PC PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007, 81:559-575. 1950838 17701901 10.1086/519795
12. Patterson N Price AL Reich D Population structure and Eigenanalysis. PLoS Genet 2006, 2:e190. 1713260 17194218 10.1371/journal.pgen.0020190