A paediatric case of acute liver failure associated with efavirenz-based highly active antiretroviral therapy and effective use of raltegravir in combination antiretroviral treatment after liver transplantation

Journal of Antimicrobial Chemotherapy

Volumn 63, Issue 3, 2009, Pages 623-625

  Turkova, Anna ^a   Ball, Colin ^a   Gilmour White, Susanna ^a   Rela, Mohamed ^a   Mieli Vergani, Giorgina ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Drug toxicity; HAART; HIV; NNRTIs

Indexed keywords

ABACAVIR PLUS LAMIVUDINE; ANTIRETROVIRUS AGENT; COTRIMOXAZOLE; DIDANOSINE; EFAVIRENZ; HLA ANTIGEN; LAMIVUDINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NELFINAVIR; PREDNISOLONE; RALTEGRAVIR; RAPAMYCIN; ZIDOVUDINE;

ABDOMINAL DISTENSION; CACHEXIA; CASE REPORT; CD4 LYMPHOCYTE COUNT; CHILD; CHRONIC GRAFT REJECTION; CLINICAL FEATURE; DRUG BLOOD LEVEL; DRUG ERUPTION; DRUG FEVER; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FATTY LIVER; HEPATIC ENCEPHALOPATHY; HEPATOMEGALY; HEPATOSPLENOMEGALY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; HYPERLIPIDEMIA; HYPERTENSION; INFANT; JAUNDICE; KIDNEY DYSFUNCTION; LETTER; LIVER BIOPSY; LIVER FAILURE; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LYMPHADENOPATHY; MALE; MYOPATHY; PHARYNGITIS; POSTOPERATIVE CARE; SIDE EFFECT; THRUSH; VIRUS LOAD; VIRUS REACTIVATION; VOMITING; WEIGHT REDUCTION;

ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BENZOXAZINES; CHILD; HIV INFECTIONS; HUMANS; LIVER FAILURE, ACUTE; LIVER TRANSPLANTATION; PYRROLIDINONES;

EID: 60649118947     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkn548     Document Type: Letter

References (5)

1. Rivero A, Mira JA, Pineda JA. Liver toxicity induced by nonnucleoside reverse transcriptase inhibitors. J Antimicrob Chemother 2007; 59: 342-6.
2. Abrescia N, Abbraccio MD, Figoni M et al. Fulminant hepatic failure after the start of an efavirenz-based HAART regimen in a treatment-naive female AIDS patient without hepatitis virus co-infection. J Antimicrob Chemother 2002; 50: 763-5.
3. Kappelhoff BS, van Leth F, Robinson PA et al. Are adverse events of nevirapine and efavirenz related to plasma concentrations? Antivir Ther 2005; 10: 489-98.
4. Isentress SPC (date of revision September 2008). electronic Medicines Compendium (eMC). http://emc.medicines.org.uk (13 October 2008, date last accessed).
5. Moreno A, Barcena R, Quereda C et al. Safe use of raltegravir and sirolimus in an HIV-infected patient with renal impairment after orthotopic liver transplantation. AIDS 2008; 22: 547-8.