메뉴 건너뛰기




Volumn 369, Issue 1-2, 2009, Pages 47-52

Use of 1H NMR to facilitate solubility measurement for drug discovery compounds

Author keywords

1H NMR; Formulation; HPLC UV; In vivo studies; Solubility studies

Indexed keywords

2 (4 HYDROXYPHENYLAZO)BENZOIC ACID; ACETAZOLAMIDE; BENDROFLUMETHIAZIDE; BENZOCAINE; CARBAMAZEPINE; GEMFIBROZIL; GRISEOFULVIN; KETOPROFEN; PREDNISOLONE; SALICYLIC ACID; SOLUBILIZER; TAMOXIFEN; TRIAMCINOLONE; TRIMETHOPRIM;

EID: 60849095491     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.10.038     Document Type: Article
Times cited : (25)

References (9)
  • 1
    • 0034006672 scopus 로고    scopus 로고
    • pH-metric solubility. 2. Correlation between the acid-base titration and the saturation shake-flask solubility-pH methods
    • Avdeef A., Berger C.M., and Brownell C. pH-metric solubility. 2. Correlation between the acid-base titration and the saturation shake-flask solubility-pH methods. Pharm. Res. 17 1 (2000) 85-89
    • (2000) Pharm. Res. , vol.17 , Issue.1 , pp. 85-89
    • Avdeef, A.1    Berger, C.M.2    Brownell, C.3
  • 2
    • 0034773359 scopus 로고    scopus 로고
    • pH-metric solubility. 3. Dissolution titration template method for solubility determination
    • Avdeef A., and Berger C.M. pH-metric solubility. 3. Dissolution titration template method for solubility determination. Eur. J. Pharm. Sci. 14 4 (2001) 281-291
    • (2001) Eur. J. Pharm. Sci. , vol.14 , Issue.4 , pp. 281-291
    • Avdeef, A.1    Berger, C.M.2
  • 3
    • 6344221288 scopus 로고    scopus 로고
    • Miniature device for aqueous and non-aqueous solubility measurements during drug discovery
    • Chen X.Q., and Venkatesh S. Miniature device for aqueous and non-aqueous solubility measurements during drug discovery. Pharm. Res. 21 10 (2004) 1758-1761
    • (2004) Pharm. Res. , vol.21 , Issue.10 , pp. 1758-1761
    • Chen, X.Q.1    Venkatesh, S.2
  • 4
    • 7444226830 scopus 로고    scopus 로고
    • Automated robotic liquid handling/laser-based nephelometry system for high throughput measurement of kinetic aqueous solubility
    • Dehring K.A., Workman H.L., Miller K.D., Mandagere A., and Poole S.K. Automated robotic liquid handling/laser-based nephelometry system for high throughput measurement of kinetic aqueous solubility. J. Pharm. Biomed. Anal. 36 3 (2004) 447-456
    • (2004) J. Pharm. Biomed. Anal. , vol.36 , Issue.3 , pp. 447-456
    • Dehring, K.A.1    Workman, H.L.2    Miller, K.D.3    Mandagere, A.4    Poole, S.K.5
  • 5
    • 0015821588 scopus 로고
    • NMR Quantitative analysis of quinidine in mixtures of quinidine and hydroquinidine
    • Huynh-Ngoc T., and Sirios G. NMR Quantitative analysis of quinidine in mixtures of quinidine and hydroquinidine. J. Pharm. Sci. 62 8 (1973) 1334-1336
    • (1973) J. Pharm. Sci. , vol.62 , Issue.8 , pp. 1334-1336
    • Huynh-Ngoc, T.1    Sirios, G.2
  • 6
    • 79960698472 scopus 로고
    • Water suppression that works. Excitation sculpting using arbitrary wave-forms and pulsed-field gradients
    • Hwang T.L., and Shaka A.J. Water suppression that works. Excitation sculpting using arbitrary wave-forms and pulsed-field gradients. J. Magn. Res. Ser. A 112 (1995) 275-279
    • (1995) J. Magn. Res. Ser. A , vol.112 , pp. 275-279
    • Hwang, T.L.1    Shaka, A.J.2
  • 7
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski C.A., Lombardo F., Dominy B.W., and Feeney P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Del. Rev. 46 1-3 (2001) 3-26
    • (2001) Adv. Drug Del. Rev. , vol.46 , Issue.1-3 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 8
    • 0035069173 scopus 로고    scopus 로고
    • Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility
    • Pan L., Ho Q., Tsutsui K., and Takahashi L. Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility. J. Pharm. Sci. 90 4 (2001) 521-529
    • (2001) J. Pharm. Sci. , vol.90 , Issue.4 , pp. 521-529
    • Pan, L.1    Ho, Q.2    Tsutsui, K.3    Takahashi, L.4
  • 9
    • 2942585051 scopus 로고    scopus 로고
    • In vitro testing of drug absorption for drug 'developability' assessment: forming an interface between in vitro preclinical data and clinical outcome
    • Sun D., Yu L.X., Hussain M.A., Wall D.A., Smith R.L., and Amidon G.L. In vitro testing of drug absorption for drug 'developability' assessment: forming an interface between in vitro preclinical data and clinical outcome. Cur. Opin. Drug Disc. Dev. 7 1 (2004) 75-85
    • (2004) Cur. Opin. Drug Disc. Dev. , vol.7 , Issue.1 , pp. 75-85
    • Sun, D.1    Yu, L.X.2    Hussain, M.A.3    Wall, D.A.4    Smith, R.L.5    Amidon, G.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.