The effect of low-dose cidofovir on the long-term outcome of polyomavirus-associated nephropathy in renal transplant recipients

Nephrology Dialysis Transplantation

Volumn 24, Issue 3, 2009, Pages 1034-1038

  Wu, Sheng Wen ^a,b   Chang, Horng Rong ^a,b   Lian, Jong Da ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Acute rejection; Cidofovir; Graft outcome; Polyomavirus associated nephropathy; Renal transplantation

Indexed keywords

CIDOFOVIR; CYCLOSPORIN; INTERLEUKIN 2 RECEPTOR ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; RAPAMYCIN; TACROLIMUS;

ACUTE GRAFT REJECTION; ADULT; AGED; ARTICLE; BONE MARROW TOXICITY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE REDUCTION; FEMALE; FEVER; FOLLOW UP; GRAFT RECIPIENT; GRAFT SURVIVAL; HUMAN; KIDNEY BIOPSY; KIDNEY DISEASE; KIDNEY GRAFT; KIDNEY INFECTION; LONG TERM CARE; LOW DRUG DOSE; MALE; NAUSEA; NEPHROTOXICITY; POLYOMA VIRUS; PRIORITY JOURNAL; RASH; VIRUS INFECTION;

ADULT; AGED; ANTIVIRAL AGENTS; CYTOSINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLLOW-UP STUDIES; HUMANS; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PHOSPHONIC ACIDS; POLYOMAVIRUS; POLYOMAVIRUS INFECTIONS; TREATMENT OUTCOME; TUMOR VIRUS INFECTIONS;

EID: 60749108065     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn675     Document Type: Article

References (22)

1. Hussain S, Bresnahan BA, Cohen EP et al. Rapid kidney allograft failure in patients with polyoma virus nephritis with prior treatment with antilymphocyte agents. Clin Transplant 2002; 16: 43
2. Ramos E, Drachenberg CB, Papadimitriou JC et al. Clinical course of polyoma virus nephropathy in 67 renal transplant patients. J Am Soc Nephrol 2002; 13: 2145
3. Hirsch HH, Knowles W, Dickenmann M et al. Prospective study of polyomavirus type BK replication and nephropathy in renal transplant recipients. N Engl J Med 2002; 347: 527
4. Buehrig CK, Lager DJ, Stegall MD et al. Influence of surveillance renal allograft biopsy on diagnosis and prognosis of polyomavirus-associated nephropathy. Kidney Int 2003; 64: 665
5. Brennan DC, Agha I, Bohl DL et al. Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction. Am J Transplant 2005; 5: 582
6. Hirsch HH, Steiger J. Polyomavirus BK. Lancet Infect Dis 2003; 3: 611
7. Hirsch HH, Brennan DC, Drachenberg CB et al. Polyomavirus- associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations. Transplantation 2005; 79: 1277
8. Fishman JA. BK nephropathy: what is the role of antiviral therapy? Am J Transplant 2003; 3: 99
9. Podoval RD, Kadambi PV, Javaid B et al. Leflunomide: a potential new therapeutic agent for BK nephropathy. Am J Transplant 2003; 3(Suppl 5): 189
10. Sener A, House AA, Jevnikar AM et al. Intravenous immunoglobulin as a treatment for BK virus associated nephropathy: one-year follow-up of renal allograft recipients. Transplantation 2006; 81: 117
11. Kuypers DRJ, Vandooren AK, Lerut E et al. Adjuvant low-dose cidofovir therapy for BK polyomavirus interstitial nephritis in renal transplant recipients. Am J Transplant 2005; 5: 1997
12. Araya CE, Lew JF, Fennel RS et al. Intermediate-dose cidofovir without probenecid in the treatment of BK virus allograft nephropathy. Pediatr Transplant 2006; 10: 32
13. Trofe J, Gaber LW, Stratta RJ et al. Polyomavirus in kidney and kidney-pancreas transplant recipients. Transplant Infect Dis 2003; 5: 21
14. Wadei HM, Rule AD, Lewin M et al. Kidney transplant function and histological clearance of virus following diagnosis of polyomavirus-associated nephropathy (PVAN). Am J Transplant 2006; 6: 1025
15. Randhawa PS, Demetris AJ. Nephropathy due to polyomavirus type BK. N Engl J Med 2000; 342: 1361
16. Vasudev B, Hariharan S, Hussian SA et al. BK virus nephritis: risk factors, timing and outcomes in renal transplant recipients. Kidney Int 2005; 68: 1834
17. Andrei G, Snoeck R, Vandeputte M et al. Activities of various compounds against murine and primate polyomaviruses. Antimicrob Agents Chemother 1997; 41: 587
18. Farasati N, Shapiro R, Vats A et al. Effect of leflunomide and cidofovir on replication of BK virus in an in vitro culture system. Transplantation 2004; 79: 116
19. Keller LS, Peh CA, Nolan J et al. BK transplant nephropathy successfully treated with cidofovir. Nephrol Dial Transplant 2003; 18: 1013
20. Kadambi PV, Josephson MA, Williams J et al. Treatment of refractory BK virus-associated nephropathy with cidofovir. Am J Transplant 2003; 3: 186
21. Drachenberg CB, Papadimitriou JC, Hirsch HH et al. Histological patterns of polyomavirus nephropathy: correlation with graft outcome and viral load. Am J Transplant 2004; 4: 2082
22. Nickeleit V, Klimkait T, Binet IF. Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy. N Engl J Med 2000; 342: 1309