Review article: Efficacy and safety of methoxyflurane analgesia in the emergency department and prehospital setting: Review Article

EMA - Emergency Medicine Australasia

Volumn 21, Issue 1, 2009, Pages 4-11

  Grindlay, Joanne ^a,b   Babl, Franz E ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Adverse effect; Analgesia; Methoxyflurane; Prehospital

Indexed keywords

METHOXYFLURANE; NITROUS OXIDE; PLACEBO; SEVOFLURANE; TRICHLOROETHYLENE;

BURN; CLINICAL TRIAL; CONFUSION; COUGHING; DIZZINESS; DROWSINESS; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SAFETY; EMERGENCY CARE; EMERGENCY WARD; FLUOROSIS; HALLUCINATION; HEADACHE; HEPATITIS; HUMAN; HYPOXIA; JAUNDICE; LIVER DYSFUNCTION; NEPHROTOXICITY; PAIN; PRIORITY JOURNAL; RETINOPATHY; REVIEW; SEDATION; SIDE EFFECT; VOMITING;

ADULT; ANALGESIA; ANESTHESIA, INHALATION; ANESTHETICS, INHALATION; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; EMERGENCY MEDICAL SERVICES; ENVIRONMENTAL MONITORING; HUMANS; KIDNEY DISEASES; LIVER DISEASES; METHOXYFLURANE; OCCUPATIONAL EXPOSURE; PAIN; TREATMENT OUTCOME;

EID: 60649098008     PISSN: 17426731     EISSN: 17426723     Source Type: Journal    
DOI: 10.1111/j.1742-6723.2009.01153.x     Document Type: Review

References (56)

1. Artusio JF, Van Ponzak AV, Hunt RE, Tiers FM, Alexander M. A clinical evaluation of methoxyflurane in man. Anesthesiology 1960 21 : 512 17.
2. Federal Drug Administration. Notice: Human drugs: New drug applications— Penthrane (methoxyflurane) Inhalation Liquid, 99.9. Fed. Regist. 2005 70 (171 53019.
3. Joshi P, Conn HO. The syndrome of methoxyflurane associated hepatitis. Ann. Intern. Med. 1974 80 : 395 401.
4. Jones NO. Methoxyflurane nephrotoxicity - a review and a case report. Can. Anaesth. Soc. J. 1972 19 : 152 9.
5. Crandell WB, Pappas SG, Macdonald A. Nephrotoxicity associated with methoxyflurane anaesthesia. Anesthesiology 1966 27 : 591 607.
6. Mazze RI. Methoxyflurane nephropathy. Environ. Health Perspect. 1976 15 : 111 19.
7. Mazze RI. Methoxyflurane revisited: tale of an anaesthetic from cradle to grave. Anesthesiology 2006 105 : 843 6.
8. New Zealand Medicines and Medical Devices Safety Authority. Data Sheet. Penthrox Cited 1 Nov 2006] Available from URL: http://www.medsafe.govt.nz/Profs/ Datasheet/p/penthroxinh.htm
9. MIMS online. Methoxyflurane Cited 20 Aug 2008] Available from URL: http://mims.hcn.net.au
10. NHMRC. A Guide to the Development, Implementation and Evaluation of Clinical Practice Guidelines. Canberra : National Health and Medical Research Council, 1999.
11. Medical Developments International. Material Safety Data Sheet. Methoxyflurane. 2001 Cited 20 Aug 2008] Available from URL: http://www. medicaldev.com/pdf-files/Products-Pain-Relief-Healthcare-Professionals-Medical/ MSDS%20-%20Penthrox%20December%202006.pdf
12. Medical Developments International. 'Penthrox' Inhaler (Product Information) Cited 20 Aug 2008] Available from URL: http://www.medicaldev.com/ pdf-files/Products-Pain-Relief-Healthcare-Professionals-Medical/ Penthrox-Product%20Information%20sheet.pdf
13. Packer KJ. Methoxyflurane analgesia for burns dressings. Postgrad. Med. J. 1972 48 : 128 32.
14. Packer KJ, Titel JH. Methoxyflurane for burns dressings: experience with the Analgizer. Br. J. Anaesth. 1969 41 : 1080 5.
15. Marshall MA, Ozorio HPL. Analgesia for burns dressings using methoxyflurane. Br. J. Anaesth. 1972 44 : 80 2.
16. Bodley PO, Mirza V, Spears JR, Spilbury RA. Obstetric analgesia with methoxyflurane. Anaesthesia 1966 21 : 457 63.
17. Josephson CA, Schwartz W. The Cardiff inhaler and Penthrane - a method of sedation-analgesia in routine dentistry. J. Dent. Assoc. S. Afr. 1974 29 : 77 80.
18. Laird SM, Gray BM. Intermittent inhalation of methoxyflurane and trichloroethylene as an analgesic in burns dressings procedures. Br. J. Anaesth. 1971 43 : 149 59.
19. Rosen M, Mushin WW, Jones PL, Jones EV. Field trial of methoxyflurane, nitrous oxide and trichloroethylene as obstetric analgesics. BMJ 1969 3 : 263 67.
20. Edmunds DH, Rosen M. Inhalation sedation for conservative dentistry. A comparison between nitrous oxide and methoxyflurane. Br. Dent. J. 1975 139 : 398 402.
21. Major V, Rosen M, Mushin W. Concentration of methoxyflurane for obstetric analgesia by self-administered intermittent inhalation. BMJ 1967 4 : 767 70.
22. Aitkenhead AR, Rowbotham DJ, Smith G. Textbook of Anaesthesia, 5th edn. Philadelphia : Churchill, Livingstone, Elsevier, 2007.
23. Tomi K, Mashimo T, Tashiro C et al. Alterations in pain threshold and psychomotor response associated with subanaesthetic concentrations of inhalational anaesthetics in humans. Br. J. Anaesth. 1993 70 : 684 6.
24. Torda TAG. The analgesic effect of methoxyflurane. Anaesthesia 1963 18 : 287 9.
25. Crankshaw DP. Methoxyflurane for relief of acute pain: interpretation of uptake and elimination curves. Anethesiology 2005 103 : A756.
26. Tomlin PJ, Jones BC, Edwards R, Robin PE. Subjective and objective sensory responses to inhalation of nitrous oxide and methoxyflurane. Br. J. Anaesth. 1973 45 : 719 25.
27. Crankshaw DP, Eagle A, Komesaroff D. Methoxyflurane dosage with the Penthrox inhaler for analgesia during short painful procedures Abstract Anaesth. Intensive Care 2004 32 : 428.
28. Flynn M. Clinical update - methoxyflurane. Sirens 2002 7 : 2.
29. Buntine P, Thom O, Babl F, Bailey M, Bernard S. Prehospital analgesia in adults using inhaled methoxyflurane. Emerg. Med. Australas. 2007 19 : 509 14.
30. Babl FE, Jamison SR, Spicer M, Bernard S. Inhaled methoxyflurane as a prehospital analgesic in children. Emerg. Med. Australas. 2006 18 : 404 10.
31. Chin R, McCaskill M, Browne G, Lam L. A radomized controlled trial of inhaled methoxyflurane in children with upper limb fracture Abstract J. Paediatr. Child Health 2002 38 : A15 16.
32. Babl F, Barnett P, Palmer G, Oakley E, Davidson A. A pilot study of inhaled methoxyflurane for procedural analgesia in children. Paediatr. Anaesth. 2007 17 : 148 53.
33. Firn S. Methoxyflurane analgesia for burns dressings and other painful ward procedures in children. Br. J. Anaesth. 1972 44 : 517 22.
34. Kharasch ED, Hankins DC, Thummel KE. Human kidney methoxyflurane and servoflurane metabolism: intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. Anesthesiology 1995 82 : 689 99.
35. Kharasch ED, Schroeder JL, Liggitt HD, Denny DVM, Park SB, Whittington D, Sheffels PBS. New insights into the mechanism of methoxyflurane nehrotoxicity and implications for anaesthetic development (part1): identification of the nephrotoxic metabolic pathway. Anesthesiology 2006 105 : 726 36.
36. Kharasch ED, Schroeder JL, Liggitt HD, Ensign D, Whittington DBS. New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anaesthetic development (part 2): identification of the nephrotoxic metabolites. Anesthesiology 2006 105 : 737 45.
37. Toomath RJ, Morrison RBI. Renal failure following methoxyflurane analgesia. N. Z. Med. J. 1987 100 : 707 8.
38. Rosen M, Latto P, Asscher AW. Kidney function after methoxyflurane analgesia during labour. BMJ 1972 1 : 81 3.
39. Clark RB, Beard AG, Thompson DS. Renal function in newborns and mothers exposed to methoxyflurane analgesia for labour and delivery. Anesthesiology 1979 51 : 464 67.
40. Novak MA, Roth AS, Levine MR. Calcium oxalate retinopathy associated with methoxyflurane abuse. Retina 1988 8 : 230 6.
41. Klemmer PJ, Hadler NM. Subacute flourosis. Ann. Intern. Med. 1978 89 : 607 11.
42. Brennan RP, Pearlstein AE, Miller SA. Computed tomography of the kidneys in a patient with methoxyflurane abuse. J. Comput. Assist. Tomog. 1988 12 : 155 6.
43. Rubinger D, Davidson JT, Melmed RN. Hepatitis following the use of methoxyflurane in obstetric analgesia. Anesthesiology 1975 43 : 593 5.
44. Delia JE, Maxson WS, Breen JL. Methoxyflurane hepatitis: two cases following obstetric analgesia. Int. J. Gynaecol. Obstet. 1983 21 : 89 93.
45. Okuno T, Takeda M, Horishi M, Okanoue T, Takino T. Hepatitis due to repeated inhalation of methoxyflurane in subanaesthetic concentrations. Can. Anaesth. Soc. J. 1985 32 : 53 5.
46. Min KW, Cain GD, Sabel JS, Gyorkey F. Methoxyflurane hepatitis. South. Med. J. 1977 70 : 1363 4.
47. Adverse Drug Reactions Unit. Therapeutic Goods Administration Cited 23 Aug 2008] Available from URL: http://www.tga.gov.au/adr/adrac.htm
48. Lindblad P, Zack M, Adami H-O, Ericson A. Maternal and perinatal risk factors for Wilms' tumor: a nationwide nested case-control study in Sweden. Int. J. Cancer 1992 51 : 38 41.
49. Corbett TH, Ball GL. Chronic exposure to methoxyflurane. A possible occupational hazard to anesthesiologists. Anesthesiology 1971 34 : 532 7.
50. Dahlgren B-E. Fluoride concentrations in urine of delivery ward personnel following exposure to low concentrations of methoxyflurane. J. Occup. Med 1979 21 : 624 6.
51. Dahlgren B-E. Hepatic and renal effects of low concentrations of methoxyflurane in exposed delivery ward personnel. J. Occup. Med. 1980 22 : 817 19.
52. Dahlgren B-E, Olander L, Ovrum P. Pollution of delivery ward air by nitrous oxide-methoxyflurane. Am. Ind. Hyg. Assoc. J. 1979 40 : 666 72.
53. Flynn M. Clinical update - methoxyflurane. Sirens 2001 6 : 4.
54. National Institute for Occupational Safety and Health. Pocket guide to chemical hazards, methoxyflurane. Publication number 2005-149.
55. Metropolitan Ambulance Service/Rural Ambulance Service. Clinical practice guideline D020. Version 4, 2005. Methoxyflurane 'Penthrane BE, Beal H, DeWald W, Cobb S. Exacerbation of subclinical myasthenia by occupational exposure to an anesthetic. Anesth. Analg. 1971 50 : 383 7.
56. De Francisco CP. Pentrane dependence: a case report. Br. J. Psychiatry 1971 119 : 609 10.