Elevated expression of the leukemia-associated antigen SSX2IP predicts survival in acute myeloid leukemia patients who lack detectable cytogenetic rearrangements

Blood

Volumn 113, Issue 5, 2009, Pages 1203-1204

  Guinn, Barbara ^a   Greiner, Jochen ^a   Schmitt, Michael ^a   Mills, Ken I ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKEMIA ANTIGEN; LEUKEMIA ASSOCIATED ANTIGEN SSX2IP; UNCLASSIFIED DRUG; EPITOPE; PEPTIDE; RNA; TUMOR ANTIGEN;

ACUTE GRANULOCYTIC LEUKEMIA; ANTIGEN EXPRESSION; CANCER SURVIVAL; CHROMOSOME ANALYSIS; CHROMOSOME REARRANGEMENT; CORRELATION COEFFICIENT; GENE EXPRESSION; KAPLAN MEIER METHOD; KARYOTYPE; LETTER; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL RATE; SURVIVAL TIME; ANIMAL; CELL STRAIN COS1; CELL STRAIN HL 60; CELL STRAIN K 562; CERCOPITHECUS; DISEASE FREE SURVIVAL; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; IMMUNOTHERAPY; MALE; METHODOLOGY; NOTE; PATHOLOGY;

ANIMALS; ANTIGENS, NEOPLASM; CERCOPITHECUS AETHIOPS; COS CELLS; DISEASE-FREE SURVIVAL; EPITOPES; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; HL-60 CELLS; HUMANS; IMMUNOTHERAPY; K562 CELLS; LEUKEMIA, MYELOID, ACUTE; MALE; PEPTIDES; PROGNOSIS; RNA, NEOPLASM; SURVIVAL RATE;

EID: 60849083533     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-09-178848     Document Type: Letter

References (7)

1. Greiner J, Schmitt M, Li L, et al. Expression of tumor-associated antigens in acute myeloid leukemia: implications for specific immunotherapeutic approaches. Blood. 2006;108:4109-4117.
2. de Bruijn DR, dos Santos NR, Kater-Baats E, et al. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. Genes Chromosomes Cancer. 2002;34:285-298.
3. Guinn BA, Bland EA, Lodi U, et al. Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. Biochem Biophys Res Commun. 2005;335:1293-1304.
4. Guinn BA, Bullinger L, Thomas NS, Mills KI, Greiner J. SSX2IP expression in acute myeloid leukaemia: an association with mitotic spindle failure in t(8;21), and cell cycle in t(15;17) patients. Br J Haematol. 2008;140:250-251.
5. Greiner J, Bullinger L, Guinn BA, Dohner H, Schmitt M. Leukaemia-associated antigens are critical for the proliferation of acute myeloid leukaemia cells. Clin Cancer Res. 2008;14:7161-7166.
6. Granziero L, Ghia P, Circosta P, et al. Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. Blood. 2001;97:2777-2783.
7. Crainie M, Belch AR, Mant MJ, Pilarski LM. Overexpression of the receptor for hyaluronan-mediated motility (RHAMM) characterizes the malignant clone in multiple myeloma: identification of 3 distinct RHAMM variants. Blood. 1999;93:1684-1696.