Bone Marrow-Derived Stem Cells and Radiation Response

Seminars in Radiation Oncology

Volumn 19, Issue 2, 2009, Pages 133-139

  Greenberger, Joel S ^a   Epperly, Michael ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FREE RADICAL;

BONE MARROW; BONE MARROW CULTURE; BONE MARROW TRANSPLANTATION; CELL ASSAY; CELL CYCLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL KILLING; CELL MIGRATION; CELL POPULATION; CELL PROTECTION; CLINICAL RESEARCH; EPITHELIUM; EPITHELIUM CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMORAL IMMUNITY; IONIZING RADIATION; IRRADIATION; MICROENVIRONMENT; NONHUMAN; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; RADIATION RESPONSE; RADIOSENSITIVITY; REVIEW; SOMATIC CELL GENETICS; STEM CELL MOBILIZATION;

ANIMALS; BONE MARROW CELLS; HUMANS; MICE; RADIATION INJURIES; STEM CELLS;

EID: 60649108441     PISSN: 10534296     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semradonc.2008.11.006     Document Type: Review

References (82)

1. Irina K., Nadia R., and Robert L. Derive and conquer: Sourcing and differentiating stem cells for therapeutic applications. Nat Rev Drug Discov 7 (2008) 131-140
2. Henry K., and Benjamin R. Stem cells in a new light. Nat Biotechnol 26 (2008) 187-195
3. - side population cells represent a functionally distinct population of long-term hematopoietic stem cells. Blood 111 (2008) 2444-2453
4. Mauch P., Greenberger J.S., Botnick L.E., et al. Evidence for structured variation in self-renewal capacity within long-term bone marrow cultures. PNAS USA 77 (1980) 2927-2930
5. Till J.E., and McCulloch E.A. Developmental Aspects of the Cell Cycle. New York, NY, Academic Press (1971) 297-313
6. Sakakeeny M.A., and Greenberger J.S. Granulopoiesis longevity in continuous bone marrow cultures and factor dependent cell line generation: Significant variation among 28 inbred mouse strains and outbred stocks. J Natl Cancer Inst 68 (1982) 305-317
7. Epperly M.W., Cao S., Goff J., et al. Increased longevity of hematopoiesis in continuous bone marrow cultures and adipocytogenesis in marrow stromal cells derived from Smad3-/-mice. Exp Hematol 33 (2005) 353-362
8. FitzGerald T.J., Rothstein L., Kase K., and Greenberger J.S. Radiosensitivity of human bone marrow granulocyte-macrophage progenitor cells: Effect of dose rate on purified target cell populations. Radiat Res 107 (1986) 205-215
9. Samuel H. Stem-cell biology and cancer therapy: The more things change. J Clin Oncol 26 (2008) 821-822
10. Greenberger J.S. Toxic effects on the hematopoietic microenvironment. Exp Hematol 19 (1991) 1101-1109
11. Parmar K., Mauch P., Vergilio J., et al. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. PNAS 104 (2007) 5431-5436
12. Eri M., Masahiro M., Shuro Y., et al. Hematopoietic origin of hepatic stellate cells in the adult liver. Blood 111 (2008) 2427-2435
13. Epperly M.W., Sikora C.A., Defilippi S., et al. Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis. Resp Am J. Mol Cell Biol 29 (2003) 213-224
14. Greenberger J.S., Anderson J., Berry L.A., et al. Effects of irradiation of CBA/Ca mice on hematopoietic stem cells and stromal cells in long-term bone marrow cultures. Leukemia 10 (1996) 514-527
15. Greenberger J.S., Epperly M.W., Jahroudi N., et al. Role of bone marrow stromal cells in irradiation leukemogenesis. Acta Haematol 96 (1996) 1-15
16. Pittenger M.F., Mackay A.M., Beck S.C., et al. Multilineage potential of adult human mesenchymal stem cells. Science 284 (1999) 143-147
17. Naparstek E., Pierce J., Metcalf D., et al. Induction of growth alterations in factor-dependent hematopoietic progenitor cell lines by cocultivation with irradiated bone marrow stromal cell lines. Blood 67 (1986) 1395-1403
18. Prockop D.J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276 (1997) 71-74
19. Zhou S., Greenberger J.S., Epperly M.W., et al. Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell 7 3 (2008) 335-343
20. Zhou S., Lechpammer S., Greenberger J.S., et al. Hypoxia inhibition of adipocytogenesis in human bone marrow stromal cells requires TGFβ/Smad3 signaling. J Biol Chem 280 (2005) 22688-22696
21. Engin F., Yao Z., Yang T., et al. Dimorphic effects of notch signaling in bone homeostasis. Nat Med 14 (2008) 299-305
22. Hilton M.J., Tu X., Wu X., et al. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med 14 (2008) 306-312
23. Goh K., and Klemperer M.R. In vivo leukemic transformation: Cytogenetic evidence of in vivo leukemic transformation of engrafted marrow cells. Am J Hematol 2 (1977) 283-290
24. Harrison D.E., and Astle C.M. Loss of stem cell repopulating ability upon transplantation: Effects of donor age, cell number, and transplantation procedure. J Exp Med 156 (1982) 1767-1779
25. Harrison D.E., Astle C.M., and Delaittre J.A. Loss of proliferative capacity immunohematopoietic stem cells caused by serial transplantation rather than aging. J Exp Med 147 (1978) 1526-1531
26. Anklesaria P., FitzGerald T.J., Kase K., et al. Improved hematopoiesis in anemic SI/SId mice by therapeutic transplantation of a hematopoietic microenvironment. Blood 74 (1989) 1144-1152
27. Quesenberry P.J., Colvin G., and Abedi M. Perspective fundamental and clinical concepts on stem cell homing and engraftment: A journey to niches and beyond. Exp Hematol 33 (2005) 9-19
28. Werts E.D., Gibson D.P., Knapp S.A., et al. Bone marrow fibroblasts circulate to replace damaged marrow sites. Radiat Res 81 (1980) 20-30
29. Anklesaria P., Kase K.R., Glowacki J., et al. Engraftment of a clonal bone marrow stromal cell line in Vivo stimulates hematopoietic recovery from total body irradiation. PNAS USA 84 (1987) 7681-7685
30. Zipori D. The nature of stem cells: State rather than entity. Nat Rev 5 (2004) 873-883
31. Mothersill C., and Seymour C.B. Radiation-induced bystander effects-Implications for cancer. Nat Rev Cancer 4 (2004) 158-164
32. Zanjani E.D., Flake A.W., Almeida-Porada G., et al. Homing of human cells in the fetal sheep model: Modulation by antibodies activating or inhibiting very late activation antigen-4-dependent function. Blood 94 (1999) 2515-2522
33. Roy V., and Verfaillie C.M. Expression and function of cell adhesion molecules on fetal liver, cord blood and bone marrow hematopoietic progenitors: Implications for anatomical localization and developmental stage specific regulation of hematopoiesis. Exp Hematol 27 (1999) 302-312
34. Ahmed F., Ings S.J., Pizzey A.R., et al. Impaired bone marrow homing of cytokine-activated CD34+ cells in the Nod/SCID model. Blood 103 (2004) 2074-2084
35. Szilvassy S.J., Bass M.J., Van Zant G., et al. Organ-selective homing defines engraftment kinetics of murine hematopoietic stem cells and is compromised by ex vivo expansion. Blood 93 (1999) 1557-1566
36. Peled A., Petit I., Kollet O., et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 283 (1999) 845-850
37. Wysoczynski M., Reca R., Ratajczak J., et al. Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient. Blood 105 (2005) 40-50
38. Zhang J., Niu C., Ye L., et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425 (2003) 836-840
39. Calvi L.M., Adams G.B., Weibrecht K.W., et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425 (2003) 844-848
40. Matsuzaki Y., Kinjo K., Mulligan R.C., et al. Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. Immunity 20 (2004) 87-93
41. Cancelas J.A., Lee A.W., Prabhakar R., et al. GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nat Med 11 (2005) 886-894
42. Adams G.B., Martin R.P., Alley I.R., et al. Therapeutic targeting of a stem cell niche. Nat Biotechnol 25 (2007) 238-242
43. cip1/waf1. Science 287 (2000) 1804-1808
44. Christopherson II K.W., Hangoc G., Mantel C.R., et al. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 305 (2004) 1000-1004
45. Desponts C., Hazen A.L., Paraiso K.H.T., et al. SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation. Blood 107 (2006) 4338-4342
46. Lapidot T., Dar A., and Kollet O. How do stem cells find their way home?. Blood 106 (2005) 1901-1908
47. Nilsson S.K., Johnston H.M., Whitty G.A., et al. Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood 106 (2005) 1232-1238
48. Bently A., Kirby L., Anklesaria P., et al. Bone marrow stromal proteoglycan heterogeneity: Phenotypic variability between cell lines and the effects of glucocorticoid. J Cell Physiol 136 (1988) 182-187
49. Sugiyama T., Kohara H., Noda M., et al. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 25 (2006) 977-988
50. Anklesaria P., Teixido J., Laiho M., et al. Cell homing and proliferation mediated by membrane TGF-α binding to EGF receptor. PNAS USA 87 (1990) 3289-3293
51. Gorbunov N.V., Pogue-Geile K.L., Epperly M.W., et al. Activation of the nitric oxide synthase 2 pathway in the response of bone marrow stromal cells to high doses of ionizing radiation. Radiat Res 154 (2000) 73-86
52. Pogue-Geile K.L., and Greenberger J.S. The effect of the irradiated microenvironment on the expression and retrotransposition of intracisternal type A particles in hematopoietic cells. Exp Hematol 1 (2000) 680-689
53. Petersen B.E., Bowen W.C., Patrene K.D., et al. Bone marrow as a potential source of hepatic oval cells. Science 284 (1999) 1168-1170
54. Epperly M.W., Sikora C., Defilippi S., et al. Inhibits irradiation-induced apoptosis by stabilization of the mitochondrial membrane against the effects of SAP kinases p38 and Jnk1 translocation. Radiat Res 157 (2002) 568-577
55. Epperly M.W., Goff J.P., Sikora C.A., et al. Bone marrow origin of cells with capacity for homing and differentiation to esophageal squamous epithelium. Radiat Res 162 (2004) 233-240
56. Krause D., Theise N., Collector M., et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105 (2001) 369-377
57. Greenberger J.S., and Epperly M.W. Antioxidant therapeutic approaches toward amelioration of the pulmonary pathophysiological damaging effects of ionizing irradiation. Curr Respir Med Rev 3 (2007) 29-37
58. Niu Y., Epperly M.W., Shen H., et al. Intraesophageal MnSOD-plasmid liposome enhances engraftment and self-renewal of bone marrow derived progenitors of esophageal squamous epithelium. Gene Ther 15 (2008) 347-356
59. Epperly MW, Smith T, Wang H, et al: Modulation of total body irradiation induced life shortening by systemic intravenous MnSOD-plasmid liposome gene therapy. Radiat Res (in press)
60. Rowland R.E., Stehney A.F., and Lucas H.F. Dose-response relationships for female radium dial workers. Radiat Res 76 (1978) 368-383
61. Court Brown W.M., and Doll R. Mortality from cancer and other causes after radiotherapy for ankylosing spondilitis. Br J Med 2 (1965) 1327-1332
62. Preston D.L., Kato K., Kopecky K.I., et al. Studies of mortality of A-bomb survivors. 8. Cancer mortality, 1950-1982. Radiat Res 111 (1987) 151-178
63. Hoppe R.T. Hodgkin's disease: Complications of therapy and excess mortality. Ann Oncol 8 (1997) 115-118
64. Tucker M., Coleman C., Cox R., et al. Risk of second cancer after treatment for Hodgkin's disease. N Engl J Med 318 (1988) 76-81
65. Houghton J., Stoicov C., Nomura S., et al. Gastric cancer originating from bone marrow-derived cells. Science 306 (2004) 1568-1571
66. Thomas E.D., Bryant J.I., Buckner C.D., et al. Leukemic transformation of engrafted human marrow. Transplant Proc 4 (1972) 567-570
67. Katz F., Reeves B.R., Alexander S., et al. Leukemia arising in donor cells following allogeneic bone marrow transplantation for beta thalassaemia demonstrated by immunological, DNA, and molecular cytogenetic analysis. Br J Haematol 85 (1993) 326-331
68. Mouratidou M., Sotiropoulos D., Deremitzaki K., et al. Recurrence of acute leukemia in donor cells after bone marrow transplantation: Documentation by in situ DNA hybridization. Bone Marrow Transplant 12 (1993) 77-80
69. Cransac M., Boiron J.M., Merel P., et al. Burkitt-type and lymphoblastic leukemia in donor cells after allogeneic bone marrow transplantation for acute nonlymphoblastic leukemia. Transplantation 56 (1993) 120-123
70. Lowsky R., Fyles G., Minden M., et al. Detection of donor cell derived acute myelogenous leukaemia in a patient transplanted for chronic myelogenous leukaemia using fluorescence in situ hybridization. Br J Haematol 93 (1996) 163-165
71. Schubach W.H., Hackman R., Neiman P.E., et al. A monoclonal immunoblastic sarcoma in donor cells bearing Epstein-Barr virus genomes following allogeneic marrow grafting for acute lymphoblastic leukemia. Blood 60 (1982) 180-187
72. Marmont A., Frassoni F., Bacigalupo A., et al. Recurrence of Ph'-positive leukemia in donor cells after marrow transplantation for chronic granulocytic leukemia. N Engl J Med 310 (1984) 903-906
73. Cooley L.D., Sears D.A., Udden M.M., et al. Donor cell leukemia: Report of a case occurring 11 years after allogeneic bone marrow transplantation and review of the literature. Am J Hematol 63 (2000) 46-53
74. Elfenbein G.J., Brogaonkar D.S., Bias W.B., et al. Cytogenetic evidence for recurrence of acute myelogenous leukemia after allogeneic bone marrow transplantation in donor hematopoietic cells. Blood 52 (1978) 627-636
75. Fialkow P.J., Thomas E.D., Bryant J.I., et al. Leukaemic transformation of engrafted human marrow cells in Vivo. Lancet 1 (1971) 251-255
76. Palka G., Calabrese G., Di Girolamo G., et al. Cytogenetic survey of 31 patients treated with bone marrow transplantation for acute nonlymphocyte and acute lymphoblastic leukemias. Cancer Genet Cytogenet 51 (1991) 223-233
77. Schmitz N., Johannson W., Schmidt G., et al. Recurrence of acute lymphoblastic leukemia in donor cells after allogeneic marrow transplantation associated with a deletion of the long arm of chromosome 6. Blood 70 (1987) 1099-1104
78. Feig S.A., Dreazen O., Simon M., et al. B cell acute lymphoblastic leukemia (ALL) in donor cells following bone marrow transplantation for T cell ALL. Bone Marrow Transplant 3 (1988) 331-337
79. Browne P.V., Lawler M., Humphries P., et al. Donor-cell leukemia after bone marrow transplantation for severe aplastic anemia. N Engl J Med 325 (1991) 710-713
80. McCann S.R., Lawler M., and Bacigalupo A. Recurrence of Philadelphia chromosome-positive leukemia in donor cells after bone marrow transplantation for chronic granulocytic leukemia. Leuk Lymph 10 (1993) 419-425
81. McCann S.R., Lawler M., Humphries P., et al. Recurrence of Philadelphia chromosome-positive leukemia in donor cells after marrow transplantation for chronic granulocytic leukemia confirmation by microsatellite studies. Blood 79 (1992) 2803-2805
82. Sala-Torra O., Hanna C., Loken M.R., et al. Evidence of donor-derived hematologic malignancies after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 12 (2006) 511-517