Aryl hydrocarbon receptor polymorphism modulates DMBA-induced inflammation and carcinogenesis in phenotypically selected mice

International Journal of Cancer

Volumn 124, Issue 6, 2009, Pages 1478-1482

  De Souza, Vinicius R C ^a   Cabrera, Wafa K ^a   Galvan, Antonella ^b   Ribeiro, Orlando G ^a   Franco, Marcelo De ^a   Vorraro, Francises ^a   Starobinas, Nancy ^a   Massa, Solange ^a   Dragani, Tommaso A ^b   Ibañez, Olga M ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Aryl hydrocarbon receptor; DMBA; Inflammation; carcinogenesis; Selected mice

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1B1; DIMETHYLBENZ[A]ANTHRACENE; INTERLEUKIN 1BETA; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; 7,12 DIMETHYLBENZ[A]ANTHRACENE; CARCINOGEN; CYTOCHROME P450 1A1; GAMMA INTERFERON; INTERLEUKIN 18; INTERLEUKIN DERIVATIVE; PRIMER DNA;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE FUNCTION; GENE SEGREGATION; GENETIC POLYMORPHISM; HOMOZYGOSITY; INFLAMMATION; LUNG ADENOCARCINOMA; LUNG CARCINOGENESIS; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; REGULATORY MECHANISM; SKIN CANCER; SKIN CARCINOGENESIS; SKIN MANIFESTATION; TISSUE LEVEL; UPREGULATION; ANIMAL; CHEMICALLY INDUCED DISORDER; EXPERIMENTAL NEOPLASM; GENETICS; SKIN TUMOR;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CARCINOGENS; CYTOCHROME P-450 CYP1A1; DNA PRIMERS; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-18; INTERLEUKINS; MICE; NEOPLASMS, EXPERIMENTAL; PHENOTYPE; POLYMORPHISM, GENETIC; RECEPTORS, ARYL HYDROCARBON; SKIN NEOPLASMS; UP-REGULATION;

EID: 60549107351     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24066     Document Type: Article

References (21)

1. Ibanez OM, Stiffel C, Ribeiro OG, Cabrera WK, Massa S, De Franco M, Sant'Anna OA, Decreusefond C, Mouton D, Siqueira M. Genetics of nonspecific immunity. I. Bidirectional selective breeding of lines of mice endowed with maximal or minimal inflammatory responsiveness. Eur J Immunol 1992;22:2555-63.
2. Biozzi G. Ribeiro OG. Saran A, Araujo ML, Maria DA, De Franco M, Cabrera WK, Sant' Anna OA, Massa S, Covelli V, Mouton D, Neveu T, et al. Effect of genetic modification of acute inflammatory responsiveness on tumorigenesis in the mouse. Carcinogenesis 1998; 19:337-46.
3. Maria DA, Manenti G, Galbiati F, Ribeiro OG, Cabrera WK, Giannì BR, Pettinicchio A, De Franco M, Starobinas N, Siqueira M, Dragani TA, Ibanez OM. Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response. Oncogene 2003;22:426-32.
4. Shimada T, Inoue K, Suzuki Y, Kawai T, Azuma E, Nakajima T, Shindo M, Kurose K, Sugie A, Yamagishi Y, Fujii-Kuriyama Y, Hashimoto M. Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice. Carcinogenesis 20O2;23:1199-207.
5. Thomas RS, Penn SG, Hoi den K, Bradfield CA, Rank DR. Sequence variation and phylogenetic historv of the mouse Ahr gene. Pharmacogenetics 2002; 12:151-63.
6. Anderson C, Hehr A, Robbins R, Hasan R, Athar M, Mukhtar H, Elmets CA. Metabolic requirements for induction of contact hypersensitivity to immunotoxic polvaromatic hydrocarbons. J Immunol 1995;155:3530-7.
7. Klemme JC, Mukhtar H, Elmets CA. Induction of contact hypersensitivity to dimethyIbenz[a]anthracene and benzo(a) pyrene in C3H/HeN mice. Cancer Res 1987;47:6074-8.
8. Schmidt IV, Carver LA, Bradfield CA. Molecular characterization of the murine Ahr gene. J Biol Chem 1993;268:22203-9.
9. Casale GP, Cheng Z, Liu I, Cavalieri EL, Singhal M. Profiles of cytokine mRNAs in the skin and lymph nodes of SENCAR mice treated epicutaneously with dibenzo[a,l]pyrene or dimethylbenz[a]anthracene reveal a direct correlation between carcinogen-induced contact hypersensitivity and epidermal hyperplasia. Mol Carcinog 2000;27:125-40.
10. Ribeiro OG, Maria DA, Adriouch S, Pechberty S, Cabrera WH, Morisset J, Ibanez OM, Seman M. Convergent alteration of granulopoiesis, chemotactic activity, and neutrophil apoptosis during mouse selection for high acute inflammatory response. J Leukoc Biol 2003:74:497-506.
11. Vigar ND, Cabrera WH, Araujo LM, Ribeiro OG, Ogata TR, Siqueira M, Ibañez OM, De Franco M. Pristane-induced arthritis in mice selected for maximal or minimal acute inflammatory reaction. Eur J Immunol 2000:30:431-7.
12. Di Pace RF, Massa S, Ribeiro OG, Cabrera WHK, De Franco M, Starobinas N, Seman M, Ibañez OM. Inverse genetic predisposition to colon vs. lung carcinogenesis in mouse lines selected based on acute inflammatory responsiveness. Carcinogenesis 2006;27:1517-25.
13. Chiaro CR, Patel RD, Marcus CB, Perdew GH. Evidence for an aryl hydrocarbon receptor-mediated cytochrome p450 autoregulatory pathway. Mol Pharmacol 2007;72:1369-79.
14. Hollingshead BD, Beischlag TV, Dinatale BC, Ramadoss P, Perdew GH. Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells. Cancer Res 2008;68:3609-17.
15. Dranoff G. Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer 2004:44 1-22.
16. Li AG, Lu SL, Han G, Hoot KE, Wang XJ. Role of TGF beta in skin inflammation and carcinogenesis. Mol Carcinog 2006;45:389-96.
17. Ishihara K, Hirano T. TL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev 2002; 13:
18. van Os R, Ausema A, Noach EJ, van Pelt K, Dontje BJ, Vellenga E, de Haan G. Identification of quantitative trait loci regulating haematopoietic parameters in B6AKRF2 mice. Br J Haematol 2006; 132:80-90.
19. Tauchi M, Hida A, Negishi T, Katsuoka F, Noda S, Mimura J, Hosoya T, Yanaka A, Aburatani H, Fujii-Kuriyama Y, Motohashi H, Yamamoto M, Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions. Mol Cell Biol 2005;25:9360-8.
20. Thatcher TH, Maggirwar SB, Baglole CJ, Lakatos HF, Gasiewicz TA, Phipps RP, Sime PJ. Aryl hydrocarbon receptor-deficient mice develop heightened nflammatory responses to cigarette smoke and endotoxin associated with rapid oss of the nuclear factor-kappaB component RelB. Am J Pathol 2007;170:855-64.
21. Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelii E, Caccamo M, Oukka M, Weiner HL. Control of T(reg) and. T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 2008: 53:65-71.