Risk factors for polyoma virus nephropathy

Nephrology Dialysis Transplantation

Volumn 24, Issue 3, 2009, Pages 1024-1033

  Prince, Olivier ^a   Savic, Spasenija ^a   Dickenmann, Michael ^a   Steiger, Jürg ^a   Bubendorf, Lukas ^a   Mihatsch, Michael J ^a,b  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

BK virus; Decoy cell; Polyoma virus associated nephropathy; Renal transplantation; Risk factors

Indexed keywords

AZATHIOPRINE; BASILIXIMAB; CYCLOSPORIN; DACLIZUMAB; LYMPHOCYTE ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; GRAFT RECIPIENT; GRAFT REJECTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY DISEASE; KIDNEY GRAFT; KIDNEY INFECTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; POLYOMA VIRUS; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; UNIVERSITY HOSPITAL; URINE CYTOLOGY; VIRUS INFECTION; VIRUS REACTIVATION;

COHORT STUDIES; FEMALE; GRAFT SURVIVAL; HUMANS; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; POLYOMAVIRUS; POLYOMAVIRUS INFECTIONS; PREVALENCE; RETROSPECTIVE STUDIES; RISK FACTORS; TUMOR VIRUS INFECTIONS;

EID: 60749131352     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn671     Document Type: Article

References (74)

1. Gardner SD, Field AM, Coleman DV et al. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet 1971; 1: 1253-1257. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&dopt=Citation&list-uids=4104714
2. Mackenzie EF, Poulding JM, Harrison PR et al. Human polyoma virus (HPV) - a significant pathogen in renal transplantation. Proc Eur Dial Transplant Assoc 1978; 15: 352-360. Available at http://www.ncbi.nlm.nih. gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&a&dopt= Citation&list-uids=216990
3. Rosen S, Harmon W, Krensky AM et al. Tubulo-interstitial nephritis associated with polyomavirus (BKtype) infection. N Engl J Med 1983; 308: 1192-1196. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&dopt=Citation&list-uids=6302506
4. Arthur RR, Shah KV, Baust SJ et al. Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants. N Engl J Med 1986; 315: 230-234. Available at http://www.ncbi.nlm.nih.gov/entrez/ query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list uids=3014334
5. Chapman C, Flower AJ, Durrant ST. The use of vidarabine in the treatment of human polyomavirus associated acute haemorrhagic cystitis. Bone Marrow Transplant 1991; 7: 481-483. Available at http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list-uids= 1651795
6. Kondo M, Kojima S, Kato K et al. Late-onset hemorrhagic cystitis after hematopoietic stem cell transplantation in children. Bone Marrow Transplant 1998; 22: 995-998. Available at http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list-uids= 9849697
7. Nevo S, Swan V, Enger C et al. Acute bleeding after bone marrow transplantation (BMT) - incidence and effect on survival. A quantitative analysis in 1,402 patients. Blood 1998; 91: 1469-1477. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=9454780
8. Seber A, Shu XO, Defor T et al. Risk factors for severe hemorrhagic cystitis following BMT. Bone Marrow Transplant 1999; 23: 35-40. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&dopt=Citation&list-uids=10037048
9. Padgett BL, Walker DL, Zu Rhein GM et al. Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet 1971; 1: 1257-1260. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=4104715
10. Purighalla R, Shapiro R, McCauley J et al. BK virus infection in a kidney allograft diagnosed by needle biopsy. Am J Kidney Dis 1995; 26: 671-673. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&dopt=Citation&list-uids=7573026
11. Pappo O, Demetris AJ, Raikow RB et al. Human polyoma virus infection of renal allografts: histopathologic diagnosis, clinical significance, and literature review. Mod Pathol 1996; 9: 105-109. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=8657714
12. Nickeleit V, Hirsch HH, Binet IF et al. Polyomavirus infection of renal allograft recipients: from latent infection tomanifest disease. J Am Soc Nephrol 1999; 10: 1080-1089. Available at http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list-uids= 10232695
13. Binet I, Nickeleit V, Hirsch HH et al. Polyomavirus disease under new immunosuppressive drugs: a cause of renal graft dysfunction and graft loss. Transplantation 1999; 67: 918-922. Available at http://www.ncbi.nlm.nih. gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list- uids=10199744
14. Randhawa PS, Finkelstein S, Scantlebury V et al. Human polyoma virus-associated interstitial nephritis in the allograft kidney. Transplantation 1999; 67: 103-109
15. Howell DN, Smith SR, Butterly DW et al. Diagnosis and management of BK polyomavirus interstitial nephritis in renal transplant recipients. Transplantation 1999; 68: 1279-1288. Available at http://www.ncbi.nlm. nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt= Citation&list-uids=10573064
16. Drachenberg CB, Beskow CO, Cangro CB et al. Human polyoma virus in renal allograft biopsies: morphological findings and correlation with urine cytology. Hum Pathol 1999; 30: 970-977. Available at http://www.ncbi.nlm. nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt= Citation&list-uids=10452511
17. Nickeleit V, Hirsch HH, Zeiler M et al. BK-virus nephropathy in renal transplants-tubular necrosis, MHC-class II expression and rejection in a puzzling game. Nephrol Dial Transplant 2000; 15: 324-332. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=10692517
18. Ahuja M, Cohen EP, Dayer AM et al. Polyoma virus infection after renal transplantation. Use of immunostaining as a guide to diagnosis. Transplantation 2001; 71: 896-899. Available at http://www.ncbi.nlm.nih. gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list- uids=11349723
19. Limaye AP, Jerome KR, Kuhr CS et al. Quantitation of BK virus load in serumfor the diagnosis of BK virus-associated nephropathy in renal transplant recipients. J Infect Dis 2001; 183: 1669-1672. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=11343217
20. Drachenberg RC, Drachenberg CB, Papadimitriou JC et al. Morphological spectrum of polyoma virus disease in renal allografts: diagnostic accuracy of urine cytology. Am J Transplant 2001; 1: 373-381. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=12099383
21. Barri YM, Ahmad I, Ketel BL et al. Polyoma viral infection in renal transplantation: the role of immunosuppressive therapy. Clin Transplant 2001; 15: 240-246. Available at http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list-uids= 11683817
22. Hussain S, Bresnahan BA, Cohen EP et al. Rapid kidney allograft failure in patients with polyoma virus nephritis with prior treatment with antilymphocyte agents. Clin Transplant 2002; 16: 43-47. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=11982614
23. Hirsch HH, Knowles W, Dickenmann M et al. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med 2002; 347: 488-496. Available at http://www.ncbi.nlm.nih. gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list- uids=12181403
24. Ramos E, Drachenberg CB, Papadimitriou JC et al. Clinical course of polyoma virus nephropathy in 67 renal transplant patients. J Am Soc Nephrol 2002; 13: 2145-2151. Available at http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list-uids= 12138148
25. Ramos E, Drachenberg CB, Portocarrero M et al. BK virus nephropathy diagnosis and treatment: experience at the University of Maryland Renal Transplant Program. Clin Transpl 2002: 143-153. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=12971444
26. Ding R, Medeiros M, Dadhania D et al. Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK virus VP1 in urine. Transplantation 2002; 74: 987-994. Available at http://www.ncbi.nlm.nih. gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list- uids=12394843
27. Kadambi PV, Josephson MA, Williams J et al. Treatment of refractory BK virus-associated nephropathy with cidofovir. Am J Transplant 2003; 3: 186-191. Available at http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list-uids= 12614296
28. Vats A, Shapiro R, Singh Randhawa P et al. Quantitative viral load monitoring and cidofovir therapy for the management of BK virus-associated nephropathy in children and adults. Transplantation 2003; 75: 105-112. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=12544881
29. Matlosz B, Mroz A, Durlik M et al. Polyomavirus BK infection. Transplant Proc 2003; 35: 2196-2198. Available at http://www.ncbi.nlm. nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt= Citation&list-uids=14529886
30. Ginevri F, De Santis R, Comoli P et al. Polyomavirus BK infection in pediatric kidney-allograft recipients: a single-center analysis of incidence, risk factors, and novel therapeutic approaches. Transplantation 2003; 75: 1266-1270. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&dopt=Citation&list-uids=12717214
31. McGilvray ID, Lajoie G, Humar A et al. Polyomavirus infection and acute vascular rejection in a kidney allograft: coincidence or mimicry? Am J Transplant 2003; 3: 501-504. Available at http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list-uids= 12694076
32. Buehrig CK, Lager DJ, Stegall MD et al. Influence of surveillance renal allograft biopsy on diagnosis and prognosis of polyomavirus-associated nephropathy. Kidney Int 2003; 64: 665-673. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=12846764
33. Schmitz M, Brause M, Hetzel G et al. Infection with polyomavirus type BK after renal transplantation. Clin Nephrol 2003; 60: 125-129. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=12940615
34. Suh KS, Kim SY, Bang BK et al. BK polyomavirus interstitial nephritis in a renal allograft recipient. Ultrastruct Pathol 2003; 27: 61-64. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&dopt=Citation&list-uids=12554538
35. Smith JM, McDonald RA, Finn LS et al. Polyomavirus nephropathy in pediatric kidney transplant recipients. Am J Transplant 2004; 4: 2109-2117. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&dopt=Citation&list-uids=15575916
36. Sachdeva MS, Nada R, Jha V et al. The high incidence of BK polyoma virus infection among renal transplant recipients in India. Transplantation 2004; 77: 429-431. Available at http://www.ncbi.nlm.nih. gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list- uids=14966420
37. Wali RK, Drachenberg C, Hirsch HH et al. BK virus-associated nephropathy in renal allograft recipients: rescue therapy by sirolimus-based immunosuppression. Transplantation 2004; 78: 1069-1073. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=15480176
38. Rocha PN, Plumb TJ, Miller SE et al. Risk factors for BK polyomavirus nephritis in renal allograft recipients. Clin Transplant 2004; 18: 456-462. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? cmd=Retrieve&db=PubMed&dopt=Citation&list-uids=15233826
39. Kim HC, Hwang EA, Kang MJ et al. BK virus infection in kidney transplant recipients. Transplant Proc 2004; 36: 2113-2115. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=15518765
40. Drachenberg CB, Papadimitriou JC, Wali R et al. Improved outcome of polyoma virus allograft nephropathy with early biopsy. Transplant Proc 2004; 36: 758-759. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? cmd=Retrieve&db=PubMed&dopt=Citation&list-uids=15110653
41. Drachenberg CB, Papadimitriou JC, Hirsch HH et al. Histological patterns of polyomavirus nephropathy: correlation with graft outcome and viral load. Am J Transplant 2004; 4: 2082-2092. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=15575913
42. Drachenberg C, Hirsch HH, Papadimitriou JC et al. Cost efficiency in the prospective diagnosis and follow-up of polyomavirus allograft nephropathy. Transplant Proc 2004; 36: 3028-3031. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=15686687
43. Awadalla Y, Randhawa P, Ruppert K et al. HLA mismatching increases the risk of BK virus nephropathy in renal transplant recipients. Am J Transplant 2004; 4: 1691-1696. Available at http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list-uids= 15367226
44. Hariharan S, Cohen EP, Vasudev B et al. BK virus-specific antibodies and BKV DNA in renal transplant recipients with BKV nephritis. Am J Transplant 2005; 5: 2719-2724. Available at http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list-uids= 16212632
45. Brennan DC, Agha I, Bohl DL et al. Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction. Am J Transplant 2005; 5: 582-594. Available at http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list-uids= 15707414
46. Bohl DL, Storch GA, Ryschkewitsch C et al. Donor origin of BK virus in renal transplantation and role of HLA C7 in susceptibility to sustained BK viremia. Am J Transplant 2005; 5: 2213-2221. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=16095500
47. Vasudev B, Hariharan S, Hussain SA et al. BK virus nephritis: risk factors, timing, and outcome in renal transplant recipients. Kidney Int 2005; 68: 1834-1839. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? cmd=Retrieve&db=PubMed&dopt=Citation&list-uids=16164661
48. Toyoda M, Puliyanda DP, Amet N et al. Co-infection of polyomavirus-BK and cytomegalovirus in renal transplant recipients. Transplantation 2005; 80: 198-205. Available at http://www.ncbi.nlm.nih. gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list- uids=16041264
49. Schmid H, Nitschko H, Gerth J et al. Polyomavirus DNA and RNA detection in renal allograft biopsies: results from a European multicenter study. Transplantation 2005; 80: 600-604. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=16177632
50. Randhawa P, Shapiro R, Vats A. Quantitation of DNA of polyomaviruses BK and JC in human kidneys. J Infect Dis 2005; 192: 504-509. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=15995966
51. Limaye AP, Smith KD, Cook L et al. Polyomavirus nephropathy in native kidneys of non-renal transplant recipients. Am J Transplant 2005; 5: 614-620. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&dopt=Citation&list-uids=15707418
52. Chang CY, Gangji A, Chorneyko K et al. Urological manifestations of BK polyomavirus in renal transplant recipients. Can J Urol 2005; 12: 2829-2836. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&dopt=Citation&list-uids=16274519
53. Bressollette-Bodin C, Coste-Burel M, Hourmant M et al. A prospective longitudinal study of BK virus infection in 104 renal transplant recipients. Am J Transplant 2005; 5: 1926-1933. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=15996241
54. Randhawa PS, Demetris AJ. Nephropathy due to polyomavirus type BK. N Engl J Med 2000; 342: 1361-1363. Available at http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list-uids= 10793170
55. Mengel M, Marwedel M, Radermacher J et al. Incidence of polyomavirus-nephropathy in renal allografts: influence of modern immunosuppressive drugs. Nephrol Dial Transplant 2003; 18: 1190-1196. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=12748354
56. Trofe J, Gaber LW, Stratta RJ et al. Polyomavirus in kidney and kidney-pancreas transplant recipients. Transpl Infect Dis 2003; 5: 21-28. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=12791071
57. Rahamimov R, Lustig S, Tovar A et al. BK polyoma virus nephropathy in kidney transplant recipient: the role of new immunosuppressive agents. Transplant Proc 2003; 35: 604-605. Available at http://www.ncbi.nlm.nih. gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list- uids=12644064
58. Li RM, Mannon RB, Kleiner D et al. BK virus and SV40 co-infection in polyomavirus nephropathy. Transplantation 2002; 74: 1497-1504. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=12490781
59. Maiza H, Fontaniere B, Dijoud F et al. Graft dysfunction and polyomavirus infection in renal allograft recipients. Transplant Proc 2002; 34: 809-811. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? cmd=Retrieve&db=PubMed&dopt=Citation&list-uids=12034191
60. Kang YN, Han SM, Park KK et al. BK virus infection in renal allograft recipients. Transplant Proc 2003; 35: 275-277. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=12591397
61. Namba Y, Moriyama T, Kyo M et al. Prevalence, characteristics, and outcome of BK virus nephropathy in Japanese renal transplant patients: analysis in protocol and episode biopsies. Clin Transplant 2005; 19: 97-101. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=15659141
62. Basse G, Mengelle C, Kamar N et al. Prospective evaluation of BK virus DNAemia in renal transplant patients and their transplant outcome. Transplant Proc 2007; 39: 84-87. Available at http://www.ncbi.nlm.nih. gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list- uids=17275480
63. Hirsch HH, Mohaupt M, Klimkait T. Prospective monitoring of BK virus load after discontinuing sirolimus treatment in a renal transplant patient with BK virus nephropathy. J Infect Dis 2001; 184: 1494-1495; author reply 1495-1496. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&dopt=Citation&list-uids=11709797
64. Hurault de Ligny B, Etienne I, Francois A et al. Polyomavirus-induced acute tubulo-interstitial nephritis in renal allograft recipients. Transplant Proc 2000; 32: 2760-2761. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=11134789
65. Kim HC, Hwang EA, Han SY et al. Polyomavirus nephropathy after renal transplantation: a single centre experience. Nephrology (Carlton) 2005; 10: 198-203. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? cmd=Retrieve&db=PubMed&dopt=Citation&list-uids=15877682
66. Khamash HA, Wadei HM, Mahale AS et al. Polyomavirus-associated nephropathy risk in kidney transplants: the influence of recipient age and donor gender. Kidney Int 2007. Available at http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list-uids= 17410099
67. Trofe J, Cavallo T, First MR et al. Polyomavirus in kidney and kidney-pancreas transplantation: a defined protocol for immunosuppression reduction and histologic monitoring. Transplant Proc 2002; 34: 1788-1789. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=12176577
68. Hymes LC, Warshaw BL. Polyomavirus (BK) in pediatric renal transplants: evaluation of viremic patients with and without BK associated nephritis. Pediatr Transplant 2006; 10: 920-922. Available at http://www.ncbi.nlm. nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt= Citation&list-uids=17096758
69. Mathur VS, Olson JL, Darragh TM et al. Polyomavirus-induced interstitial nephritis in two renal transplant recipients: case reports and review of the literature. Am J Kidney Dis 1997; 29: 754-758. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=9159311
70. Haysom L, Rosenberg AR, Kainer G et al. BK viral infection in an Australian pediatric renal transplant population. Pediatr Transplant 2004; 8: 480-484. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? cmd=Retrieve&db=PubMed&dopt=Citation&list-uids=15367284
71. Hodur DM, Mandelbrot D. Immunosuppression and BKV nephropathy. N Engl J Med 2002; 347: 2079-2080; author reply 2079-2080. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=12490694
72. Hirsch HH. Polyomavirus BK nephropathy: a (re-) emerging complication in renal transplantation. Am J Transplant 2002; 2: 25-30. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=12095052
73. Cosio FG, Amer H, Grande JP et al. Comparison of low versus high tacrolimus levels in kidney transplantation: assessment of efficacy by protocol biopsies. Transplantation 2007; 83: 411-416. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=17318073
74. Priftakis P, Bogdanovic G, Tyden G et al. Polyomaviruria in renal transplant patients is not correlated to the cold ischemia period or to rejection episodes. J Clin Microbiol 2000; 38: 406-407. Available at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=10618126