Making sense of a missense mutation: Characterization of MutT2, a nudix hydrolase from Mycobacterium tuberculosis, and the G58R mutant encoded in W-Beijing strains of M. tuberculosis

Biochemistry

Volumn 48, Issue 4, 2009, Pages 699-708

  Moreland, Nicole J ^a   Charlier, Caroline ^a   Dingley, Andrew J ^a,b   Baker, Edward N ^a   Lott, J Shaun ^a,c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF NAMUR   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CIRCULAR DICHROISMS; CLOSE PROXIMITIES; CYTIDINE; DIVALENT CATIONS; HOMOLOGY MODELING; HYDROLASES; M. TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS STRAINS; NUDIX HYDROLASE; POLYMORPHISM ANALYSIS; PROTEIN STABILITIES; WILD TYPES;

AMINO ACIDS; BINDING ENERGY; CIRCULAR DICHROISM SPECTROSCOPY; DICHROISM; ENZYMES; HYDROGEN; HYDROGEN BONDS; MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACIDS; NUCLEOTIDES; POSITIVE IONS;

BINDING SITES;

ALANINE; ARGININE; BACTERIAL PROTEIN; CYTIDINE TRIPHOSPHATE; DIVALENT CATION; GLYCINE; MAGNESIUM ION; NUDIX HYDROLASE; PROTEIN MUTT2; PYROPHOSPHATE; UNCLASSIFIED DRUG; WATER; INORGANIC PYROPHOSPHATASE; MAGNESIUM; NUDIX HYDROLASES;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL STRAIN; BINDING SITE; CIRCULAR DICHROISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROGEN BOND; MISSENSE MUTATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; WILD TYPE; AMINO ACID SEQUENCE; CHEMISTRY; COMPARATIVE STUDY; DNA REPAIR; ENZYME STABILITY; ENZYMOLOGY; GENETICS; HYDROLYSIS; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

MYCOBACTERIUM TUBERCULOSIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARGININE; CATIONS, DIVALENT; CRYSTALLOGRAPHY, X-RAY; CYTIDINE TRIPHOSPHATE; DNA REPAIR; ENZYME STABILITY; GLYCINE; HYDROLYSIS; MAGNESIUM; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN STRUCTURE, SECONDARY; PYROPHOSPHATASES;

EID: 60749117447     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi8009554     Document Type: Article

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