A human apolipoprotein E mimetic peptide effectively inhibits HSV-1 TK-positive and TK-negative acute epithelial keratitis in rabbits

Current Eye Research

Volumn 34, Issue 2, 2009, Pages 99-102

  Bhattacharjee, Partha S ^a,b   Neumann, Donna M ^a   Hill, James M ^a,c  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b XAVIER UNIVERSITY OF LOUISIANA   (United States)

^c LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Apolipoprotein E; Apolipoprotein E dimer peptide; Epithelial keratitis; Foscarnet; Herpes simplex virus; Trifluorothymidine

Indexed keywords

APOLIPOPROTEIN E; FOSCARNET; THYMIDINE KINASE; TRIFLURIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; HERPES SIMPLEX KERATITIS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; RABBIT; SLIT LAMP; TREATMENT DURATION;

ACUTE DISEASE; ANIMALS; APOLIPOPROTEINS E; DISEASE MODELS, ANIMAL; DNA, VIRAL; EPITHELIUM, CORNEAL; HERPESVIRUS 1, HUMAN; HUMANS; KERATITIS, HERPETIC; MUTATION; OPHTHALMIC SOLUTIONS; PEPTIDE FRAGMENTS; RABBITS; THYMIDINE KINASE; TREATMENT OUTCOME;

EID: 60749133832     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680802647662     Document Type: Article

References (17)

1. Bhattacharjee PS, Neumann DM, Foster TP, et al. Effective treatment of ocular HSK with a human apolipoprotein E mimetic peptide in a mouse eye model. Invest Ophthalmol Vis Sci 2008;49:4263-4268.
2. Dobson CB, Sales SD, Hoggard P, Wozniak MA, Crutcher KA. The receptor-binding region of human apolipoprotein E has direct anti-infective activity. J Infect Dis 2006;193:442-450.
3. Kaufman HE, Heidelberger C. Therapeutic antiviral action of 5-trifluoromethyl-2′-deoxyuridine in herpes simplex keratitis. Science 1964;145:585-586.
4. Griffiths A, Link MA, Furness CL, Coen DM. Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase. J Virol 2006;80:6568-6574.
5. Anand BS, Hill JM, Dey S, et al. In vivo antiviral efficacy of a dipeptide acyclovir prodrug, val-val-acyclovir, against HSV-1 epithelial and stromal keratitis in the rabbit eye model. Invest Ophthalmol Vis Sci 2003;44:2529-2534.
6. Labetoulle M, Auquier P, Conrad H, et al. Incidence of herpes simplex virus keratitis in France. Ophthalmology 2005;112:888-895.
7. Liesegang TJ. Herpes simplex virus epidemiology and ocular importance. Cornea 2001;20:1-13.
8. Rezende RA, Hammersmith K, Bisol T, et al. Comparative study of ocular herpes simplex virus in patientswith andwithout self-reported atopy. Am J Ophthalmol 2006;141:1120-1125.
9. Kaiserman I, Kaiserman N, Nakar S, Vinker S. Herpetic eye disease in diabetic patients. Ophthalmology 2005;112:2184-2188.
10. Remeijer L, Doornenbal P, Geerards AJ, Rijneveld WA, Beekhuis WH. Newly acquired herpes simplex virus keratitis after penetrating keratoplasty. Ophthalmology 1997;104:648-652.
11. Hodge WG, Margolis TP. Herpes simplex virus keratitis among patients who are positive or negative for human immunodeficiency virus: An epidemiologic study. Ophthalmology 1997;104:120-124.
12. Behrens-Baumann W. Phosphonoformate (foscarnet, PFA) versus trifluorothymidine in the treatment of keratitis dendritica in the human. A double-blind, randomized, preliminary trial. Acta Ophthalmol (Copenh)1992;70:690-692.
13. Pavan-Langston D. Clinical disease herpetic infections. In: Smolin G, Throft RA, eds. The Cornea. Boston, MA: Little, Brown; 1994:83-215.
14. Imperia PS, Lazarus HM, Dunkel EC, Pavan-Langston D, Geary PA, Lass JH. An in vitro study of ophthalmic antiviral agent toxicity on rabbit corneal epithelium. Antiviral Res 1988;9:263-272.
15. Wilhelmus KR. The epidemiology of ocular infections. In: Jaeger EA, Tasman W. eds, Duane's Foundations of Clinical Ophthalmology. Philadelphia: Lipincott-Raven; 1998.
16. Coen DM. Acyclovir-resistant, pathogenic herpes viruses. Trends Microbiol 1994;2:481-485.
17. Wilhelmus KR, Gee L, Hauck WW, et al. Herpetic Eye Disease Study. A controlled trial of topical corticosteroids for herpes simplex stromal keratitis. Ophthalmology 1994;101:1883-1895.