Is low-dose aspirin really harmful to the small bowel?

Digestion

Volumn 79, Issue 1, 2009, Pages 42-43

  Rácz, István ^a  

^a Petz Aladar Univ Teach Hosp 9024   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 2 INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT;

CAPSULE ENDOSCOPY; CARDIOVASCULAR DISEASE; CHEMOPROPHYLAXIS; CLINICAL TRIAL; CONTROLLED STUDY; DIGESTIVE SYSTEM PERFORATION; DISEASE SEVERITY; EDITORIAL; ENTERIC COATED TABLET; GASTRODUODENAL ULCER; GASTROINTESTINAL SYMPTOM; HUMAN; INTESTINE INJURY; IRON DEFICIENCY ANEMIA; LOW DRUG DOSE; MITOCHONDRIAL RESPIRATION; OCCULT BLOOD; OXIDATIVE PHOSPHORYLATION; PH; PRIORITY JOURNAL; SMALL INTESTINE DISEASE; TREATMENT DURATION;

ASPIRIN; CAPSULE ENDOSCOPY; HUMANS; INTESTINAL DISEASES; INTESTINAL MUCOSA; INTESTINE, SMALL;

EID: 60749129210     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000204464     Document Type: Editorial

References (9)

1. Yeomans ND, Lanas AI, Talley NJ, Thomson AB, Daneshjoo R, Eriksson B, Appelman-Eszczuk S, Langstrom G, Naesdal J, Serrano P, Singh M, Skelly MM, Hawkey CJ: Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. Aliment Pharmacol Ther 2005; 22: 795-801.
2. Yeomans ND, Lanas A, Labenz J, Veldhuyzen van Zanten S, van Rensburg C, Rácz I, Tchernev K, Karamanolis D, Roda E, Hawkey C, Nauclér E, Svedberg LE: Efficacy of esomeprazole (20 mg once daily) for reducing the risk of gastroduodenal ulcers associated with continuous use of low-dose aspirin. Am J Gastroenterol 2008; 103: 2465-2473.
3. Fortun JJ, Hawkey CJ: Nonsteroidal anti-inflammatory drugs and the small intestine. Curr Opin Gastroenterol 2005, 21: 169-175.
4. Graham DY, Opekun AR, Willingham FF, Qureshi WA: Visible small-intestinal mucosal injury in chronic NSAID users. Clin Gastroenterol Hepatol 2005; 3: 55-59.
5. Maiden L, Thjodleifsson B, Theodors A, Gonzalez J, Bjarnason I: A quantitative analysis of NSAID-induced small bowel pathology by capsule endoscopy. Gastroenterology 2005; 128: 1172-1178.
6. Goldstein JL, Eisen GM, Lewis B, Gralnek IM, Zlotnick S, Fort JG: Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo. Clin Gastroenterol Hepatol 2005; 3: 133-141.
7. Endo H, Hosono K, Inamori M, Kato S, Nozaki Y, Yoneda K, Akiyama T, Fujita K, Takahashi H, Yoneda M, Abe Y, Kirikoshi H, Kobayashi N, Kubota K, Saito S, Matsuhashi N, Nakajima A: Incidence of small bowel injury induced by low-dose aspirin: a crossover study using capsule endoscopy in healthy volunteers. Digestion 2009;79:44-51 .
8. Maiden L, Thjodleifsson B, Seigal A, Bjarnason II, Scott D, Birgisson S, Bjarnason I: Long-term effects of non-steroidal antiinflammatory drugs and cyclooxygenase-2 selective agents on the small bowel: a crosssectional capsule enteroscopy study. Clin Gastroenterol Hepatol 2007; 5: 1040-1045.
9. Gralnek IM, De Franchis R, Seidman E, Leighton JA, Legnani P, Lewis BS: Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change. Aliment Pharmacol Ther 2008; 27: 146-154.