Post hoc analysis of calfactant use in immunocompromised children with acute lung injury: Impact and feasibility of further clinical trials

Pediatric Critical Care Medicine

Volumn 9, Issue 5, 2008, Pages 459-464

  Tamburro, Robert F ^a   Thomas, Neal J ^a   Pon, Steven ^b   Jacobs, Brian R ^c   Dicarlo, Joseph V ^d   Markovitz, Barry P ^d   Jefferson, Larry S ^e   Willson, Douglas F ^f  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^d CHILDREN S HOSPITAL LOS ANGELES   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Acute lung injury; Hematopoietic stem cell transplantation; Immunocompromised; Pediatrics; Surfactant

Indexed keywords

CALFACTANT; OXYGEN; PLACEBO; BIOLOGICAL PRODUCT; LUNG SURFACTANT;

ACUTE LUNG INJURY; ARTICLE; BLOOD PRESSURE; CHILD; CHILDHOOD MORTALITY; CLINICAL PROTOCOL; CONTROLLED STUDY; FEASIBILITY STUDY; FEMALE; HEART ATRIUM FIBRILLATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HIGH RISK POPULATION; HOSPITAL DISCHARGE; HUMAN; HYPOXEMIA; IMMUNE DEFICIENCY; IMMUNOCOMPROMISED PATIENT; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; OXYGEN DESATURATION; OXYGENATION; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SIDE EFFECT; TERTIARY HEALTH CARE; ADOLESCENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; MULTICENTER STUDY; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ACUTE LUNG INJURY; ADOLESCENT; BIOLOGICAL PRODUCTS; CHILD; CLINICAL TRIALS AS TOPIC; FEMALE; HUMANS; IMMUNOCOMPROMISED HOST; MALE; PULMONARY SURFACTANTS; TREATMENT OUTCOME;

EID: 60849090528     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3181849bec     Document Type: Article

References (28)

1. Warwick AB, Mertens AC, Shu XO, et al. Outcomes following mechanical ventilation in children undergoing bone marrow transplantation. Bone Marrow Transplant 1998; 22:787-794
2. Hayes C, Lush RJ, Cornish JM, et al. The outcome of children requiring admission to an intensive care unit following bone marrow transplantation. Br J Haematol 1998; 102:666-670
3. Rossi R, Shemie SD, Calderwood S: Prognosis of pediatric bone marrow transplant recipients requiring mechanical ventilation. Crit Care Med 1999; 27:1181-1186
4. Diaz de Heredia C, Moreno A, Olive T, et al. Role of the intensive care unit in children undergoing bone marrow transplantation with life-threatening complications. Bone Marrow Transplant 1999; 24:163-168
5. Keenan HT, Bratton SL, Martin LD, et al. Outcome of children who require mechanical ventilatory support after bone marrow transplantation. Crit Care Med 2000; 28: 830-835
6. Hagen SA, Craig DM, Martin PL, et al. Mechanically ventilated pediatric stem cell transplant recipients: Effect of cord blood transplant and organ dysfunction on outcome. Pediatr Crit Care Med 2003; 4:206-213
7. Jacobe SJ, Hassan A, Veys P, et al. Outcome of children requiring admission to an intensive care unit after bone marrow transplantation. Crit Care Med 2003; 31:1299-1305
8. Kache S, Weiss IK, Moore TB: Changing outcomes for children requiring intensive care following hematopoietic stem cell transplantation. Pediatr Transplant 2006; 10:299-303
9. Li GS, Ye QF, Xia SS, et al. Acute respiratory distress syndrome after liver transplantation: Etiology, prevention and management. Hepatobiliary Pancreat Dis Int 2002; 1:330-334
10. Shorr AF, Abbott KC, Agadoa LY: Acute respiratory distress syndrome after kidney transplantation: Epidemiology, risk factors, and outcomes. Crit Care Med 2003; 31: 1325-1330
11. Forrest DM, Zala C, Djurdjev O, et al. Determinants of short- and long-term outcome in patients with respiratory failure caused by AIDS-related Pneumocystis carinii pneumonia. Arch Intern Med 1999; 159:741-747
12. Willson DF, Thomas NJ, Markovitz BP, et al. Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: A randomized controlled trial. JAMA 2005; 293:470-476
13. Willson D: Calfactant. Expert Opin Pharma-cother 2001; 2:1479-1493
14. Hall SB, Venkitaraman AR, Whitsett JA, et al. Importance of hydrophobic apoproteins as constituents of clinical exogenous surfac-tants. Am Rev Respir Dis 1992; 145:24-30
15. Wang Z, Notter RH: Additivity of protein and nonprotein inhibitors of lung surfactant activity. Am J Respir Crit Care Med 1998; 158: 28-35
16. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345: 1359-1367
17. Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344:699-709
18. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000; 342: 1301-1308
19. Tamburro R, Barfield R, Shaffer M, et al. Changes in outcomes (1996-2004) for pediatric oncology and HSCT patients requiring mechanical ventilation. Pediatr Crit Care Med 2008; 9:270-277
20. Atochina EN, Beck JM, Scanlon ST, et al. Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D. J Lab Clin Med 2001; 137: 429-439
21. Yang S, Panoskaltsis-Mortari A, Ingbar DH, et al. Cyclophosphamide prevents systemic keratinocyte growth factor-induced up-regulation of surfactant protein A after al-logeneic transplant in mice. Am J Respir Crit Care Med 2000; 162:1884-1890
22. Yang S, Milla C, Panoskaltsis-Mortari A, et al. Surfactant protein A decreases lung injury and mortality after murine marrow transplantation. Am J Respir Cell Mol Biol 2002; 27:297-305
23. Rubin P, Siemann DW, Shapiro DL, et al. Surfactant release as an early measure of radiation pneumonitis. Int J Radiat Oncol Biol Phys 1983; 9:1669-1673
24. Griese M, Neumann M, von Bredow T, et al. Surfactant in children with malignancies, immunosuppression, fever and pulmonary infiltrates. Eur Respir J 2002; 20:1284-1291
25. Marraro G, Casiraghi G, Riva A: [The effects of administering surfactant to two adolescents with leukemia suffering from respiratory distress]. Cah Anesthesiol 1991; 39: 227-232
26. Slater AJ, Nichani SH, Macrae D, et al. Sur-factant adjunctive therapy for Pneumocystis carinii pneumonitis in an infant with acute lymphoblastic leukaemia. Intensive Care Med 1995; 21:261-263
27. Erler T, Schmidt K, Klaber HG, et al. [Successful surfactant therapy of ARDS in an im-munodepressed child]. Klin Padiatr 2002; 214:109-112
28. Marraro GA, Luchetti M, Galassini EM, et al. Natural surfactant supplementation in ARDS in paediatric age. Minerva Anestesiol 1999; 65:92-97