Serial chimerism analyses indicate that mixed haemopoietic chimerism influences the probability of graft rejection and disease recurrence following allogeneic stem cell transplantation (SCT) for severe aplastic anaemia (SAA): Indication for routine assessment of chimerism post SCT for SAA

British Journal of Haematology

Volumn 144, Issue 6, 2009, Pages 933-945

  Lawler, Mark ^a   McCann, Shaun R ^a   Marsh, Judith C W ^b   Ljungman, Per ^c   Hows, Jill ^d   Vandenberghe, Elisabeth ^a   O'Riordan, Joan ^a   Locasciulli, Anna ^e   Socié, Gérard ^f   Kelly, Alan ^g   Schrezenmeier, Hubert ^h   Marin, Pedro ⁱ   Tichelli, André ^j   Passweg, Jakob R ^j   Dickenson, Anne ^k   Ryan, Jacqueline ^a   Bacigalupo, Andrea ^l  

^a ST JAMES S HOSPITAL   (Ireland)

^b ST GEORGE S HOSPITAL   (United Kingdom)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e SAN CAMILLO FORLANINI HOSPITAL   (Italy)

^f Service Oncologie et Hématologie Hôpital Louis Pasteur   (France)

^g TRINITY COLLEGE DUBLIN   (Ireland)

^h UNIVERSITY OF ULM   (Germany)

ⁱ HOSPITAL CLÍNIC   (Spain)

^j UNIVERSITY HOSPITAL BASEL   (Switzerland)

^k NEWCASTLE UNIVERSITY   (United Kingdom)

^l UNIVERSITY OF GENOA   (Italy)

more..

Author keywords

Allogeneic stem cell transplantation; Aplastic anaemia; Chimerism; Graft failure; Polymerase chain reaction; Short tandem repeat

Indexed keywords

ALEMTUZUMAB; BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; LYMPHOCYTE ANTIBODY; METHOTREXATE; PENTOXIFYLLINE; PREDNISOLONE; STEROID;

ADOLESCENT; ADULT; ALLOGENEIC STEM CELL TRANSPLANTATION; APLASTIC ANEMIA; ARTICLE; CHILD; CHIMERA; CONTROLLED STUDY; DISEASE SEVERITY; FANCONI ANEMIA; FEMALE; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; RECURRENT DISEASE; RISK ASSESSMENT; SCHOOL CHILD; SHORT TANDEM REPEAT; SURVIVAL RATE;

ADOLESCENT; ADULT; ANEMIA, APLASTIC; CHILD; CHILD, PRESCHOOL; CHIMERISM; CYCLOSPORINE; FANCONI ANEMIA; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECURRENCE; STEM CELL TRANSPLANTATION; SURVIVAL RATE; TANDEM REPEAT SEQUENCES; TIME FACTORS; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 60649115124     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2008.07533.x     Document Type: Article

References (53)

1. Bacigalupo, A., Oneto, R., Bruno, B., Socie, G., Passweg, J., Locasciulli, A., Van Lint, M.T., Tichelli, A., McCann, S., Marsh, J., Ljungman, P., Hows, J., Marin, P. Schrezenmeier, H. (2000) Current results of bone marrow transplantation in patients with acquired severe aplastic anaemia. Report of the European Group for Blood and Marrow transplantation. On behalf of the Working Party on Severe Aplastic Anaemia of the European Group for Blood and Marrow Transplantation. Acta Haematologica, 103, 19 25.
2. Bader, P., Hölle, W., Klingebiel, T., Handgretinger, R., Benda, N., Schlegel, P.G., Niethammer, D. Beck, J. (1997) Mixed haematopoietic chimerism after allogeneic bone marrow transplantation: the impact of quantitative PCR analysis for prediction of relapse and graft rejection in children. Bone Marrow Transplantation, 19, 697 702.
3. Bader, P., Beck, J., Frey, A., Schlegel, P.G., Hebart, H., Handgretinger, R., Einsele, H., Niemeyer, C., Benda, N., Faul, C., Kanz, L., Niethammer, D. Klingebiel, T. (1998) Serial and quantitative analysis of mixed haematopoietic chimerism by PCR in patients with acute leukaemia allows the prediction of relapse after allogeneic BMT. Bone Marrow Transplantation, 21, 487 495.
4. Baron, F. Sandmaier, B.M. (2006) Chimerism and outcomes after allogeneic hematopoietic cell transplantation following non myeloablative conditioning. Leukemia, 20, 1690 1700.
5. Boiron, J.M., Cotteret, S., Cony-Makhoul, P., Merel, P., Micheau, M., Perel, Y., Belloc, F., Bernard, P. Reiffers, J. (1998) Stable mixed chimerism without relapse after related allogeneic umbilical cord blood transplantation in a child with severe aplastic anaemia. Bone Marrow Transplantation, 22, 819 821.
6. Browne, P., Lawler, M., Humphries, P. McCann, S.R. (1991) Donor cell leukemia following bone marrow transplantation for severe aplastic anaemia. New England Journal of Medicine, 325, 710 713.
7. Casado, L.F., Steegmann, J.L., Pico, M., Requena, M.J., Ramirez, M., Madero, L., Vicario, J.L., Alegre, A., Gomez, C. Fernandez-Ranada, J.M. (1996) Study of chimerism in long term survivors after bone marrow transplantation for severe aplastic anaemia. Bone Marrow Transplantation, 18, 405 409.
8. Champlin, R.E., Horowitz, M.M., van Bekkum, D.W., Camitta, B.M., Elfenbein, G.E., Gale, R.P., Gluckman, E., Good, R.A., Rimm, A.A., Rozman, C., Speck, B. Bortin, M. (1989) Graft failure following bone marrow transplantation for severe aplastic anaemia: risk factors and treatment results. Blood, 73, 606 613.
9. Deeg, H.J., Self, S., Storb, R., Doney, K., Appelbaum, F.R., Witherspoon, R.P., Sullivan, K.M., Sheeman, K., Sanders, J., Mickelson, E. Thomas, E.D. (1986) Decreased incidence of marrow graft rejection in patients with severe aplastic anaemia; changing impact of risk factors. Blood, 68, 1363 1368.
10. Dubovsky, J., Daxberger, H., Fritsch, G., Printz, D., Peters, C., Matthes, S., Gadner, H. Lion, T. (1999) Kinetics of chimerism during the early post-transplant period in pediatric patients with malignant and non-malignant hematologic disorders: implications for timely detection of engraftment, graft failure and rejection. Leukemia, 13, 2060 2069.
11. Gluckman, E., Horowitz, M.M., Champlin, R.E., Hows, J.M., Bacigalupo, A., Biggs, J.C., Camitta, B.M., Gale, R.P., Gordon Smith, E.C., Marmont, A.M., Masoaka, T., Ramsay, N.K.C., Rimm, A.A., Rozman, C., Sobocinski, K.A., Speck, B. Bortin, M.M. (1992) Bone marrow transplantation for severe aplastic anaemia: influence of conditioning and graft versus host disease prophylaxis regimens on outcome. Blood, 79, 269 275.
12. Gomez, J.R., Garcia, M.J., Serrano, J., Sanchez, J., Falcon, M., Castillejo, J.A., Navarro, J.A., Martin, C. Torres, A. (1997) Chimerism analysis in long-term survivor patients after bone marrow transplantation for severe aplastic anaemia. Haematologica, 82, 588 591.
13. Hamblin, M., Marsh, J.C.W., Lawler, M., McCann, S.R., Dunlop, L., Ball, S., Davies, G., Hale, G., Waldmann, H. Gordon Smith, E.C. (1996) Campath 1G in vivo confers a low incidence of graft versus host disease associated with a high incidence of mixed haemopoietic chimaerism after bone marrow transplantation for severe aplastic anaemia using HLA identical sibling donors. Bone Marrow Transplantation, 17, 819 824.
14. Hassan, R., Bonamino, M.H., Braggio, E., Lobo, A.M., Seuanez, H.N., Tabak, D.G. Zalcberg, I.R. (2004) A systematic approach to molecular quantitative determination of mixed chimaerism following allogeneic bone marrow transplantation: an analysis of its applicability in a group of patients with severe aplastic anaemia. European Journal of Haematology, 73, 156 161.
15. Hill, R.S., Petersen, F.B., Storb, R., Appelbaum, F.R., Doney, K., Dahlberg, S., Ramberg, R. Thomas, E.D. (1986) Mixed hematologic chimerism after allogeneic marrow transplantation is associated with a higher incidence of graft rejection and a lessened incidence of graft versus host disease. Blood, 67, 811 816.
16. Hoelle, W., Beck, J.F., Dueckers, G., Kreyenberg, H., Lang, P., Gruhn, B., Fuhrer, M., Niethammer, D., Klingebiel, T. Bader, P. (2004) Clinical relevance of serial quantitative analysis of hematopoietic chimerism after allogeneic stem cell transplantation in children for severe aplastic anaemia. Bone Marrow Transplantation, 33, 219 223.
17. Horowitz, M.M. (2000) Current status of allogeneic bone marrow transplantation in acquired aplastic anaemia. Seminars in Hematology, 37, 30 42.
18. Hows, J.M., Marsh, J.C.W., Liu Yin, J., Durrant, S., Swirsky, D., Worsley, A., Fairhead, S.M., Chipping, P.M., Palmer, S. Gordon Smith, E.C. (1989) Bone marrow transplantation for severe aplastic anaemia using cyclosporin: long term follow up. Bone Marrow Transplantation, 4, 11 16.
19. Huss, R., Deeg, H.J., Gooley, T., Bryant, E., Leisenring, W., Clift, R., Buckner, C.D., Martin, P., Storb, R. Appelbaum, F.R. (1996) Effect of mixed chimerism on graft versus host disease, disease recurrence and survival after HLA identical marrow transplantation for aplastic anaemia or chronic myeloid leukemia. Bone Marrow Transplantation, 18, 767 776.
20. Keable, H., Bourhis, J.H., Brison, O., Lehn, P., Schenmetzler, C., Devergie, A. Gluckman, E. (1989) Long term study of chimaerism in bone marrow transplant recipients for severe aplastic anaemia. British Journal of Haematology, 71, 525 533.
21. Klingebiel, T., Niethammer, D., Dietz, K. Bader, P. (2001) Progress in chimerism analysis in childhood malignancies - the dilemma of biostatistical considerations and ethical implications. Leukemia, 15, 1989 1991.
22. Lawler, M. (2001) Prospective chimerism analysis, the time is now but can we respond? Leukemia, 15, 1992 1994.
23. Lawler, M., Humphries, P. McCann, S.R. (1991) Evaluation of mixed chimerism by in vitro amplification of dinucleotide repeat sequences using the polymerase chain reaction. Blood, 77, 2504 2514.
24. Lawler, M., Locasciulli, A., Longoni, D., Schiro, R. McCann, S.R. (2002) Leukaemic transformation of donor cells in a patient receiving a second allogeneic bone marrow transplant for severe aplastic anaemia. Bone Marrow Transplantation, 29, 453 456.
25. Lion, T. (2001) Chimerism testing after allogeneic stem cell transplantation: importance of timing and optimal technique for testing in different clinical-biological situations. Leukemia, 15, 292.
26. Lion, T. (2003) Summary: reports on quantitative analysis of chimerism after allogeneic stem cell transplantation by PCR amplification of microsatellite markers and capillary electrophoresis with fluorescence detection. Leukemia, 17, 252 254.
27. Lion, T. Muller-Berat, N. (2003) Chimerism testing after allogeneic stem cell transplantation: importance of timing and optimal technique for testing in different clinical-biological situations. Leukemia, 17, 612.
28. Lion, T., Daxberger, H., Dubovsky, J., Filipcik, P., Fritsch, G., Peters, C., Matthes-Martin, S., Lawitschka, A. Gadner, H. (2001) Analysis of chimerism within specific leukocyte subsets for detection of residual or recurrent leukemia in pediatric patients after allogeneic stem cell transplantation. Leukemia, 15, 307 310.
29. Locatelli, F., Bruno, B., Zecca, M., Van-Lint, M.T., McCann, S., Arcese, W., Dallorso, S., Di Bartolomeo, P., Fagioli, F., Locasciulli, A., Lawler, M. Bacigalupo, A. (2000) Cyclosporin A and short-term methotrexate versus cyclosporin A as graft versus host disease prophylaxis in patients with severe aplastic anaemia given allogeneic bone marrow transplantation from an HLA-identical sibling: results of a GITMO/EBMT randomized trial. Blood, 96, 1690 1697.
30. MacKinnon, S., Barnett, L., Heller, G. O Reilly, R.J. (1994) Minimal residual disease is more common in patients who have mixed T cell chimerism after bone marrow transplantation for chronic myelogenous leukemia. Blood, 83, 3409 3416.
31. Mao, P., Zhu, Z., Wang, H., Wang, S., Mo, W., Ying, Y., Li, Q. Xu, Y. (2005) Sustained and stable hematopoietic donor-recipient mixed chimerism after unrelated cord blood transplantation for adult patients with severe aplastic anaemia. European Journal of Haematology, 75, 430 435.
32. Marsh, J.C. (2000) Treatment of aplastic anaemia: first do no harm. Lancet, 356, 1536 1537.
33. McCann, S.R., Bacigalupo, A., Gluckman, E., Hinterberger, W., Hows, J., Ljungman, P., Marin, P., Nissen, C., van't Veer Kerthof, E. Raghavachar, A. (1994) Graft rejection and second bone marrow transplants for acquired aplastic anaemia: a report from the Aplastic Anaemia Working Party of the European Bone Marrow Transplant Group. Bone Marrow Transplantation, 13, 233 237.
34. McCann, S.R., Passweg, J.R., Storb, R. Deeg, H.J. (2000) HLA-identical sibling bone marrow transplantation to treat severe aplastic anaemia. In : Aplastic Anaemia. Pathophysiology and Treatment (ed. by H. Schrezenmeier A. Bacigalupo pp. 230 257. Cambridge University Press, UK.
35. McCann, S.R., Crampe, M., Molloy, K. Lawler, M. (2005) Hemopoietic chimerism following stem cell transplantation. Transfusion and Apheresis Science, 32, 55 61.
36. McCann, S.R., Bacigalupo, A., Passweg, J., Staines, A., Locasciulli, A., Locatelli, F., Ryan, J., Schrezenmeier, H. Lawler, M. (2007) Influence of cyclosporine alone, or cyclosporine and methotrexate on the incidence of mixed hemopoietic chimerism following allogeneic sibling BMT for Severe Aplastic Anaemia. Bone Marrow Transplantation, 39, 109 114.
37. Molloy, K., Goulden, N., Lawler, M., Cornish, J., Oakhill, A., Pamphilon, D., Potter, M., Steward, C., Langlands, K., Humphries, P. McCann, S.R. (1996) Patterns of hemopoietic chimerism following BMT for childhood acute lymphoblastic leukaemia from volunteer unrelated donors. Blood, 87, 3027 3031.
38. Muller-Berat, N. Lion, T. (2006) Chimerism and transplant-related diagnostics. Leukemia, 20, 1358 1360.
39. Nakao, S., Nakatsumi, T., Chuhjo, T., Ohtaguro, M., Tsuchiya, H., Niki, T., Shiobara, S., Mori, T. Matsuda, T. (1992) Analysis of late graft failure after allogeneic bone marrow transplantation: detection of residual host cells using amplification of variable number tandem repeat loci. Bone Marrow Transplantation, 9, 107 111.
40. Ozyurek, E., Cowan, M.J., Koerper, M.A., Baxter-Lowe, L.A., Dvorak, C.C. Horn, B.N. (2008) Increasing mixed chimerism and the risk of graft loss in children undergoing allogeneic hematopoietic stem cell transplantation for non malignant disorders. Bone Marrow Transplantation, 42, 83 91.
41. Roux, E., Abdi, K., Speiser, D., Helg, C., Chapuis, B., Jeannet, M. Roosnek, E. (1993) Characterisation of mixed chimerism in patients with chronic myeloid leukemia transplanted with T cell-depleted marrow: involvement of different hematopoietic lineages before and after relapse. Blood, 81, 243 248.
42. Socie, G., Landman, J., Gluckman, E., Devergie, A., Raynal, B., Esperou-Bordeau, H. Brison, O. (1992) Short term study of chimaerism after bone marrow transplantation for severe aplastic anaemia. British Journal of Haematology, 80, 391 398.
43. Socie, G., Gluckman, E., Raynal, B., Petit, T., Landman, J., Devergie, A. Brison, O. (1993a) Bone marrow transplantation for Fanconi anaemia using low dose cyclophosphamide-thoracoabdominal irradiation as conditioning regimen: chimerism study by the polymerase chain reaction. Blood, 82, 2249 2256.
44. Socie, G., Henry Amar, M., Bacigalupo, A., Hows, J., Tichelli, A., Ljungman, P., McCann, S.R., Frickhofen, N., Vant veer-Kerthof, E. Gluckman, E. (1993b) Malignancies occuring after treatment of aplastic anaemia: a survey conducted by the severe aplastic anaemia working party of the European group for Bone Marrow Transplantation. New England Journal of Medicine, 329, 1152 1157.
45. Socie, G., Lawler, M., Gluckman, E., McCann, S.R. Brison, O. (1995) Studies on hemopoietic chimerism following allogeneic bone marrow transplantation in the molecular biology era. Leukemia Research, 19, 497 504.
46. Spitzer, T.R., Himoe, E., Cottler Fox, M., Cahill, R. Deeg, H.J. (1990) Long term stable mixed chimaerism following allogeneic marrow transplantation for severe aplastic anaemia. British Journal of Haematology, 76, 146 147.
47. Storb, R. Champlin, R.E. (1991) Bone Marrow transplantation for severe aplastic anaemia. Bone Marrow Transplantation, 8, 69 72.
48. Storb, R., Thomas, E.D., Buckner, C.D., Clift, R.A., Fefer, A., Fernando, L.P., Giblett, E.R., Johnson, F.L. Neiman, P.E. (1976) Allogeneic marrow grafting for treatment of aplastic anaemia: a follow-up on long-term survivors. Blood, 48, 485 490.
49. Storb, R., Etzioni, R., Anasetti, C., Appelbaum, F.R., Buckner, C.D., Bensinger, W., Bryant, E., Clift, R., Deeg, H.J., Doney, K., Flowers, M., Hansen, J., Martin, P., Pepe, M., Sale, G., Sanders, J., Singer, J., Sullivan, K.M., Thomas, E.D. Witherspoon, R.P. (1994a) Cyclophosphamide combined with antithymocyte globulin in preparation for allogeneic marrow transplants in patients with aplastic anaemia. Blood, 84, 941 949.
50. Storb, R., Deeg, H.J., Farewell, D., Doney, K., Appelbaum, F.R., Beatty, P., Bensinger, W., Buckner, C.D., Clift, R., Hansen, J., Hill, R., Longton, G., Lum, L., Martin, P., McCann, S.R., Bacigalupo, A., Gluckman, E., Hinterberger, W., Hows, J., Ljungman, P., Marin, P., Nissen, C., van't Veer Kerthof, E., Raghavachar, A., Socie, G., Frickhofen, N., Locasciulli, A. Schrezenmeier, H. (1994b) Graft rejection and second bone marrow transplants for acquired aplastic anaemia: a report from the Aplastic Anaemia Working Party of the European Bone Marrow Transplant group. Bone Marrow Transplant, 13, 233 237.
51. Stratford May, W., Sensenbrenner, L.L., Burns, W.H., Ambinder, R., Carroll, M.P., Griffin, C.A., Jones, R.J., Miller, C.B., Mellits, E.D., Vogelsang, G.B., Wagner, J.E., Wingard, J.R., Yeager, A.M. Santos, G.W. (1993) BMT for severe aplastic anaemia using cyclosporine. Bone Marrow Transplantation, 11, 459 464.
52. Weitzel, J.N., Hows, J., Jeffreys, A.J., Gao Ling, M. Goldman, J.M. (1988) Use of a hypervariable minisatellite DNA probe(33.15) for evaluating engraftment two or more years after bone marrow transplantation for aplastic anaemia. British Journal of Haematology, 70, 91 97.
53. Zetterquist, H., Mattsson, J., Uzunel, M., Nasman-Bjork, I., Svenberg, P., Tammik, L., Bayat, G., Winiarski, J. Ringden, O. (2000) Mixed chimerism in the B cell lineage is a rapid and sensitive indicator of minimal residual disease in bone marrow transplant recipients with pre-B cell acute lymphoblastic leukemia. Bone Marrow Transplantation, 25, 843 851.