The Ebola virus ribonucleoprotein complex: A novel VP30-L interaction identified

Virus Research

Volumn 140, Issue 1-2, 2009, Pages 8-14

  Groseth, A ^a,b   Charton, J E ^a,c   Sauerborn, M ^a,d   Feldmann, F ^a   Jones, S M ^a,b   Hoenen, T ^a,d   Feldmann, H ^a,b  

^a PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Ebola virus; Polymerase; Protein protein interaction; Ribonucleoprotein complex; VP30

Indexed keywords

RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG; VIRUS NUCLEOPROTEIN; VP30 PROTEIN; VP35 PROTEIN;

ANIMAL CELL; ARTICLE; CELL INCLUSION; CELL NUCLEUS INCLUSION BODY; CONTROLLED STUDY; CYTOPLASM; EBOLA VIRUS; FEMALE; HUMAN; HUMAN CELL; MARBURG VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

ANIMALS; CERCOPITHECUS AETHIOPS; EBOLAVIRUS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, VIRAL; HUMANS; MICE; MICE, INBRED BALB C; NUCLEOPROTEINS; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, QUATERNARY; TRANSCRIPTION FACTORS; VERO CELLS; VIRAL CORE PROTEINS; VIRAL PROTEINS;

EBOLA VIRUS; LAKE VICTORIA MARBURGVIRUS; MARBURGVIRUS;

EID: 60749103168     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virusres.2008.10.017     Document Type: Article

References (23)

1. Towner J.S., Sealy T.K., Khristova M.L., Albariño C.G., Conlan S., Reeder S.A., Quan P.L., Lipkin W.I., Downing R., Tappero J.W., Okware S., Lutwama J., Bakamutumaho B., Kayiwa J., Comer J.A., Rollin P.E., Ksiazek T.G., and Nichol ST. Newly discovered ebola virus associated with hemorrhagic Fever outbreak in Uganda. PLoS Pathog 4 11 (2008) e1000212 Epub 2008 Nov 21. PMID: 19023410 [PubMed - in process]
2. Becker S., Rinne C., Hofsass U., Klenk H.D., and Mühlberger E. Interactions of Marburg virus nucleocapsid proteins. Virology 249 (1998) 406-417
3. Boehmann Y., Enterlein S., Randolf A., and Mühlberger E. A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire. Virology 332 (2005) 406-417
4. Duprex W.P., Collins F.M., and Rima B.K. Modulating the function of the measles virus RNA-dependent RNA polymerase by insertion of green fluorescent protein into the open reading frame. J. Virol. 76 (2002) 7322-7328
5. Elliott L.H., Kiley M.P., and McCormick J.B. Descriptive analysis of Ebola virus proteins. Virology 147 (1985) 169-176
6. Enterlein S., Volchkov V., Weik M., Kolesnikova L., Volchkova V., Klenk H.D., and Mühlberger E. Rescue of recombinant Marburg virus from cDNA is dependent on nucleocapsid protein VP30. J. Virol. 80 (2006) 1038-1043
7. Feldmann H., Geisbert T., Jahrling P., Klenk H.D., Netesov S.V., Peters C.J., Sanchez A., Swanepoel R., and Volchkov V. Filoviridae. In: Fauqet C.M. (Ed). Virus Taxonomy: Eighth Report of the International Committee on Taxonomy of Viruses (2004), Elsevier Academic Press, San Diego 645-653
8. Groseth A., Feldmann H., Theriault S., Mehmetoglu G., and Flick R. RNA polymerase I-driven minigenome system for ebola viruses. J. Virol. 79 (2005) 4425-4433
9. Hartlieb B., Muziol T., Weissenhorn W., and Becker S. Crystal structure of the C-terminal domain of Ebola virus VP30 reveals a role in transcription and nucleocapsid association. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 624-629
10. Huang Y., Xu L., Sun Y., and Nabel G.J. The assembly of Ebola virus nucleocapsid requires virion-associated proteins 35 and 24 and posttranslational modification of nucleoprotein. Mol. Cell. 10 (2002) 307-316
11. Kyte J., and Doolittle R.F. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157 (1982) 105-132
12. Modrof J., Mühlberger E., Klenk H.D., and Becker S. Phosphorylation of VP30 impairs Ebola virus transcription. J. Biol. Chem. 277 (2002) 33099-33104
13. Möller P., Pariente N., Klenk H.D., and Becker S. Homo-oligomerization of Marburgvirus VP35 is essential for its function in replication and transcription. J. Virol. 79 (2005) 14876-14886
14. Mühlberger E., Lötfering B., Klenk H.D., and Becker S. Three of the four nucleocapsid proteins of Marburg virus, NP, VP35, and L, are sufficient to mediate replication and transcription of Marburg virus-specific monocistronic minigenomes. J. Virol. 72 (1998) 8756-8764
15. Mühlberger E., Weik M., Volchkov V.E., Klenk H.D., and Becker S. Comparison of the transcription and replication strategies of Marburg virus and Ebola virus by using artificial replication systems. J. Virol. 73 (1999) 2333-2342
16. Mühlberger E. Genome organization, replication and transcription of filoviruses. In: Klenk H.D., and Feldmann H. (Eds). Ebola and Marburg Viruses: Molecular and Cellular Biology (2004), Cromwell Press, Trowbridge, UK 1-26
17. Niwa H., Yamamura K., and Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108 (1991) 193-199
18. Reid S.P., Cárdenas W.B., and Basler C.F. Homo-oligomerization facilitates the interferon-antagonist activity of the ebolavirus VP35 protein. Virology 341 (2005) 179-189
19. Sänger C., Mühlberger E., Klenk H.D., and Becker S. Adverse effects of MVA-T7 on the transport of Marburg virus glycoprotein. J. Virol. Methods 91 (2001) 29-35
20. Sanchez A., Geisbert T.W., and Feldmann H. Filoviridae: Marburg and Ebola viruses. In: Knipe D.M., and Howley P.M. (Eds). Fields Virology. fifth ed. (2007), Wolters Kluwer/Lippincott Williams and Wilkins, Philadelphia 1409-1448
21. Theriault S., Groseth A., Neumann G., Kawaoka Y., and Feldmann H. Rescue of Ebola virus from cDNA using heterologous support proteins. Virus Res. 106 (2004) 43-50
22. Watanabe S., Noda T., and Kawaoka Y. Functional mapping of the nucleoprotein of Ebola virus. J. Virol. 80 (2006) 3743-3751
23. Weik M., Modrof J., Klenk H.D., Becker S., and Mühlberger E. Ebola virus VP30-mediated transcription is regulated by RNA secondary structure formation. J. Virol. 76 (2002) 8532-8539