Bystander effect induced changes in apoptosis related proteins and terminal differentiation in in vitro murine bladder cultures

International Journal of Radiation Biology

Volumn 85, Issue 1, 2009, Pages 48-56

  Vines, A M ^a   Lyng, F M ^a   McClean, B ^b   Seymour, C ^c   Mothersill, C E ^c  

^a DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

^b ST LUKE S HOSPITAL   (Ireland)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

Bcl2; Bystander effect; cMyc; Differentiation; Radiation

Indexed keywords

APOPTOSIS RELATED PROTEIN; BIOLOGICAL MARKER; CELL PROTEIN; MYC PROTEIN; PROTEIN BCL 2; UNCLASSIFIED DRUG; UROPLAKIN; UROPLAKIN 3;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; BLADDER; BYSTANDER EFFECT; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOSE RESPONSE; FRAGMENTATION REACTION; GAMMA RADIATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; MULTICELLULAR SPHEROID; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION RESPONSE; SIGNAL TRANSDUCTION; TERMINAL SEQUENCE; TISSUE CULTURE;

ANIMALS; BYSTANDER EFFECT; CELL DIFFERENTIATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; KERATINOCYTES; MALE; MEMBRANE GLYCOPROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; RATS; RATS, WISTAR; URINARY BLADDER;

MURINAE;

EID: 60749116076     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.1080/09553000802635047     Document Type: Article

References (40)

1. Albanese J, Dainiak N. 2000. Ionising radiation alters FAS antigen ligand at the cell surface and on exfoliated plasma membrane-derived vesicles: Implication for apoptosis and intercellular signaling. Radiation Research 153:49-61.
2. Azzam EI, de Toledo SM, Spitz DR, Little JB. 2002. Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from a particles-irradiated normal human fibroblast cultures. Cancer Research 62:5436-5442.
3. Belyakov OV, Folkard M, Mothersill C, Prise KM, Michael BD. 2002. Bystander-induced apoptosis and premature differentiation in primary urothelial explants after charged particle microbeam irradiation. Radiation Protection Dosimetry 99:249-251.
4. Belyakov OV, Folkard M, Mothersill C, Prise KM, Michael BD. 2003. A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation. British Journal of Cancer 88:767-774.
5. Belyakov OV, Mitchell SA, Parikh D, Randers-Pehrsom G, Marino SA, Amundson SA, Geard CR, Brenner DJ. 2005. Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. Proceedings of the National Academy of Sciences 102:14203-14208.
6. Belyakov OV, Folkard M, Mothersill C, Prise KM, Michael BD. 2006. Bystander induced differentiation: A major response to targeted irradiation of a urothelial explant model. Mutation Research 597:43-49.
7. Bishayee A, Hill HZ, Stein A, Rao DV, Howell RW. 2001. Free radical initiated and gap junction mediated bystander effect due to nonuniform distribution of incorporated radioactivity on a three dimensional tissue culture model. Radiation Research 155:335-44.
8. Coates PJ, Lorimore SA, Wright EG. 2004. Damaging and protective cell signalling in the untargeted effects of ionising radiation. Mutation Research 568:5-20.
9. Gardner L, Lee L, Dang C. 2002. The c-Myc oncogenic transcription factor. Adapted from Myc oncogene. Encyclopedia of Cancer. 1st ed. Springer Reference.
10. Hollowell JG, Littlefield LG. 1968. Chromosome damage induced by plasma of X-rayed patient: an indirect effect of X-ray. Pro Soc Exp Biol Med 129:240-244.
11. Kowaltowski A, Cosso RG, Campos CB, Fiskum G. 2002. Effect of Bcl-2 overexpression on mitochondrial structure and function. Journal of Biological Chemistry 277:42802-42807.
12. Lehnert BE, Goodwin EH, Deshpande A. 1997. Extracellular factors following exposure to alpha particles can cause sister chromatid exchanges in normal human cells. Cancer Research 57:2164-2171.
13. Little JB, Azzam EI, de Toledo SM, Nagasawa H. 2002. Bystander effects: Intercellular transmission of radiation damage signals. Radiation Protection Dosimetry 99:159-162.
14. Little JB. 2006. Cellular radiation effects and the bystander response. Mutation Research 597:113-118.
15. Lorimore S, Coates P, Scbie G, Milne G, Wright EG. 2001. Inflammatory-type responses after exposure to ionizing radiation in vivo: A mechanism for radiation induced bystander effects? Oncogene 20:7085-7095.
16. Lyng F, Maguire P, McClean B, Seymour C, Mothersill C. 2006a. The involvement of calcium and MAP kinase signalling pathways in the production of radiation-induced bystander effects. Radiation Research 165:400-409.
17. Lyng FM, Maguire P, Kilmurrary N, Mothersill C, Shao C, Folkard M, Prise K. 2006b. Apoptosis is initiated in human keratinocytes exposed to signalling factors from microbeam irradiated cells. International Journal of Radiation Biology 82:393-399.
18. Maguire P, Mothersill C, Seymour C, Lyng F. 2005. Medium from irradiated cells induces dose-dependent mitochondrial changes and Bcl2 responses in unirradiated human keratinocytes. Radiation Research 163:384-390.
19. Matsumoto H, Hayashi S, Hatashita M, Ohnishi K, Shioura H, Ohtsubo T, Kitai R, Ohnishi T, Kano E. 2001. Induction of radioresistance by nitric oxide mediated bystander effect. Radiation Research 155:387-396.
20. Morgan WF. 2003. Is there a common mechanism underlying genomic instability, bystander effects and other non-targeted effects of exposure to ionizing radiation. Oncogene 22:7094-7099.
21. Mothersill CE, O'Malley KJ, Murphy DM, Seymour CB, Lorimore SA, Wright EG. 1999. Identification and characterisation of three subtypes of radiation response in normal human urothelial cultures exposed to ionising radiation. Carcinogensis 20:2273-2278.
22. Mothersill C, Rea D, Right EG, Lorimore SA, Murphy D, Seymour C, O'Malley K. 2001. Individual variation in the production of a 'bystander signal' following irradiation of primary cultures of human urothelium. Carcinogenesis 22:1465-1471.
23. Mothersill C, Seymour C. 2001. Radiation-induced bystander effects: Past history and future directions. Radiation Research 155:759-767.
24. Mothersill C, Seymour C. 2002. Characterisation of a bystander effect induced in human tissue explant cultures by low LET radiation. Radiation Protection Dosimetry 99:163-167.
25. Mothersill C, Seymour C. 2003. Radiation-induced bystander effects, carcinogenesis and models. Oncogene 22:7028-7033.
26. Mothersill C, Lyng F, Seymour C, Maguire P, Lorimore S, Wright E. 2005. Genetic factors influencing bystander signaling in murine bladder epithelium after low-dose irradiation in-vivo. Radiation Research 163:391-399.
27. Mothersill C, Seymour C. 2006. Radiation induced bystander effects and the DNA paradigm: An "out of field" perspective. Mutation Research 597:5-10.
28. Nagasawa H, Little JB. 1992. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Research 52:6394-6396.
29. Narayanan PK, Goodwin EH, Lehnert BE. 1997. Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Research 57:3963-3971.
30. Parsons WB, Watkins CH, Pease GL, Childs DS. 1954. Changes in sternal bone marrow following roentgen ray therapy to the spleen in chronic granulocytic leukaemia. Cancer 7:179-189.
31. Pirisi L, Creek KE, Doniger J, DiPaolo JA. 1988. Continuous cell lines with altered and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA. Carcinogenesis 9:1573-1579.
32. Prise KM, Belyakov OV, Folkard M, Michael BD. 1998. Studies of bystander effects in human fibroblasts using a charged particle microbeam. International Journal of Radiation Biology 74:793-798.
33. Prise KM, Folkard M, Michael BD. 2003. A review of the bystander effect and its implications for low-dose exposure. Radiation Protection Dosimetry 104:347-355.
34. Prise KM, Folkard M, Michael BD. 2005. New insights on cell death from radiation exposure. Lancet Oncology 6:520-528.
35. Puck TT, Marcus PI. 1956. Action of x-rays on mammalian cells. Journal of Experimental Medicine 653-666.
36. Shao C, Stewart V, Folkard M, Michael BD, Prise KM. 2003. Nitric oxide mediated signalling in the bystander response of individually targeted glioma cells. Cancer Research 63:8437-8442.
37. Shimizu S, Eguchi Y, Kamiike W, Funahashi Y, Mignon A, Lacronique V, Matsuda H, Tsujimoto Y, Eguchi Y, Kamiike W, Funahashi Y, Mignon A, Lacronique V, Matsuda H, and Tsujimoto Y. 1998. Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux. Biochemistry 95:1455-1459.
38. Souto J. 1962. Tumors development in the rat induced by the blood of irradiated animals. Nature 195:1317-1318.
39. Suzuki M, Zhou H, Gread, CR, Hei TK. 2004. Effect of medium on chromatin damage in bystander mammalian cells. Radiation Research 162:264-269.
40. Watson GE, Lorimore SA, Wright EG. 1996. Long term in-vivo transmission of alpha particle-induced chromosomal instability in murine haemopoietic cells. International Journal of Radiation Biology 69:175-182.